Drug Name
Drug Name |Dosage & Route |Action |Indication |Adverse Effects |Contraindication |Nursing Responsibility | |
LOSARTAN POTASSIUM
(lo-sar'tan)
Cozaar
Classifications: cardiovascular agent; angiotensin ii receptor antagonist; antihypertensive
|
Hypertension
Adult: PO 25–50 mg in 1–2 divided doses (max: 100 mg/d); start with 25 mg/d if volume depleted (i.e., on diuretics) |
Angiotensin II receptor (type AT1) antagonist acts as a potent vasoconstrictor and primary vasoactive hormone of the renin–angiotensin–aldosterone system. |
Hypertension |
CNS: Dizziness, insomnia, headache. GI: Diarrhea, dyspepsia. Musculoskeletal: Muscle cramps, myalgia, back or leg pain. Respiratory: Nasal congestion, cough, upper respiratory infection, sinusitis. |
Hypersensitivity to losartan, pregnancy [category C (first trimester), category D (second and third trimesters)], lactation |
Assessment & Drug Effects
• Monitor BP at drug trough (prior to a scheduled dose).
• Monitor drug effectiveness, especially in African-Americans when losartan is used as monotherapy.
• Inadequate response may be improved by splitting the daily dose into twice-daily dose.
• Lab tests: Monitor CBC, electrolytes, liver & kidney function with long-term therapy.
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