Uterine_
Flucytosine (like 5-FU) tx systemic mycoses only in combo w/amphotericin B ( synergistic (amphotericin pokes holes for flucytosine to enter) and prevents R. For subcut chromomycosis, used alone. Mech: Converted to 5-FdUMP, which inh thymidylate synthetase. Also met to 5-FUTP and incorp. into fungal RNA ( disruption of protein synth. ................
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