PDF ACUTE CONJUNCTIVITIS - RPS Diagnostics
ACUTE CONJUNCTIVITIS
Conjunctivitis (also known as pink eye) is a common condition, affecting approximately 6 million Americans each year.1 Conjunctivitis can be caused by virus, bacteria, or allergens, and prevalence varies based on time of year and geographic location.2 Globally, up to 70% of acute conjunctivitis is viral,3 and up to 90% of viral conjunctivitis is caused by Adenovirus.4 In the United States, approximately one in four patients with acute conjunctivitis have confirmed Adenoviral conjunctivitis.
Adenovirus can live on inanimate surfaces for 4-5 weeks4 and is highly contagious. Transmission rates of up to 50% have been reported;4 modes of transmission are hand-to-eye and airborne respiratory droplets. Co-infections occur in 1-2% of conjunctivitis cases and do not require antibiotic therapy,5-6 and misdiagnosis of conjunctivitis occurs in approximately 50% of all conjunctivitis cases.2
Overlap in Clinical Signs and Symptoms of Acute Conjunctivitis
Redness/infected
81%
conjunctiva
83%
Purulent
25%
discharge
28%
Viral Bacterial
Mucoidal
19%
discharge 17%
Irritation/foreign
19%
body sensation
17%
47%
Follicles
42%
Watery discharge/tearing
50% 39%
Itching
38% 33%
ADENOPLUS?
AdenoPlus? is the first and only FDA cleared, CLIA-waived, point-of-care (POC) test that detects all serotypes known to typically cause Adenoviral conjunctivitis.
Results in 10 minutes Single-use disposable test Utilizes direct tear sample; no extraction or dilution steps
No ancillary analyzer, equipment, or reagent required Dedicated CPT reimbursement code (87809QW) Accurate ? 90% sensitive and 96% specific7
RECOMMENDED IN PROFESSIONAL GUIDELINES
American Academy of Ophthalmology: Conjunctivitis Preferred Practice Patterns
American Academy of Pediatrics: Red Book
American College of Physicians: Physician Information and Education Resource
Evidence-based clinical website UpToDate?
NATIONAL CAMPAIGN ? CHOOSING WISELY?
The American Academy of Ophthalmology recently partnered with the American Board of Internal Medicine's national campaign, Choosing Wisely, to publicize the importance against providing antibiotics to patients with Adenoviral conjunctivitis.
Originally conceived by the National Physicians Alliance, the Choosing Wisely program helps physicians and patients engage about proper testing and treatment to aid in reducing unnecessary tests and antibiotics and to focus on appropriate and necessary treatments.
CLINICAL AND ECONOMIC VALUE
Conjunctivitis, due to its common occurrence, contagiousness, and potentially debilitating morbidities, is a global economic burden. By helping improve accuracy and timeliness of diagnosis, AdenoPlus may help facilitate appropriate management and treatment of conjunctivitis, resulting in overall reduction in spread of disease and reduction in total healthcare costs.
Antibiotic resistance costs in the United States may create up to $20 billion a year in excess direct healthcare costs; lost productivity may add an additional $15 billion in annual costs8 Approximately $800 million is spent annually in the United States to treat conjunctivitis Employee absenteeism, lost wages, and decreased productivity attributable to conjunctivitis represent $1.9 billion of additional indirect costs in the United States each year9 Adenoviral conjunctivitis is associated with significant morbidity, such as decreased visual acuity or light sensitivity from subepithelial infiltrates,10 chronic epiphora from lacrimal drainage problems,11 or visual loss from conjunctival foreshortening and symblepharon formation.12
RAPID PATHOGEN SCREENING, INC. (RPS)
RPS's novel POC tests bridge the gap between current clinical practice and the standard of care, helping physicians provide the best possible patient management while acting as good stewards of therapeutic resources. Founded in 2004, RPS is an emerging developer, manufacturer, and marketer of POC diagnostic tests based in Sarasota, Florida. RPS tests have high sensitivity and specificity, and can be easily performed by a clinician or their staff without extensive training or additional equipment.
References: [1] Thomson Reuters Medstat Marketscan Data, 2005. [2] Marangon FB, Miller D, Alfonso E. Laboratory results in ocular viral disease: Implications in clinical-laboratory correlation. Arq Bras Oftalmol 2007;70(2):189-94. [3] Infectious Agents Surveillance Center of Japan. Viruses isolated from the eye, Japan, 1990-1994. Infect Agents Surveil Rep 1995;16:97-8. [4] O'Brien TP, Jeng BH, McDonald M, et al. Acute Conjunctivitis: truth and misconceptions. Curr Med Res Opin 2009;25(8):1953-61. [5] Watanabe Y, Uchio E, Itoh N, et al. Bacterial Infection in the Conjunctiva of Patients with Adenoviral Conjunctivitis. Jpn J Ophthalmol 2001;45:115. [6] Gigliotti F, Williams WT, Hayden FG, et al. Etiology of acute conjunctivitis in children. J Pediatr 1981;98(4):531-6. [7] 510(k) K110722: RPS Adeno Detector PlusTM. [8] Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States, 2013. Retrieved from . [9] Schneider JE, Scheibling CM, Segall D, et al. Epidemiology and Economic Burden of Conjunctivitis: A Managed Care Perspective. Journal of Managed Care Medicine 2014;17(1):78-83. [10] Butt AL, Chodosh J. Adenoviral keratoconjunctivis in tertiary care eye clinic. Cornea. 2006;25: 199-202. [11] Hyde KJ, Berger ST. Epidemic keratoconjunctivitis and lacrimal excretory system obstruction. Ophthalmology. 1988; 95: 1477-1449. [12] Hammer LH, Perry HD, Donnenfeld ED, et al. Symblepharon formation in epidemic keratoconjunctivitis. Cornea. 1990; 9: 338-340.
Rapid Pathogen Screening, Inc. 7227 Delainey Court ? Sarasota, FL 34240 USA ? +1.941.556.1850 ?
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