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Supplement Table 1. Perioperative use of glucocorticoidsVariablesAll patients (n=215)Full cohort (n=215)Matched cohort (n=128)With glucocorticoids (n=112)Without glucocorticoids (n=103)With glucocorticoids (n=64)Without glucocorticoids (n=64)Intraoperative dexamethasone89 (41.4%)89 (79.5%)0 (0.0%)54 (84.4%)0 (0.0%)5 mg3232015010 mg57570390Intraoperative methylprednisolone23 (10.7%)23 (20.5%)0 (0.0%)10 (15.6%)0 (0.0%)40mg1101060 mg3301080 mg1919080Postoperative dexamethasone9 (4.2%)9 (8.0%)0 (0.0%)5 (7.8%)0 (0.0%)5 mg5502010 mg44030Results are presented as number (%).Supplement Table 2. Perioperative use of opioidsVariableAll patients (n=215)Full cohort (n=215)Matched cohort (n=128)With glucocorticoids (n=112)Without glucocorticoids (n=103)P valueWith glucocorticoids (n=64)Without glucocorticoids (n=64)P valueIntraoperative opioidsFentanyl76 (35.3%)34 (30.4%)42 (40.8%)0.11823 (35.9%) 19 (29.7%)0.573Fentanyl dosage (ug)a150 (100-200)120 (100-200)200 (100-200)0.049120 (100-200)100 (100-200)0.983Sufentanil139 (64.7%)77 (68.8%)62 (60.2%)0.20244 (46.8%)47 (50.0%)0.697 Sufentanil dose (ug) a20 (15-30)20 (15-30)25 (20-30)0.88820 (15-30)25 (20-35)0.115 Oxycodone36 (16.7%)28 (25.0%)8 (7.8%)0.00112 (18.8%)8 (12.5%)0.466 Oxycodone dose (mg)a12 (5-20)12 (10-20)10 (5-20)0.00513 (12-20)10 (5-20)0.393 Dezocine58 (27.0%)41 (36.6%)17 (16.5%)0.00119 (29.7%)16 (25.%)0.692 Dezocine dose (mg) a10 (10-18)10 (10-20)10 (10-12)<0.00110 (10-20)10 (10-12)0.272Postoperative opioids None b13 (6.0%)2 (1.8%)11 (10.7%)0.0081 (1.6%)3 (4.7%)0.619 Morphine12 (5.6%)5 (4.5%)7 (6.8%)0.5584 (6.3%)0 (0.0%)0.119Morphine dose (mg) a30 (10-100)30 (10-100)50 (8-100)0.50030 (10-80)0 (0-0)0.082Fentanyl5 (2.3%)3 (2.7%)2 (1.9%)>0.9992 (3.1%)1 (1.6%)>0.999Fentanyl dosage (ug) a500 (400-500)500 (400-500)500 (200-500)0.527500 (400-500)500 (500-500)0.622Sufentanil143 (66.5%)78 (69.6%)65 (63.1%)0.31644 (6.9%)47 (73.4%)0.697 Sufentanil dose (ug) a300 (225-300)300 (225-300)300 (225-300)0.526300 (225-300)300 (225-300)0.770 Oxycodone23 (10.7%)18 (16.1%)5 (4.9%)0.0089 (14.1%) 4 (6.3%)0.241 Oxycodone dose (mg)a30 (20-40)20 (20-30)60 (40-75)0.29820 (10-20)40 (40-75)0.941 Dezocine65 (30.2%)43 (38.4%)22 (21.4%)0.00819 (29.7%)19 (29.7%)>0.999 Dezocine dose (mg) a65 (55-70)10 (10-20)60 (50-70)0.00710 (10-20)60 (50-70)0.955Results are presented as number (%) or median (interquartile range). P values in bold indicate those of <0.05.a Dose of patients who received the medication. b These patients received epidural analgesia through epidural catheter and only local anesthetics were used.Supplement Table 3. Perioperative use of NSAIDsVariableAll patients (n=215)Full cohort (n=215)Matched cohort (n=128)With glucocorticoids (n=112)Without