Iris.unica.it
Influenza burden, prevention and treatment in asthma – a scoping review by the EAACI Influenza in Asthma Task ForceJürgen Schwarze1, MD, PhD, Peter Openshaw2, FMedSci, Akhilesh Jha2, MRCP (UK), Stefano R del Giacco3, MD, Davide Firinu3, MD, Olympia Tsilochristou4, MD, Graham Roberts5, DM, FRCPCH, Anna Selby5, BM BCh, Cezmi Akdis6, MD, PhD, Ioana Agache7, MD, PhD, Adnan Custovic8, MD, PhD, Enrico Heffler9, MD, PhD, Georgia Pinna10, MD, Musa Khaitov11 , PhD, Alexandra Nikonova11, Nikolaos Papadopoulos12, MD, PhD, Ather Akhlaq13, PhD, Ulugbek Nurmatov14, Harald Renz15, MD, Aziz Sheikh16, FRSE, FMedSci, Chrysanthi Skevaki15, MD, PhDAuthor affiliations:1 Centre for Inflammation Research, University of Edinburgh, The Queens Medical Research Institute, Edinburgh, UK2 Respiratory Sciences, National Heart and Lung Institute, Imperial College London, UK3 Department of Medical Sciences and Public Health “M. Aresu”, University of Cagliari, Cagliari, Italy4 Department of Pediatric Allergology, King’s College, London, UK5 Faculty of Medicine, University of Southampton, Southampton and David Hide Asthma and Allergy Centre, St Mary’s Hospital, Newport, Isle of Wight, UK6 Swiss Institute of Allergy and Asthma Research, University of Zurich, Davos, Switzerland7 Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University Brasov, Brasov, Romania8 Department of Paediatrics, Imperial College London, UK9 Personalized Medicine, Asthma and Allergy Clinic, Department of Biomedical Sciences, Humanitas University, Milan, Italy10 Department of Medical Microbiology, National Kapodistrian University of Athens, Athens, Greece11 National Research Center Institute of Immunology of Federal Medicobiological Agency, Moscow, Russia12 Division of Infection, Inflammation & Respiratory Medicine, The University of Manchester, Manchester, UK and Allergy Dpt, 2nd Paediatric Clinic, National Kapodistrian University of Athens, Greece13 Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK14 Department of Health and Hospital Management, Institute of Business Management, Korangi Creek, Karachi - 75190, Pakistan15 Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen & Marburg, Marburg, Germany16 Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK Author for correspondenceChrysanthi Skevaki, MD, PhDInstitute of Laboratory Medicine, Philipps University MarburgBaldingerstrasse, 35043 Marburg, GermanyPhone +49 6421 586 6235email: Chrysanthi.Skevaki@uk-gm.deKey words: <5 maximum>Viral infection, vaccination, antivirals, respiratory, heath care utilizationShort title: <50 characters>Influenza burden in asthma – a scoping reviewAbstract <Unstructured: 200 word limit>To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma. The strongest evidence of an association was seen in studies of children. Countries in the European Union currently recommend influenza vaccination of adults with asthma; however, coverage varied between regions. Coverage was lower among children with asthma. Coverage was lower among asthmatic children (redundant). Limited data suggest that good seroprotection and seroconversion can be achieved in both children and adults with asthma and that vaccination confers a degree of protection against influenza illness and asthma related morbidity to children with asthma. There were insufficient data to determine efficacy in adults. Overall, influenza vaccines appeared to be safe for people with asthma. We identify knowledge gaps and make recommendations on future research needs in relation to influenza in patients with asthma. IntroductionAsthma is a heterogeneous chronic inflammatory lung disease characterized by intermittent airflow obstruction and increased reactivity to bronchoconstrictive triggers. Presently, an estimated 300 million people worldwide suffer from asthma ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>230</RecNum><DisplayText>(1)</DisplayText><record><rec-number>230</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481280825">230</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Global Atlas of Asthma. Published by the European Academy of Allergy and Clinical Immunology. Editors: Cezmi A. Akdis, Ioana Agache, 2013</title></titles><dates></dates><urls></urls></record></Cite></EndNote>(1). In Europe, more than 30 million people are affected, with six million suffering severe symptoms and 1.5 million life-threatening attacks ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>231</RecNum><DisplayText>(2)</DisplayText><record><rec-number>231</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481280864">231</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>ERS: The European Lung White Book 2003.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>(2). Asthma onset and acute asthma exacerbations (ΑΑΕ) have been strongly associated with respiratory viral and (to a lesser extent) bacterial infections PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXJ2ZWF1eDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXJ2ZWF1eDwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (3-7). Influenza viruses cause respiratory infections, typically during winter months. Most significant disease is caused by influenza A and B, which may escape immune pressure by undergoing antigenic drift and recombination; such genetic changes lead to new subtypes, which can cause epidemic or pandemic outbreaks PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1vbnNlbjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1vbnNlbjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+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==
ADDIN EN.CITE.DATA (8, 9). I would elaborate here about the immune response against the virus and how vaccines can modify it. The importance of influenza as a cause of serious illness and AAE is increasingly appreciated PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2VobGluZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb2VobGluZzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE.DATA (10, 11). Despite uncertainties about their effectiveness, influenza vaccines are widely recommended for those with asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl
Y051bT42MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTIpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjYxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEy
MDk3MjAiPjYxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXRlcywg
Qy4gSi48L2F1dGhvcj48YXV0aG9yPlJvd2UsIEIuIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29u
dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UG9wdWxhdGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIEVk
dWNhdGlvbiwgU3QgR2VvcmdlJmFwb3M7cywgVW5pdmVyc2l0eSBvZiBMb25kb24sIExvbmRvbiwg
VUsuY2NhdGVzQHNndWwuYWMudWsuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VmFjY2lu
ZXMgZm9yIHByZXZlbnRpbmcgaW5mbHVlbnphIGluIHBlb3BsZSB3aXRoIGFzdGhtYTwvdGl0bGU+
PHNlY29uZGFyeS10aXRsZT5Db2NocmFuZSBEYXRhYmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8
L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNvY2hyYW5lIERhdGFiYXNlIFN5c3QgUmV2PC9h
bHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPkNEMDAwMzY0PC9wYWdlcz48dm9sdW1lPjI8L3ZvbHVt
ZT48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+KkFzdGhtYS9jbyBb
Q29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+
RGlzZWFzZSBQcm9ncmVzc2lvbjwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtl
eXdvcmQ+SW5mbHVlbnphIFZhY2NpbmVzL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxr
ZXl3b3JkPipJbmZsdWVuemEgVmFjY2luZXMvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+
PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtl
eXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tl
eXdvcmQ+PGtleXdvcmQ+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFscyBhcyBUb3BpYzwva2V5
d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3RpdmF0ZWQvYWUgW0FkdmVyc2UgRWZmZWN0c108
L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luZXMsIEluYWN0aXZhdGVkL3R1IFtUaGVyYXBldXRpYyBV
c2VdPC9rZXl3b3JkPjxrZXl3b3JkPjAgKEluZmx1ZW56YSBWYWNjaW5lcyk8L2tleXdvcmQ+PGtl
eXdvcmQ+MCAoVmFjY2luZXMsIEluYWN0aXZhdGVkKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRl
cz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTQ2OS00OTNYPC9pc2JuPjxhY2Nlc3Np
b24tbnVtPjIzNDUwNTI5PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TWV0YS1BbmFseXNpcyYj
eEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3PC93b3Jr
LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3Zp
ZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7
RD1tZWRsJmFtcDtBTj0yMzQ1MDUyOTwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRo
ZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElO
RSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjM0NTA1MjkmYW1wO2lkPTEwLjEwMDIlMkYxNDY1MTg1OC5D
RDAwMDM2NC5wdWI0JmFtcDtpc3NuPTEzNjEtNjEzNyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yJmFt
cDtpc3N1ZT0mYW1wO3NwYWdlPUNEMDAwMzY0JmFtcDtwYWdlcz1DRDAwMDM2NCZhbXA7ZGF0ZT0y
MDEzJmFtcDt0aXRsZT1Db2NocmFuZStEYXRhYmFzZStvZitTeXN0ZW1hdGljK1Jldmlld3MmYW1w
O2F0aXRsZT1WYWNjaW5lcytmb3IrcHJldmVudGluZytpbmZsdWVuemEraW4rcGVvcGxlK3dpdGgr
YXN0aG1hLiZhbXA7YXVsYXN0PUNhdGVzJmFtcDtwaWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZn
dDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0Ozwv
dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDov
L2R4LmRvaS5vcmcvMTAuMTAwMi8xNDY1MTg1OC5DRDAwMDM2NC5wdWI0PC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNl
LW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3Rl
LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48
L0NpdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051
bT42MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NjE8L3JlYy1udW1iZXI+PGZvcmVpZ24t
a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6
dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwOTcyMCI+NjE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVm
LXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48
YXV0aG9ycz48YXV0aG9yPkNhdGVzLCBDLiBKLjwvYXV0aG9yPjxhdXRob3I+Um93ZSwgQi4gSC48
L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Qb3B1bGF0aW9u
IEhlYWx0aCBTY2llbmNlcyBhbmQgRWR1Y2F0aW9uLCBTdCBHZW9yZ2UmYXBvcztzLCBVbml2ZXJz
aXR5IG9mIExvbmRvbiwgTG9uZG9uLCBVSy5jY2F0ZXNAc2d1bC5hYy51ay48L2F1dGgtYWRkcmVz
cz48dGl0bGVzPjx0aXRsZT5WYWNjaW5lcyBmb3IgcHJldmVudGluZyBpbmZsdWVuemEgaW4gcGVv
cGxlIHdpdGggYXN0aG1hPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNvY2hyYW5lIERhdGFiYXNl
IG9mIFN5c3RlbWF0aWMgUmV2aWV3czwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q29jaHJh
bmUgRGF0YWJhc2UgU3lzdCBSZXY8L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+Q0QwMDAzNjQ8
L3BhZ2VzPjx2b2x1bWU+Mjwvdm9sdW1lPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29y
ZD48a2V5d29yZD4qQXN0aG1hL2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5D
aGlsZDwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIFByb2dyZXNzaW9uPC9rZXl3b3JkPjxrZXl3
b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgVmFjY2luZXMvYWUgW0FkdmVy
c2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5lcy90dSBbVGhl
cmFwZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuL2NvIFtDb21w
bGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9wYyBbUHJldmVu
dGlvbiAmYW1wOyBDb250cm9sXTwva2V5d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xs
ZWQgVHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBJbmFjdGl2YXRl
ZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3Rp
dmF0ZWQvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnph
IFZhY2NpbmVzKTwva2V5d29yZD48a2V5d29yZD4wIChWYWNjaW5lcywgSW5hY3RpdmF0ZWQpPC9r
ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48aXNibj4x
NDY5LTQ5M1g8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjM0NTA1Mjk8L2FjY2Vzc2lvbi1udW0+PHdv
cmstdHlwZT5NZXRhLUFuYWx5c2lzJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym
YXBvczt0JiN4RDtSZXZpZXc8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1O
JmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIzNDUwNTI5PC91cmw+PHVybD5o
dHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3Bs
YXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMzQ1MDUyOSZhbXA7
aWQ9MTAuMTAwMiUyRjE0NjUxODU4LkNEMDAwMzY0LnB1YjQmYW1wO2lzc249MTM2MS02MTM3JmFt
cDtpc2JuPSZhbXA7dm9sdW1lPTImYW1wO2lzc3VlPSZhbXA7c3BhZ2U9Q0QwMDAzNjQmYW1wO3Bh
Z2VzPUNEMDAwMzY0JmFtcDtkYXRlPTIwMTMmYW1wO3RpdGxlPUNvY2hyYW5lK0RhdGFiYXNlK29m
K1N5c3RlbWF0aWMrUmV2aWV3cyZhbXA7YXRpdGxlPVZhY2NpbmVzK2ZvcitwcmV2ZW50aW5nK2lu
Zmx1ZW56YStpbitwZW9wbGUrd2l0aCthc3RobWEuJmFtcDthdWxhc3Q9Q2F0ZXMmYW1wO3BpZD0m
bHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZs
dDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJv
bmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAyLzE0NjUxODU4LkNEMDAw
MzY0LnB1YjQ8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5N
RURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92
aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xp
c2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA (12). To address uncertainties over the prevention and management of influenza in patients with asthma, we performed a scoping review and discuss the current knowledge of the burden imposed by influenza on patients with asthma, current vaccine recommendations and vaccination coverage in various regions, the evidence regarding immunogenicity, efficacy, effectiveness and safety of influenza vaccines, and the possible benefits of antiviral drugs in patients with asthma. We conclude by identifying knowledge gaps and future research needs in relation to influenza in asthma patients. Methods We systematically searched relevant published, unpublished and in-progress original research and systematic reviews that were pertinent to the subject matter of this EAACI Task Force. This involved searching databases of peer-reviewed published literature (Cochrane Library, EMBASE and CINAHL, MEDLINE and Google Scholar) and research in progress (i.e. and ) for the period 2000–2015. In addition, we wrote to a panel of international experts in an attempt to identify additional unpublished or in-progress work. There were no restrictions on language of publication. We were particularly interested in randomized controlled trials (RCTs) on questions relating to the immunogenicity, efficacy and/or effectiveness of influenza vaccine among asthmatics, and epidemiological studies relating to the influenza incidence/prevalence and public health burden and safety of influenza vaccine. Systematic reviews with or without meta-analysis were of interest if they focused on any of the questions of interest. The searches (see Appendix 1) were undertaken and allocated to relevant sub-group leads depending on the focus of the inquiry. Where possible, studies reported in languages other than English were translated. Within subgroups, two reviewers independently reviewed the titles and if necessary abstracts of potentially eligible studies to decide on eligibility; disagreements on study eligibility were resolved through discussion among the reviewers. Studies were then – in the specific context of asthma/allergy – categorized by topic area, namely: i) Global burden of influenza; ii) Influenza vaccination recommendations and coverage; iii) Immunogenicity of influenza vaccines; iv) Efficacy of influenza vaccines; v) Effectiveness of influenza vaccines; vi). Safety of influenza vaccines; and vii). Antiviral treatments against influenza. Reports were then scrutinized and interpreted by experts on the subject matter. Any disagreements on issues to do with interpretation were resolved through discussion.The searches were first conducted in 2014 and then updated in October 2015.The key characteristics and findings of all eligible studies were summarized in data tables, and the findings narratively synthesized. These are presented by topic in Table 1.Global burden of influenza in patients with asthma 2a. Influenza-attributable health care utilization in asthma patients Asthma is the most common underlying disease in patients with influenza admitted to healthcare facilities, both in adults cj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRo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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXNzZXR0aTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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==
ADDIN EN.CITE.DATA cj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRo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=
ADDIN EN.CITE.DATA (13-27) (7.6–46% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eam9yZGpldmljPC9BdXRob3I+PFllYXI+MjAxMTwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Eam9yZGpldmljPC9BdXRob3I+PFllYXI+MjAxMTwvWWVh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ADDIN EN.CITE.DATA (28, 29)) and children L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5PYmVzaXR5L2NvIFtDb21w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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXdvb2Q8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5PYmVzaXR5L2NvIFtDb21w
bGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5Pc2VsdGFtaXZpci90dSBbVGhlcmFwZXV0aWMg
VXNlXTwva2V5d29yZD48a2V5d29yZD5QbmV1bW9uaWEsIEJhY3RlcmlhbC9jbyBbQ29tcGxpY2F0
aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxr
ZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TZWl6dXJlcy9jbyBbQ29tcGxp
Y2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+U2luZ2Fwb3JlPC9rZXl3b3JkPjxrZXl3b3JkPjAg
KEFudGl2aXJhbCBBZ2VudHMpPC9rZXl3b3JkPjxrZXl3b3JkPjIwTzkzTDZGOUggKE9zZWx0YW1p
dmlyKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDMwNC00NjAyPC9p
c2JuPjxhY2Nlc3Npb24tbnVtPjIzNzcxMTEwPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29t
cGFyYXRpdmUgU3R1ZHk8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov
L292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFt
cDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIzNzcxMTEwPC91cmw+PHVybD5odHRw
Oi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/
c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMzc3MTExMCZhbXA7aWQ9
JmFtcDtpc3NuPTAzMDQtNDYwMiZhbXA7aXNibj0mYW1wO3ZvbHVtZT00MiZhbXA7aXNzdWU9NSZh
bXA7c3BhZ2U9MjMyJmFtcDtwYWdlcz0yMzItNiZhbXA7ZGF0ZT0yMDEzJmFtcDt0aXRsZT1Bbm5h
bHMrb2YrdGhlK0FjYWRlbXkrb2YrTWVkaWNpbmUlMkMrU2luZ2Fwb3JlJmFtcDthdGl0bGU9Umlz
aytGYWN0b3JzK2ZvcitDb21wbGljYXRlZCtJbmZsdWVuemErQSslMjhIMU4xJTI5KzIwMDkrRGlz
ZWFzZStpbitDaGlsZHJlbi4mYW1wO2F1bGFzdD1DaG9uZyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7
Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0
Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1l
Pk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+
T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5n
bGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+RGF3b29kPC9BdXRo
b3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVtPjc5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl
cj43OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVleGR4
MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgxMjA5NzIwIj43
OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3
PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RGF3b29kLCBGLiBTLjwv
YXV0aG9yPjxhdXRob3I+RmlvcmUsIEEuPC9hdXRob3I+PGF1dGhvcj5LYW1pbW90bywgTC48L2F1
dGhvcj48YXV0aG9yPkJyYW1sZXksIEEuPC9hdXRob3I+PGF1dGhvcj5SZWluZ29sZCwgQS48L2F1
dGhvcj48YXV0aG9yPkdlcnNobWFuLCBLLjwvYXV0aG9yPjxhdXRob3I+TWVlaywgSi48L2F1dGhv
cj48YXV0aG9yPkhhZGxlciwgSi48L2F1dGhvcj48YXV0aG9yPkFybm9sZCwgSy4gRS48L2F1dGhv
cj48YXV0aG9yPlJ5YW4sIFAuPC9hdXRob3I+PGF1dGhvcj5MeW5maWVsZCwgUi48L2F1dGhvcj48
YXV0aG9yPk1vcmluLCBDLjwvYXV0aG9yPjxhdXRob3I+TXVlbGxlciwgTS48L2F1dGhvcj48YXV0
aG9yPkJhdW1iYWNoLCBKLjwvYXV0aG9yPjxhdXRob3I+WmFuc2t5LCBTLjwvYXV0aG9yPjxhdXRo
b3I+QmVubmV0dCwgTi4gTS48L2F1dGhvcj48YXV0aG9yPlRob21hcywgQS48L2F1dGhvcj48YXV0
aG9yPlNjaGFmZm5lciwgVy48L2F1dGhvcj48YXV0aG9yPktpcnNjaGtlLCBELjwvYXV0aG9yPjxh
dXRob3I+RmluZWxsaSwgTC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt
YWRkcmVzcz4oRGF3b29kLCBGaW9yZSwgS2FtaW1vdG8sIEJyYW1sZXksIEZpbmVsbGkpIEluZmx1
ZW56YSBEaXZpc2lvbiwgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250cm9sIGFuZCBQcmV2ZW50aW9u
LCAxNjAwIENsaWZ0b24gUmQgTVMgQS0zMiwgQXRsYW50YSwgR0EgMzAzMzMsIFVuaXRlZCBTdGF0
ZXMgKFJlaW5nb2xkKSBDYWxpZm9ybmlhIEVtZXJnaW5nIEluZmVjdGlvbnMgUHJvZ3JhbSwgT2Fr
bGFuZCwgQ0EsIFVuaXRlZCBTdGF0ZXMgKEdlcnNobWFuKSBDb2xvcmFkbyBEZXBhcnRtZW50IG9m
IFB1YmxpYyBIZWFsdGggYW5kIEVudmlyb25tZW50LCBEZW52ZXIsIENPLCBVbml0ZWQgU3RhdGVz
IChNZWVrLCBIYWRsZXIpIENvbm5lY3RpY3V0IEVtZXJnaW5nIEluZmVjdGlvbnMgUHJvZ3JhbSwg
WWFsZSBVbml2ZXJzaXR5LCBOZXcgSGF2ZW4sIENULCBVbml0ZWQgU3RhdGVzIChBcm5vbGQpIEdl
b3JnaWEgRW1lcmdpbmcgSW5mZWN0aW9ucyBQcm9ncmFtLCBHZW9yZ2lhIERlcGFydG1lbnQgb2Yg
SHVtYW4gUmVzb3VyY2VzLCBEaXZpc2lvbiBvZiBQdWJsaWMgSGVhbHRoLCBBdGxhbnRhLCBHQSwg
VW5pdGVkIFN0YXRlcyAoUnlhbikgTWFyeWxhbmQgRGVwYXJ0bWVudCBvZiBIZWFsdGggYW5kIE1l
bnRhbCBIeWdpZW5lLCBCYWx0aW1vcmUsIE1ELCBVbml0ZWQgU3RhdGVzIChMeW5maWVsZCwgTW9y
aW4pIE1pbm5lc290YSBEZXBhcnRtZW50IG9mIEhlYWx0aCwgU3QuIFBhdWwsIE1OLCBVbml0ZWQg
U3RhdGVzIChNdWVsbGVyLCBCYXVtYmFjaCkgTmV3IE1leGljbyBEZXBhcnRtZW50IG9mIEhlYWx0
aCwgU2FudGEgRmUsIE5NLCBVbml0ZWQgU3RhdGVzIChaYW5za3kpIEVtZXJnaW5nIEluZmVjdGlv
bnMgUHJvZ3JhbSwgTmV3IFlvcmsgU3RhdGUgRGVwYXJ0bWVudCBvZiBIZWFsdGgsIEFsYmFueSwg
TlksIFVuaXRlZCBTdGF0ZXMgKEJlbm5ldHQpIERlcGFydG1lbnQgb2YgTWVkaWNpbmUsIFNjaG9v
bCBvZiBNZWRpY2luZSBhbmQgRGVudGlzdHJ5IGFuZCBNb25yb2UgQ291bnR5LCBVbml2ZXJzaXR5
IG9mIFJvY2hlc3RlciwgUm9jaGVzdGVyLCBOWSwgVW5pdGVkIFN0YXRlcyAoVGhvbWFzKSBPcmVn
b24gUHVibGljIEhlYWx0aCBEaXZpc2lvbiwgUG9ydGxhbmQsIE9SLCBVbml0ZWQgU3RhdGVzIChT
Y2hhZmZuZXIsIEtpcnNjaGtlKSBEZXBhcnRtZW50IG9mIFByZXZlbnRpdmUgTWVkaWNpbmUsIFZh
bmRlcmJpbHQgVW5pdmVyc2l0eSwgU2Nob29sIG9mIE1lZGljaW5lLCBOYXNodmlsbGUsIFROLCBV
bml0ZWQgU3RhdGVzJiN4RDtGLiBTLiBEYXdvb2QsIEluZmx1ZW56YSBEaXZpc2lvbiwgQ2VudGVy
cyBmb3IgRGlzZWFzZSBDb250cm9sIGFuZCBQcmV2ZW50aW9uLCAxNjAwIENsaWZ0b24gUmQuIE1T
IEEtMzIsIEF0bGFudGEsIEdBIDMwMzMzLCBVbml0ZWQgU3RhdGVzLiBFLW1haWw6IGZkYXdvb2RA
Y2RjLmdvdjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkJ1cmRlbiBvZiBzZWFzb25hbCBp
bmZsdWVuemEgaG9zcGl0YWxpemF0aW9uIGluIGNoaWxkcmVuLCBVbml0ZWQgU3RhdGVzLCAyMDAz
IHRvIDIwMDg8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBQZWRpYXRyaWNzPC9z
ZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBv
ZiBQZWRpYXRyaWNzPC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gUGVkaWF0ci48L2FiYnItMT48YWJi
ci0yPkogUGVkaWF0cjwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+ODA4LTgxNDwvcGFnZXM+
PHZvbHVtZT4xNTc8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+
Y2RjPC9rZXl3b3JkPjxrZXl3b3JkPkNlbnRlcnMgZm9yIERpc2Vhc2UgQ29udHJvbCBhbmQgUHJl
dmVudGlvbjwva2V5d29yZD48a2V5d29yZD5laXA8L2tleXdvcmQ+PGtleXdvcmQ+RW1lcmdpbmcg
SW5mZWN0aW9ucyBQcm9ncmFtPC9rZXl3b3JkPjxrZXl3b3JkPmFkb2xlc2NlbnQ8L2tleXdvcmQ+
PGtleXdvcmQ+YWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+YWdlIGRpc3RyaWJ1dGlvbjwva2V5d29y
ZD48a2V5d29yZD5hcnRpY2xlPC9rZXl3b3JkPjxrZXl3b3JkPmFzdGhtYTwva2V5d29yZD48a2V5
d29yZD5iYWN0ZXJpYWwgaW5mZWN0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmNoaWxkPC9rZXl3b3Jk
PjxrZXl3b3JkPmNoaWxkaG9vZCBkaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPmRlYXRoPC9rZXl3
b3JkPjxrZXl3b3JkPmRlbW9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+ZGV2ZWxvcG1lbnRhbCBk
aXNvcmRlcjwva2V5d29yZD48a2V5d29yZD5kaWFnbm9zdGljIHRlc3Q8L2tleXdvcmQ+PGtleXdv
cmQ+ZGlzZWFzZSBhc3NvY2lhdGlvbjwva2V5d29yZD48a2V5d29yZD5kaXNlYXNlIGNvdXJzZTwv
a2V5d29yZD48a2V5d29yZD5kaXNlYXNlIHNldmVyaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5ob3NwaXRhbCBwYXRpZW50PC9rZXl3b3JkPjxrZXl3b3JkPmhv
c3BpdGFsaXphdGlvbjwva2V5d29yZD48a2V5d29yZD5odW1hbjwva2V5d29yZD48a2V5d29yZD5p
bnRlbnNpdmUgY2FyZSB1bml0PC9rZXl3b3JkPjxrZXl3b3JkPm1ham9yIGNsaW5pY2FsIHN0dWR5
