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SUPPLEMENTAL DIGITAL CONTENTSupplemental Table S1. Study Investigators and Centers for RELEASE-1 and RELEASE-2The following investigators participated in the RELEASE-1 trial:S. Ali, MD (Acclaim Dermatology, PLLC, Sugarland, TX)D. Bank, MD (The Center for Dermatology, Cosmetic & Laser Surgery, Mount Kisco, NY)L.S. Bass, MD (Bass Plastic Surgery, PLLC, New York, NY)R. Chiong, MD (Kendall South Medical Center, Inc., Miami, FL)J. Clark, MD (Charlottesville Medical Research Center, LLC, Charlottesville, VA)M. Couvillion, MD (Suzanne Bruce and Associates, PA, Houston TX)S. Fabi, MD (Cosmetic Laser Dermatology, San Diego, CA)B. Heller, MD (Long Beach Clinical Trials, Long Beach, CA)S. Jackson, MD (DelRicht Research, New Orleans, LA)C. Jacob, MD (Chicago Cosmetic Surgery and Dermatology, Chicago, IL)M. Kaminer, MD (SkinCare Physicians, Chestnut Hill, MA)B. Katz, MD (Juva Skin and Laser Center, New York, NY)S. Kempers, MD (Minnesota Clinical Study Center, Fridley, MN)V. Kuohong, MD (Beacon Clinical Research, LLC, Quincy, MA)E. Lain, MD (Austin Institute for Clinical Research, Inc., Pflugerville, TX)C. Lucas-Anthony, MD (Skin Care Research LLC, Boca Raton, FL)Richard C. Martin, MD (Research Specialists of Arizona, Scottsdale, AZ)M. Noss, MD (Synexus Clinical Research, Cincinnati, OH)J. Peterson, MD (Suzanne Bruce and Associates, PA, Houston, TX)M. Rendon, MD (Skin Care Research, LLC, Boca Raton, FL)A. Rivkin, MD (Westside Aesthetics, Los Angeles, CA) N. Sadick, MD (Sadick Research Group, LLC, New York, NY)J. Schlessinger, MD (Skin Specialists, PC, Omaha, NE)S. Smith, MD (California Dermatology & Clinical Research Institute, Encinitas, CA)A. Venkat, MD (Dermatology Specialists Inc., Oceanside, CA)J. Weiss, MD (Gwinnett Clinical Research Center, Inc., Snellville, GA)V.L. Young, MD (Mercy Health Research, Washington, MO)M. Zook, MD (Olympian Clinical Research, Largo, FL)The following investigators participated in the RELEASE-2 trial:L. Baumann, MD (Baumann Cosmetic & Research Institute, Miami, FL)S. Bruce, MD (Suzanne Bruce and Associates, PA, Katy, TX)J. Cohen, MD (AboutSkin Research, LLC, Greenwood Village, CO)W. Coleman, III, MD (Coleman Center for Cosmetic Dermatologic Surgery, Metairie, LA)A. Dagum, MD (Stony Brook Plastic Surgery Outpatient Offices, East Setauket, NY)R. Dakour, MD (DiscoveResearch, Inc., Beaumont, TX)J. Downie, MD (Image Dermatology, P.C., Montclair, NJ)J. DuBois, MD (DermResearch Inc., Austin, TX)R. Fixler, MD (CITI Clinical Research Center, Cincinnati, OH)R. Geronemus, MD (Laser & Skin Surgery Center of New York, New York, NY)M. Gold, MD (Tennessee Clinical Research Center, Nashville, TN)M. Goldman, MD (Dermatology Cosmetic Laser Medical Associates of La Jolla, Inc., San Diego, CA)S. Grekin, DO (Grekin Skin Institute, Warren, MI)C.W. Hanke, III, MD (Laser and Skin Surgery Center of Indiana, Carmel, IN)R. Harris, MD (Dermatology Center of Canyon Country, Nampa, ID)J. Joseph, MD (The Clinical Testing Center of Beverly Hills, Encino, CA)J. Kaufman-Janette, MD (Skin Research Institute, Coral Cables, FL)M. Lupo, MD (Lupo Center for Aesthetic and General Dermatology, New Orleans, LA)T. Nutt, MD (Clinical Trials of Texas, Inc., San Antonio, TX)K. Peddy, MD (The Education & Research Foundation, Lynchburg, VA)J. Pehoushek, MD (Advanced Research Associates, Glendale, AZ)G. Petrus, MD (The Petrus Center for Aesthetic Surgery and Hair Transplantation, North Little Rock, AR)M. Taylor, MD (Advanced Clinical Research/Gateway Aesthetic Institute & Laser Center, Salt Lake City, UT)J. Thiele, MD, PhD (Dermatology Specialists, Inc., Murrieta, CA)S. Yoelin, MD (Steve Yoelin MD Medical Associates. Inc., Newport Beach, CA)RELEASE, Randomized Evaluation of Cellulite Reduction by Collagenase Clostridium Histolyticum.Supplemental Table S2. Patient Reported Cellulite Impact ScaleItemDomainQuestionScale1HappyThinking about the areas selected for treatment, how happy are you with the appearance of your cellulite?0 (not at all) – 10 (extremely)2BotheredThinking about the areas selected for treatment, how bothered are you by the appearance of your cellulite?0 (not at all) – 10 (extremely)3Self-consciousThinking about the areas selected for treatment, how self-conscious are you by the appearance of your cellulite?0 (not at all) – 10 (extremely)4EmbarrassedThinking about the areas selected for treatment, how embarrassed are you about the appearance of your cellulite?0 (not at all) – 10 (extremely)5Looking olderThinking about the areas selected for treatment, how much older do you look because of your cellulite?0 (not at all) – 10 (extremely)6Looking overweight or out of shapeThinking about the areas selected for treatment, how overweight or out of shape do you look because of your cellulite?0 (not at all) – 10 (extremely)? 2020 Endo Pharmaceuticals Inc.Supplemental Table S3. Subject Satisfaction With Cellulite Treatment AssessmentQuestion: “Today, how satisfied are you with the results of the cellulite treatment you received on the specific area or areas on your buttocks that were treated?”RatingDescription+2I am very satisfied with the cellulite treatment on my buttocks.+1I am satisfied with the cellulite treatment on my buttocks.0I am neither dissatisfied nor satisfied with the cellulite treatment on my buttocks.-1I am dissatisfied with the cellulite treatment on my buttocks.-2I am very dissatisfied with the cellulite treatment on my buttocks.? 2020 Endo Pharmaceuticals Inc.Figure S1.Figure S1. Study disposition. AE, adverse event; CCH, collagenase clostridium histolyticum-aaes; ITT, intent-to-treat; RELEASE, Randomized Evaluation of Cellulite Reduction by Collagenase Clostridium Histolyticum.Figure S2.Figure S2. Composite response at Day 71 in nontarget buttock. Composite response was defined as a ≥2-level or ≥1-level severity improvement from baseline in CR-PCSS and PR-PCSS ratings at Day 71. CCH, collagenase clostridium histolyticum-aaes; CR-PCSS, Clinician Reported Photonumeric Cellulite Severity Scale; PR-PCSS, Patient Reported Photonumeric Cellulite Severity Scale; RELEASE, Randomized Evaluation of Cellulite Reduction by Collagenase Clostridium Histolyticum. ................
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