glucocorticoids(n=103)P valueWith glucocorticoids (n=64)Without glucocorticoids(n=64)P valueIntraoperative flurbiprofen axetil99 (46.0%)48 (42.9%)51 (49.5%)0.34133 (51.6%)35 (54.7%)0.86050 mg 211--11--100 mg944549--3134--200 mg321--10--Postoperative flurbiprofen axetil102 (47.4%)51 (45.5%)51 (49.5%)0.58635 (54.7%)38 (59.4%)0.721100 mg523--21--150 mg303--03--200 mg401723--1217--250 mg330--10--300 mg452520--1815--350 mg110--10--400 mg532--12--Intraoperative parecoxib 20 (9.3%)13 (11.6%)7 (6.8%)0.2497 (10.9%)6 (9.4%)>0.99920 mg211--11--40 mg954--23--60 mg422--22--80 mg550--20--Results are presented as number (%).NSAIDs, non-steroid anti-inflammatory drugs. Supplement Table 4. Postoperative individual complications a.VariableAll patients (n=215)Full cohort (n=215)Matched cohort (n=128)With glucocorticoids (n=112)Without glucocorticoids (n=103)P valueWith glucocorticoids (n=64)Without glucocorticoids (n=64)P valueAcute coronary syndrome b1 (0.5%)1 (0.9%)0 (0.0%)0.5211 (1.6%)0 (0.0%)>0.999Atelectasis c7 (3.3%)5 (4.5%)2 (1.9%)0.4482 (3.1%)1 (1.6%)>0.999Pleural effusion d5 (2.5%)1 (0.9%)4 (3.9%)0.1961 (1.6%)2 (3.1%)>0.999Acute respiratory failure e2 (0.9%)1 (0.9%)1 (1.0%)>0.9991 (1.6%)0 (0.0%)>0.999Respiratory infection f2 (0.9%)0 (0.0%)2 (1.9%)0.2280 (0.0%)1 (1.6%)>0.999Delayed gastric emptying g15 (7.0%)8 (7.1%)7 (6.8%)>0.9996 (9.4%)4 (6.3%)0.744Pancreatic fistula h12 (5.6%)3 (2.7%)9 (8.7%)0.0741 (1.6%)7 (10.9%)0.062Hepatic insufficiency i6 (2.8%)3 (2.7%)3 (2.9%)>0.9991 (1.6%)1 (1.6%)>0.999Biliary fistula j1 (0.5%)0 (0.0%)1 (1.0%)0.4790 (0.0%)1 (1.6%)>0.999Chylous fistula k1 (0.5%)0 (0.0%)1 (1.0%)0.4790 (0.0%)0 (0.0%)>0.999Acute kidney injury l2 (0.9%)0 (0.0%)2 (1.9%)0.2280 (0.0%)2 (3.1%)0.496Postoperative bleeding m6 (2.8%)2 (1.8%)4 (3.9%)0.4301 (1.6%)3 (4.7%)0.619Deep venous thrombosis n3 (1.4%)2 (1.8%)1 (1.0%)>0.9991 (1.6%)1 (1.6%)>0.999Surgical site infection o6 (2.8%)3 (2.7%)3 (2.9%)>0.9992 (3.1%)2 (3.1%)>0.999In-hospital death 2 (0.9%)1 (0.9%)1 (1.0%)>0.9991 (1.6%)1 (1.6%)>0.999Data are median (95% confidence interval), number (%), or median (interquartile range). 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ADDIN EN.CITE.DATA 27 b Confirmed by clinical symptoms, electrocardiographic changes and elevated cardiac troponin I levels.c Confirmed by chest x-rays, with desaturation, and necessitated physiotherapy and/or bronchoscopy.d Confirmed by chest X-ray and required thoracentesis or chest tube drainage. e Arterial oxygen partial pressure <60 mmHg, with/without arterial carbon dioxide partial pressure >50 mmHg, when respirating room air.f New infiltration on chest X-ray with fever and treated with intravenous antibiotics.g Gastric tube drainage >800 ml/d, with no other obvious reasons. h The concentration