COVID-19 Vaccine Effectiveness for Moderna and Janssen ...

COVID-19 Vaccine Effectiveness for Moderna and Janssen Vaccines

Jefferson Jones, MD MPH FAAP CDC COVID-19 Response CDR, US Public Health Service

coronavirus

Monitoring vaccine effectiveness (VE) evidence by risk group, outcome, and product over time

Risk group X Outcome X Product X Pre-Delta vs. Post-Delta or Time Since Vaccination

VE against infection or hospitalization by Delta predominance*

100% 90% 80% 70% 60%

65 years of age

COVID-NET (mRNA) NYS (all products)

VISION (Moderna) NYS (all products)

VISION (Pfizer)

100% 90% 80% 70% 60%

Underlying medical conditions

100%

SUPERNOVA (mRNA)

90%

IVY 1

80%

underlying

condition (all

70%

products) 60%

Frontline workers

HEROESRECOVER (mRNA)

Vaccine effectiveness (%) Vaccine effectiveness (%) Vaccine effectiveness (%)

50%

NHSN (mRNA)

50%

50%

40%

40%

40%

30%

30%

30%

20%

20%

20%

10%

10%

10%

0%

Pre-Delta

Delta

NHSN:

COVID-NET: CDC unpublished

IVY: CDC unpublished data NYS:

0%

Pre-Delta

Delta

0%

Pre-Delta

Delta

VISION:

SUPERNOVA: HEROES-RECOVER:

*Pre-delta: May 2021 or earlier

Delta: June 2021 or later

3

Rates of COVID-19 cases and hospitalizations among vaccinated

4 state public health departments: COVID-19 infection rates by month of vaccination, vaccine product, and age -- July 2021*

SARS-CoV-2 case rate per 100,000 vaccinated persons

SARS-CoV-2 case rate per 100,000 vaccinated persons

Moderna

500

18?491y8?49y

500

50?645y0?64y

400

400

65y 65y

300

300

Janssen

18?49y 50?64y 65y

200

200

100

100

0

FEB

MAR

APR

MAY

JUN

Month of vaccination

0

FEB

MAR

APR

MAY

JUN

Month of vaccination

*Utah, Indiana, New Mexico and New Jersey. A fully vaccinated case had SARS-CoV-2 RNA or antigen detected on a respiratory specimen collected 14

days after completing the primary series of an FDA-authorized or approved COVID-19 vaccine.

5

Cosmos: COVID-19 hospitalization rates by month of vaccination by month of vaccination, vaccine product, and age -- United States, August 2021*

SARS-CoV2-2 admission rate per 100,000 vaccinated persons

SARS-CoV2-2 admission rate per 100,000 vaccinated persons

Moderna

600

Janssen

600

500

500

400

400

300

300

200

200

100

100

0

JAN

FEB

MAR

APR

MAY

JUN

JUL

Month of vaccination

18-49 50-64 65+

0

JAN

FEB

MAR

APR

MAY

JUN

JUL

Month of vaccination

18-49 50-64 65+

* Hospitals and clinics that use Epic health record system and participate in Cosmos data set. See supplemental slides. COVID-19 hospitalization = hospital admission during

which patient had a COVID-19 diagnosis or hospital admission with any respiratory diagnosis within 14 days of a +PCR test or COVID-19 diagnosis

6

VE among people aged 65 years

COVID-19 VE against infection by month of vaccination, vaccine product, and age -- New York State, May?Aug 2021

8 Rosenberg et al. MedRxIV.

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