PC9rZXl3b3JkPjxrZXl3b3JkPm1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+bWVkaWNhbCBoaXN0b3J5
PC9rZXl3b3JkPjxrZXl3b3JkPm1lZGljYWwgcmVjb3JkIHJldmlldzwva2V5d29yZD48a2V5d29y
ZD5wb3B1bGF0aW9uIHJlc2VhcmNoPC9rZXl3b3JkPjxrZXl3b3JkPnByZW1hdHVyaXR5PC9rZXl3
b3JkPjxrZXl3b3JkPnByZXNjaG9vbCBjaGlsZDwva2V5d29yZD48a2V5d29yZD5wcmlvcml0eSBq
b3VybmFsPC9rZXl3b3JkPjxrZXl3b3JkPnF1YW50aXRhdGl2ZSBhbmFseXNpczwva2V5d29yZD48
a2V5d29yZD5yZXNwaXJhdG9yeSBmYWlsdXJlPC9rZXl3b3JkPjxrZXl3b3JkPnJldHJvc3BlY3Rp
dmUgc3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+c2Nob29sIGNoaWxkPC9rZXl3b3JkPjxrZXl3b3Jk
PnNlYXNvbmFsIGluZmx1ZW56YS9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD50
cmVhdG1lbnQgb3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5Vbml0ZWQgU3RhdGVzPC9rZXl3b3Jk
PjxrZXl3b3JkPmFkYW1hbnRhbmUvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+
YW50aXZpcnVzIGFnZW50L2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPmluZmx1
ZW56YSB2YWNjaW5lL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz
Pjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3ZlbWJlcjwvZGF0ZT48L3B1Yi1k
YXRlcz48L2RhdGVzPjxpc2JuPjAwMjItMzQ3NjwvaXNibj48YWNjZXNzaW9uLW51bT4yMDEwNTc3
MTM1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNw
Lm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9
ZnVsbHRleHQmYW1wO0Q9ZW1lZDkmYW1wO0FOPTIwMTA1NzcxMzU8L3VybD48dXJsPmh0dHA6Ly9v
cGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9
T1ZJRDpFbWJhc2UmYW1wO2lkPXBtaWQ6JmFtcDtpZD0xMC4xMDE2JTJGai5qcGVkcy4yMDEwLjA1
LjAxMiZhbXA7aXNzbj0wMDIyLTM0NzYmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTU3JmFtcDtpc3N1
ZT01JmFtcDtzcGFnZT04MDgmYW1wO3BhZ2VzPTgwOC04MTQmYW1wO2RhdGU9MjAxMCZhbXA7dGl0
bGU9Sm91cm5hbCtvZitQZWRpYXRyaWNzJmFtcDthdGl0bGU9QnVyZGVuK29mK3NlYXNvbmFsK2lu
Zmx1ZW56YStob3NwaXRhbGl6YXRpb24raW4rY2hpbGRyZW4lMkMrVW5pdGVkK1N0YXRlcyUyQysy
MDAzK3RvKzIwMDgmYW1wO2F1bGFzdD1EYXdvb2QmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtw
MTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4m
Z3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5o
dHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouanBlZHMuMjAxMC4wNS4wMTI8L2VsZWN0cm9uaWMt
cmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5FbWJhc2U8L3JlbW90ZS1kYXRhYmFz
ZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90
ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+
PC9DaXRlPjxDaXRlPjxBdXRob3I+TWFuc291cjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl
Y051bT44OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+ODk8L3JlYy1udW1iZXI+PGZvcmVp
Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5
ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwOTcyMCI+ODk8L2tleT48L2ZvcmVpZ24ta2V5cz48
cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y
cz48YXV0aG9ycz48YXV0aG9yPk1hbnNvdXIsIE0uIE0uPC9hdXRob3I+PGF1dGhvcj5BbCBIYWRp
ZGliLCBLLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz
PlBlZGlhdHJpYyBEZXBhcnRtZW50LCBDYWlybyBVbml2ZXJzaXR5LCBDYWlybywgRWd5cHQsIENs
aW5pY2FsIFBhdGhvbG9neSBEZXBhcnRtZW50LCBBaW4gU2hhbXMgVW5pdmVyc2l0eSwgQ2Fpcm8s
IEVneXB0LiBmcmFjdGFsZWRnZTNAeWFob28uY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0
bGU+MjAwOSBIMU4xIGluZmx1ZW56YSBBIGluIGNoaWxkcmVuOiBhIGRlc2NyaXB0aXZlIGNsaW5p
Y2FsIHN0dWR5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFubmFscyBvZiBTYXVkaSBNZWRpY2lu
ZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QW5uIFNhdWRpIE1lZDwvYWx0LXRpdGxlPjwv
dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFubmFscyBvZiBTYXVkaSBNZWRpY2luZTwv
ZnVsbC10aXRsZT48YWJici0xPkFubi4gU2F1ZGkgTWVkLjwvYWJici0xPjxhYmJyLTI+QW5uIFNh
dWRpIE1lZDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
QW5uYWxzIG9mIFNhdWRpIE1lZGljaW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+QW5uLiBTYXVkaSBN
ZWQuPC9hYmJyLTE+PGFiYnItMj5Bbm4gU2F1ZGkgTWVkPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNh
bD48cGFnZXM+NTktNjM8L3BhZ2VzPjx2b2x1bWU+MzI8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJl
cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD4qQXN0aG1h
L2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5
d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48
a2V5d29yZD5Ib3NwaXRhbGl6YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk
PjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgQSBWaXJ1cywgSDFO
MSBTdWJ0eXBlL2dlIFtHZW5ldGljc108L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphIEEgVmly
dXMsIEgxTjEgU3VidHlwZS9pcCBbSXNvbGF0aW9uICZhbXA7IFB1cmlmaWNhdGlvbl08L2tleXdv
cmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBBIFZpcnVzLCBIMU4xIFN1YnR5cGU8L2tleXdvcmQ+PGtl
eXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdv
cmQ+SW5mbHVlbnphLCBIdW1hbi9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5J
bmZsdWVuemEsIEh1bWFuL3BwIFtQaHlzaW9wYXRob2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipJ
bmZsdWVuemEsIEh1bWFuPC9rZXl3b3JkPjxrZXl3b3JkPkludGVuc2l2ZSBDYXJlIFVuaXRzLCBQ
ZWRpYXRyaWM8L2tleXdvcmQ+PGtleXdvcmQ+KkxldWtvcGVuaWEvY28gW0NvbXBsaWNhdGlvbnNd
PC9rZXl3b3JkPjxrZXl3b3JkPipMeW1waG9wZW5pYS9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdv
cmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5QYW5kZW1pY3M8L2tleXdvcmQ+PGtl
eXdvcmQ+KlBuZXVtb25pYSwgVmlyYWwvY28gW0NvbXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3
b3JkPlNhdWRpIEFyYWJpYS9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5TZXZl
cml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIw
MTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW4tRmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0
ZXM+PGlzYm4+MDk3NS00NDY2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIyMTU2NjQ3PC9hY2Nlc3Np
b24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292
aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1w
O0Q9bWVkbCZhbXA7QU49MjIxNTY2NDc8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFjLnVrL2F0
aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlkK01FRExJ
TkUlMjhSJTI5JmFtcDtpZD1wbWlkOjIyMTU2NjQ3JmFtcDtpZD0mYW1wO2lzc249MDI1Ni00OTQ3
JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMyJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT01OSZhbXA7cGFn
ZXM9NTktNjMmYW1wO2RhdGU9MjAxMiZhbXA7dGl0bGU9QW5uYWxzK29mK1NhdWRpK01lZGljaW5l
JmFtcDthdGl0bGU9MjAwOStIMU4xK2luZmx1ZW56YStBK2luK2NoaWxkcmVuJTNBK2ErZGVzY3Jp
cHRpdmUrY2xpbmljYWwrc3R1ZHkuJmFtcDthdWxhc3Q9TWFuc291ciZhbXA7cGlkPSZsdDthdXRo
b3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8m
Z3Q7Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFz
ZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJv
dmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3Vh
Z2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+U2lsdmVu
bm9pbmVuPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjkwPC9SZWNOdW0+PHJlY29y
ZD48cmVjLW51bWJlcj45MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIx
NDgxMjA5NzIwIj45MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2ls
dmVubm9pbmVuLCBILjwvYXV0aG9yPjxhdXRob3I+UGVsdG9sYSwgVi48L2F1dGhvcj48YXV0aG9y
PlZhaW5pb25wYWEsIFIuPC9hdXRob3I+PGF1dGhvcj5SdXVza2FuZW4sIE8uPC9hdXRob3I+PGF1
dGhvcj5IZWlra2luZW4sIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo
LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBUdXJrdSBVbml2ZXJzaXR5IEhvc3Bp
dGFsLCAyMDUyMCwgVHVya3UsIEZpbmxhbmQuIGhlbGkuc2lsdmVubm9pbmVuQHV0dS5maTwvYXV0
aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkFkbWlzc2lvbiBkaWFnbm9zZXMgb2YgY2hpbGRyZW4g
MC0xNiB5ZWFycyBvZiBhZ2UgaG9zcGl0YWxpemVkIHdpdGggaW5mbHVlbnphPC90aXRsZT48c2Vj
b25kYXJ5LXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5ICZh
bXA7IEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1ciBK
IENsaW4gTWljcm9iaW9sIEluZmVjdCBEaXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh
bD48ZnVsbC10aXRsZT5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neSBh
bmQgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkV1ci4gSi4gQ2xpbi4g
TWljcm9iaW9sLiBJbmZlY3QuIERpcy48L2FiYnItMT48YWJici0yPkV1ciBKIENsaW4gTWljcm9i
aW9sIEluZmVjdCBEaXM8L2FiYnItMj48YWJici0zPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmlj
YWwgTWljcm9iaW9sb2d5ICZhbXA7IEluZmVjdGlvdXMgRGlzZWFzZXM8L2FiYnItMz48L3Blcmlv
ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xp
bmljYWwgTWljcm9iaW9sb2d5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxh
YmJyLTE+RXVyLiBKLiBDbGluLiBNaWNyb2Jpb2wuIEluZmVjdC4gRGlzLjwvYWJici0xPjxhYmJy
LTI+RXVyIEogQ2xpbiBNaWNyb2Jpb2wgSW5mZWN0IERpczwvYWJici0yPjxhYmJyLTM+RXVyb3Bl
YW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91cyBEaXNl
YXNlczwvYWJici0zPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIyNS0zMTwvcGFnZXM+PHZvbHVt
ZT4zMTwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNj
ZW50PC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVz
Y2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIb3NwaXRh
bGl6YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFu
dDwva2V5d29yZD48a2V5d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+Kklu
Zmx1ZW56YSwgSHVtYW4vZGkgW0RpYWdub3Npc108L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56
YSwgSHVtYW4vdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl
eXdvcmQ+UmV0cm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlNlcHNpcy9kaSBb
RGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD5TZXBzaXMvbWkgW01pY3JvYmlvbG9neV08L2tl
eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRl
Pk1hcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzUtNDM3MzwvaXNibj48YWNj
ZXNzaW9uLW51bT4yMTY0Mzg2NzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNoIFN1
cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxz
Pjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZh
bXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIxNjQzODY3PC91
cmw+PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQ
bHVzL0Rpc3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMTY0
Mzg2NyZhbXA7aWQ9MTAuMTAwNyUyRnMxMDA5Ni0wMTEtMTI5Ny04JmFtcDtpc3NuPTA5MzQtOTcy
MyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zMSZhbXA7aXNzdWU9MyZhbXA7c3BhZ2U9MjI1JmFtcDtw
YWdlcz0yMjUtMzEmYW1wO2RhdGU9MjAxMiZhbXA7dGl0bGU9RXVyb3BlYW4rSm91cm5hbCtvZitD
bGluaWNhbCtNaWNyb2Jpb2xvZ3krJTI2K0luZmVjdGlvdXMrRGlzZWFzZXMmYW1wO2F0aXRsZT1B
ZG1pc3Npb24rZGlhZ25vc2VzK29mK2NoaWxkcmVuKzAtMTYreWVhcnMrb2YrYWdlK2hvc3BpdGFs
aXplZCt3aXRoK2luZmx1ZW56YS4mYW1wO2F1bGFzdD1TaWx2ZW5ub2luZW4mYW1wO3BpZD0mbHQ7
YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtw
MTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj
LXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDA3L3MxMDA5Ni0wMTEtMTI5Ny04
PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwv
cmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hu
b2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5n
dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5UYXNhcjwvQXV0aG9yPjxZZWFyPjIw
MTI8L1llYXI+PFJlY051bT45MTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTE8L3JlYy1u
dW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3
c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwOTcyMCI+OTE8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRhc2FyLCBNLiBBLjwvYXV0aG9yPjxhdXRo
b3I+RGFsbGFyLCBZLjwvYXV0aG9yPjxhdXRob3I+U295ZXIsIE8uIFUuPC9hdXRob3I+PGF1dGhv
cj5ZaWxkaXJpbSwgUy48L2F1dGhvcj48YXV0aG9yPlRhc2FyLCBNLjwvYXV0aG9yPjxhdXRob3I+
QXJpa2FuLCBGLiBJLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy
ZXNzPihUYXNhciwgRGFsbGFyLCBTb3llciwgWWlsZGlyaW0sIEFyaWthbikgRGVwYXJ0bWVudCBv
ZiBQZWRpYXRyaWNzLCBBbmthcmEgUmVzZWFyY2ggYW5kIEVkdWNhdGlvbiBIb3NwaXRhbCwgMDYw
MzAgQW5rYXJhLCBUdXJrZXkgKFRhc2FyKSBEZXBhcnRtZW50IG9mIFJhZGlvbG9neSwgR3VsaGFu
ZSBNaWxpdGFyeSBNZWRpY2FsIEFjYWRlbXksIEFua2FyYSwgVHVya2V5JiN4RDtNLiBBLiBUYXNh
ciwgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBBbmthcmEgUmVzZWFyY2ggYW5kIEVkdWNhdGlv
biBIb3NwaXRhbCwgMDYwMzAgQW5rYXJhLCBUdXJrZXkuIEUtbWFpbDogYXlzaW50YXNhckB5YWhv
by5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5SaXNrIGZhY3RvcnMgYW5kIHByb2du
b3NpcyBpbiBjaGlsZHJlbiBob3NwaXRhbGl6ZWQgZHVlIHRvIHBhbmRlbWljIEgxTjEgaW5mbHVl
bnphIEEgdmlydXMgaW5mZWN0aW9uIGluIEFua2FyYSwgVHVya2V5PC90aXRsZT48c2Vjb25kYXJ5
LXRpdGxlPlR1cmtpc2ggSm91cm5hbCBvZiBNZWRpY2FsIFNjaWVuY2VzPC9zZWNvbmRhcnktdGl0
bGU+PC90aXRsZXM+PHBhZ2VzPjQzMy00NDA8L3BhZ2VzPjx2b2x1bWU+NDI8L3ZvbHVtZT48bnVt
YmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QXN0aG1hPC9rZXl3b3JkPjxrZXl3b3Jk
Pk9zZWx0YW1pdmlyPC9rZXl3b3JkPjxrZXl3b3JkPlBhbmRlbWljIEgxTjEgaW5mbHVlbnphIEE8
L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ25vc2lzPC9rZXl3b3JkPjxrZXl3b3JkPjIwMDkgSDFOMSBp
bmZsdWVuemEvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+YWJkb21pbmFsIHBh
aW48L2tleXdvcmQ+PGtleXdvcmQ+YXJ0aWNsZTwva2V5d29yZD48a2V5d29yZD5jaGlsZDwva2V5
d29yZD48a2V5d29yZD5jaHJvbmljIHJlc3BpcmF0b3J5IHRyYWN0IGRpc2Vhc2U8L2tleXdvcmQ+
PGtleXdvcmQ+Y29ob3J0IGFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPmNvbnRyb2xsZWQgc3R1
ZHk8L2tleXdvcmQ+PGtleXdvcmQ+Y291Z2hpbmc8L2tleXdvcmQ+PGtleXdvcmQ+ZGVtb2dyYXBo
eTwva2V5d29yZD48a2V5d29yZD5kaWFycmhlYTwva2V5d29yZD48a2V5d29yZD5kaXNlYXNlIGR1
cmF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmRpc2Vhc2UgbWFya2VyPC9rZXl3b3JkPjxrZXl3b3Jk
PmRpc2Vhc2Ugc2V2ZXJpdHk8L2tleXdvcmQ+PGtleXdvcmQ+ZGlzZWFzZSB0cmFuc21pc3Npb248
L2tleXdvcmQ+PGtleXdvcmQ+ZHlzcG5lYTwva2V5d29yZD48a2V5d29yZD5mZW1hbGU8L2tleXdv
cmQ+PGtleXdvcmQ+ZmV2ZXI8L2tleXdvcmQ+PGtleXdvcmQ+Zmx1IGxpa2Ugc3luZHJvbWU8L2tl
eXdvcmQ+PGtleXdvcmQ+Zm9sbG93IHVwPC9rZXl3b3JkPjxrZXl3b3JkPmhlYWRhY2hlPC9rZXl3
b3JkPjxrZXl3b3JkPmhvc3BpdGFsaXplZCBjaGlsZDwva2V5d29yZD48a2V5d29yZD5odW1hbjwv
a2V5d29yZD48a2V5d29yZD5odW1hbiB0aXNzdWU8L2tleXdvcmQ+PGtleXdvcmQ+aW5mYW50PC9r
ZXl3b3JkPjxrZXl3b3JkPm1ham9yIGNsaW5pY2FsIHN0dWR5PC9rZXl3b3JkPjxrZXl3b3JkPm1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+bXlhbGdpYTwva2V5d29yZD48a2V5d29yZD5uZXdib3JuPC9r
ZXl3b3JkPjxrZXl3b3JkPm91dGNvbWUgYXNzZXNzbWVudDwva2V5d29yZD48a2V5d29yZD5veHln
ZW4gY29uc3VtcHRpb248L2tleXdvcmQ+PGtleXdvcmQ+cHJlc2Nob29sIGNoaWxkPC9rZXl3b3Jk
PjxrZXl3b3JkPnJoaW5vcnJoZWE8L2tleXdvcmQ+PGtleXdvcmQ+cmlzayBhc3Nlc3NtZW50PC9r
ZXl3b3JkPjxrZXl3b3JkPnJpc2sgZmFjdG9yPC9rZXl3b3JkPjxrZXl3b3JkPnNjaG9vbCBjaGls
ZDwva2V5d29yZD48a2V5d29yZD5zZWl6dXJlPC9rZXl3b3JkPjxrZXl3b3JkPnNvcmUgdGhyb2F0
PC9rZXl3b3JkPjxrZXl3b3JkPnRhY2h5cG5lYTwva2V5d29yZD48a2V5d29yZD50aHJvYXQgY3Vs
dHVyZTwva2V5d29yZD48a2V5d29yZD5UdXJrZXkgKHJlcHVibGljKTwva2V5d29yZD48a2V5d29y
ZD52b21pdGluZzwva2V5d29yZD48a2V5d29yZD53aGVlemluZzwva2V5d29yZD48a2V5d29yZD5v
c2VsdGFtaXZpci9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48
eWVhcj4yMDEyPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTMwMC0wMTQ0PC9pc2JuPjxhY2Nlc3Npb24t
bnVtPjIwMTIyMTY0MjE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0
dHA6Ly9qb3VybmFscy50dWJpdGFrLmdvdi50ci9tZWRpY2FsL2lzc3Vlcy9zYWctMTItNDItMy9z
YWctNDItMy05LTEwMTEtMTMwOC5wZGY8L3VybD48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20v
b3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZh
bXA7RD1lbWVkMTAmYW1wO0FOPTIwMTIyMTY0MjE8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFj
LnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpFbWJh
c2UmYW1wO2lkPXBtaWQ6JmFtcDtpZD0xMC4zOTA2JTJGc2FnLTEwMTEtMTMwOCZhbXA7aXNzbj0x
MzAwLTAxNDQmYW1wO2lzYm49JmFtcDt2b2x1bWU9NDImYW1wO2lzc3VlPTMmYW1wO3NwYWdlPTQz
MyZhbXA7cGFnZXM9NDMzLTQ0MCZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRsZT1UdXJraXNoK0pvdXJu
YWwrb2YrTWVkaWNhbCtTY2llbmNlcyZhbXA7YXRpdGxlPUFua2FyYSUyN2RhK1BhbmRlbWlrK0lu
Zmx1ZW56YStBK3ZpcnVzK2VuZmVrc2l5b24rbmVkZW5peWxlK2hhc3RhbmV5ZSt5YXRpJTdCZG90
bGVzcyU3RHJpJTdCZG90bGVzcyU3RGxhbitjb2N1a2xhcmRhK3Jpc2srZmFrdG9ybGVyaSt2ZStw
cm9nbm96JmFtcDthdWxhc3Q9VGFzYXImYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0
OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8v
ZHguZG9pLm9yZy8xMC4zOTA2L3NhZy0xMDExLTEzMDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5FbWJhc2U8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1v
dGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1w
cm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaCwgVHVya2lzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9D
aXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA (20, 30-41) (8.3–42% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JenVyaWV0YTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JenVyaWV0YTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+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ADDIN EN.CITE.DATA (42, 43)). Children with asthma accounted for a significantly larger proportion of those hospitalized with pandemic H1N1 than with seasonal influenza PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXdvb2Q8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXdvb2Q8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (18, 44-47). Asthma was also the most common comorbidity among pregnant women hospitalized with H1N1 infection, with a prevalence ranging from 8-33% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS
ZWNOdW0+OTc8L1JlY051bT48RGlzcGxheVRleHQ+KDQ4LTUxKTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj45NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIx
NDgxMjA5NzIwIj45Nzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWls
bGVyLCBBLiBDLjwvYXV0aG9yPjxhdXRob3I+U2FmaSwgRi48L2F1dGhvcj48YXV0aG9yPkh1c3Nh
aW4sIFMuPC9hdXRob3I+PGF1dGhvcj5TdWJyYW1hbmlhbiwgUi4gQS48L2F1dGhvcj48YXV0aG9y
PkVsYW1pbiwgRS4gTS48L2F1dGhvcj48YXV0aG9yPlNpbmVydCwgUi48L2F1dGhvcj48L2F1dGhv
cnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEludGVybmFsIE1l
ZGljaW5lLCBTdGF0ZSBVbml2ZXJzaXR5IG9mIE5ldyBZb3JrIERvd25zdGF0ZSBNZWRpY2FsIENl
bnRlciBhbmQgS2luZ3MgQ291bnR5IEhvc3BpdGFsIENlbnRlciwgQnJvb2tseW4sIE5ZLCBVU0Eu
IHRhcXdhMUBnbWFpbC5jb208L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Ob3ZlbCBpbmZs
dWVuemEgQShIMU4xKSB2aXJ1cyBhbW9uZyBncmF2aWQgYWRtaXNzaW9uczwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5BcmNoaXZlcyBvZiBJbnRlcm5hbCBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxl
PjxhbHQtdGl0bGU+QXJjaCBJbnRlcm4gTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj
YWw+PGZ1bGwtdGl0bGU+QXJjaGl2ZXMgb2YgSW50ZXJuYWwgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+
PGFiYnItMT5BcmNoLiBJbnRlcm4uIE1lZC48L2FiYnItMT48YWJici0yPkFyY2ggSW50ZXJuIE1l
ZDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QXJjaGl2
ZXMgb2YgSW50ZXJuYWwgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5BcmNoLiBJbnRlcm4u
IE1lZC48L2FiYnItMT48YWJici0yPkFyY2ggSW50ZXJuIE1lZDwvYWJici0yPjwvYWx0LXBlcmlv
ZGljYWw+PHBhZ2VzPjg2OC04NzM8L3BhZ2VzPjx2b2x1bWU+MTcwPC92b2x1bWU+PG51bWJlcj4x
MDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRp
dmlyYWwgQWdlbnRzL3R1IFtUaGVyYXBldXRpYyBVc2VdPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBB
IFZpcnVzLCBIMU4xIFN1YnR5cGUvaXAgW0lzb2xhdGlvbiAmYW1wOyBQdXJpZmljYXRpb25dPC9r
ZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL2NvIFtDb21wbGljYXRpb25zXTwva2V5
d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48
a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3
b3JkPlByZWduYW5jeTwva2V5d29yZD48a2V5d29yZD4qUHJlZ25hbmN5IENvbXBsaWNhdGlvbnMs
IEluZmVjdGlvdXM8L2tleXdvcmQ+PGtleXdvcmQ+UmV2ZXJzZSBUcmFuc2NyaXB0YXNlIFBvbHlt
ZXJhc2UgQ2hhaW4gUmVhY3Rpb248L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8
L2tleXdvcmQ+PGtleXdvcmQ+MCAoQW50aXZpcmFsIEFnZW50cyk8L2tleXdvcmQ+PC9rZXl3b3Jk
cz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heSAyNDwvZGF0ZT48
L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzgtMzY3OTwvaXNibj48YWNjZXNzaW9uLW51bT4y
MDQ5ODQxNDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZlIFN0dWR5PC93b3Jr
LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3Zp
ZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7
RD1tZWRsJmFtcDtBTj0yMDQ5ODQxNDwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRo
ZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElO
RSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjA0OTg0MTQmYW1wO2lkPTEwLjEwMDElMkZhcmNoaW50ZXJu
bWVkLjIwMTAuMTI2JmFtcDtpc3NuPTAwMDMtOTkyNiZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xNzAm
YW1wO2lzc3VlPTEwJmFtcDtzcGFnZT04NjgmYW1wO3BhZ2VzPTg2OC03MyZhbXA7ZGF0ZT0yMDEw
JmFtcDt0aXRsZT1BcmNoaXZlcytvZitJbnRlcm5hbCtNZWRpY2luZSZhbXA7YXRpdGxlPU5vdmVs
K2luZmx1ZW56YStBJTI4SDFOMSUyOSt2aXJ1cythbW9uZytncmF2aWQrYWRtaXNzaW9ucy4mYW1w
O2F1bGFzdD1NaWxsZXImYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0
aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxh
dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9y
Zy8xMC4xMDAxL2FyY2hpbnRlcm5tZWQuMjAxMC4xMjY8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVt
b3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2Ut
cHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0
ZT48QXV0aG9yPk1pbGxlcjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT45ODwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRp
bWVzdGFtcD0iMTQ4MTIwOTcyMCI+OTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPk1pbGxlciwgQS4gQy48L2F1dGhvcj48YXV0aG9yPlN1YnJhbWFuaWFuLCBSLiBBLjwv
YXV0aG9yPjxhdXRob3I+U2FmaSwgRi48L2F1dGhvcj48YXV0aG9yPlNpbmVydCwgUi48L2F1dGhv
cj48YXV0aG9yPlplaHRhYmNoaSwgUy48L2F1dGhvcj48YXV0aG9yPkVsYW1pbiwgRS4gTS48L2F1
dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9m
IEVtZXJnZW5jeSBNZWRpY2luZSwgU3RhdGUgVW5pdmVyc2l0eSBvZiBOZXcgWW9yayBEb3duc3Rh
dGUgTWVkaWNhbCBDZW50ZXIgJmFtcDsgS2luZ3MgQ291bnR5IEhvc3BpdGFsIENlbnRlciwgQnJv
b2tseW4sIE5ZLCBVU0EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+SW5mbHVlbnphIEEg
MjAwOSAoSDFOMSkgdmlydXMgaW4gYWRtaXR0ZWQgYW5kIGNyaXRpY2FsbHkgaWxsIHBhdGllbnRz
PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgSW50ZW5zaXZlIENhcmUgTWVkaWNp
bmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogSW50ZW5zaXZlIENhcmUgTWVkPC9hbHQt
dGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBJbnRlbnNp
dmUgQ2FyZSBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJici0xPkouIEludGVuc2l2ZSBDYXJlIE1l
ZC48L2FiYnItMT48YWJici0yPkogSW50ZW5zaXZlIENhcmUgTWVkPC9hYmJyLTI+PC9wZXJpb2Rp
Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEludGVuc2l2ZSBDYXJl
IE1lZGljaW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gSW50ZW5zaXZlIENhcmUgTWVkLjwvYWJi
ci0xPjxhYmJyLTI+SiBJbnRlbnNpdmUgQ2FyZSBNZWQ8L2FiYnItMj48L2FsdC1wZXJpb2RpY2Fs
PjxwYWdlcz4yNS0zMTwvcGFnZXM+PHZvbHVtZT4yNzwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVy
PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5CaW9sb2dpY2FsIE1h
cmtlcnMvYmwgW0Jsb29kXTwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48
a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVtYXRvbG9naWMgVGVzdHM8L2tleXdv
cmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEgQSBWaXJ1cywg
SDFOMSBTdWJ0eXBlPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4vZGkgW0RpYWdu
b3Npc108L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9pbSBbSW1tdW5vbG9neV08
L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9wcCBbUGh5c2lvcGF0aG9sb2d5XTwv
a2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbjwva2V5d29yZD48a2V5d29yZD4qSW50
ZW5zaXZlIENhcmUgVW5pdHMvc24gW1N0YXRpc3RpY3MgJmFtcDsgTnVtZXJpY2FsIERhdGFdPC9r
ZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TmV3IFlvcmsgQ2l0eTwva2V5
d29yZD48a2V5d29yZD4qUGF0aWVudCBBZG1pc3Npb24vc24gW1N0YXRpc3RpY3MgJmFtcDsgTnVt
ZXJpY2FsIERhdGFdPC9rZXl3b3JkPjxrZXl3b3JkPlByYWN0aWNlIEd1aWRlbGluZXMgYXMgVG9w
aWM8L2tleXdvcmQ+PGtleXdvcmQ+UHJlZ25hbmN5PC9rZXl3b3JkPjxrZXl3b3JkPlJhZGlvZ3Jh
cGh5LCBUaG9yYWNpYzwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4
PC9rZXl3b3JkPjxrZXl3b3JkPlVyYmFuIEhlYWx0aCBTZXJ2aWNlczwva2V5d29yZD48a2V5d29y
ZD4wIChCaW9sb2dpY2FsIE1hcmtlcnMpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy
PjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl
cz48aXNibj4xNTI1LTE0ODk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzMDA2NzE8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3Zp
ZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7
RD1tZWRsJmFtcDtBTj0yMTMwMDY3MTwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRo
ZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElO
RSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjEzMDA2NzEmYW1wO2lkPTEwLjExNzclMkYwODg1MDY2NjEw
MzkzNjI2JmFtcDtpc3NuPTA4ODUtMDY2NiZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yNyZhbXA7aXNz
dWU9MSZhbXA7c3BhZ2U9MjUmYW1wO3BhZ2VzPTI1LTMxJmFtcDtkYXRlPTIwMTImYW1wO3RpdGxl
PUpvdXJuYWwrb2YrSW50ZW5zaXZlK0NhcmUrTWVkaWNpbmUmYW1wO2F0aXRsZT1JbmZsdWVuemEr
QSsyMDA5KyUyOEgxTjElMjkrdmlydXMraW4rYWRtaXR0ZWQrYW5kK2NyaXRpY2FsbHkraWxsK3Bh
dGllbnRzLiZhbXA7YXVsYXN0PU1pbGxlciZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8m
Z3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8
L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6
Ly9keC5kb2kub3JnLzEwLjExNzcvMDg4NTA2NjYxMDM5MzYyNjwvZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1l
PjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRh
YmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRl
PjxDaXRlPjxBdXRob3I+TWljaGFhbjwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT45
OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+OTk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5
cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYw
enQiIHRpbWVzdGFtcD0iMTQ4MTIwOTcyMCI+OTk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5
cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0
aG9ycz48YXV0aG9yPk1pY2hhYW4sIE4uPC9hdXRob3I+PGF1dGhvcj5BbXphbGxhZywgUy48L2F1
dGhvcj48YXV0aG9yPkxhc2tvdiwgSS48L2F1dGhvcj48YXV0aG9yPkNvaGVuLCBZLjwvYXV0aG9y
PjxhdXRob3I+RnJpZWQsIE0uPC9hdXRob3I+PGF1dGhvcj5MZXNzaW5nLCBKLiBCLjwvYXV0aG9y
PjxhdXRob3I+TWFueSwgQS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgt
YWRkcmVzcz5MaXMgTWF0ZXJuaXR5IEhvc3BpdGFsLCBTb3VyYXNreSBUZWwtQXZpdiBNZWRpY2Fs
IENlbnRlciwgVGVsLUF2aXYgVW5pdmVyc2l0eSwgVGVsLUF2aXYsIElzcmFlbC48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5NYXRlcm5hbCBhbmQgbmVvbmF0YWwgb3V0Y29tZSBvZiBwcmVn
bmFudCB3b21lbiBpbmZlY3RlZCB3aXRoIEgxTjEgaW5mbHVlbnphIHZpcnVzIChzd2luZSBmbHUp
PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgTWF0ZXJuYWwtRmV0YWwgJmFtcDsg
TmVvbmF0YWwgTWVkaWNpbmU8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogTWF0ZXJuIEZl
dGFsIE5lb25hdGFsIE1lZDwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRp
dGxlPkpvdXJuYWwgb2YgTWF0ZXJuYWwtRmV0YWwgJmFtcDsgTmVvbmF0YWwgTWVkaWNpbmU8L2Z1
bGwtdGl0bGU+PGFiYnItMT5KLiBNYXRlcm4uIEZldGFsIE5lb25hdGFsIE1lZC48L2FiYnItMT48
YWJici0yPkogTWF0ZXJuIEZldGFsIE5lb25hdGFsIE1lZDwvYWJici0yPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBNYXRlcm5hbC1GZXRhbCAmYW1w
OyBOZW9uYXRhbCBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJici0xPkouIE1hdGVybi4gRmV0YWwg
TmVvbmF0YWwgTWVkLjwvYWJici0xPjxhYmJyLTI+SiBNYXRlcm4gRmV0YWwgTmVvbmF0YWwgTWVk
PC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTMwLTI8L3BhZ2VzPjx2b2x1bWU+MjU8
L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdv
cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5
d29yZD5JbmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBBIFZpcnVz
LCBIMU4xIFN1YnR5cGU8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vZXAgW0Vw
aWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi92aSBbVmlyb2xv
Z3ldPC9rZXl3b3JkPjxrZXl3b3JkPklzcmFlbC9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48
a2V5d29yZD5QcmVnbmFuY3k8L2tleXdvcmQ+PGtleXdvcmQ+KlByZWduYW5jeSBDb21wbGljYXRp
b25zLCBJbmZlY3Rpb3VzL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipQcmVn
bmFuY3kgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3
b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy
PjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5GZWI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl
cz48aXNibj4xNDc2LTQ5NTQ8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjE0NzY3OTQ8L2FjY2Vzc2lv
bi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3Zp
ZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7
RD1tZWRsJmFtcDtBTj0yMTQ3Njc5NDwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRo
ZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElO
RSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjE0NzY3OTQmYW1wO2lkPTEwLjMxMDklMkYxNDc2NzA1OC4y
MDExLjU2MjU2OSZhbXA7aXNzbj0xNDc2LTQ5NTQmYW1wO2lzYm49JmFtcDt2b2x1bWU9MjUmYW1w
O2lzc3VlPTImYW1wO3NwYWdlPTEzMCZhbXA7cGFnZXM9MTMwLTImYW1wO2RhdGU9MjAxMiZhbXA7
dGl0bGU9Sm91cm5hbCtvZitNYXRlcm5hbC1GZXRhbCslMjYrTmVvbmF0YWwrTWVkaWNpbmUmYW1w
O2F0aXRsZT1NYXRlcm5hbCthbmQrbmVvbmF0YWwrb3V0Y29tZStvZitwcmVnbmFudCt3b21lbitp
bmZlY3RlZCt3aXRoK0gxTjEraW5mbHVlbnphK3ZpcnVzKyUyOHN3aW5lK2ZsdSUyOS4mYW1wO2F1
bGFzdD1NaWNoYWFuJmFtcDtwaWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhv
ciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcv
MTAuMzEwOS8xNDc2NzA1OC4yMDExLjU2MjU2OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl
bW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUt
ZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92
aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB
dXRob3I+VGFoYTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT45PC9SZWNOdW0+PHJl
Y29yZD48cmVjLW51bWJlcj45PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9
IjE0ODEyMDgzMTEiPjk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRh
aGEsIEluYXNzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxl
PkNoYXJhY3RlcmlzdGljcyBvZiBwcmVnbmFudCBXb21lbiBhZG1pdHRlZCB3aXRoIDIwMDkgSDFO
MSBJbmZsdWVuemEgaW4gYSByZWZlcnJhbCBtYXRlcm5pdHkgaG9zcGl0YWwgYXQgQWwtTWFkaW5h
aCwgU2F1ZGkgQXJhYmlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkVneXB0aWFuIEpvdXJuYWwg
b2YgSG9zcGl0YWwgTWVkaWNpbmUgKEp1bHkgMjAxMyk8L3NlY29uZGFyeS10aXRsZT48L3RpdGxl
cz48cGFnZXM+NjUwLTY1NzwvcGFnZXM+PHZvbHVtZT41Mjwvdm9sdW1lPjxkYXRlcz48eWVhcj4y
MDE0PC95ZWFyPjwvZGF0ZXM+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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 EN.CITE.DATA (48-51).Asthma represented a risk factor for hospitalization during influenza seasons in the general population PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DdWxsZW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DdWxsZW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (52), with an OR of 2.6 (95% CI 1.6–4.0) in two Canadian studies PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaWxjYTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HaWxjYTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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ADDIN EN.CITE.DATA (53, 54), and a relative risk (RR) of 4.47 (95% CI 1.49–13.39) in Israel PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGltb25pPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGltb25pPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA (55). The same applied to children PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DcmlzaW5lbDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DcmlzaW5lbDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+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=
ADDIN EN.CITE.DATA (41, 56, 57), where asthma conferred a 4-fold risk of hospitalization (USA PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWNrZXJtYW48L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWNrZXJtYW48L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy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ADDIN EN.CITE.DATA (58), Germany PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XZWlnbDwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XZWlnbDwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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 EN.CITE.DATA (35), and Argentina ADDIN EN.CITE <EndNote><Cite><Author>Libster</Author><Year>2010</Year><RecNum>107</RecNum><DisplayText>(59)</DisplayText><record><rec-number>107</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209720">107</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Libster, R.</author><author>Coviello, S.</author><author>Cavalieri, M. L.</author><author>Morosi, A.</author><author>Alabart, N.</author><author>Alvarez, L.</author><author>Ferrero, F.</author><author>Edwards, K. M.</author><author>Polack, F. P.</author></authors></contributors><titles><title>Pediatric hospitalizations due to influenza in 2010 in Argentina</title><secondary-title>N Engl J Med</secondary-title><alt-title>The New England journal of medicine</alt-title></titles><periodical><full-title>New England Journal of Medicine</full-title><abbr-1>N. Engl. J. Med.</abbr-1><abbr-2>N Engl J Med</abbr-2></periodical><pages>2472-3</pages><volume>363</volume><number>25</number><keywords><keyword>Argentina/epidemiology</keyword><keyword>Child</keyword><keyword>Cost of Illness</keyword><keyword>Hospitalization/*statistics & numerical data</keyword><keyword>Humans</keyword><keyword>*Influenza A Virus, H1N1 Subtype</keyword><keyword>Influenza, Human/*epidemiology/virology</keyword><keyword>Pandemics/statistics & numerical data</keyword></keywords><dates><year>2010</year><pub-dates><date>Dec 16</date></pub-dates></dates><isbn>1533-4406 (Electronic)
0028-4793 (Linking)</isbn><accession-num>21158677</accession-num><urls><related-urls><url>;(59)), with a 21-fold risk observed in South Korea PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (60). Interestingly, influenza-related hospitalization costs in children with asthma may be lower than in children with other chronic conditions, and were very close to costs in children without comorbidity PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXNzYW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYXNzYW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxS
ZWNOdW0+MTA5PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig2MSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MTA5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDk3MjAiPjEwOTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SGFz
c2FuLCBGLjwvYXV0aG9yPjxhdXRob3I+TGV3aXMsIFQuIEMuPC9hdXRob3I+PGF1dGhvcj5EYXZp
cywgTS4gTS48L2F1dGhvcj48YXV0aG9yPkdlYnJlbWFyaWFtLCBBLjwvYXV0aG9yPjxhdXRob3I+
RG9tYmtvd3NraSwgSy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk
cmVzcz5EaXZpc2lvbiBvZiBTbGVlcCBNZWRpY2luZSwgQ2hpbGQgSGVhbHRoIEV2YWx1YXRpb24g
YW5kIFJlc2VhcmNoIFVuaXQsIFVuaXZlcnNpdHkgb2YgTWljaGlnYW4sIEFubiBBcmJvciwgTWlj
aGlnYW4gNDgxMDktNTQ1NiwgVVNBLiBmaGFzQG1lZC51bWljaC5lZHU8L2F1dGgtYWRkcmVzcz48
dGl0bGVzPjx0aXRsZT5Ib3NwaXRhbCB1dGlsaXphdGlvbiBhbmQgY29zdHMgYW1vbmcgY2hpbGRy
ZW4gd2l0aCBpbmZsdWVuemEsIDIwMDM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW1lcmljYW4g
Sm91cm5hbCBvZiBQcmV2ZW50aXZlIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs
ZT5BbSBKIFByZXYgTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+QW1lcmljYW4gSm91cm5hbCBvZiBQcmV2ZW50aXZlIE1lZGljaW5lPC9mdWxsLXRpdGxlPjxh
YmJyLTE+QW0uIEouIFByZXYuIE1lZC48L2FiYnItMT48YWJici0yPkFtIEogUHJldiBNZWQ8L2Fi
YnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpv
dXJuYWwgb2YgUHJldmVudGl2ZSBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJici0xPkFtLiBKLiBQ
cmV2LiBNZWQuPC9hYmJyLTE+PGFiYnItMj5BbSBKIFByZXYgTWVkPC9hYmJyLTI+PC9hbHQtcGVy
aW9kaWNhbD48cGFnZXM+MjkyLTY8L3BhZ2VzPjx2b2x1bWU+MzY8L3ZvbHVtZT48bnVtYmVyPjQ8
L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5D
aGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3Jk
PkNvaG9ydCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPipDb3N0IG9mIElsbG5lc3M8L2tleXdv
cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIENvc3RzPC9rZXl3
b3JkPjxrZXl3b3JkPipIb3NwaXRhbHMvdXQgW1V0aWxpemF0aW9uXTwva2V5d29yZD48a2V5d29y
ZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPkluZmFu
dCwgTmV3Ym9ybjwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9lYyBbRWNvbm9t
aWNzXTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi90aCBbVGhlcmFweV08L2tl
eXdvcmQ+PGtleXdvcmQ+Kkxlbmd0aCBvZiBTdGF5L2VjIFtFY29ub21pY3NdPC9rZXl3b3JkPjxr
ZXl3b3JkPipMZW5ndGggb2YgU3RheS9zbiBbU3RhdGlzdGljcyAmYW1wOyBOdW1lcmljYWwgRGF0
YV08L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5SZXRyb3NwZWN0aXZl
IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlczwva2V5d29yZD48L2tleXdv
cmRzPjxkYXRlcz48eWVhcj4yMDA5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwv
cHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3My0yNjA3PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE5
MjAxMTQ3PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkgu
LCBFeHRyYW11cmFsPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9v
dmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7
UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xOTIwMTE0NzwvdXJsPjx1cmw+aHR0cDov
L29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3Np
ZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MTkyMDExNDcmYW1wO2lkPTEw
LjEwMTYlMkZqLmFtZXByZS4yMDA4LjExLjAxNiZhbXA7aXNzbj0wNzQ5LTM3OTcmYW1wO2lzYm49
JmFtcDt2b2x1bWU9MzYmYW1wO2lzc3VlPTQmYW1wO3NwYWdlPTI5MiZhbXA7cGFnZXM9MjkyLTYm
YW1wO2RhdGU9MjAwOSZhbXA7dGl0bGU9QW1lcmljYW4rSm91cm5hbCtvZitQcmV2ZW50aXZlK01l
ZGljaW5lJmFtcDthdGl0bGU9SG9zcGl0YWwrdXRpbGl6YXRpb24rYW5kK2Nvc3RzK2Ftb25nK2No
aWxkcmVuK3dpdGgraW5mbHVlbnphJTJDKzIwMDMuJmFtcDthdWxhc3Q9SGFzc2FuJmFtcDtwaWQ9
Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsm
bHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmFtZXByZS4yMDA4
LjExLjAxNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1F
RExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3Zp
ZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlz
aDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA (61).Asthma patients seemed to have a higher risk of being admitted to the intensive care unit (ICU) or to have a more severe disease course when hospitalized for influenza W0NvbXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPkJyb25jaGl0aXMvZHQgW0RydWcgVGhl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbCBTdWJhaWU8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy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==
ADDIN EN.CITE.DATA W0NvbXBsaWNhdGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPkJyb25jaGl0aXMvZHQgW0RydWcgVGhl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 EN.CITE.DATA (20, 27, 37, 39, 44, 60, 62-64), with an OR of 4.92 (95% CI 1.38–17.33) in Argentinian children PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaWJzdGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaWJzdGVyPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48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ADDIN EN.CITE.DATA (63) and a RR of 15.20 (95% CI 1.16-199.63) in China >15 years of age ADDIN EN.CITE <EndNote><Cite><Author>Jiang</Author><Year>2015</Year><RecNum>4</RecNum><DisplayText>(65)</DisplayText><record><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jiang, H</author><author>Yu, D</author><author>Ruan, F</author><author>Xu, W</author><author>Huang, T</author><author>Li, L</author><author>Wang, K</author><author>Liu, S</author><author>Zhang, H</author><author>Jia, P</author></authors></contributors><titles><title>Clinical characteristics of adult influenza inpatients in ten provinces in China and analysis of severe risk factors</title><secondary-title>Zhonghua liuxingbingxue zazhi</secondary-title></titles><pages>216-221</pages><volume>36</volume><number>3</number><dates><year>2015</year></dates><isbn>0254-6450</isbn><urls></urls></record></Cite></EndNote>(65). Severe disease was especially common in those developing pneumonia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0tlbm5hPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
UmVjTnVtPjc2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyNyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+NzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4
MTIwOTcyMCI+NzY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1jS2Vu
bmEsIEouIEouPC9hdXRob3I+PGF1dGhvcj5CcmFtbGV5LCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+
U2thcmJpbnNraSwgSi48L2F1dGhvcj48YXV0aG9yPkZyeSwgQS4gTS48L2F1dGhvcj48YXV0aG9y
PkZpbmVsbGksIEwuPC9hdXRob3I+PGF1dGhvcj5KYWluLCBTLjwvYXV0aG9yPjxhdXRob3I+UGFu
ZGVtaWMgSW5mbHVlbnphLCBBLiBWaXJ1cyBIb3NwaXRhbGl6YXRpb25zIEludmVzdGlnYXRpb24g
VGVhbTwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkluZmx1
ZW56YSBEaXZpc2lvbiwgQ2VudGVycyBmb3IgRGlzZWFzZSBDb250cm9sIGFuZCBQcmV2ZW50aW9u
IEF0bGFudGEsIEF0bGFudGEsIEdBLCBVU0EuIGpqbWNrZW5uQHdpc2MuZWR1PC9hdXRoLWFkZHJl
c3M+PHRpdGxlcz48dGl0bGU+QXN0aG1hIGluIHBhdGllbnRzIGhvc3BpdGFsaXplZCB3aXRoIHBh
bmRlbWljIGluZmx1ZW56YSBBKEgxTjEpcGRtMDkgdmlydXMgaW5mZWN0aW9uLVVuaXRlZCBTdGF0
ZXMsIDIwMDk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1DIEluZmVjdCBEaXM8L3NlY29uZGFy
eS10aXRsZT48YWx0LXRpdGxlPkJNQyBpbmZlY3Rpb3VzIGRpc2Vhc2VzPC9hbHQtdGl0bGU+PC90
aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Qk1DIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1
bGwtdGl0bGU+PGFiYnItMT5CTUMgSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5CTUMgSW5m
ZWN0IERpczwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
Qk1DIEluZmVjdGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5CTUMgSW5mZWN0LiBE
aXMuPC9hYmJyLTE+PGFiYnItMj5CTUMgSW5mZWN0IERpczwvYWJici0yPjwvYWx0LXBlcmlvZGlj
YWw+PHBhZ2VzPjU3PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1bWU+PGtleXdvcmRzPjxrZXl3b3Jk
PkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdl
ZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29yZD48a2V5d29yZD5B
c3RobWEvKmNvbXBsaWNhdGlvbnMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxk
PC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+Q29t
b3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3Bp
dGFsIE1vcnRhbGl0eTwva2V5d29yZD48a2V5d29yZD4qSG9zcGl0YWxpemF0aW9uPC9rZXl3b3Jk
PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgx
TjEgU3VidHlwZTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuLypjb21wbGljYXRp
b25zL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3Jk
Pk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5
PC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz
Pjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48aXNibj4xNDcxLTIzMzQgKEVsZWN0cm9uaWMpJiN4
RDsxNDcxLTIzMzQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzMzY5MDM0PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzIzMzY5MDM0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y
PjM1ODU1MTA8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExODYvMTQ3MS0y
MzM0LTEzLTU3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO
b3RlPn==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY0tlbm5hPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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ADDIN EN.CITE.DATA (27), but did not seem to be related to the severity of underlying asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PJmFwb3M7UmlvcmRhbjwvQXV0aG9yPjxZZWFyPjIwMTA8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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PJmFwb3M7UmlvcmRhbjwvQXV0aG9yPjxZZWFyPjIwMTA8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ADDIN EN.CITE.DATA (45). In a multivariate analysis of H1N1 pediatric patients, asthma was associated with increased mortality in ICU-admitted children and adolescents (OR 1.34, p=0.05) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3JyZXM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
ZWNOdW0+MTEwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig2Mik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MTEwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDk3MjAiPjExMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VG9y
cmVzLCBTLiBGLjwvYXV0aG9yPjxhdXRob3I+SW9sc3RlciwgVC48L2F1dGhvcj48YXV0aG9yPlNj
aG5pdHpsZXIsIEUuIEouPC9hdXRob3I+PGF1dGhvcj5GYXJpYXMsIEouIEEuPC9hdXRob3I+PGF1
dGhvcj5Cb3Jkb2duYSwgQS4gQy48L2F1dGhvcj48YXV0aG9yPlJ1ZmFjaCwgRC48L2F1dGhvcj48
YXV0aG9yPk1vbnRlcywgTS4gSi48L2F1dGhvcj48YXV0aG9yPlNpYWJhLCBBLiBKLjwvYXV0aG9y
PjxhdXRob3I+Um9kcmlndWV6LCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+SmFib3JuaXNreSwgUi48
L2F1dGhvcj48YXV0aG9yPkNvbG1hbiwgQy48L2F1dGhvcj48YXV0aG9yPkZlcm5hbmRleiwgQS48
L2F1dGhvcj48YXV0aG9yPkNhcHJvdHRhLCBHLjwvYXV0aG9yPjxhdXRob3I+RGlheiwgUy48L2F1
dGhvcj48YXV0aG9yPlBvdGVyYWxhLCBSLjwvYXV0aG9yPjxhdXRob3I+RGUgTWV5ZXIsIE0uPC9h
dXRob3I+PGF1dGhvcj5QZW5henppLCBNLiBFLjwvYXV0aG9yPjxhdXRob3I+R29uemFsZXosIEcu
PC9hdXRob3I+PGF1dGhvcj5TYWVueiwgUy48L2F1dGhvcj48YXV0aG9yPlJlY3VwZXJvLCBPLjwv
YXV0aG9yPjxhdXRob3I+WmFwaWNvLCBMLjwvYXV0aG9yPjxhdXRob3I+QWxhcmNvbiwgQi48L2F1
dGhvcj48YXV0aG9yPkFyaWVsLCBFLjwvYXV0aG9yPjxhdXRob3I+TWluY2VzLCBQLjwvYXV0aG9y
PjxhdXRob3I+TWFyaSwgRS48L2F1dGhvcj48YXV0aG9yPkNhcm5pZSwgQS48L2F1dGhvcj48YXV0
aG9yPkdhcmVhLCBNLjwvYXV0aG9yPjxhdXRob3I+SmFlbiwgUi48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Ib3NwaXRhbCBVbml2ZXJzaXRhcmlvIEF1c3Ry
YWwsIEFyZ2VudGluYS4gc3RvcnJlc0BjYXMuYXVzdHJhbC5lZHUuYXI8L2F1dGgtYWRkcmVzcz48
dGl0bGVzPjx0aXRsZT5IaWdoIG1vcnRhbGl0eSBpbiBwYXRpZW50cyB3aXRoIGluZmx1ZW56YSBB
IHBIMU4xIDIwMDkgYWRtaXR0ZWQgdG8gYSBwZWRpYXRyaWMgaW50ZW5zaXZlIGNhcmUgdW5pdDog
YSBwcmVkaWN0aXZlIG1vZGVsIG9mIG1vcnRhbGl0eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Q
ZWRpYXRyaWMgQ3JpdGljYWwgQ2FyZSBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0
bGU+UGVkaWF0ciBDcml0IENhcmUgTWVkPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+UGVkaWF0cmljIENyaXRpY2FsIENhcmUgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+
PGFiYnItMT5QZWRpYXRyLiBDcml0LiBDYXJlIE1lZC48L2FiYnItMT48YWJici0yPlBlZGlhdHIg
Q3JpdCBDYXJlIE1lZDwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+UGVkaWF0cmljIENyaXRpY2FsIENhcmUgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5QZWRpYXRyLiBDcml0LiBDYXJlIE1lZC48L2FiYnItMT48YWJici0yPlBlZGlhdHIgQ3JpdCBD
YXJlIE1lZDwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPmU3OC04MzwvcGFnZXM+PHZv
bHVtZT4xMzwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5Bcmdl
bnRpbmEvZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9v
bDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Kkhvc3BpdGFsIE1v
cnRhbGl0eTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50
PC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEgQSBWaXJ1cywgSDFOMSBTdWJ0eXBlPC9rZXl3
b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL21vIFtNb3J0YWxpdHldPC9rZXl3b3JkPjxr
ZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4vdGggW1RoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPipJ
bnRlbnNpdmUgQ2FyZSBVbml0cywgUGVkaWF0cmljL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVy
aWNhbCBEYXRhXTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipNb2Rl
bHMsIFN0YXRpc3RpY2FsPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0aW9uLCBBcnRpZmljaWFs
PC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29y
ZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdv
cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1h
cjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjktNzUzNTwvaXNibj48YWNjZXNz
aW9uLW51bT4yMTU1MjE4MDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+
aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX
Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIxNTUyMTgwPC91cmw+PHVy
bD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rp
c3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMTU1MjE4MCZh
bXA7aWQ9MTAuMTA5NyUyRlBDQy4wYjAxM2UzMTgyMTkyNjZiJmFtcDtpc3NuPTE1MjktNzUzNSZh
bXA7aXNibj0mYW1wO3ZvbHVtZT0xMyZhbXA7aXNzdWU9MiZhbXA7c3BhZ2U9ZTc4JmFtcDtwYWdl
cz1lNzgtODMmYW1wO2RhdGU9MjAxMiZhbXA7dGl0bGU9UGVkaWF0cmljK0NyaXRpY2FsK0NhcmUr
TWVkaWNpbmUmYW1wO2F0aXRsZT1IaWdoK21vcnRhbGl0eStpbitwYXRpZW50cyt3aXRoK2luZmx1
ZW56YStBK3BIMU4xKzIwMDkrYWRtaXR0ZWQrdG8rYStwZWRpYXRyaWMraW50ZW5zaXZlK2NhcmUr
dW5pdCUzQSthK3ByZWRpY3RpdmUrbW9kZWwrb2YrbW9ydGFsaXR5LiZhbXA7YXVsYXN0PVRvcnJl
cyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsm
bHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwOTcvUEND
LjBiMDEzZTMxODIxOTI2NmI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJh
c2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXBy
b3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1
YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ub3JyZXM8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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 EN.CITE.DATA (62). However, a retrospective analysis performed in the UK on 1,520 patients showed that patients with asthma hospitalized because of influenza A infection were less likely to require ICU or die compared with those without asthma, with an OR of 0.51 (95%CI 0.36–0.72) for severe outcome PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA (22). Two other studies confirmed this finding PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZ3V5ZW4tVmFuLVRhbTwvQXV0aG9yPjxZZWFyPjIwMTA8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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZ3V5ZW4tVmFuLVRhbTwvQXV0aG9yPjxZZWFyPjIwMTA8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==
ADDIN EN.CITE.DATA (19, 23), which may be even more pronounced in those with pre-admission inhaled (OR 0.34; 95% CI 0.18–0.66) or systemic corticosteroid treatment (OR 0.36 95% CI 0.18–0.72) for asthma and an earlier hospital admission (within 4 days from symptom onset - adjusted OR 0.60 95%CI 0.38–0.94) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NeWxlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl
Y051bT43MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMjIpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjcxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEy
MDk3MjAiPjcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NeWxlcywg
UC48L2F1dGhvcj48YXV0aG9yPk5ndXllbi1WYW4tVGFtLCBKLiBTLjwvYXV0aG9yPjxhdXRob3I+
U2VtcGxlLCBNLiBHLjwvYXV0aG9yPjxhdXRob3I+QnJldHQsIFMuIEouPC9hdXRob3I+PGF1dGhv
cj5CYW5uaXN0ZXIsIEIuPC9hdXRob3I+PGF1dGhvcj5SZWFkLCBSLiBDLjwvYXV0aG9yPjxhdXRo
b3I+VGF5bG9yLCBCLiBMLjwvYXV0aG9yPjxhdXRob3I+TWNNZW5hbWluLCBKLjwvYXV0aG9yPjxh
dXRob3I+RW5zdG9uZSwgSi4gRS48L2F1dGhvcj48YXV0aG9yPk5pY2hvbHNvbiwgSy4gRy48L2F1
dGhvcj48YXV0aG9yPk9wZW5zaGF3LCBQLiBKLjwvYXV0aG9yPjxhdXRob3I+TGltLCBXLiBTLjwv
YXV0aG9yPjxhdXRob3I+SW5mbHVlbnphIENsaW5pY2FsIEluZm9ybWF0aW9uIE5ldHdvcmssIEZs
dS1DaW48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Vbml2
ZXJzaXR5IG9mIE5vdHRpbmdoYW0sIE5vdHRpbmdoYW0uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48
dGl0bGU+RGlmZmVyZW5jZXMgYmV0d2VlbiBhc3RobWF0aWNzIGFuZCBub25hc3RobWF0aWNzIGhv
c3BpdGFsaXNlZCB3aXRoIGluZmx1ZW56YSBBIGluZmVjdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10
aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10
aXRsZT5FdXIgUmVzcGlyIEo8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10
aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVy
LiBSZXNwaXIuIEouPC9hYmJyLTE+PGFiYnItMj5FdXIgUmVzcGlyIEo8L2FiYnItMj48L3Blcmlv
ZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIFJlc3BpcmF0b3J5IEpv
dXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIFJlc3Bpci4gSi48L2FiYnItMT48YWJici0y
PkV1ciBSZXNwaXIgSjwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjgyNC0zMTwvcGFn
ZXM+PHZvbHVtZT40MTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29y
ZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkcmVuYWwgQ29ydGV4IEhvcm1vbmVzL3R1
IFtUaGVyYXBldXRpYyBVc2VdPC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3
b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92ZXI8L2tleXdvcmQ+PGtl
eXdvcmQ+KkFzdGhtYS9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+Q2FzZS1D
b250cm9sIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+
Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5Db21vcmJpZGl0eTwva2V5d29yZD48
a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R3JlYXQgQnJpdGFpbjwva2V5d29yZD48
a2V5d29yZD5Ib3NwaXRhbGl6YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk
PjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgQSBWaXJ1cywgSDFO
MSBTdWJ0eXBlPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL2NvIFtDb21wbGlj
YXRpb25zXTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9kaSBbRGlhZ25vc2lz
XTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r
ZXl3b3JkPjxrZXl3b3JkPk11bHRpdmFyaWF0ZSBBbmFseXNpczwva2V5d29yZD48a2V5d29yZD5P
ZGRzIFJhdGlvPC9rZXl3b3JkPjxrZXl3b3JkPlByb2dub3Npczwva2V5d29yZD48a2V5d29yZD5Q
dWJsaWMgSGVhbHRoIFN1cnZlaWxsYW5jZTwva2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgTWVk
aWNpbmUvbXQgW01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgU3R1ZGll
czwva2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRt
ZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+WW91bmcgQWR1bHQ8L2tleXdvcmQ+PGtleXdv
cmQ+MCAoQWRyZW5hbCBDb3J0ZXggSG9ybW9uZXMpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVz
Pjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+PC9wdWItZGF0ZXM+
PC9kYXRlcz48aXNibj4xMzk5LTMwMDM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjI5MDM5NjM8L2Fj
Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7UmVzZWFyY2ggU3Vw
cG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+
PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFt
cDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjI5MDM5NjM8L3Vy
bD48dXJsPmh0dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBs
dXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjIyOTAz
OTYzJmFtcDtpZD0xMC4xMTgzJTJGMDkwMzE5MzYuMDAwMTU1MTImYW1wO2lzc249MDkwMy0xOTM2
JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTQxJmFtcDtpc3N1ZT00JmFtcDtzcGFnZT04MjQmYW1wO3Bh
Z2VzPTgyNC0zMSZhbXA7ZGF0ZT0yMDEzJmFtcDt0aXRsZT1FdXJvcGVhbitSZXNwaXJhdG9yeStK
b3VybmFsJmFtcDthdGl0bGU9RGlmZmVyZW5jZXMrYmV0d2Vlbithc3RobWF0aWNzK2FuZCtub25h
c3RobWF0aWNzK2hvc3BpdGFsaXNlZCt3aXRoK2luZmx1ZW56YStBK2luZmVjdGlvbi4mYW1wO2F1
bGFzdD1NeWxlcyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3Im
Z3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQt
dXJscz48L3VybHM+PGN1c3RvbTI+UE1DMzYxMjU4MDwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNv
dXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE4My8wOTAzMTkzNi4wMDAxNTUxMjwvZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90
ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dp
ZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+
PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA (22).2b. Influenza-induced acute asthma exacerbationsInfluenza, like other respiratory viral infections, can lead to AAE and was found to account for 32.0% ADDIN EN.CITE <EndNote><Cite><Author>Wark</Author><Year>2001</Year><RecNum>162</RecNum><DisplayText>(66)</DisplayText><record><rec-number>162</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">162</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wark, P. A. B.</author><author>Johnston, S. L.</author><author>Moric, I.</author><author>Simpson, J. L.</author><author>Hensley, M. J.</author><author>Gibson, P. G.</author></authors></contributors><titles><title>Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma</title><secondary-title>European Respiratory Journal</secondary-title></titles><periodical><full-title>European Respiratory Journal</full-title><abbr-1>Eur. Respir. J.</abbr-1><abbr-2>Eur Respir J</abbr-2></periodical><pages>68-75</pages><volume>19</volume><number>1</number><dates><year>2001</year><pub-dates><date>2001/01/01</date></pub-dates></dates><publisher>European Respiratory Society (ERS)</publisher><isbn>0903-1936
1399-3003</isbn><urls><related-urls><url>;(66) and 9.8% ADDIN EN.CITE <EndNote><Cite><Author>Atmar</Author><Year>1998</Year><RecNum>165</RecNum><DisplayText>(67)</DisplayText><record><rec-number>165</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">165</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Atmar, Robert L.</author><author>Guy, Elizabeth</author><author>Guntupalli, Kalpalatha K.</author><author>Zimmerman, Janice L.</author><author>Bandi, Venkata D.</author><author>Baxter, Barbara D.</author><author>Greenberg, Stephen B.</author></authors></contributors><titles><title>Respiratory Tract Viral Infections in Inner-City Asthmatic Adults</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>2453</pages><volume>158</volume><number>22</number><dates><year>1998</year><pub-dates><date>1998/12/07</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(67) of AAEs in two studies of adults with asthma outpatients. However, the method used to identify the presence of influenza in AAE episodes largely determines the outcome. A direct comparison of molecular (PCR), serological, and immunofluorescent (IFA) detection in the same cohort of adults with asthma found influenza rates of 24.0%, 18.3%, and 2.0% respectively in AAEs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1wc29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1wc29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE.DATA (68). Thus, the validity of studies that applied conventional influenza identification techniques such as cytopathic effect in cell culture followed by indirect immunofluoresence to confirm viral presence PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE.DATA (69) is questionable. Among hospitalized adults with asthma patients, rates of influenza-induced AAE were reported at 10.0% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JaWt1cmE8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JaWt1cmE8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS
ZWNOdW0+MjQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig3MCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MjQ2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
OTI1OTMwMTAiPjI0Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SWlr
dXJhLCBNLjwvYXV0aG9yPjxhdXRob3I+SG9qbywgTS48L2F1dGhvcj48YXV0aG9yPktva2V0c3Us
IFIuPC9hdXRob3I+PGF1dGhvcj5XYXRhbmFiZSwgUy48L2F1dGhvcj48YXV0aG9yPlNhdG8sIEEu
PC9hdXRob3I+PGF1dGhvcj5DaGlubywgSC48L2F1dGhvcj48YXV0aG9yPlJvLCBTLjwvYXV0aG9y
PjxhdXRob3I+TWFzYWtpLCBILjwvYXV0aG9yPjxhdXRob3I+SGlyYXNoaW1hLCBKLjwvYXV0aG9y
PjxhdXRob3I+SXNoaWksIFMuPC9hdXRob3I+PGF1dGhvcj5OYWthLCBHLjwvYXV0aG9yPjxhdXRo
b3I+VGFrYXNha2ksIEouPC9hdXRob3I+PGF1dGhvcj5JenVtaSwgUy48L2F1dGhvcj48YXV0aG9y
PktvYmF5YXNoaSwgTi48L2F1dGhvcj48YXV0aG9yPllhbWFndWNoaSwgUy48L2F1dGhvcj48YXV0
aG9yPk5ha2FlLCBTLjwvYXV0aG9yPjxhdXRob3I+U3VnaXlhbWEsIEguPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9y
eSBNZWRpY2luZSwgTmF0aW9uYWwgQ2VudGVyIGZvciBHbG9iYWwgSGVhbHRoIGFuZCBNZWRpY2lu
ZSwgVG9reW8sIEphcGFuLiYjeEQ7TGFib3JhdG9yeSBvZiBTeXN0ZW1zIEJpb2xvZ3ksIENlbnRl
ciBmb3IgRXhwZXJpbWVudGFsIE1lZGljaW5lIGFuZCBTeXN0ZW1zIEJpb2xvZ3ksIFRoZSBJbnN0
aXR1dGUgb2YgTWVkaWNhbCBTY2llbmNlLCBUaGUgVW5pdmVyc2l0eSBvZiBUb2t5bywgVG9reW8s
IEphcGFuLiYjeEQ7TGFib3JhdG9yeSBvZiBTeXN0ZW1zIEJpb2xvZ3ksIENlbnRlciBmb3IgRXhw
ZXJpbWVudGFsIE1lZGljaW5lIGFuZCBTeXN0ZW1zIEJpb2xvZ3ksIFRoZSBJbnN0aXR1dGUgb2Yg
TWVkaWNhbCBTY2llbmNlLCBUaGUgVW5pdmVyc2l0eSBvZiBUb2t5bywgVG9reW8sIEphcGFuOyBQ
cmVjdXJzb3J5IFJlc2VhcmNoIGZvciBFbWJyeW9uaWMgU2NpZW5jZSBhbmQgVGVjaG5vbG9neSwg
SmFwYW4gU2NpZW5jZSBhbmQgVGVjaG5vbG9neSBBZ2VuY3ksIFNhaXRhbWEsIEphcGFuLjwvYXV0
aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRoZSBpbXBvcnRhbmNlIG9mIGJhY3RlcmlhbCBhbmQg
dmlyYWwgaW5mZWN0aW9ucyBhc3NvY2lhdGVkIHdpdGggYWR1bHQgYXN0aG1hIGV4YWNlcmJhdGlv
bnMgaW4gY2xpbmljYWwgcHJhY3RpY2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UExvUyBPbmU8
L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QbG9TIE9u
ZTwvZnVsbC10aXRsZT48YWJici0xPlBMb1MgT25lPC9hYmJyLTE+PGFiYnItMj5QTG9TIE9uZTwv
YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAxMjM1ODQ8L3BhZ2VzPjx2b2x1bWU+MTA8L3Zv
bHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+
PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29y
ZD48a2V5d29yZD5Bc3RobWEvY29tcGxpY2F0aW9ucy9lcGlkZW1pb2xvZ3kvKm1pY3JvYmlvbG9n
eS8qdmlyb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QmFjdGVyaWFsIEluZmVjdGlvbnMvKmNvbXBs
aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+Q29tb3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+
RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r
ZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5hc29waGFyeW54
L21pY3JvYmlvbG9neS92aXJvbG9neTwva2V5d29yZD48a2V5d29yZD5QbmV1bW9uaWEvZXBpZGVt
aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlB1bG1vbmFyeSBEaXNlYXNlLCBDaHJvbmljIE9ic3Ry
dWN0aXZlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5WaXJ1cyBEaXNlYXNlcy8qY29t
cGxpY2F0aW9uczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE1PC95ZWFyPjwv
ZGF0ZXM+PGlzYm4+MTkzMi02MjAzIChFbGVjdHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5n
KTwvaXNibj48YWNjZXNzaW9uLW51bT4yNTkwMTc5NzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs
YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU5MDE3
OTc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDQwNjY4OTwvY3VzdG9t
Mj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3MS9qb3VybmFsLnBvbmUuMDEyMzU4NDwv
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA (70), 19.0% ADDIN EN.CITE <EndNote><Cite><Author>Teichtahl</Author><Year>1997</Year><RecNum>164</RecNum><DisplayText>(71)</DisplayText><record><rec-number>164</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">164</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Teichtahl, Harry</author><author>Buckmaster, Nicholas</author><author>Pertnikovs, Eric</author></authors></contributors><titles><title>The Incidence of Respiratory Tract Infection in Adults Requiring Hospitalization for Asthma</title><secondary-title>Chest</secondary-title></titles><periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1><abbr-2>Chest</abbr-2></periodical><pages>591-596</pages><volume>112</volume><number>3</number><dates><year>1997</year><pub-dates><date>1997/09</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0012-3692</isbn><urls><related-urls><url>;(71), 20.7% ADDIN EN.CITE <EndNote><Cite><Author>Tan</Author><Year>2003</Year><RecNum>115</RecNum><DisplayText>(72)</DisplayText><record><rec-number>115</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209720">115</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tan, Wan C</author><author>Xiang, Xueyu</author><author>Qiu, Diwen</author><author>Ng, Tze Pin</author><author>Lam, Sin F</author><author>Hegele, Richard G</author></authors></contributors><titles><title>Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease</title><secondary-title>The American Journal of Medicine</secondary-title></titles><pages>272-277</pages><volume>115</volume><number>4</number><dates><year>2003</year></dates><isbn>0002-9343</isbn><urls></urls></record></Cite><Cite><Author>Tan</Author><Year>2003</Year><RecNum>115</RecNum><record><rec-number>115</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209720">115</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tan, Wan C</author><author>Xiang, Xueyu</author><author>Qiu, Diwen</author><author>Ng, Tze Pin</author><author>Lam, Sin F</author><author>Hegele, Richard G</author></authors></contributors><titles><title>Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease</title><secondary-title>The American Journal of Medicine</secondary-title></titles><pages>272-277</pages><volume>115</volume><number>4</number><dates><year>2003</year></dates><isbn>0002-9343</isbn><urls></urls></record></Cite></EndNote>(72), and as high as 37.9% ADDIN EN.CITE <EndNote><Cite><Author>Atmar</Author><Year>1998</Year><RecNum>165</RecNum><DisplayText>(67)</DisplayText><record><rec-number>165</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">165</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Atmar, Robert L.</author><author>Guy, Elizabeth</author><author>Guntupalli, Kalpalatha K.</author><author>Zimmerman, Janice L.</author><author>Bandi, Venkata D.</author><author>Baxter, Barbara D.</author><author>Greenberg, Stephen B.</author></authors></contributors><titles><title>Respiratory Tract Viral Infections in Inner-City Asthmatic Adults</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>2453</pages><volume>158</volume><number>22</number><dates><year>1998</year><pub-dates><date>1998/12/07</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(67). Available data on influenza-associated AAE among children vary considerably. For outpatient visits, three studies did not detect any influenza-positive samples PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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=
ADDIN EN.CITE.DATA (69, 73, 74), while several groups identified influenza infection as the cause of AAE, with most reporting rates of influenza-positive samples between 2.4% and 15.5% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (57, 75-78). A recent study showed an accentuated propensity for loss of asthma control when children were infected with pH1N1 (38%) compared with other common respiratory virus infections ADDIN EN.CITE <EndNote><Cite><Author>Kloepfer</Author><Year>2012</Year><RecNum>161</RecNum><DisplayText>(79)</DisplayText><record><rec-number>161</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">161</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kloepfer, Kirsten M.</author><author>Olenec, Jaime P.</author><author>Lee, Wai Ming</author><author>Liu, Guiyan</author><author>Vrtis, Rose F.</author><author>Roberg, Kathy A.</author><author>Evans, Michael D.</author><author>Gangnon, Ronald E.</author><author>Lemanske, Robert F.</author><author>Gern, James E.</author></authors></contributors><titles><title>Increased H1N1 Infection Rate in Children with Asthma</title><secondary-title>American Journal of Respiratory and Critical Care Medicine</secondary-title></titles><periodical><full-title>American Journal of Respiratory and Critical Care Medicine</full-title><abbr-1>Am. J. Respir. Crit. Care Med.</abbr-1><abbr-2>Am J Respir Crit Care Med</abbr-2><abbr-3>American Journal of Respiratory & Critical Care Medicine</abbr-3></periodical><pages>1275-1279</pages><volume>185</volume><number>12</number><dates><year>2012</year><pub-dates><date>2012/06/15</date></pub-dates></dates><publisher>American Thoracic Society</publisher><isbn>1073-449X
1535-4970</isbn><urls><related-urls><url>;(79). Among children with asthma hospitalized for severe AAE, three studies reported an influenza-associated burden of 2.6% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll
YXI+PFJlY051bT4xMTc8L1JlY051bT48RGlzcGxheVRleHQ+KDc2KTwvRGlzcGxheVRleHQ+PHJl
Y29yZD48cmVjLW51bWJlcj4xMTc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFt
cD0iMTQ4MTIwOTcyMCI+MTE3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv
dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv
cj5NYW5kZWxjd2FqZywgQS48L2F1dGhvcj48YXV0aG9yPk1vdWxpbiwgRi48L2F1dGhvcj48YXV0
aG9yPk1lbmFnZXIsIEMuPC9hdXRob3I+PGF1dGhvcj5Sb3plbmJlcmcsIEYuPC9hdXRob3I+PGF1
dGhvcj5MZWJvbiwgUC48L2F1dGhvcj48YXV0aG9yPkdlbmRyZWwsIEQuPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UGVkaWF0cmljIFVuaXQsIFBhcmlzIERl
c2NhcnRlcyBVbml2ZXJzaXR5LCBhbmQgQVAtSFAgU2FpbnQgVmluY2VudCBkZSBQYXVsLUNvY2hp
biBIb3NwaXRhbCwgUGFyaXMsIEZyYW5jZS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5V
bmRlcmVzdGltYXRpb24gb2YgaW5mbHVlbnphIHZpcmFsIGluZmVjdGlvbiBpbiBjaGlsZGhvb2Qg
YXN0aG1hIGV4YWNlcmJhdGlvbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiBQ
ZWRpYXRyaWNzPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIFBlZGlhdHI8L2FsdC10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIFBlZGlhdHJpY3M8
L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBQZWRpYXRyLjwvYWJici0xPjxhYmJyLTI+SiBQZWRpYXRy
PC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFs
IG9mIFBlZGlhdHJpY3M8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBQZWRpYXRyLjwvYWJici0xPjxh
YmJyLTI+SiBQZWRpYXRyPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NTA1LTY8L3Bh
Z2VzPjx2b2x1bWU+MTU3PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3
b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QW1idWxhdG9yeSBDYXJlL3NuIFtTdGF0
aXN0aWNzICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5d29yZD48a2V5d29yZD4qQXN0aG1hL2Nv
IFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29y
ZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsaXphdGlvbi9zbiBb
U3RhdGlzdGljcyAmYW1wOyBOdW1lcmljYWwgRGF0YV08L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBI
dW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1
ZGllczwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3Jk
Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8
L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk3LTY4MzM8L2lzYm4+PGFjY2Vzc2lv
bi1udW0+MjA1NDIyOTE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0
dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9
TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMDU0MjI5MTwvdXJsPjx1cmw+
aHR0cDovL29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNw
bGF5P3NpZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjA1NDIyOTEmYW1w
O2lkPTEwLjEwMTYlMkZqLmpwZWRzLjIwMTAuMDQuMDY3JmFtcDtpc3NuPTAwMjItMzQ3NiZhbXA7
aXNibj0mYW1wO3ZvbHVtZT0xNTcmYW1wO2lzc3VlPTMmYW1wO3NwYWdlPTUwNSZhbXA7cGFnZXM9
NTA1LTYmYW1wO2RhdGU9MjAxMCZhbXA7dGl0bGU9Sm91cm5hbCtvZitQZWRpYXRyaWNzJmFtcDth
dGl0bGU9VW5kZXJlc3RpbWF0aW9uK29mK2luZmx1ZW56YSt2aXJhbCtpbmZlY3Rpb24raW4rY2hp
bGRob29kK2FzdGhtYStleGFjZXJiYXRpb25zLiZhbXA7YXVsYXN0PU1hbmRlbGN3YWpnJmFtcDtw
aWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZn
dDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmpwZWRzLjIw
MTAuMDQuMDY3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+
TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5P
dmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5Fbmds
aXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwv
QXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4xMTc8L1JlY051bT48cmVjb3JkPjxyZWMt
bnVtYmVyPjExNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9
IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgxMjA5
NzIwIj4xMTc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRp
Y2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1hbmRlbGN3
YWpnLCBBLjwvYXV0aG9yPjxhdXRob3I+TW91bGluLCBGLjwvYXV0aG9yPjxhdXRob3I+TWVuYWdl
ciwgQy48L2F1dGhvcj48YXV0aG9yPlJvemVuYmVyZywgRi48L2F1dGhvcj48YXV0aG9yPkxlYm9u
LCBQLjwvYXV0aG9yPjxhdXRob3I+R2VuZHJlbCwgRC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250
cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QZWRpYXRyaWMgVW5pdCwgUGFyaXMgRGVzY2FydGVzIFVu
aXZlcnNpdHksIGFuZCBBUC1IUCBTYWludCBWaW5jZW50IGRlIFBhdWwtQ29jaGluIEhvc3BpdGFs
LCBQYXJpcywgRnJhbmNlLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlVuZGVyZXN0aW1h
dGlvbiBvZiBpbmZsdWVuemEgdmlyYWwgaW5mZWN0aW9uIGluIGNoaWxkaG9vZCBhc3RobWEgZXhh
Y2VyYmF0aW9uczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3VybmFsIG9mIFBlZGlhdHJpY3M8
L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogUGVkaWF0cjwvYWx0LXRpdGxlPjwvdGl0bGVz
PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUGVkaWF0cmljczwvZnVsbC10aXRs
ZT48YWJici0xPkouIFBlZGlhdHIuPC9hYmJyLTE+PGFiYnItMj5KIFBlZGlhdHI8L2FiYnItMj48
L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUGVkaWF0
cmljczwvZnVsbC10aXRsZT48YWJici0xPkouIFBlZGlhdHIuPC9hYmJyLTE+PGFiYnItMj5KIFBl
ZGlhdHI8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MDUtNjwvcGFnZXM+PHZvbHVt
ZT4xNTc8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVz
Y2VudDwva2V5d29yZD48a2V5d29yZD5BbWJ1bGF0b3J5IENhcmUvc24gW1N0YXRpc3RpY3MgJmFt
cDsgTnVtZXJpY2FsIERhdGFdPC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvY28gW0NvbXBsaWNh
dGlvbnNdPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQ
cmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxpemF0aW9uL3NuIFtTdGF0aXN0aWNz
ICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+
PGtleXdvcmQ+SW5mYW50PC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL2NvIFtD
b21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3
b3JkPjxrZXl3b3JkPlNldmVyaXR5IG9mIElsbG5lc3MgSW5kZXg8L2tleXdvcmQ+PC9rZXl3b3Jk
cz48ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcDwvZGF0ZT48L3B1
Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwOTctNjgzMzwvaXNibj48YWNjZXNzaW9uLW51bT4yMDU0
