Drug Name



Drug Name |Dosage & Route |Action |Indication |Adverse Effects |Contraindication |Nursing Responsibility | |

LOSARTAN POTASSIUM

(lo-sar'tan)

Cozaar

Classifications: cardiovascular agent; angiotensin ii receptor antagonist; antihypertensive

|

Hypertension

Adult: PO 25–50 mg in 1–2 divided doses (max: 100 mg/d); start with 25 mg/d if volume depleted (i.e., on diuretics) |

Angiotensin II receptor (type AT1) antagonist acts as a potent vasoconstrictor and primary vasoactive hormone of the renin–angiotensin–aldosterone system. |

Hypertension |

CNS: Dizziness, insomnia, headache. GI: Diarrhea, dyspepsia. Musculoskeletal: Muscle cramps, myalgia, back or leg pain. Respiratory: Nasal congestion, cough, upper respiratory infection, sinusitis. |

Hypersensitivity to losartan, pregnancy [category C (first trimester), category D (second and third trimesters)], lactation |

Assessment & Drug Effects

• Monitor BP at drug trough (prior to a scheduled dose).

• Monitor drug effectiveness, especially in African-Americans when losartan is used as monotherapy.

• Inadequate response may be improved by splitting the daily dose into twice-daily dose.

• Lab tests: Monitor CBC, electrolytes, liver & kidney function with long-term therapy.

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