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In contrast, activation of adenosine receptor A2A by a selective agonist CGS21680 increased ILC3 production of IL-22 in a concentration-dependent manner (Fig. ure. s. 4. e,f). This is in agreement with our observation that ILC3s highly express the A2A gene (encoded by . Adora2a), rather than other adenosine receptors (Supplementary Fig. ure . 6 ................
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