MjI5MTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRz
cC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdF
PWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIwNTQyMjkxPC91cmw+PHVybD5odHRwOi8vb3Bl
bnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/c2lkPU9W
SUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMDU0MjI5MSZhbXA7aWQ9MTAuMTAx
NiUyRmouanBlZHMuMjAxMC4wNC4wNjcmYW1wO2lzc249MDAyMi0zNDc2JmFtcDtpc2JuPSZhbXA7
dm9sdW1lPTE1NyZhbXA7aXNzdWU9MyZhbXA7c3BhZ2U9NTA1JmFtcDtwYWdlcz01MDUtNiZhbXA7
ZGF0ZT0yMDEwJmFtcDt0aXRsZT1Kb3VybmFsK29mK1BlZGlhdHJpY3MmYW1wO2F0aXRsZT1VbmRl
cmVzdGltYXRpb24rb2YraW5mbHVlbnphK3ZpcmFsK2luZmVjdGlvbitpbitjaGlsZGhvb2QrYXN0
aG1hK2V4YWNlcmJhdGlvbnMuJmFtcDthdWxhc3Q9TWFuZGVsY3dhamcmYW1wO3BpZD0mbHQ7YXV0
aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYv
Jmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouanBlZHMuMjAxMC4wNC4wNjc8
L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9y
ZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5v
bG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1
YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (76), 3.4% ADDIN EN.CITE <EndNote><Cite><Author>Biscardi</Author><Year>2004</Year><RecNum>155</RecNum><DisplayText>(80)</DisplayText><record><rec-number>155</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">155</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Biscardi, S.</author><author>Lorrot, M.</author><author>Marc, E.</author><author>Moulin, F.</author><author>Boutonnat-Faucher, B.</author><author>Heilbronner, C.</author><author>Iniguez, J. L.</author><author>Chaussain, M.</author><author>Nicand, E.</author><author>Raymond, J.</author><author>Gendrel, D.</author></authors></contributors><titles><title>Mycoplasma pneumoniae and Asthma in Children</title><secondary-title>Clinical Infectious Diseases</secondary-title></titles><periodical><full-title>Clinical Infectious Diseases</full-title><abbr-1>Clin. Infect. Dis.</abbr-1><abbr-2>Clin Infect Dis</abbr-2></periodical><pages>1341-1346</pages><volume>38</volume><number>10</number><dates><year>2004</year><pub-dates><date>2004/05/15</date></pub-dates></dates><publisher>Oxford University Press (OUP)</publisher><isbn>1058-4838
1537-6591</isbn><urls><related-urls><url>;(80) and 3.7% PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (57) of AAEs. In summary, there were significant inter- and intra-group variations in the reported influenza-induced AAE burden among children and adults with asthma, with fewer studies on adults. Various factors compromise the interpretation of the available data. First, the use of different diagnostic methods for influenza detection may significantly influence the study outcome. The advent of molecular techniques and their universal use may solve this issue. Second, the absence of harmonized criteria for appropriate inclusion of patients and the lack of a standardized definition and diagnosis of influenza infection disallow direct comparison of results and complicate the identification of relevant studies. Third, the lack of large cohorts of patients with asthma studied for influenza induced AAE, raises questions about the validity of the currently available findings. Furthermore, seasonal rather than perennial influenza testing and selective testing only in hospitalized AAE cases, where rates of influenza may be lower PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll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ADDIN EN.CITE.DATA (76), (short explanation about this) could lead to inaccurate estimation of the actual contribution of influenza to AAEs. 3. Current influenza vaccine recommendations and coverage for people with asthma In common with most economically-developed nations (Fig. 1), all 28 countries of the European Union currently recommend influenza vaccination of people with chronic respiratory disease, including asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmVlbmhhd3Q8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HcmVlbmhhd3Q8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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ADDIN EN.CITE.DATA (81-83). Trivalent (TIV) and quadrivalent inactivated split-virus influenza vaccines are available, with TIV the most widely used throughout the EU. An intradermal vaccine is also available and more recently a quadrivalent live attenuated intranasal vaccine (LAIV) was approved for use in the UK in children aged 2–18 years ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>232</RecNum><DisplayText>(82, 84)</DisplayText><record><rec-number>232</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481282485">232</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>O’Flanagan, D, Cotter, S, Mereckiene, J. Seasonal influenza vaccination in EU / EEA, influenza season 2011-12, VENICE II Consortium. 1–67, 2013.</title></titles><dates></dates><urls></urls></record></Cite><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>234</RecNum><record><rec-number>234</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481282604">234</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Public Health England. Influenza: the green book. Immun. against Infect. Dis. 185–218. Public Health England, 2014.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>(82, 84). However, vaccine uptake for clinical risk groups varied from 31% in Portugal to 82% in Northern Ireland PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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=
ADDIN EN.CITE.DATA (82, 85), as did influenza vaccination coverage of adults with asthma, with 30–50% in Spain PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw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 EN.CITE.DATA (86-89) and 40% in the UK PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (90). Self-reported uptake of seasonal influenza vaccine amongst adults with asthma in the US varied from 54% in the community to 71% in secondary care PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZW88L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZW88L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (91). Children with asthma had significantly lower coverage rates of approximately 18-20% in Spain PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3Blei1kZS1BbmRyZXM8L0F1dGhvcj48WWVhcj4yMDA4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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Mb3Blei1kZS1BbmRyZXM8L0F1dGhvcj48WWVhcj4yMDA4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ADDIN EN.CITE.DATA (87, 92), 15% in France PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYW5jZTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SYW5jZTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
Y051bT4xMjQ8L1JlY051bT48RGlzcGxheVRleHQ+KDkzKTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4xMjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4
MTIwOTcyMSI+MTI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5SYW5j
ZSwgRi48L2F1dGhvcj48YXV0aG9yPkNoYXZlLCBDLjwvYXV0aG9yPjxhdXRob3I+RGUgQmxpYywg
Si48L2F1dGhvcj48YXV0aG9yPkRlc2NoaWxkcmUsIEEuPC9hdXRob3I+PGF1dGhvcj5Eb25hdG8s
IEwuPC9hdXRob3I+PGF1dGhvcj5EdWJ1cywgSi48L2F1dGhvcj48YXV0aG9yPkZheW9uLCBNLjwv
YXV0aG9yPjxhdXRob3I+TGFiYmUsIEEuPC9hdXRob3I+PGF1dGhvcj5MZSBCb3VyZ2VvaXMsIE0u
PC9hdXRob3I+PGF1dGhvcj5MbGVyZW5hLCBDLjwvYXV0aG9yPjxhdXRob3I+TGUgTWFuYWNoLCBH
LjwvYXV0aG9yPjxhdXRob3I+UGluLCBJLjwvYXV0aG9yPjxhdXRob3I+U2FudG9zLCBDLjwvYXV0
aG9yPjxhdXRob3I+VGh1bWVyZWxsZSwgQy48L2F1dGhvcj48YXV0aG9yPkF1YmVydCwgTS48L2F1
dGhvcj48YXV0aG9yPldlaWwtT2xpdmllciwgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5Ib3BpdGFsIGRlcyBFbmZhbnRzLCBUb3Vsb3VzZSwgRnJhbmNl
LiByYW5jZS5mQGNodS10b3Vsb3VzZS5mcjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkxv
dyBpbmZsdWVuemEgdmFjY2luYXRpb24gY292ZXJhZ2UgaW4gYXN0aG1hdGljIGNoaWxkcmVuIGlu
IEZyYW5jZSBpbiAyMDA2LTc8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVybyBTdXJ2ZWlsbGFu
Y2U6IEV1cm9wZWFuIENvbW11bmljYWJsZSBEaXNlYXNlIEJ1bGxldGluPC9zZWNvbmRhcnktdGl0
bGU+PGFsdC10aXRsZT5FdXJvIFN1cnZlaWxsPC9hbHQtdGl0bGU+PC90aXRsZXM+PGFsdC1wZXJp
b2RpY2FsPjxmdWxsLXRpdGxlPkV1cm8gU3VydmVpbGxhbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+
RXVybyBTdXJ2ZWlsbC48L2FiYnItMT48YWJici0yPkV1cm8gU3VydmVpbGw8L2FiYnItMj48L2Fs
dC1wZXJpb2RpY2FsPjxwYWdlcz4yMzwvcGFnZXM+PHZvbHVtZT4xMzwvdm9sdW1lPjxudW1iZXI+
NDM8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29y
ZD4qQXN0aG1hPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5GcmFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3
b3JkPjxrZXl3b3JkPipJbW11bml6YXRpb24gUHJvZ3JhbXMvdXQgW1V0aWxpemF0aW9uXTwva2V5
d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1w
OyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL3BjIFtQcmV2ZW50
aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdv
cmQ+UGh5c2ljaWFuJmFwb3M7cyBQcmFjdGljZSBQYXR0ZXJucy9zbiBbU3RhdGlzdGljcyAmYW1w
OyBOdW1lcmljYWwgRGF0YV08L2tleXdvcmQ+PGtleXdvcmQ+UXVlc3Rpb25uYWlyZXM8L2tleXdv
cmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0IDIzPC9kYXRlPjwvcHVi
LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU2MC03OTE3PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4OTQ3
NTIxPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4g
R292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3Zp
ZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BB
R0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MTg5NDc1MjE8L3VybD48dXJsPmh0dHA6Ly9v
cGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9
T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjE4OTQ3NTIxJmFtcDtpZD0mYW1w
O2lzc249MTAyNS00OTZYJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTEzJmFtcDtpc3N1ZT00MyZhbXA7
c3BhZ2U9JmFtcDtwYWdlcz0mYW1wO2RhdGU9MjAwOCZhbXA7dGl0bGU9RXVybytTdXJ2ZWlsbGFu
Y2UlM0ErQnVsbGV0aW4rRXVyb3BlZW4rc3VyK2xlcytNYWxhZGllcytUcmFuc21pc3NpYmxlcysl
M0QrRXVyb3BlYW4rQ29tbXVuaWNhYmxlK0Rpc2Vhc2UrQnVsbGV0aW4mYW1wO2F0aXRsZT1Mb3cr
aW5mbHVlbnphK3ZhY2NpbmF0aW9uK2NvdmVyYWdlK2luK2FzdGhtYXRpYytjaGlsZHJlbitpbitG
cmFuY2UraW4rMjAwNi03LiZhbXA7YXVsYXN0PVJhbmNlJmFtcDtwaWQ9Jmx0O2F1dGhvciZndDsm
bHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsmbHQ7
L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+
TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5P
dmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5Fbmds
aXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SYW5jZTwvQXV0aG9y
PjxZZWFyPjIwMDg8L1llYXI+PFJlY051bT4xMjQ8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy
PjEyNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVleGR4
MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgxMjA5NzIxIj4x
MjQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJhbmNlLCBGLjwvYXV0
aG9yPjxhdXRob3I+Q2hhdmUsIEMuPC9hdXRob3I+PGF1dGhvcj5EZSBCbGljLCBKLjwvYXV0aG9y
PjxhdXRob3I+RGVzY2hpbGRyZSwgQS48L2F1dGhvcj48YXV0aG9yPkRvbmF0bywgTC48L2F1dGhv
cj48YXV0aG9yPkR1YnVzLCBKLjwvYXV0aG9yPjxhdXRob3I+RmF5b24sIE0uPC9hdXRob3I+PGF1
dGhvcj5MYWJiZSwgQS48L2F1dGhvcj48YXV0aG9yPkxlIEJvdXJnZW9pcywgTS48L2F1dGhvcj48
YXV0aG9yPkxsZXJlbmEsIEMuPC9hdXRob3I+PGF1dGhvcj5MZSBNYW5hY2gsIEcuPC9hdXRob3I+
PGF1dGhvcj5QaW4sIEkuPC9hdXRob3I+PGF1dGhvcj5TYW50b3MsIEMuPC9hdXRob3I+PGF1dGhv
cj5UaHVtZXJlbGxlLCBDLjwvYXV0aG9yPjxhdXRob3I+QXViZXJ0LCBNLjwvYXV0aG9yPjxhdXRo
b3I+V2VpbC1PbGl2aWVyLCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0
aC1hZGRyZXNzPkhvcGl0YWwgZGVzIEVuZmFudHMsIFRvdWxvdXNlLCBGcmFuY2UuIHJhbmNlLmZA
Y2h1LXRvdWxvdXNlLmZyPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TG93IGluZmx1ZW56
YSB2YWNjaW5hdGlvbiBjb3ZlcmFnZSBpbiBhc3RobWF0aWMgY2hpbGRyZW4gaW4gRnJhbmNlIGlu
IDIwMDYtNzwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5FdXJvIFN1cnZlaWxsYW5jZTogRXVyb3Bl
YW4gQ29tbXVuaWNhYmxlIERpc2Vhc2UgQnVsbGV0aW48L3NlY29uZGFyeS10aXRsZT48YWx0LXRp
dGxlPkV1cm8gU3VydmVpbGw8L2FsdC10aXRsZT48L3RpdGxlcz48YWx0LXBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+RXVybyBTdXJ2ZWlsbGFuY2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXJvIFN1cnZl
aWxsLjwvYWJici0xPjxhYmJyLTI+RXVybyBTdXJ2ZWlsbDwvYWJici0yPjwvYWx0LXBlcmlvZGlj
YWw+PHBhZ2VzPjIzPC9wYWdlcz48dm9sdW1lPjEzPC92b2x1bWU+PG51bWJlcj40MzwvbnVtYmVy
PjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWE8
L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk
PjxrZXl3b3JkPkZyYW5jZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdv
cmQ+KkltbXVuaXphdGlvbiBQcm9ncmFtcy91dCBbVXRpbGl6YXRpb25dPC9rZXl3b3JkPjxrZXl3
b3JkPipJbmZsdWVuemEgVmFjY2luZXMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08
L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsg
Q29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5QaHlzaWNp
YW4mYXBvcztzIFByYWN0aWNlIFBhdHRlcm5zL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVyaWNh
bCBEYXRhXTwva2V5d29yZD48a2V5d29yZD5RdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29y
ZD4wIChJbmZsdWVuemEgVmFjY2luZXMpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy
PjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5PY3QgMjM8L2RhdGU+PC9wdWItZGF0ZXM+PC9k
YXRlcz48aXNibj4xNTYwLTc5MTc8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg5NDc1MjE8L2FjY2Vz
c2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0
PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j
b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4
dCZhbXA7RD1tZWQ1JmFtcDtBTj0xODk0NzUyMTwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMu
dWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQr
TUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MTg5NDc1MjEmYW1wO2lkPSZhbXA7aXNzbj0xMDI1
LTQ5NlgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTMmYW1wO2lzc3VlPTQzJmFtcDtzcGFnZT0mYW1w
O3BhZ2VzPSZhbXA7ZGF0ZT0yMDA4JmFtcDt0aXRsZT1FdXJvK1N1cnZlaWxsYW5jZSUzQStCdWxs
ZXRpbitFdXJvcGVlbitzdXIrbGVzK01hbGFkaWVzK1RyYW5zbWlzc2libGVzKyUzRCtFdXJvcGVh
bitDb21tdW5pY2FibGUrRGlzZWFzZStCdWxsZXRpbiZhbXA7YXRpdGxlPUxvdytpbmZsdWVuemEr
dmFjY2luYXRpb24rY292ZXJhZ2UraW4rYXN0aG1hdGljK2NoaWxkcmVuK2luK0ZyYW5jZStpbisy
MDA2LTcuJmFtcDthdWxhc3Q9UmFuY2UmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0
OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9y
ZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5v
bG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1
YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (93) and 2.5–20% in Italy, across multiple seasons PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+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ADDIN EN.CITE.DATA (85). In comparison, in the USA vaccination coverage reached around 50% in adults and children ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>235</RecNum><DisplayText>(94)</DisplayText><record><rec-number>235</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481283151">235</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Centre for Disease Control and Prevention. Vaccination Coverage Among Persons with Asthma — United States 2010–2011 Influenza Season.</title><secondary-title>MMWR</secondary-title></titles><pages>973–978</pages><volume>62</volume><dates><year>2013</year></dates><urls></urls></record></Cite></EndNote>(94). To address the question of such historically low vaccination rates amongst those with asthma, many studies employed cross-sectional surveys to analyse the socio-demographic variables that predict vaccine uptake. The strongest factors associated with higher vaccine coverage, were older age, recent contact with healthcare providers, non-smoking status, presence of co-morbidities, more severe asthma, and (surprisingly) lower household income PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw
OTwvWWVhcj48UmVjTnVtPjE4MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oODYtODksIDk0LTEwMCk8
L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTgyPC9yZWMtbnVtYmVyPjxmb3JlaWdu
LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1
enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMTAyNDciPjE4Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+Smltw6luZXotR2FyY8OtYSwgUi48L2F1dGhvcj48YXV0aG9yPkhl
cm7DoW5kZXotQmFycmVyYSwgVi48L2F1dGhvcj48YXV0aG9yPkNhcnJhc2NvLUdhcnJpZG8sIFAu
PC9hdXRob3I+PGF1dGhvcj5kZSBBbmRyw6lzLCBBLiBMb3BlejwvYXV0aG9yPjxhdXRob3I+ZGUg
TWlndWVsIERpZXosIEouPC9hdXRob3I+PGF1dGhvcj5kZSBNaWd1ZWwsIMOBIEdpbDwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Db3ZlcmFnZSBhbmQgUHJl
ZGljdG9ycyBvZiBBZGhlcmVuY2UgdG8gSW5mbHVlbnphIFZhY2NpbmF0aW9uIGFtb25nIFNwYW5p
c2ggQ2hpbGRyZW4gYW5kIEFkdWx0cyB3aXRoIEFzdGhtYTwvdGl0bGU+PHNlY29uZGFyeS10aXRs
ZT5JbmZlY3Rpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10
aXRsZT5JbmZlY3Rpb248L2Z1bGwtdGl0bGU+PGFiYnItMT5JbmZlY3Rpb248L2FiYnItMT48YWJi
ci0yPkluZmVjdGlvbjwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NTItNTc8L3BhZ2VzPjx2
b2x1bWU+Mzg8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAwOTwveWVh
cj48cHViLWRhdGVzPjxkYXRlPjIwMDkvMTEvMTA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48
cHVibGlzaGVyPlNwcmluZ2VyIE5hdHVyZTwvcHVibGlzaGVyPjxpc2JuPjAzMDAtODEyNiYjeEQ7
MTQzOS0wOTczPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9y
Zy8xMC4xMDA3L3MxNTAxMC0wMDktOTA2OS00PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl
bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDA3L3MxNTAxMC0wMDktOTA2OS00PC9lbGVjdHJv
bmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Mb3Blei1kZS1B
bmRyZXM8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxSZWNOdW0+MTIyPC9SZWNOdW0+PHJlY29y
ZD48cmVjLW51bWJlcj4xMjI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0i
MTQ4MTIwOTcyMSI+MTIyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu
YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5M
b3Blei1kZS1BbmRyZXMsIEEuPC9hdXRob3I+PGF1dGhvcj5DYXJyYXNjby1HYXJyaWRvLCBQLjwv
YXV0aG9yPjxhdXRob3I+SGVybmFuZGV6LUJhcnJlcmEsIFYuPC9hdXRob3I+PGF1dGhvcj5kZSBN
aWd1ZWwsIEEuIEcuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LUdhcmNpYSwgUi48L2F1dGhvcj48
L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QcmV2ZW50aXZlIE1lZGljaW5l
IGFuZCBQdWJsaWMgSGVhbHRoIFRlYWNoaW5nIGFuZCBSZXNlYXJjaCBVbml0LCBIZWFsdGggU2Np
ZW5jZXMgRmFjdWx0eSwgUmV5IEp1YW4gQ2FybG9zIFVuaXZlcnNpdHksIEF2ZGEgZGUgQXRlbmFz
IHMvbiwgQWxjb3Jjb24gMjg0MDIgTWFkcmlkLCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVz
Pjx0aXRsZT5Db3ZlcmFnZXMgYW5kIGZhY3RvcnMgYXNzb2NpYXRlZCB3aXRoIGluZmx1ZW56YSB2
YWNjaW5hdGlvbiBhbW9uZyBzdWJqZWN0cyB3aXRoIGNocm9uaWMgcmVzcGlyYXRvcnkgZGlzZWFz
ZXMgaW4gU3BhaW48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBQ
dWJsaWMgSGVhbHRoPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5FdXIgSiBQdWJsaWMgSGVh
bHRoPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+RXVyb3BlYW4g
Sm91cm5hbCBvZiBQdWJsaWMgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBQdWJs
aWMgSGVhbHRoPC9hYmJyLTE+PGFiYnItMj5FdXIgSiBQdWJsaWMgSGVhbHRoPC9hYmJyLTI+PC9w
ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJvcGVhbiBKb3VybmFsIG9m
IFB1YmxpYyBIZWFsdGg8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIEouIFB1YmxpYyBIZWFsdGg8
L2FiYnItMT48YWJici0yPkV1ciBKIFB1YmxpYyBIZWFsdGg8L2FiYnItMj48L2FsdC1wZXJpb2Rp
Y2FsPjxwYWdlcz4xNzMtNzwvcGFnZXM+PHZvbHVtZT4xODwvdm9sdW1lPjxudW1iZXI+MjwvbnVt
YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2UgRmFjdG9y
czwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaHJvbmljIERpc2Vh
c2U8L2tleXdvcmQ+PGtleXdvcmQ+Q3Jvc3MtU2VjdGlvbmFsIFN0dWRpZXM8L2tleXdvcmQ+PGtl
eXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBTdXJ2ZXlzPC9rZXl3b3JkPjxr
ZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2FkIFtB
ZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSwg
SHVtYW4vaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFu
L3BjIFtQcmV2ZW50aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRpb24gRGlzb3JkZXJzL2VwIFtFcGlkZW1pb2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPipSZXNwaXJhdGlvbiBEaXNvcmRlcnMvaW0gW0ltbXVub2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPlNvY2lvZWNvbm9taWMgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5T
cGFpbi9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5hdGlvbi9lYyBb
RWNvbm9taWNzXTwva2V5d29yZD48a2V5d29yZD4qVmFjY2luYXRpb24vdXQgW1V0aWxpemF0aW9u
XTwva2V5d29yZD48a2V5d29yZD4wIChJbmZsdWVuemEgVmFjY2luZXMpPC9rZXl3b3JkPjwva2V5
d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMTAxLTEyNjI8L2lzYm4+PGFjY2Vzc2lvbi1udW0+
MTc4NzU1Nzc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24t
VS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6
Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZh
bXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzg3NTU3NzwvdXJsPjx1cmw+aHR0
cDovL29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5
P3NpZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MTc4NzU1NzcmYW1wO2lk
PSZhbXA7aXNzbj0xMTAxLTEyNjImYW1wO2lzYm49JmFtcDt2b2x1bWU9MTgmYW1wO2lzc3VlPTIm
YW1wO3NwYWdlPTE3MyZhbXA7cGFnZXM9MTczLTcmYW1wO2RhdGU9MjAwOCZhbXA7dGl0bGU9RXVy
b3BlYW4rSm91cm5hbCtvZitQdWJsaWMrSGVhbHRoJmFtcDthdGl0bGU9Q292ZXJhZ2VzK2FuZCtm
YWN0b3JzK2Fzc29jaWF0ZWQrd2l0aCtpbmZsdWVuemErdmFjY2luYXRpb24rYW1vbmcrc3ViamVj
dHMrd2l0aCtjaHJvbmljK3Jlc3BpcmF0b3J5K2Rpc2Vhc2VzK2luK1NwYWluLiZhbXA7YXVsYXN0
PUxvcGV6LWRlLUFuZHJlcyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9h
dXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1k
YXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8
L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9y
ZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWF5byBNb250ZXJvPC9BdXRob3I+PFllYXI+MjAw
NzwvWWVhcj48UmVjTnVtPjE4NDwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTg0PC9yZWMt
bnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmll
d3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMTAyNDciPjE4NDwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWF5byBNb250ZXJvLCBFbGdhPC9hdXRo
b3I+PGF1dGhvcj5IZXJuw6FuZGV6LUJhcnJlcmEsIFZhbGVudMOtbjwvYXV0aG9yPjxhdXRob3I+
Q2FycmFzY28tR2FycmlkbywgUGlsYXI8L2F1dGhvcj48YXV0aG9yPkdpbCBkZSBNaWd1ZWwsIMOB
bmdlbDwvYXV0aG9yPjxhdXRob3I+Smltw6luZXotR2FyY8OtYSwgUm9kcmlnbzwvYXV0aG9yPjwv
YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5JbmZsdWVuemEgdmFjY2luYXRp
b24gYW1vbmcgcGVyc29ucyB3aXRoIGNocm9uaWMgcmVzcGlyYXRvcnkgZGlzZWFzZXM6IENvdmVy
YWdlLCByZWxhdGVkIGZhY3RvcnMgYW5kIHRpbWUtdHJlbmQsIDE5OTPigJMyMDAxPC90aXRsZT48
c2Vjb25kYXJ5LXRpdGxlPlB1YmxpYyBIZWFsdGg8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QdWJsaWMgSGVhbHRoPC9mdWxsLXRpdGxlPjxhYmJyLTE+
UHVibGljIEhlYWx0aDwvYWJici0xPjxhYmJyLTI+UHVibGljIEhlYWx0aDwvYWJici0yPjwvcGVy
aW9kaWNhbD48cGFnZXM+MTEzLTEyMTwvcGFnZXM+PHZvbHVtZT4xMjE8L3ZvbHVtZT48bnVtYmVy
PjI8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMDcv
MDI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPkVsc2V2aWVyIEJWPC9wdWJs
aXNoZXI+PGlzYm4+MDAzMy0zNTA2PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw
Oi8vZHguZG9pLm9yZy8xMC4xMDE2L2oucHVoZS4yMDA2LjA5LjAwOTwvdXJsPjwvcmVsYXRlZC11
cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLnB1aGUuMjAwNi4w
OS4wMDk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0
aG9yPlNhbnRvcy1TYW5jaG88L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MTg1PC9S
ZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4xODU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48
a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQi
IHRpbWVzdGFtcD0iMTQ4MTIxMDI0NyI+MTg1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBl
IG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhv
cnM+PGF1dGhvcj5TYW50b3MtU2FuY2hvLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+TMOzcGV6LWRl
IEFuZHLDqXMsIEEuPC9hdXRob3I+PGF1dGhvcj5KaW1lbmV6LVRydWppbGxvLCBJLjwvYXV0aG9y
PjxhdXRob3I+SGVybsOhbmRlei1CYXJyZXJhLCBWLjwvYXV0aG9yPjxhdXRob3I+Q2FycmFzY28t
R2FycmlkbywgUC48L2F1dGhvcj48YXV0aG9yPkFzdGFzaW8tQXJiaXphLCBQLjwvYXV0aG9yPjxh
dXRob3I+SmltZW5lei1HYXJjaWEsIFIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
