Www.heartrhythmjournal.com



Supplemental MethodsPatient characteristicsPOAF, defined as new-onset AF in the immediate period (within 30 days) after cardiothoracic surgery, is the most important type of secondary AF PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW51YXJ5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW51YXJ5PC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48

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ADDIN EN.CITE.DATA 1. In the current study, SR patients were included that developed POAF within 7 days after cardiac surgery. The control group consisted of persons who either had Wolff-Parkinson-White syndrome, premature ventricular beats or referred to Brugada syndrome screening (Ajmaline testing). These patients were eligible for inclusion in case of absence of any atrial tachyarrhythmia. Follow-up was not performed in this group. According to the classification of American College of Cardiology guidelines: normal LVF is 50% to 70% (midpoint 60%) LVEF; mild impairment of LVF is 40% to 49% (midpoint 45%) LVEF; moderate impairment of LVF is 30% to 39% (midpoint 35%) LVEF; severe impairment of LVF is less than 30% LVEF PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5jeTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 2. AF patients underwent ECV (N=75) or PVI (N=88) for either PAF or PeAF. Exclusion criteria withdrew patients with paced atrial rhythms. Patients undergoing PVI, were screened for AF recurrences at 3, 6 and 12 months after the procedure. 3 months post-procedural follow-up telephone consultation was scheduled with patients undergoing ECV. AF recurrence was defined as an AF episode documented on either a 12-lead surface ECG or other rhythm recording devices, including Holter recordings or implantable loop recorders. Clinical characteristics were obtained from the electronic patient file. In addition, clinical tests, including creatinine, leucocytes and CRP were performed to determine the presence of inflammation and renal dysfunction. Patients revealing inflammation and/or renal dysfunction were excluded from the study. DNA damage marker 8-OHdG measurementBlood samples were collected in BDTM VacutainerTM SSTTM II Advance Tubes (Thermo Fisher Scientific, The Netherlands) as described in the Halt and Reverse study (MEC 2014-393) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW50ZXJzPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48

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ADDIN EN.CITE.DATA 3. Serum was collected after centrifugation at 2000xg for 10 min at 4°C and appropriately stored at -80°C. In human serum samples, the level of 8-OHdG was measured with the oxidative DNA damage enzyme linked immunosorbent assay (ELISA) kit (STA-320-5, Cell Biolabs, Inc. CA, USA). On the day of the measurement, the human serum samples were defrosted and then utilized for 8-OHdG measurements according to the instructions of the manufacturer. Reference ADDIN EN.REFLIST 1.January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation Dec 2 2014;130:e199-267.2.Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol Oct 15 2013;62:e147-239.3.Lanters EA, van Marion DM, Kik C, Steen H, Bogers AJ, Allessie MA, Brundel BJ, de Groot NM. HALT & REVERSE: Hsf1 activators lower cardiomyocyt damage; towards a novel approach to REVERSE atrial fibrillation. J Transl Med Nov 5 2015;13:347. ................
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