Stability of Common Insulins in Vials and Pens - Diabetes In Control

 Insulin Vials

Novolog (aspart) Humalog (lispro)

Stability of Common Insulins in Vials and Pens1,2

Stability Unopened and Stored in the

Refrigerator

Opened at Room or Refrigerator Temperature (days)1

Rapid-Acting Insulim

The expiration date on the label

28

The expiration date on the label

28

Unopened at Room

Temperature (days)1

28

28

Apidra (glulisine)

The expiration date on the label

28

28

Short-Acting Insulin

Humulin R (regular)

The expiration date on the label

31

31

42

Novolin R (regular)

The expiration date on the label

Do not refrigerate

42

Humulin R U-500

The expiration date on the label

40

40

Intermediate-Acting Insulin (NPH)

Humulin N

The expiration date on the label

31

31

Originally prepared by: Brandon Flohr Pharm.D. Candidate Originally edited by: Janice Li Pharm D. Candidate

Updated: November ?

Image

Novolin N

Humulin 70/30

Stability of Common Insulins in Vials and Pens1,2

The expiration date on the label

42 Do not refrigerate

42

Pre-Mixed Insulin

31

The expiration date on the label

Do not refrigerate

31

Novolin 70/30

The expiration date on the label

42

42

Humalog 75/25

The expiration date on the label

28

28

Humalog 50/50

The expiration date on the label

28

28

Novolog 70/30

The expiration date on the label

28

28

Long-Acting Insulin

The expiration date on

Lantus (glargine)

the label

28

28

The expiration date on

Levemir (detemir)

the label

42

42

Originally prepared by: Brandon Flohr Pharm.D. Candidate Originally edited by: Janice Li Pharm D. Candidate

Updated: November ?

Insulin Pens

Humalog KwikPen (lispro)

Novolog FlexPen (aspart)

NovoPen Echo (aspart)

Apidra Solostar (glulisine)

Apidra OptiClik

Humulin R U-500 KwikPen

Stability of Common Insulins in Vials and Pens1,2

Stability Unopened Opened at Room or

and Stored in the

Refrigerator

Refrigerator

Temperature (days)1

Rapid-Acting Insulin

The expiration date on

28

the label

Do not refrigerate

The expiration date on

28

the label

Do not refrigerate

The expiration date on

28

the label

Do not refrigerate

The expiration date on

28

the label

Do not refrigerate

The expiration date on

28

the label

Do not refrigerate

The expiration date on the label

28 Do not refrigerate

Unopened at Room

Temperature (days)1

28 28 28 28 28

28

Humulin N pen Novolin N pen

Intermediate-Acting Insulin (NPH)

The expiration date on

14

14

the label

The expiration date on

14

14

the label

Long-Acting Insulin

Lantus SoloStar

The expiration date on

28

28

the label

Do not refrigerate

Lantus OptiClik

The expiration date on

28

28

the label

Do not refrigerate

Levmir FlexPen

The expiration date on

42

42

the label

Do not refrigerate

Originally prepared by: Brandon Flohr Pharm.D. Candidate Originally edited by: Janice Li Pharm D. Candidate

Updated: November ?

Image

Novolog Mix 70/30 Flexpen Tresiba Flextouch Pen (degludec) Toujeo (glargine)

Baslaglar

Stability of Common Insulins in Vials and Pens1,2

The expiration date on

14

14

the label

Do not refrigerate

The expiration date on

56

56

the label

The expiration date on

42

42

the label

Do not refrigerate

The expiration date on

28

28

the label

Do not refrigerate

Humalog Mix KwikPen 50/50 Humalog Mix 75/25

KwikPen Humulin 70/30 Pen

Ryzodeg 7030

Byetta (exenatide)

Pre-Mixed Insulin

The expiration date on

10

10

the label

Do not refrigerate

The expiration date on

10

10

the label

Do not refrigerate

The expiration date on

10

10

the label

Do not refrigerate

The expiration date on

28

28

the label

Miscellaneous Non-Insulin Agents Incretin Mimetics

The expiration date on

30

30

the label

Bydureon (exenatide) The expiration date on

28

28

the label

Victoza (liraglutide) The expiration date on

30

30

the label

Tanzeum (albiglutide) The expiration date on

28

28

the label

Trulicity (dulaglutide) The expiration date on

14

14

the label

Originally prepared by: Brandon Flohr Pharm.D. Candidate Originally edited by: Janice Li Pharm D. Candidate

Updated: November ?

Adlyxin (lixisenatide)

Stability of Common Insulins in Vials and Pens1,2

14

The expiration date on

14

Do not store unopened

the label

at room temp

Amylin analogs

Symlin pen

The expiration date on

30

30

(pramlintide)

the label

The expiration date on

Symlin (pramlintide)

the label

30

30

Xultophy (degludec/liraglutide)

Soliqua (glargine/lixisenatide)

Mixed long acting insulin/Incretin Mimetics

The expiration date on

21

21

the label

Do not store unopened

at room temp

The expiration date on the label

28 Do not refrigerate

28 Do not store unopened

at room temp

1. Room temperature considered 15-30oC (59-86oF)

Tablets adapted from Dipro and Pharmacist letter

References:

1. Triplitt CL, Reasner CA, Isley W. Diabetes Mellitus. In: DiPiro JT, Talbert RL, Yee GC, eds. Pharmacotherapy: A Pathophysiologic Approach, 7th ed. New York, NY: McGraw-Hill;2008:1205-41.

2. Comparison of Insulins and Injectable Diabetes Meds. Pharmacist's Letter/ Prescribers Letter. Stockton, CA. March 2010;26(260304):1-10.

3. Drugs for Type 2 Diabetes. Pharmacist's Letter/ Prescribers Letter. Stockton, CA. June 2015.

Originally prepared by: Brandon Flohr Pharm.D. Candidate Originally edited by: Janice Li Pharm D. Candidate

Updated: November ?

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