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Cholinergic Agonists Acetylcholine Non-selective M & N NONE PNS effects NOT effect PO, shortest duration (plasma ChE) Carbachol M-agonist (ester) Miosis, (IOP PNS & ganglia (N) effects Longer-acting (resistant to both AChE) Bethanechol Selective M3-agonist (ester) Urinary retention, GI atony PNS effects (NOT heart) Long-duration (NO ChE ... ................
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