of pancreatic enzyme in the peritoneal drainage fluid was 3 times higher than the serum value for more than 3 days after surgery. i Prolonged prothrombin time (>18s) and elevated serum total bilirubin concentration (>30 μmol/l or 1.7 mg/dl) within 7 days after surgery, requiring interventions. j Bile-like fluid in the abdominal drainage fluid with a volume >100 ml per day after surgery, or bile-like fluid extracted from the local peritoneal effusion under ultrasound and computed tomography positioning. k Triglyceride content in the liquid leakage >110 mg/dl. l Increased serum creatinine ≥0.3 mg/dl (≥26.5 μmol/l) within 7 days after surgery. m Required second surgery for hemostasis.n Confirmed by lower limbs venous ultrasonography and treated with anticoagulants.o Pus expressed from the incision, and bacteria cultured from the pus or purulent puncture extract.Supplement Table 5. Estimated survival rate after surgeryVariableAll patients (n=215)Full cohort (n=215)Matched cohort (n=128)With glucocorticoids (n=112)Without glucocorticoids (n=103)With glucocorticoids (n=64)Without glucocorticoids (n=64)Recurrence-free survival rate (%)1 year 44.9 (38.2-51.6)53.9 (44.5-63.3)35.3 (26.1-44.5)53.2 (40.8-65.5)36.5 (24.5-48.5)2 years 24.6 (18.7-30.5)33.0 (24.0-42.0)15.7 (8.6-22.8)31.6 (19.8-43.4)15.9 (6.9-24.9)3 years 13.2 (8.5-17.9)19.9 (12.1-27.7)6.1 (1.2-11.0)21.1 (10.7-31.5)7.9 (1.2-14.6)5 years 10.8 (6.5-15.1)16.4 (9.1-23.7)4.9 (0.6-9.2)17.4 (7.6-27.2)4.2 (1.1-9.5)Overall survival rate (%)1 year 70.8 (64.7-76.9)78.4 (70.8-86.0)62.4 (53.0-71.8)73.4 (62.6-84.2)66.8 (55.2-78.4)2 years 36.4 (29.9-42.9)45.4 (36.0-54.8)26.5 (17.7-35.3)42.1 (29.9-54.3)29.8 (18.4-41.2)3 years 24.6 (18.5-30.7)32.9 (23.9-41.9)15.4 (8.0-22.8)28.0 (16.6-39.4)19.4 (9.4-29.4)5 years 11.1 (6.2-16.0)16.0 (8.0-24.0)5.8 (0.5-11.1)18.6 (7.8-29.4.)9.7 (1.0-18.3)Results are presented as % (95% CI).Supplement Table 6. Univariable association with recurrence-free and overall survival (full cohort, n=215; Cox proportional hazard ratio model).Recurrence-free survivalOverall survivalEvents/totalHR (95% CI)P valueEvents/totalHR (95% CI)P valueAge (y)<6069/82169/82160-6964/740.93 (0.66-1.31)0.68261/740.95 (0.68-1.35)0.783≥7056/591.46 (1.02-2.08)0.03752/591.52 (1.06-2.18)0.024SexFemale78/90177/901Male111/1251.12 (0.84-1.50)0.438105/1251.04 (0.77-1.40)0.799Body mass index (kg/m2)24.9145/1631139/16312544/520.81 (0.58-1.14)0.23543/520.87 (0.62-1.22)0.411History of stroke No182/2071175/2071Yes7/81.08 (0.50-2.36)0.8387/81.06 (0.49-2.31)0.880Coronary heart diseaseNo176/2001171/2001Yes13/151.02 (0.58-1.79)0.95311/150.985 (0.53-1.82)0.960HypertensionNo136/1501131/1501Yes53/650.78 (0.57-1.08)0.41951/650.856 (0.62-1.18)0.347ArrhythmiaNo147/1681138/1681Yes42/471.11 (0.79-1.56)0.56044/471.15 (0.82-1.62)0.409DiabetesNo145/1671141/1671Yes44/480.87 (0.62-1.22)0.41941/480.85 (0.60-1.21)0.375Hepatorenal dysfunction aNo100/113194/1131Yes89/1021.22 (0.91-1.62)0.18488/1021.22 (0.91-1.63)0.191Chronic pulmonary disease bNo167/1911164/1911Yes22/240.99 (0.63-1.54)0.95818/240.85 (0.52-1.39)0.528ASA grade0.357I, II173/1971167/1971III16/181.28 (0.76-2.13)0.35415/181.28 (0.76-2.18)0.357Preoperative CA19-9 <240 U/ml94/108194/1081≥240 U/ml95/1071.21 (0.91-1.61)0.19788/1071.09 (0.81-1.46)0.570Preoperative albumin <35 g/LNo177/2011170/2011Yes12/140.82 (0.45-1.48)0.50712/140.93 (0.51-1.67)0.797Preoperative anemia cNo156/1811151/1811Yes33/341.27 (0.87-1.85)0.21831/341.20 (0.82-1.77)0.353Pathological diagnosisDuctal adenocarcinoma181/2031172/2031 Others d8/120.39 (0.19-0.79)0.00910/120.49 (0.26-0.95)0.034Maximum diameter<30 mm98/113198/1131≥30 mm91/1021.00 (0.75-1.33)0.98284/1020.97 (0.72-1.30)0.821pTNM stage eIA,IB,IIA76/90172/901IIB,III,IV113/1251.92 (1.42-2.58)<0.001110/1252.02 (1.48-2.75)<0.001Differentiation gradeModerate and high105/123179/921Low 84/921.81 (1.35-2.42)<0.001103/1231.83 (1.36-2.47)<0.001Period of surgery 2005-April 200732/35132/351 May 2007-201286/1000.97 (0.64-1.45)0.87687/1000.93 (0.62-1.39)0.717 2013-201671/800.81 (0.53-1.23)0.07963/800.68 (0.44-1.04)0.073Type of surgery Pancreaticoduodenectomy/total pancreatectomy134/1541132/1541Distal pancreatosplenectomy55/610.87 (0.64-1.20)0.40150/610.86 (0.62-1.20)0.369Duration of surgery <300 min91/102187/1021≥300 min98/1131.05 (0.79-1.40)0.74895/1131.03 (0.77-1.38)0.831Margin statusNegative165/1901159/1901Positive24/252.11 (1.37-3.26)0.00123/252.64 (1.69-4.13)<0.001Type of anesthesia General 177/2001168/2001Combined 12/150.75 (0.42-1.36)0.34314/150.94 (0.54-1.64)0.838Duration of anesthesia <330 min93/104188/1041 ≥330 min96/1111.08 (0.81-1.44)0.58194/1111.10 (0.82-1.47)0.540Use of propofolNo15/15111/151Yes174/2000.860 (0.50-1.48)0.587171/2001.34 (0.72-2.51)0.356Use of etomidateNo109/1231104/1231Yes80/921.04 (0.78-1.39)0.77878/921.10 (0.82-1.47)0.542Inhalational anesthetics Sevoflurane134/1541128/1541Isoflurane 55/611.19 (0.87-1.64)0.27254/611.36 (0.99-1.88)0.059Sufentanil equivalent (ug)f<255 ug96/107190/1071≥255 ug93/1080.84 (0.63-1.12)0.24492/1080.89 (0.66-1.19)0.413Estimated blood loss<400 ml110/1291100/1291≥400 ml79/861.43 (1.06-1.91)0.01782/861.58 (1.17-2.12)0.002Intraoperative blood transfusion gNo146/1671140/1671Yes43/481.09 (0.77-1.53)0.64042/481.22 (0.86-1.73)0.265Intraoperative artificial colloid<1000 ml h43/46138/461≥1000 ml146/1690.81 (0.58-1.14)0.229144/1690.91 (0.63-1.31)0.600Perioperative NSAIDs iNo76/85170/851Yes113/1300.92 (0.69-1.23)0.564112/1300.99 (0.73-1.34)0.947Perioperative glucocorticoids jNo98/103192/1031Yes91/1120.57 (0.43-0.77)<0.00190/1120.59 (0.44-0.79)<0.001Postoperative complications kNo142/1641134/1641Yes47/511.48 (1.06-2.06)0.02148/511.62 (1.16-2.25)0.005Postoperative radiotherapyNo169/1931167/1931Yes20/221.01 (0.64-1.61)0.96015/220.73 (0.43-1.24)0.240Postoperative chemotherapyNo98/112195/1121Yes91/1030.66 (0.50-0.88)0.00587/1030.60 (0.45-0.81)0.001Results are presented as median (95% CI). 