COVID-19 Vaccine Effectiveness for Moderna and Janssen ...
COVID-19 Vaccine Effectiveness for Moderna and Janssen Vaccines
Jefferson Jones, MD MPH FAAP CDC COVID-19 Response CDR, US Public Health Service
coronavirus
Monitoring vaccine effectiveness (VE) evidence by risk group, outcome, and product over time
Risk group X Outcome X Product X Pre-Delta vs. Post-Delta or Time Since Vaccination
VE against infection or hospitalization by Delta predominance*
100% 90% 80% 70% 60%
65 years of age
COVID-NET (mRNA) NYS (all products)
VISION (Moderna) NYS (all products)
VISION (Pfizer)
100% 90% 80% 70% 60%
Underlying medical conditions
100%
SUPERNOVA (mRNA)
90%
IVY 1
80%
underlying
condition (all
70%
products) 60%
Frontline workers
HEROESRECOVER (mRNA)
Vaccine effectiveness (%) Vaccine effectiveness (%) Vaccine effectiveness (%)
50%
NHSN (mRNA)
50%
50%
40%
40%
40%
30%
30%
30%
20%
20%
20%
10%
10%
10%
0%
Pre-Delta
Delta
NHSN:
COVID-NET: CDC unpublished
IVY: CDC unpublished data NYS:
0%
Pre-Delta
Delta
0%
Pre-Delta
Delta
VISION:
SUPERNOVA: HEROES-RECOVER:
*Pre-delta: May 2021 or earlier
Delta: June 2021 or later
3
Rates of COVID-19 cases and hospitalizations among vaccinated
4 state public health departments: COVID-19 infection rates by month of vaccination, vaccine product, and age -- July 2021*
SARS-CoV-2 case rate per 100,000 vaccinated persons
SARS-CoV-2 case rate per 100,000 vaccinated persons
Moderna
500
18?491y8?49y
500
50?645y0?64y
400
400
65y 65y
300
300
Janssen
18?49y 50?64y 65y
200
200
100
100
0
FEB
MAR
APR
MAY
JUN
Month of vaccination
0
FEB
MAR
APR
MAY
JUN
Month of vaccination
*Utah, Indiana, New Mexico and New Jersey. A fully vaccinated case had SARS-CoV-2 RNA or antigen detected on a respiratory specimen collected 14
days after completing the primary series of an FDA-authorized or approved COVID-19 vaccine.
5
Cosmos: COVID-19 hospitalization rates by month of vaccination by month of vaccination, vaccine product, and age -- United States, August 2021*
SARS-CoV2-2 admission rate per 100,000 vaccinated persons
SARS-CoV2-2 admission rate per 100,000 vaccinated persons
Moderna
600
Janssen
600
500
500
400
400
300
300
200
200
100
100
0
JAN
FEB
MAR
APR
MAY
JUN
JUL
Month of vaccination
18-49 50-64 65+
0
JAN
FEB
MAR
APR
MAY
JUN
JUL
Month of vaccination
18-49 50-64 65+
* Hospitals and clinics that use Epic health record system and participate in Cosmos data set. See supplemental slides. COVID-19 hospitalization = hospital admission during
which patient had a COVID-19 diagnosis or hospital admission with any respiratory diagnosis within 14 days of a +PCR test or COVID-19 diagnosis
6
VE among people aged 65 years
COVID-19 VE against infection by month of vaccination, vaccine product, and age -- New York State, May?Aug 2021
8 Rosenberg et al. MedRxIV.
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