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ACE inhibitor ODEpidemiologyBenignToxic doseToxic MechanismIn paedsCan ingest up to 2-3x normal daily dose without any effectsPharmacologyACEi reversibleHalf LifePeak Level1-2hrsSymptomsOnset within 2hrs, may last several hours; mod hypotension that responds well to IVFInvestigationsMay be mild hyperK and renal impairmentTreatmentIVF 10-20ml/kg bolusDecontaminationCharcoal: if <1hrs, but unlikely to alter clinical courseEliminationNoAntidoteNoMonitoringDispositionObserve 4hrs; if symptomatic, admit non-mon bed until symptoms resolve ................
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