Pjx0aXRsZXM+PHRpdGxlPkFkaGVyZW5jZSBhbmQgZmFjdG9ycyBhc3NvY2lhdGVkIHdpdGggaW5m
bHVlbnphIHZhY2NpbmF0aW9uIGFtb25nIHN1YmplY3RzIHdpdGggYXN0aG1hIGluIFNwYWluPC90
aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkluZmVjdGlvbjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVz
PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkluZmVjdGlvbjwvZnVsbC10aXRsZT48YWJici0xPklu
ZmVjdGlvbjwvYWJici0xPjxhYmJyLTI+SW5mZWN0aW9uPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxw
YWdlcz40NjUtNDcxPC9wYWdlcz48dm9sdW1lPjQxPC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+
PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDEzLzAyLzEyPC9kYXRl
PjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5TcHJpbmdlciBOYXR1cmU8L3B1Ymxpc2hl
cj48aXNibj4wMzAwLTgxMjYmI3hEOzE0MzktMDk3MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxz
Pjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwNy9zMTUwMTAtMDEzLTA0MTQtMjwvdXJsPjwv
cmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwNy9zMTUw
MTAtMDEzLTA0MTQtMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxD
aXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRlWWVhcj0iMSI+PFJlY051bT4yMzU8L1JlY051bT48
cmVjb3JkPjxyZWMtbnVtYmVyPjIzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0
YW1wPSIxNDgxMjgzMTUxIj4yMzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i
Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48L2NvbnRyaWJ1dG9y
cz48dGl0bGVzPjx0aXRsZT5DZW50cmUgZm9yIERpc2Vhc2UgQ29udHJvbCBhbmQgUHJldmVudGlv
bi4gVmFjY2luYXRpb24gQ292ZXJhZ2UgQW1vbmcgUGVyc29ucyB3aXRoIEFzdGhtYSDigJQgVW5p
dGVkIFN0YXRlcyAyMDEw4oCTMjAxMSBJbmZsdWVuemEgU2Vhc29uLjwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5NTVdSPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjk3M+KAkzk3ODwv
cGFnZXM+PHZvbHVtZT42Mjwvdm9sdW1lPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+
PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkRvd2VyPC9BdXRob3I+
PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjE4ODwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+
MTg4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4ZHgy
ZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMTAyNDciPjE4
ODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3
PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RG93ZXIsIEpvPC9hdXRo
b3I+PGF1dGhvcj5Eb25hbGQsIE1hcmlhPC9hdXRob3I+PGF1dGhvcj5CZWd1bSwgTmVsdWZhPC9h
dXRob3I+PGF1dGhvcj5WbGFjaywgU3VlPC9hdXRob3I+PGF1dGhvcj5Pem9saW5zLCBJZXZhPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBhdHRlcm5zIGFu
ZCBkZXRlcm1pbmFudHMgb2YgaW5mbHVlbnphIGFuZCBwbmV1bW9jb2NjYWwgaW1tdW5pc2F0aW9u
IGFtb25nIGFkdWx0cyB3aXRoIGNocm9uaWMgZGlzZWFzZSBsaXZpbmcgaW4gUXVlZW5zbGFuZCwg
QXVzdHJhbGlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlZhY2NpbmU8L3NlY29uZGFyeS10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5WYWNjaW5lPC9mdWxsLXRpdGxlPjxh
YmJyLTE+VmFjY2luZTwvYWJici0xPjxhYmJyLTI+VmFjY2luZTwvYWJici0yPjwvcGVyaW9kaWNh
bD48cGFnZXM+MzAzMS0zMDM3PC9wYWdlcz48dm9sdW1lPjI5PC92b2x1bWU+PG51bWJlcj4xNjwv
bnVtYmVyPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAxMS8wNDwv
ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxwdWJsaXNoZXI+RWxzZXZpZXIgQlY8L3B1Ymxpc2hl
cj48aXNibj4wMjY0LTQxMFg8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9k
eC5kb2kub3JnLzEwLjEwMTYvai52YWNjaW5lLjIwMTEuMDEuMTE2PC91cmw+PC9yZWxhdGVkLXVy
bHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2oudmFjY2luZS4yMDEx
LjAxLjExNjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB
dXRob3I+RmlnYXJvPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjE5MDwvUmVjTnVt
PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTkwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh
cHA9IkVOIiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1l
c3RhbXA9IjE0ODEyMTAyNDciPjE5MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l
PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh
dXRob3I+RmlnYXJvLCBNLiBLYXRobGVlbjwvYXV0aG9yPjxhdXRob3I+QmVsdWUsIFJob25kYTwv
YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5QcmV2YWxlbmNl
IG9mIEluZmx1ZW56YSBWYWNjaW5hdGlvbiBpbiBhIEhpZ2gtcmlzayBQb3B1bGF0aW9uPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkpvdXJuYWwgb2YgQW1idWxhdG9yeSBDYXJlIE1hbmFnZW1lbnQ8
L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Kb3VybmFs
IG9mIEFtYnVsYXRvcnkgQ2FyZSBNYW5hZ2VtZW50PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQW1i
dWwuIENhcmUgTWFuYWdlLjwvYWJici0xPjxhYmJyLTI+SiBBbWJ1bCBDYXJlIE1hbmFnZTwvYWJi
ci0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MjQtMjk8L3BhZ2VzPjx2b2x1bWU+Mjg8L3ZvbHVtZT48
bnVtYmVyPjE8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRl
PjIwMDUvMDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPk92aWQgVGVjaG5v
bG9naWVzIChXb2x0ZXJzIEtsdXdlciBIZWFsdGgpPC9wdWJsaXNoZXI+PGlzYm4+MDE0OC05OTE3
PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDk3
LzAwMDA0NDc5LTIwMDUwMTAwMC0wMDAwNDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA5Ny8wMDAwNDQ3OS0yMDA1MDEwMDAtMDAwMDQ8L2Vs
ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkZvdHk8
L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNOdW0+MTg5PC9SZWNOdW0+PHJlY29yZD48cmVj
LW51bWJlcj4xODk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk
PSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIx
MDI0NyI+MTg5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Gb3R5LCBS
aWNoYXJkIEcuPC9hdXRob3I+PGF1dGhvcj5HdXR0bWFubiwgQXN0cmlkPC9hdXRob3I+PGF1dGhv
cj5Ld29uZywgSmVmZnJleSBDLjwvYXV0aG9yPjxhdXRob3I+TWFhdGVuLCBTYXJhaDwvYXV0aG9y
PjxhdXRob3I+TWFudWVsLCBEb3VnPC9hdXRob3I+PGF1dGhvcj5TdGllYiwgRGF2aWQgTS48L2F1
dGhvcj48YXV0aG9yPkRlbGwsIFNoYXJvbiBELjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1
dG9ycz48dGl0bGVzPjx0aXRsZT5QcmVkaWN0b3JzIG9mIHVuaXZlcnNhbCBpbmZsdWVuemEgdmFj
Y2luYXRpb24gdXB0YWtlIGluIGdyYWRlcyAxIGFuZCAyIFRvcm9udG8gc2Nob29sIGNoaWxkcmVu
OiBFZmZlY3RpdmUgdmFjY2luYXRpb24gc3RyYXRlZ2llcyBzaG91bGQgbm90IGVuZCB3aXRoIGF0
IHJpc2sgY2hpbGRyZW48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+VmFjY2luZTwvc2Vjb25kYXJ5
LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlZhY2NpbmU8L2Z1bGwtdGl0
bGU+PGFiYnItMT5WYWNjaW5lPC9hYmJyLTE+PGFiYnItMj5WYWNjaW5lPC9hYmJyLTI+PC9wZXJp
b2RpY2FsPjxwYWdlcz42NTE4LTY1MjI8L3BhZ2VzPjx2b2x1bWU+Mjg8L3ZvbHVtZT48bnVtYmVy
PjM5PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDEw
LzA5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5FbHNldmllciBCVjwvcHVi
bGlzaGVyPjxpc2JuPjAyNjQtNDEwWDwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnZhY2NpbmUuMjAxMC4wNi4wOTc8L3VybD48L3JlbGF0
ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai52YWNjaW5l
LjIwMTAuMDYuMDk3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENp
dGU+PEF1dGhvcj5MdTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT4xOTI8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE5MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGlt
ZXN0YW1wPSIxNDgxMjEwMjQ3Ij4xOTI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPkx1LCBQZW5nLWp1bjwvYXV0aG9yPjxhdXRob3I+Q2FsbGFoYW4sIERhdmlkIEIuPC9h
dXRob3I+PGF1dGhvcj5EaW5nLCBIZWxlbjwvYXV0aG9yPjxhdXRob3I+RXVsZXIsIEdhcnkgTC48
L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+SW5mbHVlbnph
IEEgKEgxTjEpIDIwMDkgTW9ub3ZhbGVudCBWYWNjaW5hdGlvbiBBbW9uZyBBZHVsdHMgd2l0aCBB
c3RobWEsIFUuUy4sIDIwMTA8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW1lcmljYW4gSm91cm5h
bCBvZiBQcmV2ZW50aXZlIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+QW1lcmljYW4gSm91cm5hbCBvZiBQcmV2ZW50aXZlIE1lZGljaW5l
PC9mdWxsLXRpdGxlPjxhYmJyLTE+QW0uIEouIFByZXYuIE1lZC48L2FiYnItMT48YWJici0yPkFt
IEogUHJldiBNZWQ8L2FiYnItMj48L3BlcmlvZGljYWw+PHBhZ2VzPjYxOS02MjY8L3BhZ2VzPjx2
b2x1bWU+NDE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxMTwveWVh
cj48cHViLWRhdGVzPjxkYXRlPjIwMTEvMTI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVi
bGlzaGVyPkVsc2V2aWVyIEJWPC9wdWJsaXNoZXI+PGlzYm4+MDc0OS0zNzk3PC9pc2JuPjx1cmxz
PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2ouYW1lcHJlLjIw
MTEuMDguMDA0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC4xMDE2L2ouYW1lcHJlLjIwMTEuMDguMDA0PC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5MdTwvQXV0aG9yPjxZZWFyPjIwMDk8L1ll
YXI+PFJlY051bT4xOTE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjE5MTwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhw
Mjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgxMjEwMjQ3Ij4xOTE8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkx1LCBQZW5nLWp1bjwvYXV0aG9yPjxhdXRob3I+
RXVsZXIsIEdhcnkgTC48L2F1dGhvcj48YXV0aG9yPkNhbGxhaGFuLCBEYXZpZCBCLjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5JbmZsdWVuemEgVmFjY2lu
YXRpb24gQW1vbmcgQWR1bHRzIHdpdGggQXN0aG1hPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFt
ZXJpY2FuIEpvdXJuYWwgb2YgUHJldmVudGl2ZSBNZWRpY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjwv
dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJuYWwgb2YgUHJldmVu
dGl2ZSBNZWRpY2luZTwvZnVsbC10aXRsZT48YWJici0xPkFtLiBKLiBQcmV2LiBNZWQuPC9hYmJy
LTE+PGFiYnItMj5BbSBKIFByZXYgTWVkPC9hYmJyLTI+PC9wZXJpb2RpY2FsPjxwYWdlcz4xMDkt
MTE1PC9wYWdlcz48dm9sdW1lPjM3PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGRhdGVzPjx5
ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDA5LzA4PC9kYXRlPjwvcHViLWRhdGVz
PjwvZGF0ZXM+PHB1Ymxpc2hlcj5FbHNldmllciBCVjwvcHVibGlzaGVyPjxpc2JuPjA3NDktMzc5
NzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAx
Ni9qLmFtZXByZS4yMDA5LjAzLjAyMTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmFtZXByZS4yMDA5LjAzLjAyMTwvZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VHVwcGluPC9BdXRo
b3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjE5MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i
ZXI+MTkzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4
ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMTAyNDci
PjE5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi
PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VHVwcGluLCBQLjwv
YXV0aG9yPjxhdXRob3I+U2Ftc29uLCBTLjwvYXV0aG9yPjxhdXRob3I+V2VpbGwsIEEuPC9hdXRo
b3I+PGF1dGhvcj5SaWNvcmRlYXUsIFAuPC9hdXRob3I+PGF1dGhvcj5BbGxlbWFuZCwgSC48L2F1
dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+U2Vhc29uYWwgaW5m
bHVlbnphIHZhY2NpbmF0aW9uIGNvdmVyYWdlIGluIEZyYW5jZSBkdXJpbmcgdHdvIGluZmx1ZW56
YSBzZWFzb25zICgyMDA3IGFuZCAyMDA4KSBhbmQgZHVyaW5nIGEgY29udGV4dCBvZiBwYW5kZW1p
YyBpbmZsdWVuemEgQShIMU4xKSBpbiAyMDA5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlZhY2Np
bmU8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5WYWNj
aW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+VmFjY2luZTwvYWJici0xPjxhYmJyLTI+VmFjY2luZTwv
YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+NDYzMi00NjM3PC9wYWdlcz48dm9sdW1lPjI5PC92
b2x1bWU+PG51bWJlcj4yODwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+MjAxMS8wNjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxwdWJsaXNoZXI+RWxz
ZXZpZXIgQlY8L3B1Ymxpc2hlcj48aXNibj4wMjY0LTQxMFg8L2lzYm4+PHVybHM+PHJlbGF0ZWQt
dXJscz48dXJsPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMTYvai52YWNjaW5lLjIwMTEuMDQuMDY0
PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4x
MDE2L2oudmFjY2luZS4yMDExLjA0LjA2NDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNv
cmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw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ADDIN EN.CITE.DATA (86-89, 94-100), although regarding there are conflicting reports for the latter ADDIN EN.CITE <EndNote><Cite><Author>Vázquez-Fernández del Pozo</Author><Year>2007</Year><RecNum>123</RecNum><DisplayText>(92)</DisplayText><record><rec-number>123</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209721">123</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vázquez-Fernández del Pozo, S</author><author>Hernández-Barrera, V</author><author>Carrasco-Garrido, P</author><author>Alvarez-Martín, E</author><author>López-de Andrés, A</author><author>Gil de Miguel, A</author><author>Jiménez-García, R</author></authors></contributors><titles><title>Influenza vaccination coverage and related factors among Spanish children</title><secondary-title>Journal of Infection</secondary-title></titles><periodical><full-title>Journal of Infection</full-title><abbr-1>J. Infect.</abbr-1><abbr-2>J Infect</abbr-2></periodical><pages>483-489</pages><volume>54</volume><number>5</number><dates><year>2007</year></dates><isbn>0163-4453</isbn><urls></urls></record></Cite></EndNote>(92). Variables that were associated with lower vaccination uptake included younger age groups PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (90, 94, 101, 102), belonging to certain ethnic groups PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GaWdhcm88L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GaWdhcm88L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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 EN.CITE.DATA (96, 99, 102) and lack of awareness about the vaccine PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48UmVjTnVtPjIz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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48UmVjTnVtPjIz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==
ADDIN EN.CITE.DATA (85, 93, 94). A more detailed exploration assessing health attitudes suggested that the misbelief that the vaccination was not necessary or could actually cause influenza or side effects was predictive of non-adherence PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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ADDIN EN.CITE.DATA (91, 103-106) and contributed to lower vaccination coverage PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LZWVuYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (90, 101, 102). Reports of low effectiveness probably also contributed to poor uptake PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48
UmVjTnVtPjE3MjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTIsIDEwNywgMTA4KTwvRGlzcGxheVRl
eHQ+PHJlY29yZD48cmVjLW51bWJlcj4xNzI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRp
bWVzdGFtcD0iMTQ4MTIxMDI0NyI+MTcyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h
bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+
PGF1dGhvcj5CdWV2aW5nLCBIZXJtYW4gSi48L2F1dGhvcj48YXV0aG9yPlRob21hcywgU2llcDwv
YXV0aG9yPjxhdXRob3I+V291ZGVuLCBKb2hhbm5lcyBDLiB2YW4gZGVyPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPklzIGluZmx1ZW56YSB2YWNjaW5hdGlv
biBpbiBhc3RobWEgaGVscGZ1bD88L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q3VycmVudCBPcGlu
aW9uIGluIEFsbGVyZ3kgYW5kIENsaW5pY2FsIEltbXVub2xvZ3k8L3NlY29uZGFyeS10aXRsZT48
L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DdXJyZW50IE9waW5pb24gaW4gQWxsZXJn
eSBhbmQgQ2xpbmljYWwgSW1tdW5vbG9neTwvZnVsbC10aXRsZT48YWJici0xPkN1cnIuIE9waW4u
IEFsbGVyZ3kgQ2xpbi4gSW1tdW5vbC48L2FiYnItMT48YWJici0yPkN1cnIgT3BpbiBBbGxlcmd5
IENsaW4gSW1tdW5vbDwvYWJici0yPjxhYmJyLTM+Q3VycmVudCBPcGluaW9uIGluIEFsbGVyZ3kg
JmFtcDsgQ2xpbmljYWwgSW1tdW5vbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+NjUt
NzA8L3BhZ2VzPjx2b2x1bWU+NTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxkYXRlcz48eWVh
cj4yMDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAwNS8wMjwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxwdWJsaXNoZXI+T3ZpZCBUZWNobm9sb2dpZXMgKFdvbHRlcnMgS2x1d2VyIEhlYWx0
aCk8L3B1Ymxpc2hlcj48aXNibj4xNTI4LTQwNTA8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48
dXJsPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwOTcvMDAxMzA4MzItMjAwNTAyMDAwLTAwMDEyPC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDk3
LzAwMTMwODMyLTIwMDUwMjAwMC0wMDAxMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNv
cmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+Q2F0ZXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
ZWNOdW0+NjE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjYxPC9yZWMtbnVtYmVyPjxmb3Jl
aWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6
OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMDk3MjAiPjYxPC9rZXk+PC9mb3JlaWduLWtleXM+
PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv
cnM+PGF1dGhvcnM+PGF1dGhvcj5DYXRlcywgQy4gSi48L2F1dGhvcj48YXV0aG9yPlJvd2UsIEIu
IEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+UG9wdWxh
dGlvbiBIZWFsdGggU2NpZW5jZXMgYW5kIEVkdWNhdGlvbiwgU3QgR2VvcmdlJmFwb3M7cywgVW5p
dmVyc2l0eSBvZiBMb25kb24sIExvbmRvbiwgVUsuY2NhdGVzQHNndWwuYWMudWsuPC9hdXRoLWFk
ZHJlc3M+PHRpdGxlcz48dGl0bGU+VmFjY2luZXMgZm9yIHByZXZlbnRpbmcgaW5mbHVlbnphIGlu
IHBlb3BsZSB3aXRoIGFzdGhtYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Db2NocmFuZSBEYXRh
YmFzZSBvZiBTeXN0ZW1hdGljIFJldmlld3M8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkNv
Y2hyYW5lIERhdGFiYXNlIFN5c3QgUmV2PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPkNEMDAw
MzY0PC9wYWdlcz48dm9sdW1lPjI8L3ZvbHVtZT48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tl
eXdvcmQ+PGtleXdvcmQ+KkFzdGhtYS9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdv
cmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBQcm9ncmVzc2lvbjwva2V5d29yZD48
a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphIFZhY2NpbmVzL2FlIFtB
ZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEgVmFjY2luZXMvdHUg
W1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBb
Q29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vcGMgW1By
ZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+UmFuZG9taXplZCBDb250
cm9sbGVkIFRyaWFscyBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3Rp
dmF0ZWQvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luZXMsIElu
YWN0aXZhdGVkL3R1IFtUaGVyYXBldXRpYyBVc2VdPC9rZXl3b3JkPjxrZXl3b3JkPjAgKEluZmx1
ZW56YSBWYWNjaW5lcyk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoVmFjY2luZXMsIEluYWN0aXZhdGVk
KTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PGlz
Ym4+MTQ2OS00OTNYPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNDUwNTI5PC9hY2Nlc3Npb24tbnVt
Pjx3b3JrLXR5cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4g
R292JmFwb3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs
Pmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05F
V1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMzQ1MDUyOTwvdXJsPjx1
cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9E
aXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjM0NTA1Mjkm
YW1wO2lkPTEwLjEwMDIlMkYxNDY1MTg1OC5DRDAwMDM2NC5wdWI0JmFtcDtpc3NuPTEzNjEtNjEz
NyZhbXA7aXNibj0mYW1wO3ZvbHVtZT0yJmFtcDtpc3N1ZT0mYW1wO3NwYWdlPUNEMDAwMzY0JmFt
cDtwYWdlcz1DRDAwMDM2NCZhbXA7ZGF0ZT0yMDEzJmFtcDt0aXRsZT1Db2NocmFuZStEYXRhYmFz
ZStvZitTeXN0ZW1hdGljK1Jldmlld3MmYW1wO2F0aXRsZT1WYWNjaW5lcytmb3IrcHJldmVudGlu
ZytpbmZsdWVuemEraW4rcGVvcGxlK3dpdGgrYXN0aG1hLiZhbXA7YXVsYXN0PUNhdGVzJmFtcDtw
aWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZn
dDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi8xNDY1MTg1OC5D
RDAwMDM2NC5wdWI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5h
bWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRl
cj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5F
bmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5GbGVtaW5nPC9B
dXRob3I+PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjE3MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u
dW1iZXI+MTczPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i
NWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMTAy
NDciPjE3Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj
bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmxlbWluZywg
RG91Z2xhcyBNLjwvYXV0aG9yPjxhdXRob3I+TW9udG8sIEFybm9sZCBTLjwvYXV0aG9yPjwvYXV0
aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5JbmZsdWVuemEgVmFjY2luYXRpb24g
aW4gQ2hpbGRyZW4gd2l0aCBBc3RobWE8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QW1lcmljYW4g
Sm91cm5hbCBvZiBSZXNwaXJhdG9yeSBhbmQgQ3JpdGljYWwgQ2FyZSBNZWRpY2luZTwvc2Vjb25k
YXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFtZXJpY2FuIEpvdXJu
YWwgb2YgUmVzcGlyYXRvcnkgYW5kIENyaXRpY2FsIENhcmUgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+
PGFiYnItMT5BbS4gSi4gUmVzcGlyLiBDcml0LiBDYXJlIE1lZC48L2FiYnItMT48YWJici0yPkFt
IEogUmVzcGlyIENyaXQgQ2FyZSBNZWQ8L2FiYnItMj48YWJici0zPkFtZXJpY2FuIEpvdXJuYWwg
b2YgUmVzcGlyYXRvcnkgJmFtcDsgQ3JpdGljYWwgQ2FyZSBNZWRpY2luZTwvYWJici0zPjwvcGVy
aW9kaWNhbD48cGFnZXM+OTMxLTkzMTwvcGFnZXM+PHZvbHVtZT4xNzE8L3ZvbHVtZT48bnVtYmVy
Pjg8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMDUv
MDQvMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPkFtZXJpY2FuIFRob3Jh
Y2ljIFNvY2lldHk8L3B1Ymxpc2hlcj48aXNibj4xMDczLTQ0OVgmI3hEOzE1MzUtNDk3MDwvaXNi
bj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTE2NC9hanJj
Y20uMTcxLjguOTUwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291
cmNlLW51bT4xMC4xMTY0L2FqcmNjbS4xNzEuOC45NTA8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (12, 107, 108).Healthcare worker endorsement of vaccination was highly predictive of adherence PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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 EN.CITE.DATA (103, 104, 106). A survey of 1225 US allergists suggested that 85% of these offered influenza vaccinations to adults and children. Younger allergists (<45 years) were more likely to offer vaccination, especially to children ADDIN EN.CITE <EndNote><Cite><Author>Clark</Author><Year>2012</Year><RecNum>177</RecNum><DisplayText>(109)</DisplayText><record><rec-number>177</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">177</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Clark, Sarah J.</author><author>Cowan, Anne E.</author><author>Wortley, Pascale M.</author></authors></contributors><titles><title>Perspectives of Allergists/Immunologists on the 2009–2010 H1N1 Vaccination Effort</title><secondary-title>Journal of Asthma</secondary-title></titles><periodical><full-title>Journal of Asthma</full-title><abbr-1>J. Asthma</abbr-1><abbr-2>J Asthma</abbr-2></periodical><pages>184-189</pages><volume>49</volume><number>2</number><dates><year>2012</year><pub-dates><date>2012/02/02</date></pub-dates></dates><publisher>Informa Healthcare</publisher><isbn>0277-0903