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ADDIN EN.CITE.DATA [21-23]. g Packed red blood cells were transfused. h Includes 1 patient who did not receive artificial colloids during surgery. i Includes flurbiprofen axetil and parecoxib sodium. j Includes dexamethasone and methylprednisolone. k Defined as new onset conditions that required medical intervention. Includes delayed gastric emptying, biliary leak, pancreatic leak, chylous leak, surgical site infection, atelectasis, pleural effusion, pulmonary infection, acute respiratory failure, and deep vein thrombosis.Supplement Table 7. Univariable association with recurrence-free and overall survival (matched cohort, n=128; Cox proportional hazard ratio model).Recurrence-free survivalOverall survivalEvents/total NHR (95% CI)P valueEvents/total NHR (95% CI)P valueAge (y)<6041/49140/49160-6937/430.93 (0.60-1.46)0.76236/430.95 (0.61-1.50)0.834≥7035/361.42 (0.91-2.24)0.12631/361.34 (0.84-2.14)0.226SexFemale47/54146/541Male66/741.12 (0.77-1.64)0.54461/740.98 (0.67-1.44)0.926Body mass index (kg/m2)24.985/94180/9412528/340.76 (0.49-1.160)0.19927/340.84 (0.54-1.30)0.430History of stroke No108/1231102/1231Yes5/51.25 (0.49-3.18)0.6435/51.24 (0.49-3.15)0.650Coronary heart diseaseNo103/117198/1151Yes10/111.10 (0.57-2.11)0.7769/130.93 (0.45-1.92)0.846HypertensionNo79/89176/891Yes34/391.02 (0.68-1.53)0.93931/390.96 (0.63-1.47)0.860ArrhythmiaNo81/94175/941Yes32/341.28 (0.85-1.93)0.24432/341.30 (0.86-1.97)0.219DiabetesNo87/100184/1001Yes26/280.84 (0.54-1.31)0.44823/280.82 (0.52-1.30)0.401Hepatorenal dysfunction aNo59/67155/671Yes54/611.63 (1.11-2.37)0.01252/611.50 (1.02-2.20)0.040Chronic pulmonary disease bNo101/115199/1151Yes12/131.16 (0.63-2.11)0.6379/130.94 (0.48-1.87)0.867ASA gradeI, II105/1191100/1191III8/91.00 (0.49-2.07)0.9947/90.80 (0.37-1.73)0.578Preoperative CA19-9 <240 U/ml57/65155/651≥240 U/ml56/631.27 (0.88-1.85)0.20752/631.23 (0.84-1.81)0.282Preoperative albumin <35 g/LNo104/117198/1171Yes9/110.83 (0.42-1.66)0.6039/110.93 (0.47-1.86)0.838Preoperative anemia cNo93/108190/1081Yes20/201.28 (0.79-2.08)0.32317/200.97 (0.57-1.63)0.896Pathological diagnosisDuctal adenocarcinoma110/1241103/1241 Others d3/40.28 (0.09-0.88)0.0304/40.39 (0.14-1.08)0.071Maximum diameter<30 mm52/63152/631≥30 mm61/651.15 (0.79-1.67)0.45755/661.06 (0.72-1.55)0.779pTNM stage eIA,IB,IIA48/57145/571IIB,III,IV65/712.08 (1.41-3.05)<0.00162/711.93 (1.30-2.87)0.001Differentiation gradeModerate and high59/69156/691Low 54/591.73 (1.19-2.51)0.00451/591.73 (1.17-2.55)0.006Period of surgery 2005-April 200710/11111/111 May 2007-201264/731.44 (0.74-2.83)0.28563/731.28 (0.67-2.45)0.455 2013-201639/441.14 (0.56-2.31)0.71433/440.88 (0.44-1.76)0.718Type of surgery Pancreaticoduodenectomy/total pancreatectomy80/90177/901Distal pancreatosplenectomy33/380.73 (0.48-1.10)0.13030/380.72 (0.47-1.10)0.129Duration of surgery <300 min56/64154/641≥300 min57/641.20 (40.85-1.79)0.26353/641.16 (0.79-1.69)0.457Margin statusNegative103/118197/1181Positive10/103.73 (1.90-7.33)<0.00110/104.02 (2.05-7.88)<0.001Type of anesthesia General 108/1221101/1221Combined 5/60.50 (0.20-1.25)0.1376/60.71 (0.31-1.66)0.433Duration of anesthesia <330 min55/63153/631 ≥330 min58/651.28 (0.88-1.85)0.19454/651.18 (0.81-1.73)0.393Use of propofolNo9/919/91Yes104/1190.76 (0.38-1.53)0.44798/1190.95 (0.48-1.90)0.886Use of etomidateNo63/72158/721Yes50/561.23 (0.85-1.78)0.28349/561.28 (0.87-1.88)0.204Inhalational anestheticsSevoflurane83/96178/961Isoflurane 30/321.53 (1.00-2.33)0.04929/321.67 (1.08-2.57)0.021Sufentanil equivalent (ug)f<255 g58/64154/641≥255 g55/640.91 (0.63-1.32)0.62853/640.92 (0.63-1.35)0.664Estimated blood loss<400 ml71/82163/821≥400 ml42/461.45 (0.99-2.14)0.05944/461.59 (1.08-2.35)0.020Intraoperative blood transfusion gNo92/104186/1041Yes21/241.14 (0.70-1.86)0.59421/241.18 (0.72-1.92)0.507Intraoperative artificial colloid<1000 ml h25/28123/281≥1000 ml88/1000.85 (0.54-1.33)0.48184/1000.91 (0.57-1.45)0.691Perioperative NSAIDs iNo37/40132/401Yes76/881.08 (0.73-1.60)0.70775/881.20 (0.79-1.82)0.387Perioperative glucocorticoids jNo61/64156/641Yes52/640.63 (0.43-0.92)0.01751/640.73 (0.50-1.07)0.107Postoperative complications kNo84/95177/951Yes29/331.30 (0.85-1.98)0.22930/331.53 (1.00-2.34)0.050Postoperative radiotherapyNo102/1161100/1161Yes11/121.07 (0.57-2.00)0.8307/120.71 (0.33-1.53)0.377Postoperative chemotherapyNo59/68157/681Yes54/600.81 (0.56-1.17)0.25050/600.73 (0.50-1.07)0.111Results are presented as median (95% CI). 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ADDIN EN.CITE.DATA [21-23]. g Packed red blood cells were transfused. h Includes 1 patient who did not receive artificial colloids during surgery. i Includes flurbiprofen axetil and parecoxib sodium. j Includes dexamethasone and methylprednisolone. k Defined as new onset conditions that required medical intervention. Includes delayed gastric emptying, biliary leak, pancreatic leak, chylous leak, surgical site infection, atelectasis, pleural effusion, pulmonary infection, acute respiratory failure, and deep vein thrombosis. ................
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