1532-4303</isbn><urls><related-urls><url>;(109). Pediatricians were more likely than family physicians to routinely recommend influenza vaccination to children with asthma (adjusted OR 3.49, 95% CI 1.68-7.22), with decisions also being made depending on asthma phenotype (i.e. intermittent vs. persistent) ADDIN EN.CITE <EndNote><Cite><Author>Dombkowski</Author><Year>2008</Year><RecNum>178</RecNum><DisplayText>(110)</DisplayText><record><rec-number>178</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">178</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dombkowski, Kevin J.</author><author>Leung, Sonia W.</author><author>Clark, Sarah J.</author></authors></contributors><titles><title>Physician Perspectives Regarding Annual Influenza Vaccination Among Children With Asthma</title><secondary-title>Ambulatory Pediatrics</secondary-title></titles><periodical><full-title>Ambulatory Pediatrics</full-title><abbr-1>Ambul. Pediatr.</abbr-1><abbr-2>Ambul Pediatr</abbr-2></periodical><pages>294-299</pages><volume>8</volume><number>5</number><dates><year>2008</year><pub-dates><date>2008/09</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>1530-1567</isbn><urls><related-urls><url>;(110).The success of vaccination programmes was affected by complex factors such as the nature of healthcare provision (e.g. free care or insurance based), education levels, and cultural acceptance of the vaccine. Therefore, national health surveys with information on vaccination status linked with medical and socio-demographic details, (such as that of Spain with data spanning more than two decades PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KaW3DqW5lei1HYXJjw61hPC9BdXRob3I+PFllYXI+MjAw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ADDIN EN.CITE.DATA (86-89, 111) can aid in assessing the impact of influenza vaccination, at population level.Simple interventions such as allowing for year-round scheduling of appointments for vaccination can be effective ADDIN EN.CITE <EndNote><Cite><Author>Paul</Author><Year>2006</Year><RecNum>197</RecNum><DisplayText>(112)</DisplayText><record><rec-number>197</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">197</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Paul, Ian M.</author><author>Eleoff, Sara B.</author><author>Shaffer, Michele L.</author><author>Bucher, Ryan M.</author><author>Moyer, Kathleen M.</author><author>Gusic, Maryellen E.</author></authors></contributors><titles><title>Improving Influenza Vaccination Rates for Children Through Year-round Scheduling</title><secondary-title>Ambulatory Pediatrics</secondary-title></titles><periodical><full-title>Ambulatory Pediatrics</full-title><abbr-1>Ambul. Pediatr.</abbr-1><abbr-2>Ambul Pediatr</abbr-2></periodical><pages>230-234</pages><volume>6</volume><number>4</number><dates><year>2006</year><pub-dates><date>2006/07</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>1530-1567</isbn><urls><related-urls><url>;(112). Nevertheless, it is likely that only major policy shifts will lead to significantly higher vaccination rates, due to more clear and consistent messaging about the importance and acceptability of influenza vaccination to patients and healthcare workers alike. This is illustrated by the increase in influenza vaccination uptake among children with asthma from 36% (2005–2006) to 50% (2010–2011) after the US Centre for Disease Control and prevention (CDC) advised vaccinating all children, regardless of risk ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>235</RecNum><DisplayText>(94)</DisplayText><record><rec-number>235</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481283151">235</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Centre for Disease Control and Prevention. Vaccination Coverage Among Persons with Asthma — United States 2010–2011 Influenza Season.</title><secondary-title>MMWR</secondary-title></titles><pages>973–978</pages><volume>62</volume><dates><year>2013</year></dates><urls></urls></record></Cite></EndNote>(94). With its favourable safety and cost-benefit profile PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA (12, 113, 114) there is a need for health campaigns to raise awareness amongst the public and clinicians of the benefits of influenza vaccination and to improve implementation of guidelines.4. Immunogenicity of influenza vaccines in asthma There is uncertainty about the level of protection that influenza vaccines afford in people with asthma. Influenza vaccine immunogenicity, a prerequisite for protection, is usually assessed by haemagglutinin inhibition assay (HI) measuring seroprotection rate (percentage of subjects with antibody titres ≥1:40), seroconversion rate (percentage of subjects with ≥4-fold increase in antibody titre), antibody geometric mean titre (GMT), and GMT ratio (GMT post vaccination/GMT pre-vaccination). We identified limited data on influenza vaccine immunogenicity in asthma. Only one study of TIV in children aged 0.5–3 years compared healthy controls to recurrent wheezers. It found good and similar seroconversion and seroprotection rates to all three vaccine strains (H1N1, H3N2, and B) in both groups (after 1 month), with higher pre-and post-vaccination GMTs in children with wheeze, but a higher GMT ratio in healthy controls PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE.DATA (115). In children with asthma, TIV and a virosomal inactivated subunit influenza vaccine induced good seroprotection and seroconversion at 1 month in both pre-school and school-age children, with some reduction in GMTs by 6 months PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZWRyb3phPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48
UmVjTnVtPjE5ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTE2LCAxMTcpPC9EaXNwbGF5VGV4dD48
cmVjb3JkPjxyZWMtbnVtYmVyPjE5ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0
YW1wPSIxNDgxMjEwMjQ3Ij4xOTg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i
Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0
aG9yPlBlZHJvemEsIEFsdmFybzwvYXV0aG9yPjxhdXRob3I+SHVlcnRhLCBKb3PDqSBHLjwvYXV0
aG9yPjxhdXRob3I+ZGUgbGEgTHV6IEdhcmNpYSwgTWFyaWE8L2F1dGhvcj48YXV0aG9yPlJvamFz
LCBBcnNoZWxpPC9hdXRob3I+PGF1dGhvcj5Mw7NwZXotTWFydMOtbmV6LCBJcm1hPC9hdXRob3I+
PGF1dGhvcj5QZW5hZ29zLCBNYXJ0w61uPC9hdXRob3I+PGF1dGhvcj5GcmFuY28tUGFyZWRlcywg
Q2FybG9zPC9hdXRob3I+PGF1dGhvcj5EZXJvY2hlLCBDaHJpc3RlbGU8L2F1dGhvcj48YXV0aG9y
Pk1hc2NhcmXDsWFzLCBDZXNhcjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0
bGVzPjx0aXRsZT5UaGUgc2FmZXR5IGFuZCBpbW11bm9nZW5pY2l0eSBvZiBpbmZsdWVuemEgdmFj
Y2luZSBpbiBjaGlsZHJlbiB3aXRoIGFzdGhtYSBpbiBNZXhpY288L3RpdGxlPjxzZWNvbmRhcnkt
dGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIEluZmVjdGlvdXMgRGlzZWFzZXM8L3NlY29u
ZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5JbnRlcm5hdGlvbmFs
IEpvdXJuYWwgb2YgSW5mZWN0aW91cyBEaXNlYXNlczwvZnVsbC10aXRsZT48YWJici0xPkludC4g
Si4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5JbnQgSiBJbmZlY3QgRGlzPC9hYmJyLTI+
PC9wZXJpb2RpY2FsPjxwYWdlcz40NjktNDc1PC9wYWdlcz48dm9sdW1lPjEzPC92b2x1bWU+PG51
bWJlcj40PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMDk8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4y
MDA5LzA3PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5FbHNldmllciBCVjwv
cHVibGlzaGVyPjxpc2JuPjEyMDEtOTcxMjwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+
aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLmlqaWQuMjAwOC4wOC4wMTU8L3VybD48L3JlbGF0
ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5pamlkLjIw
MDguMDguMDE1PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+
PEF1dGhvcj5adWNjb3R0aTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT4yMDwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRp
bWVzdGFtcD0iMTQ4MTIwODMxMSI+MjA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPlp1Y2NvdHRpLCBHLjwvYXV0aG9yPjxhdXRob3I+QW1lbmRvbGEsIEEuPC9hdXRob3I+
PGF1dGhvcj5WaWdhbm8sIEEuPC9hdXRob3I+PGF1dGhvcj5QYXJpYW5pLCBFLjwvYXV0aG9yPjxh
dXRob3I+WmFwcGEsIEEuPC9hdXRob3I+PGF1dGhvcj5Qb2dsaWFuaSwgTC48L2F1dGhvcj48YXV0
aG9yPkdpYWNvbWV0LCBWLjwvYXV0aG9yPjxhdXRob3I+U2F2YXJpbm8sIEEuPC9hdXRob3I+PGF1
dGhvcj5Qb2Rlc3RhLCBBLjwvYXV0aG9yPjxhdXRob3I+Um90dG9saSwgQS48L2F1dGhvcj48YXV0
aG9yPlRhbnppLCBFLjwvYXV0aG9yPjxhdXRob3I+WmFuZXR0aSwgQS48L2F1dGhvcj48YXV0aG9y
PlJhZGFlbGxpLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy
ZXNzPkRlcGFydG1lbnQgb2YgUGVkaWF0cmljcywgVW5pdmVyc2l0eSBvZiBNaWxhbiwgTHVpZ2kg
U2FjY28gSG9zcGl0YWwsIFZpYSBHQiBHcmFzc2kgNzQsIDIwMTU3IE1pbGFuLCBJdGFseS4gZ2lh
bnZpbmNlbnpvLnp1Y2NvdHRpQHVuaW1pLml0PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+
TG9uZy10ZXJtIGltbXVub2dlbmljaXR5IG9mIGEgdmlyb3NvbWFsIHN1YnVuaXQgaW5hY3RpdmF0
ZWQgaW5mbHVlbnphIHZhY2NpbmUgaW4gY2hpbGRyZW4gd2l0aCBhc3RobWE8L3RpdGxlPjxzZWNv
bmRhcnktdGl0bGU+VmFjY2luZTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VmFjY2luZTwv
YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlZhY2NpbmU8L2Z1bGwt
dGl0bGU+PGFiYnItMT5WYWNjaW5lPC9hYmJyLTE+PGFiYnItMj5WYWNjaW5lPC9hYmJyLTI+PC9w
ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5WYWNjaW5lPC9mdWxsLXRpdGxl
PjxhYmJyLTE+VmFjY2luZTwvYWJici0xPjxhYmJyLTI+VmFjY2luZTwvYWJici0yPjwvYWx0LXBl
cmlvZGljYWw+PHBhZ2VzPjY2OTItODwvcGFnZXM+PHZvbHVtZT4yNTwvdm9sdW1lPjxudW1iZXI+
MzctMzg8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWN1dGUgRGlzZWFzZTwva2V5d29yZD48
a2V5d29yZD5BbnRpYm9kaWVzLCBWaXJhbC9ibCBbQmxvb2RdPC9rZXl3b3JkPjxrZXl3b3JkPkFu
dGlib2RpZXMsIFZpcmFsL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qQXN0aG1h
L2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29y
ZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5
d29yZD5JbmZsdWVuemEgQSBWaXJ1cywgSDFOMSBTdWJ0eXBlL2ltIFtJbW11bm9sb2d5XTwva2V5
d29yZD48a2V5d29yZD5JbmZsdWVuemEgQSBWaXJ1cywgSDNOMiBTdWJ0eXBlL2ltIFtJbW11bm9s
b2d5XTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgQiB2aXJ1cy9pbSBbSW1tdW5vbG9neV08
L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphIFZhY2NpbmVzL2FlIFtBZHZlcnNlIEVmZmVjdHNd
PC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSBWYWNjaW5lcy9jaCBbQ2hlbWlzdHJ5XTwva2V5
d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2ltIFtJbW11bm9sb2d5XTwva2V5d29y
ZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFj
dG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29y
ZD5WYWNjaW5lcywgSW5hY3RpdmF0ZWQvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtl
eXdvcmQ+KlZhY2NpbmVzLCBJbmFjdGl2YXRlZC9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtl
eXdvcmQ+VmFjY2luZXMsIFN1YnVuaXQvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtl
eXdvcmQ+KlZhY2NpbmVzLCBTdWJ1bml0L2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29y
ZD4qVmlyb3NvbWVzL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD4wIChBbnRpYm9k
aWVzLCBWaXJhbCk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5
d29yZD48a2V5d29yZD4wIChWYWNjaW5lcywgSW5hY3RpdmF0ZWQpPC9rZXl3b3JkPjxrZXl3b3Jk
PjAgKFZhY2NpbmVzLCBTdWJ1bml0KTwva2V5d29yZD48a2V5d29yZD4wIChWaXJvc29tZXMpPC9r
ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0
ZT5TZXAgMTc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMjY0LTQxMFg8L2lzYm4+
PGFjY2Vzc2lvbi1udW0+MTc2OTc3MzA8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5NdWx0aWNl
bnRlciBTdHVkeTwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3Zp
ZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BB
R0U9ZnVsbHRleHQmYW1wO0Q9bWVkNSZhbXA7QU49MTc2OTc3MzA8L3VybD48dXJsPmh0dHA6Ly9v
cGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9
T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjE3Njk3NzMwJmFtcDtpZD0mYW1w
O2lzc249MDI2NC00MTBYJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTI1JmFtcDtpc3N1ZT0zNyZhbXA7
c3BhZ2U9NjY5MiZhbXA7cGFnZXM9NjY5Mi04JmFtcDtkYXRlPTIwMDcmYW1wO3RpdGxlPVZhY2Np
bmUmYW1wO2F0aXRsZT1Mb25nLXRlcm0raW1tdW5vZ2VuaWNpdHkrb2YrYSt2aXJvc29tYWwrc3Vi
dW5pdCtpbmFjdGl2YXRlZCtpbmZsdWVuemErdmFjY2luZStpbitjaGlsZHJlbit3aXRoK2FzdGht
YS4mYW1wO2F1bGFzdD1adWNjb3R0aSZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7
Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3Vy
bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3Jl
bW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9s
b2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3Vh
Z2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QZWRyb3phPC9BdXRob3I+PFllYXI+MjAwOTwvWWVhcj48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ADDIN EN.CITE.DATA (116, 117). A 2009 H1N1 vaccine given to adolescents and adults induced equally good seroprotection if 15 ?g or 30 ?g vaccine were given in those with mild-to-moderate asthma. In contrast, in severe asthma the higher dose resulted in better seroprotection, which in elderly severe asthma patients (≥60 years) was only achieved with the high 30 ?g dose PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNzZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNzZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (118). In the latter group and in young children with recurrent wheeze, corticosteroid treatment or dose (I would add corticosteroid treatment and corticosteroid dose to make it clearer) did not influence influenza vaccine immunogenicity PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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=
ADDIN EN.CITE.DATA (115, 118). 5. Efficacy of influenza vaccines in asthmaData on the efficacy of influenza vaccination in asthma are limited, with only two randomized studies addressing the efficacy of TIV in patients with stable asthma. One study, conducted in Turkey, included 128 adults with asthma who received either TIV or no vaccination PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmFkb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmFkb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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 EN.CITE.DATA (119). No significant difference in the frequency of upper respiratory tract infections (URTI) or AAE rate was found between vaccinated and non-vaccinated participants; however, this study had significant limitations (see Table 1). In a larger randomized, double-blind, placebo-controlled trial from the Netherlands PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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=
ADDIN EN.CITE.DATA (75) in 6–18 year-old children with asthma, TIV had no significant effect on the number, severity, or duration of AAEs caused by confirmed influenza infection, or on the respiratory symptoms recorded; however, it moderately improved quality of life during the weeks of in?uenza-positive illness PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48
UmVjTnVtPjIyPC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMjApPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjIyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjIyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CdWV2
aW5nLCBILiBKLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBXb3VkZW4sIEouIEMuPC9hdXRob3I+
PGF1dGhvcj5SYWF0LCBILjwvYXV0aG9yPjxhdXRob3I+QmVybnNlbiwgUi4gTS48L2F1dGhvcj48
YXV0aG9yPmRlIEpvbmdzdGUsIEouIEMuPC9hdXRob3I+PGF1dGhvcj52YW4gU3Vpamxla29tLVNt
aXQsIEwuIFcuPC9hdXRob3I+PGF1dGhvcj5Pc3RlcmhhdXMsIEEuIEQuPC9hdXRob3I+PGF1dGhv
cj5SaW1tZWx6d2FhbiwgRy4gRi48L2F1dGhvcj48YXV0aG9yPk1vbGtlbiwgTS4gUi48L2F1dGhv
cj48YXV0aG9yPlRob21hcywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1
dGgtYWRkcmVzcz5EZXB0IG9mIEdlbmVyYWwgUHJhY3RpY2UsIHJvb20gRmYzMDUsIEVyYXNtdXMg
TUMgLSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyIFJvdHRlcmRhbSwgUE8gQm94LCAxNzM4LCBU
aGUgTmV0aGVybGFuZHMuIGoudmFuZGVyd291ZGVuQGVyYXNtdXNtYy5ubDwvYXV0aC1hZGRyZXNz
Pjx0aXRsZXM+PHRpdGxlPkluZmx1ZW56YSB2YWNjaW5hdGlvbiBpbiBhc3RobWF0aWMgY2hpbGRy
ZW46IGVmZmVjdHMgb24gcXVhbGl0eSBvZiBsaWZlIGFuZCBzeW1wdG9tczwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9zZWNvbmRhcnktdGl0bGU+
PGFsdC10aXRsZT5FdXIgUmVzcGlyIEo8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJy
LTE+RXVyLiBSZXNwaXIuIEouPC9hYmJyLTE+PGFiYnItMj5FdXIgUmVzcGlyIEo8L2FiYnItMj48
L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIFJlc3BpcmF0
b3J5IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIFJlc3Bpci4gSi48L2FiYnItMT48
YWJici0yPkV1ciBSZXNwaXIgSjwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjkyNS0z
MTwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48
a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNl
PC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvcHAgW1BoeXNpb3BhdGhvbG9neV08L2tleXdvcmQ+
PGtleXdvcmQ+QXN0aG1hL3ZpIFtWaXJvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tl
eXdvcmQ+PGtleXdvcmQ+RG91YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEg
VmFjY2luZXMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdv
cmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+
KkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+
PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5OZXRoZXJsYW5kczwva2V5d29yZD48a2V5
d29yZD4qUXVhbGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxrZXl3b3JkPlNwaXJvbWV0cnk8L2tleXdv
cmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1NTcyNTMz
PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1JhbmRvbWl6ZWQg
Q29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7
dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu
Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl
eHQmYW1wO0Q9bWVkNSZhbXA7QU49MTU1NzI1MzM8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFj
LnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlk
K01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjE1NTcyNTMzJmFtcDtpZD0mYW1wO2lzc249MDkw
My0xOTM2JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTI0JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT05MjUm
YW1wO3BhZ2VzPTkyNS0zMSZhbXA7ZGF0ZT0yMDA0JmFtcDt0aXRsZT1FdXJvcGVhbitSZXNwaXJh
dG9yeStKb3VybmFsJmFtcDthdGl0bGU9SW5mbHVlbnphK3ZhY2NpbmF0aW9uK2luK2FzdGhtYXRp
YytjaGlsZHJlbiUzQStlZmZlY3RzK29uK3F1YWxpdHkrb2YrbGlmZSthbmQrc3ltcHRvbXMuJmFt
cDthdWxhc3Q9QnVldmluZyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9h
dXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1k
YXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8
L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9y
ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA (120). In contrast, a conference abstract PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXl5YXogSmFoYW5pPC9BdXRob3I+PFllYXI+MjAxMjwv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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXl5YXogSmFoYW5pPC9BdXRob3I+PFllYXI+MjAxMjwv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ADDIN EN.CITE.DATA (121) reported significantly lower AAE rates in children <5 years with asthma following TIV (13%) compared with placebo (53%).For LAIV, we found no efficacy data in asthma compared to non-vaccination. A large European multi-center, randomized, open-label trial compared intranasal cold-adapted LAIV to intramuscular TIV in children and adolescents aged 6–17 years with asthma, and reported a 34.7% reduction in culture-con?rmed in?uenza illness after LAIV PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GbGVtaW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GbGVtaW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA (122). A re-analysis of efficacy data from two randomized, multinational trials PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc2hrZW5hemk8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bc2hrZW5hemk8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFy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ADDIN EN.CITE.DATA (123, 124) comparing LAIV to TIV, demonstrated that 2–5 year old children with mild-to-moderate asthma or prior wheezing, receiving LAIV had fewer cases of culture-confirmed influenza illness than TIV recipients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE.DATA (125).6. Effectiveness of influenza vaccination in asthma While efficacy studies reflect a treatment’s performance in tightly controlled clinical trials, effectiveness studies reflect how well a treatment works in practice and are more representative of real life. Influenza vaccination may be less effective than expected due to differences between the characteristics of patients vaccinated in the general population and those recruited into efficacy trials. Furthermore, the influenza vaccine may not contain the prevalent virus strain, and vaccine coverage may be suboptimal. There are limited data on the effectiveness of influenza vaccination in patients with asthma or high-risk populations that included asthma. Six studies assessed the effectiveness of seasonal influenza vaccines, while one other studied the H1N1 pandemic vaccine PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+NDI8L1JlY051bT48RGlzcGxheVRleHQ+KDEyNik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+NDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4
MTIwODMxMSI+NDI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvc2hp
bywgTi48L2F1dGhvcj48YXV0aG9yPkhhc2VnYXdhLCBULjwvYXV0aG9yPjxhdXRob3I+U3V6dWtp
LCBLLjwvYXV0aG9yPjxhdXRob3I+VGFuYWJlLCBZLjwvYXV0aG9yPjxhdXRob3I+S295YSwgVC48
L2F1dGhvcj48YXV0aG9yPlNha2FnYW1pLCBULjwvYXV0aG9yPjxhdXRob3I+QW9raSwgTi48L2F1
dGhvcj48YXV0aG9yPkhvc2hpbm8sIFkuPC9hdXRob3I+PGF1dGhvcj5LYWdhbXUsIEguPC9hdXRo
b3I+PGF1dGhvcj5Uc3VrYWRhLCBILjwvYXV0aG9yPjxhdXRob3I+QXJha2F3YSwgTS48L2F1dGhv
cj48YXV0aG9yPkdlanlvLCBGLjwvYXV0aG9yPjxhdXRob3I+TmFyaXRhLCBJLjwvYXV0aG9yPjxh
dXRob3I+U3V6dWtpLCBFLjwvYXV0aG9yPjxhdXRob3I+TmlpZ2F0YSBBc3RobWEgVHJlYXRtZW50
IFN0dWR5LCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy
ZXNzPktvc2hpbyxOYW8uIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRh
IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNl
cywgTmlpZ2F0YSwgSmFwYW4uIEhhc2VnYXdhLFRha2FzaGkuIERlcGFydG1lbnQgb2YgR2VuZXJh
bCBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IE1lZGljYWwgYW5kIERlbnRhbCBIb3NwaXRh
bCwgTmlpZ2F0YSwgSmFwYW4uIFN1enVraSxLYXp1by4gRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwg
UHJlZmVjdHVyYWwgTXVpa2FtYWNoaSBIb3NwaXRhbCwgTmlpZ2F0YSwgSmFwYW4uIFRhbmFiZSxZ
b3NoaW5hcmkuIERpdmlzaW9uIG9mIEluZmVjdGlvbiBDb250cm9sIGFuZCBQcmV2ZW50aW9uLCBO
aWlnYXRhIFVuaXZlcnNpdHkgTWVkaWNhbCBhbmQgRGVudGFsIEhvc3BpdGFsLCBOaWlnYXRhLCBK
YXBhbi4gS295YSxUb3NoaXl1a2kuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBO
aWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBT
Y2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIFNha2FnYW1pLFRha3Vyby4gRGl2aXNpb24gb2YgUmVz
cGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2Yg
TWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2VzLCBOaWlnYXRhLCBKYXBhbi4gQW9raSxOb2J1bWFz
YS4gRGl2aXNpb24gb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBH
cmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2VzLCBOaWlnYXRhLCBK
YXBhbi4gSG9zaGlubyxZb3NoaWZ1bWkuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5l
LCBOaWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRh
bCBTY2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIEthZ2FtdSxIaXJvc2hpLiBEaXZpc2lvbiBvZiBS
ZXNwaXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBv
ZiBNZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEsIEphcGFuLiBUc3VrYWRhLEhp
cm9raS4gRGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9yeSBEaXNlYXNlLCBOaWlnYXRhIENpdGl6ZW4g
SG9zcGl0YWwsIE5paWdhdGEsIEphcGFuLiBBcmFrYXdhLE1hc2Fha2kuIERpdmlzaW9uIG9mIFJl
c3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9m
IE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIEdlanlvLEZ1bWl0
YWtlLiBEaXZpc2lvbiBvZiBSZXNwaXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5
IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEs
IEphcGFuLiBOYXJpdGEsSWNoaWVpLiBEaXZpc2lvbiBvZiBSZXNwaXJhdG9yeSBNZWRpY2luZSwg
TmlpZ2F0YSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIGFuZCBEZW50YWwg
U2NpZW5jZXMsIE5paWdhdGEsIEphcGFuLiBTdXp1a2ksRWlpY2hpLiBEZXBhcnRtZW50IG9mIEdl
bmVyYWwgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBNZWRpY2FsIGFuZCBEZW50YWwgSG9z
cGl0YWwsIE5paWdhdGEsIEphcGFuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkFuYWx5
c2lzIG9mIHRoZSBpbmZsdWVuemEgQSAoSDFOMSkgMjAwOSBwYW5kZW1pYyBpbmZlY3Rpb24gaW4g
SmFwYW5lc2UgYXN0aG1hdGljIHBhdGllbnRzOiB1c2luZyBhIHF1ZXN0aW9ubmFpcmUtYmFzZWQg
c3VydmV5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFsbGVyZ29sb2d5IEludGVybmF0aW9uYWw8
L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFsbGVyZ29sPC9hbHQtdGl0bGU+PC90aXRsZXM+
PHBhZ2VzPjY3LTc0PC9wYWdlcz48dm9sdW1lPjYzPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+
PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+
PGtleXdvcmQ+KkFzdGhtYS9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+RmVt
YWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8
L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBBIFZpcnVzLCBIMU4xIFN1YnR5cGU8L2tleXdv
cmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vY28gW0NvbXBsaWNhdGlvbnNdPC9rZXl3b3Jk
PjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxr
ZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tl
eXdvcmQ+PGtleXdvcmQ+SmFwYW4vZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+
TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QdWJs
aWMgSGVhbHRoIFN1cnZlaWxsYW5jZTwva2V5d29yZD48a2V5d29yZD5RdWVzdGlvbm5haXJlczwv
a2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luYXRp
b248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVz
PjxkYXRlPk1hcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NDAtMTU5MjwvaXNi
bj48YWNjZXNzaW9uLW51bT4yNDQ1NzgxNDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9
WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0NDU3ODE0
PC91cmw+PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5k
ZXJQbHVzL0Rpc3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoy
NDQ1NzgxNCZhbXA7aWQ9MTAuMjMzMiUyRmFsbGVyZ29saW50LjEzLU9BLTA2MDkmYW1wO2lzc249
MTMyMy04OTMwJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTYzJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT02
NyZhbXA7cGFnZXM9NjctNzQmYW1wO2RhdGU9MjAxNCZhbXA7dGl0bGU9QWxsZXJnb2xvZ3krSW50
ZXJuYXRpb25hbCZhbXA7YXRpdGxlPUFuYWx5c2lzK29mK3RoZStpbmZsdWVuemErQSslMjhIMU4x
JTI5KzIwMDkrcGFuZGVtaWMraW5mZWN0aW9uK2luK0phcGFuZXNlK2FzdGhtYXRpYytwYXRpZW50
cyUzQSt1c2luZythK3F1ZXN0aW9ubmFpcmUtYmFzZWQrc3VydmV5LiZhbXA7YXVsYXN0PUtvc2hp
byZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsm
bHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjIzMzIvYWxs
ZXJnb2xpbnQuMTMtT0EtMDYwOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh
YmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2Ut
cHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu
Z3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA (126). In children, two retrospective cohort studies found that influenza vaccination was associated with a reduction in the rate of asthma exacerbations PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmFtYXJ6PC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmFtYXJ6PC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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=
ADDIN EN.CITE.DATA (127) and fewer acute respiratory problems (only in those less than 6 years of age) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl
Y051bT4yOTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTI4KTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4yOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgx
MjA4MzExIj4yOTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy
dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U21pdHMs
IEEuIEouPC9hdXRob3I+PGF1dGhvcj5IYWssIEUuPC9hdXRob3I+PGF1dGhvcj5TdGFsbWFuLCBX
LiBBLiBCLjwvYXV0aG9yPjxhdXRob3I+dmFuIEVzc2VuLCBHLiBBLjwvYXV0aG9yPjxhdXRob3I+
SG9lcywgQS4gVy48L2F1dGhvcj48YXV0aG9yPlZlcmhlaWosIFRoIEouIE0uPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBNZWRpY2FsIENl
bnRlciBVdHJlY2h0LCBKdWxpdXMgQ2VudGVyIGZvciBHZW5lcmFsIFByYWN0aWNlIGFuZCBQYXRp
ZW50IE9yaWVudGVkIFJlc2VhcmNoLCBUaGUgTmV0aGVybGFuZHM8L2F1dGgtYWRkcmVzcz48dGl0
bGVzPjx0aXRsZT5DbGluaWNhbCBlZmZlY3RpdmVuZXNzIG9mIGNvbnZlbnRpb25hbCBpbmZsdWVu
emEgdmFjY2luYXRpb24gaW4gYXN0aG1hdGljIGNoaWxkcmVuPC90aXRsZT48c2Vjb25kYXJ5LXRp
dGxlPkVwaWRlbWlvbG9neSAmYW1wOyBJbmZlY3Rpb248L3NlY29uZGFyeS10aXRsZT48L3RpdGxl
cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FcGlkZW1pb2xvZ3kgYW5kIEluZmVjdGlvbjwvZnVs
bC10aXRsZT48YWJici0xPkVwaWRlbWlvbC4gSW5mZWN0LjwvYWJici0xPjxhYmJyLTI+RXBpZGVt
aW9sIEluZmVjdDwvYWJici0yPjxhYmJyLTM+RXBpZGVtaW9sb2d5ICZhbXA7IEluZmVjdGlvbjwv
YWJici0zPjwvcGVyaW9kaWNhbD48cGFnZXM+MjA1LTIxMTwvcGFnZXM+PHZvbHVtZT4xMjg8L3Zv
bHVtZT48bnVtYmVyPjI8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QXN0aG1hIC0tIENvbXBs
aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphIFZhY2NpbmUgLS0gUGhhcm1hY29k
eW5hbWljczwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEsIEh1bWFuIC0tIFByZXZlbnRpb24g
YW5kIENvbnRyb2w8L2tleXdvcmQ+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdv
cmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5
d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkNvbW9yYmlkaXR5PC9r
ZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbjwva2V5d29yZD48
a2V5d29yZD5JbW11bml6YXRpb24gUHJvZ3JhbXM8L2tleXdvcmQ+PGtleXdvcmQ+SW5mYW50PC9r
ZXl3b3JkPjxrZXl3b3JkPkluZmFudCwgTmV3Ym9ybjwva2V5d29yZD48a2V5d29yZD5JbmZsdWVu
emEgVmFjY2luZSAtLSBBZG1pbmlzdHJhdGlvbiBhbmQgRG9zYWdlPC9rZXl3b3JkPjxrZXl3b3Jk
PkluZmx1ZW56YSwgSHVtYW4gLS0gRXBpZGVtaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8
L2tleXdvcmQ+PGtleXdvcmQ+TW9yYmlkaXR5PC9rZXl3b3JkPjxrZXl3b3JkPk5ldGhlcmxhbmRz
PC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3RpdmUgRGVzaWduPC9rZXl3b3JkPjxrZXl3b3Jk
PlNlYXNvbnM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48L2Rh
dGVzPjxpc2JuPjA5NTAtMjY4ODwvaXNibj48YWNjZXNzaW9uLW51bT4yMDExMDg2MDYzLiBMYW5n
dWFnZTogRW5nbGlzaC4gRW50cnkgRGF0ZTogMjAxMTA2MTAuIFJldmlzaW9uIERhdGU6IDIwMTIw
MzAyLiBQdWJsaWNhdGlvbiBUeXBlOiBqb3VybmFsIGFydGljbGU8L2FjY2Vzc2lvbi1udW0+PHVy
bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9zZWFyY2guZWJzY29ob3N0LmNvbS9sb2dpbi5h
c3B4P2RpcmVjdD10cnVlJmFtcDtkYj1qbGgmYW1wO0FOPTIwMTEwODYwNjMmYW1wO3NpdGU9ZWhv
c3QtbGl2ZTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u
dW0+MTAuMTAxNy9TMDk1MDI2ODgwMTAwNjU3NDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJl
bW90ZS1kYXRhYmFzZS1uYW1lPmpsaDwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRh
YmFzZS1wcm92aWRlcj5FQlNDT2hvc3Q8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48L3JlY29y
ZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA (128). A survey found that vaccination in children with asthma was associated with less use of rescue prednisolone PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (129), while a nested case-control study suggested that influenza vaccination was associated with fewer acute general practice visits for respiratory problems in children with long-term conditions ADDIN EN.CITE <EndNote><Cite><Author>Hak</Author><Year>2005</Year><RecNum>208</RecNum><DisplayText>(130)</DisplayText><record><rec-number>208</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">208</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hak, Eelko</author></authors></contributors><titles><title>Clinical Effectiveness of Influenza Vaccination in Persons Younger Than 65 Years With High-Risk Medical Conditions</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>274</pages><volume>165</volume><number>3</number><dates><year>2005</year><pub-dates><date>2005/02/14</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(130). However, another case-control study suggested that vaccination was associated with an increased risk of unscheduled attendance for asthma care ADDIN EN.CITE <EndNote><Cite><Author>Christy</Author><Year>2004</Year><RecNum>27</RecNum><DisplayText>(131)</DisplayText><record><rec-number>27</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">27</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Christy, C</author><author>Aligne, CA</author><author>Auinger, P</author><author>Pulcino, T</author><author>Weitzman, M</author></authors></contributors><titles><title>Effectiveness of influenza vaccine for the prevention of asthma exacerbations</title><secondary-title>Archives of disease in childhood</secondary-title></titles><periodical><full-title>Archives of Disease in Childhood</full-title><abbr-1>Arch. Dis. Child.</abbr-1><abbr-2>Arch Dis Child</abbr-2></periodical><pages>734-735</pages><volume>89</volume><number>8</number><dates><year>2004</year></dates><isbn>1468-2044</isbn><urls></urls></record></Cite></EndNote>(131). In this study, the cases and controls were poorly balanced in terms of ethnicity and likelihood of vaccination in previous years. Although an adjusted analysis was undertaken, this may not have taken into account all the differences between the groups.Only one study focused on adults with asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+NDI8L1JlY051bT48RGlzcGxheVRleHQ+KDEyNik8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+NDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4
MTIwODMxMSI+NDI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktvc2hp
bywgTi48L2F1dGhvcj48YXV0aG9yPkhhc2VnYXdhLCBULjwvYXV0aG9yPjxhdXRob3I+U3V6dWtp
LCBLLjwvYXV0aG9yPjxhdXRob3I+VGFuYWJlLCBZLjwvYXV0aG9yPjxhdXRob3I+S295YSwgVC48
L2F1dGhvcj48YXV0aG9yPlNha2FnYW1pLCBULjwvYXV0aG9yPjxhdXRob3I+QW9raSwgTi48L2F1
dGhvcj48YXV0aG9yPkhvc2hpbm8sIFkuPC9hdXRob3I+PGF1dGhvcj5LYWdhbXUsIEguPC9hdXRo
b3I+PGF1dGhvcj5Uc3VrYWRhLCBILjwvYXV0aG9yPjxhdXRob3I+QXJha2F3YSwgTS48L2F1dGhv
cj48YXV0aG9yPkdlanlvLCBGLjwvYXV0aG9yPjxhdXRob3I+TmFyaXRhLCBJLjwvYXV0aG9yPjxh
dXRob3I+U3V6dWtpLCBFLjwvYXV0aG9yPjxhdXRob3I+TmlpZ2F0YSBBc3RobWEgVHJlYXRtZW50
IFN0dWR5LCBHcm91cDwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy
ZXNzPktvc2hpbyxOYW8uIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRh
IFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNl
cywgTmlpZ2F0YSwgSmFwYW4uIEhhc2VnYXdhLFRha2FzaGkuIERlcGFydG1lbnQgb2YgR2VuZXJh
bCBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IE1lZGljYWwgYW5kIERlbnRhbCBIb3NwaXRh
bCwgTmlpZ2F0YSwgSmFwYW4uIFN1enVraSxLYXp1by4gRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwg
UHJlZmVjdHVyYWwgTXVpa2FtYWNoaSBIb3NwaXRhbCwgTmlpZ2F0YSwgSmFwYW4uIFRhbmFiZSxZ
b3NoaW5hcmkuIERpdmlzaW9uIG9mIEluZmVjdGlvbiBDb250cm9sIGFuZCBQcmV2ZW50aW9uLCBO
aWlnYXRhIFVuaXZlcnNpdHkgTWVkaWNhbCBhbmQgRGVudGFsIEhvc3BpdGFsLCBOaWlnYXRhLCBK
YXBhbi4gS295YSxUb3NoaXl1a2kuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBO
aWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBT
Y2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIFNha2FnYW1pLFRha3Vyby4gRGl2aXNpb24gb2YgUmVz
cGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2Yg
TWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2VzLCBOaWlnYXRhLCBKYXBhbi4gQW9raSxOb2J1bWFz
YS4gRGl2aXNpb24gb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBH
cmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2VzLCBOaWlnYXRhLCBK
YXBhbi4gSG9zaGlubyxZb3NoaWZ1bWkuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5l
LCBOaWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRh
bCBTY2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIEthZ2FtdSxIaXJvc2hpLiBEaXZpc2lvbiBvZiBS
ZXNwaXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBv
ZiBNZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEsIEphcGFuLiBUc3VrYWRhLEhp
cm9raS4gRGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9yeSBEaXNlYXNlLCBOaWlnYXRhIENpdGl6ZW4g
SG9zcGl0YWwsIE5paWdhdGEsIEphcGFuLiBBcmFrYXdhLE1hc2Fha2kuIERpdmlzaW9uIG9mIFJl
c3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9m
IE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIEdlanlvLEZ1bWl0
YWtlLiBEaXZpc2lvbiBvZiBSZXNwaXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5
IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEs
IEphcGFuLiBOYXJpdGEsSWNoaWVpLiBEaXZpc2lvbiBvZiBSZXNwaXJhdG9yeSBNZWRpY2luZSwg
TmlpZ2F0YSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIGFuZCBEZW50YWwg
U2NpZW5jZXMsIE5paWdhdGEsIEphcGFuLiBTdXp1a2ksRWlpY2hpLiBEZXBhcnRtZW50IG9mIEdl
bmVyYWwgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBNZWRpY2FsIGFuZCBEZW50YWwgSG9z
cGl0YWwsIE5paWdhdGEsIEphcGFuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkFuYWx5
c2lzIG9mIHRoZSBpbmZsdWVuemEgQSAoSDFOMSkgMjAwOSBwYW5kZW1pYyBpbmZlY3Rpb24gaW4g
SmFwYW5lc2UgYXN0aG1hdGljIHBhdGllbnRzOiB1c2luZyBhIHF1ZXN0aW9ubmFpcmUtYmFzZWQg
c3VydmV5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFsbGVyZ29sb2d5IEludGVybmF0aW9uYWw8
L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkFsbGVyZ29sPC9hbHQtdGl0bGU+PC90aXRsZXM+
PHBhZ2VzPjY3LTc0PC9wYWdlcz48dm9sdW1lPjYzPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+
PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+
PGtleXdvcmQ+KkFzdGhtYS9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+RmVt
YWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmNpZGVuY2U8
L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBBIFZpcnVzLCBIMU4xIFN1YnR5cGU8L2tleXdv
cmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vY28gW0NvbXBsaWNhdGlvbnNdPC9rZXl3b3Jk
PjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxr
ZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tl
eXdvcmQ+PGtleXdvcmQ+SmFwYW4vZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+
TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QdWJs
aWMgSGVhbHRoIFN1cnZlaWxsYW5jZTwva2V5d29yZD48a2V5d29yZD5RdWVzdGlvbm5haXJlczwv
a2V5d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luYXRp
b248L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVz
PjxkYXRlPk1hcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NDAtMTU5MjwvaXNi
bj48YWNjZXNzaW9uLW51bT4yNDQ1NzgxNDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9
WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTI0NDU3ODE0
PC91cmw+PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5k
ZXJQbHVzL0Rpc3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoy
NDQ1NzgxNCZhbXA7aWQ9MTAuMjMzMiUyRmFsbGVyZ29saW50LjEzLU9BLTA2MDkmYW1wO2lzc249
MTMyMy04OTMwJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTYzJmFtcDtpc3N1ZT0xJmFtcDtzcGFnZT02
NyZhbXA7cGFnZXM9NjctNzQmYW1wO2RhdGU9MjAxNCZhbXA7dGl0bGU9QWxsZXJnb2xvZ3krSW50
ZXJuYXRpb25hbCZhbXA7YXRpdGxlPUFuYWx5c2lzK29mK3RoZStpbmZsdWVuemErQSslMjhIMU4x
JTI5KzIwMDkrcGFuZGVtaWMraW5mZWN0aW9uK2luK0phcGFuZXNlK2FzdGhtYXRpYytwYXRpZW50
cyUzQSt1c2luZythK3F1ZXN0aW9ubmFpcmUtYmFzZWQrc3VydmV5LiZhbXA7YXVsYXN0PUtvc2hp
byZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsm
bHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjIzMzIvYWxs
ZXJnb2xpbnQuMTMtT0EtMDYwOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRh
YmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2Ut
cHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu
Z3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+S29z
aGlvPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVjTnVtPjQyPC9SZWNOdW0+PHJlY29yZD48
cmVjLW51bWJlcj40MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgx
MjA4MzExIj40Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFy
dGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S29zaGlv
LCBOLjwvYXV0aG9yPjxhdXRob3I+SGFzZWdhd2EsIFQuPC9hdXRob3I+PGF1dGhvcj5TdXp1a2ks
IEsuPC9hdXRob3I+PGF1dGhvcj5UYW5hYmUsIFkuPC9hdXRob3I+PGF1dGhvcj5Lb3lhLCBULjwv
YXV0aG9yPjxhdXRob3I+U2FrYWdhbWksIFQuPC9hdXRob3I+PGF1dGhvcj5Bb2tpLCBOLjwvYXV0
aG9yPjxhdXRob3I+SG9zaGlubywgWS48L2F1dGhvcj48YXV0aG9yPkthZ2FtdSwgSC48L2F1dGhv
cj48YXV0aG9yPlRzdWthZGEsIEguPC9hdXRob3I+PGF1dGhvcj5BcmFrYXdhLCBNLjwvYXV0aG9y
PjxhdXRob3I+R2VqeW8sIEYuPC9hdXRob3I+PGF1dGhvcj5OYXJpdGEsIEkuPC9hdXRob3I+PGF1
dGhvcj5TdXp1a2ksIEUuPC9hdXRob3I+PGF1dGhvcj5OaWlnYXRhIEFzdGhtYSBUcmVhdG1lbnQg
U3R1ZHksIEdyb3VwPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl
c3M+S29zaGlvLE5hby4gRGl2aXNpb24gb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEg
VW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2Vz
LCBOaWlnYXRhLCBKYXBhbi4gSGFzZWdhd2EsVGFrYXNoaS4gRGVwYXJ0bWVudCBvZiBHZW5lcmFs
IE1lZGljaW5lLCBOaWlnYXRhIFVuaXZlcnNpdHkgTWVkaWNhbCBhbmQgRGVudGFsIEhvc3BpdGFs
LCBOaWlnYXRhLCBKYXBhbi4gU3V6dWtpLEthenVvLiBEZXBhcnRtZW50IG9mIE1lZGljaW5lLCBQ
cmVmZWN0dXJhbCBNdWlrYW1hY2hpIEhvc3BpdGFsLCBOaWlnYXRhLCBKYXBhbi4gVGFuYWJlLFlv
c2hpbmFyaS4gRGl2aXNpb24gb2YgSW5mZWN0aW9uIENvbnRyb2wgYW5kIFByZXZlbnRpb24sIE5p
aWdhdGEgVW5pdmVyc2l0eSBNZWRpY2FsIGFuZCBEZW50YWwgSG9zcGl0YWwsIE5paWdhdGEsIEph
cGFuLiBLb3lhLFRvc2hpeXVraS4gRGl2aXNpb24gb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUsIE5p
aWdhdGEgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBhbmQgRGVudGFsIFNj
aWVuY2VzLCBOaWlnYXRhLCBKYXBhbi4gU2FrYWdhbWksVGFrdXJvLiBEaXZpc2lvbiBvZiBSZXNw
aXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IEdyYWR1YXRlIFNjaG9vbCBvZiBN
ZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEsIEphcGFuLiBBb2tpLE5vYnVtYXNh
LiBEaXZpc2lvbiBvZiBSZXNwaXJhdG9yeSBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IEdy
YWR1YXRlIFNjaG9vbCBvZiBNZWRpY2FsIGFuZCBEZW50YWwgU2NpZW5jZXMsIE5paWdhdGEsIEph
cGFuLiBIb3NoaW5vLFlvc2hpZnVtaS4gRGl2aXNpb24gb2YgUmVzcGlyYXRvcnkgTWVkaWNpbmUs
IE5paWdhdGEgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2YgTWVkaWNhbCBhbmQgRGVudGFs
IFNjaWVuY2VzLCBOaWlnYXRhLCBKYXBhbi4gS2FnYW11LEhpcm9zaGkuIERpdmlzaW9uIG9mIFJl
c3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9m
IE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIFRzdWthZGEsSGly
b2tpLiBEZXBhcnRtZW50IG9mIFJlc3BpcmF0b3J5IERpc2Vhc2UsIE5paWdhdGEgQ2l0aXplbiBI
b3NwaXRhbCwgTmlpZ2F0YSwgSmFwYW4uIEFyYWthd2EsTWFzYWFraS4gRGl2aXNpb24gb2YgUmVz
cGlyYXRvcnkgTWVkaWNpbmUsIE5paWdhdGEgVW5pdmVyc2l0eSBHcmFkdWF0ZSBTY2hvb2wgb2Yg
TWVkaWNhbCBhbmQgRGVudGFsIFNjaWVuY2VzLCBOaWlnYXRhLCBKYXBhbi4gR2VqeW8sRnVtaXRh
a2UuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBOaWlnYXRhIFVuaXZlcnNpdHkg
R3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBTY2llbmNlcywgTmlpZ2F0YSwg
SmFwYW4uIE5hcml0YSxJY2hpZWkuIERpdmlzaW9uIG9mIFJlc3BpcmF0b3J5IE1lZGljaW5lLCBO
aWlnYXRhIFVuaXZlcnNpdHkgR3JhZHVhdGUgU2Nob29sIG9mIE1lZGljYWwgYW5kIERlbnRhbCBT
Y2llbmNlcywgTmlpZ2F0YSwgSmFwYW4uIFN1enVraSxFaWljaGkuIERlcGFydG1lbnQgb2YgR2Vu
ZXJhbCBNZWRpY2luZSwgTmlpZ2F0YSBVbml2ZXJzaXR5IE1lZGljYWwgYW5kIERlbnRhbCBIb3Nw
aXRhbCwgTmlpZ2F0YSwgSmFwYW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QW5hbHlz
aXMgb2YgdGhlIGluZmx1ZW56YSBBIChIMU4xKSAyMDA5IHBhbmRlbWljIGluZmVjdGlvbiBpbiBK
YXBhbmVzZSBhc3RobWF0aWMgcGF0aWVudHM6IHVzaW5nIGEgcXVlc3Rpb25uYWlyZS1iYXNlZCBz
dXJ2ZXk8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QWxsZXJnb2xvZ3kgSW50ZXJuYXRpb25hbDwv
c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QWxsZXJnb2w8L2FsdC10aXRsZT48L3RpdGxlcz48
cGFnZXM+NjctNzQ8L3BhZ2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48
a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48
a2V5d29yZD4qQXN0aG1hL2NvIFtDb21wbGljYXRpb25zXTwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lkZW5jZTwv
a2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIEEgVmlydXMsIEgxTjEgU3VidHlwZTwva2V5d29y
ZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+
PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vZXAgW0VwaWRlbWlvbG9neV08L2tleXdvcmQ+PGtl
eXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXTwva2V5
d29yZD48a2V5d29yZD5KYXBhbi9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5N
YWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlB1Ymxp
YyBIZWFsdGggU3VydmVpbGxhbmNlPC9rZXl3b3JkPjxrZXl3b3JkPlF1ZXN0aW9ubmFpcmVzPC9r
ZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5WYWNjaW5hdGlv
bjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ0MC0xNTkyPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjI0NDU3ODE0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1Z
JmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjQ0NTc4MTQ8
L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRl
clBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjI0
NDU3ODE0JmFtcDtpZD0xMC4yMzMyJTJGYWxsZXJnb2xpbnQuMTMtT0EtMDYwOSZhbXA7aXNzbj0x
MzIzLTg5MzAmYW1wO2lzYm49JmFtcDt2b2x1bWU9NjMmYW1wO2lzc3VlPTEmYW1wO3NwYWdlPTY3
JmFtcDtwYWdlcz02Ny03NCZhbXA7ZGF0ZT0yMDE0JmFtcDt0aXRsZT1BbGxlcmdvbG9neStJbnRl
cm5hdGlvbmFsJmFtcDthdGl0bGU9QW5hbHlzaXMrb2YrdGhlK2luZmx1ZW56YStBKyUyOEgxTjEl
MjkrMjAwOStwYW5kZW1pYytpbmZlY3Rpb24raW4rSmFwYW5lc2UrYXN0aG1hdGljK3BhdGllbnRz
JTNBK3VzaW5nK2ErcXVlc3Rpb25uYWlyZS1iYXNlZCtzdXJ2ZXkuJmFtcDthdWxhc3Q9S29zaGlv
JmFtcDtwaWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZs
dDtBTiZndDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs
cz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMjMzMi9hbGxl
cmdvbGludC4xMy1PQS0wNjA5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFi
YXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1w
cm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5n
dWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE.DATA (126). In this study, the H1N1 influenza vaccine was found to be protective against influenza in those aged under 61 years, but not in older patients. Also, it did not protect against AAE. Two other studies enrolled adults with long-term ADDIN EN.CITE <EndNote><Cite><Author>Hak</Author><Year>2005</Year><RecNum>208</RecNum><DisplayText>(130)</DisplayText><record><rec-number>208</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">208</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hak, Eelko</author></authors></contributors><titles><title>Clinical Effectiveness of Influenza Vaccination in Persons Younger Than 65 Years With High-Risk Medical Conditions</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>274</pages><volume>165</volume><number>3</number><dates><year>2005</year><pub-dates><date>2005/02/14</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(130) or high-risk conditions ADDIN EN.CITE <EndNote><Cite><Author>Herrera</Author><Year>2007</Year><RecNum>207</RecNum><DisplayText>(132)</DisplayText><record><rec-number>207</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">207</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Herrera, Guillermo A.</author><author>Iwane, Marika K.</author><author>Cortese, Margaret</author><author>Brown, Cedric</author><author>Gershman, Ken</author><author>Shupe, Alyson</author><author>Averhoff, Francisco</author><author>Chaves, Sandra S.</author><author>Gargiullo, Paul</author><author>Bridges, Carolyn B.</author></authors></contributors><titles><title>Influenza vaccine effectiveness among 50–64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003–2004</title><secondary-title>Vaccine</secondary-title></titles><periodical><full-title>Vaccine</full-title><abbr-1>Vaccine</abbr-1><abbr-2>Vaccine</abbr-2></periodical><pages>154-160</pages><volume>25</volume><number>1</number><dates><year>2007</year><pub-dates><date>2007/01</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0264-410X</isbn><urls><related-urls><url>;(132); the first demonstrated a reduction in general practice visits, hospitalization and deaths from respiratory problems, while the second demonstrated a protective effect against influenza and influenza related hospitalization. Asthma was not analysed separately in these studies and it is thus not clear if influenza vaccination was beneficial for people with asthma.A recent systematic review reports a 59-78% reduction in asthma attacks leading to emergency visits and/or hospitalizations after influenza vaccination and a vaccine effectiveness of 45% (95% CI 31 to 56) for laboratory-confirmed influenza in people with asthma based on a metanalysis of two test-negative design case-control studies ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>248</RecNum><DisplayText>(133)</DisplayText><record><rec-number>248</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1496656515">248</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">Vasiliou E. et al Effectiveness of influenza vaccines in asthma: a systematic review and meta-analysis. Clin Infect Dis. </style><style face="italic" font="default" size="100%">In press</style></title></titles><dates></dates><urls></urls></record></Cite></EndNote>(133). 7. Safety of influenza vaccines in asthma Large retrospective and prospective studies have demonstrated the safety of influenza vaccines in children and adults with asthma, for both TIV and LAIV PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXN0cm88L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS
ZWNOdW0+Mzc8L1JlY051bT48RGlzcGxheVRleHQ+KDEyNSwgMTM0LTEzNik8L0Rpc3BsYXlUZXh0
PjxyZWNvcmQ+PHJlYy1udW1iZXI+Mzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVz
dGFtcD0iMTQ4MTIwODMxMSI+Mzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i
Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0
aG9yPkNhc3RybywgTS48L2F1dGhvcj48YXV0aG9yPkRvem9yLCBBLjwvYXV0aG9yPjxhdXRob3I+
RmlzaCwgSi48L2F1dGhvcj48YXV0aG9yPklydmluLCBDLjwvYXV0aG9yPjxhdXRob3I+U2NoYXJm
LCBTLjwvYXV0aG9yPjxhdXRob3I+U2NoZWlwZXRlciwgTS4gRS48L2F1dGhvcj48YXV0aG9yPkhv
bGJyb29rLCBKLjwvYXV0aG9yPjxhdXRob3I+VG9uYXNjaWEsIEouPC9hdXRob3I+PGF1dGhvcj5X
aXNlLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPihD
YXN0cm8sIERvem9yLCBGaXNoLCBJcnZpbiwgU2NoYXJmLCBTY2hlaXBldGVyLCBIb2xicm9vaywg
VG9uYXNjaWEsIFdpc2UpIFdhc2hpbmd0b24gVW5pdi4gU2Nob29sIG9mIE1lZGljaW5lLCBCb3gg
ODA1MiwgNjYwIFMuIEV1Y2xpZCBBdmUuLCBTdC4gTG91aXMsIE1PIDYzMTEwLTEwOTMsIFVuaXRl
ZCBTdGF0ZXMmI3hEO00uIENhc3RybywgV2FzaGluZ3RvbiBVbml2LiBTY2hvb2wgb2YgTWVkaWNp
bmUsIEJveCA4MDUyLCA2NjAgUy4gRXVjbGlkIEF2ZS4sIFN0LiBMb3VpcywgTU8gNjMxMTAtMTA5
MywgVW5pdGVkIFN0YXRlcy4gRS1tYWlsOiBtY2FzdHJvQGltLnd1c3RsLmVkdTwvYXV0aC1hZGRy
ZXNzPjx0aXRsZXM+PHRpdGxlPlRoZSBzYWZldHkgb2YgaW5hY3RpdmF0ZWQgaW5mbHVlbnphIHZh
Y2NpbmUgaW4gYWR1bHRzIGFuZCBjaGlsZHJlbiB3aXRoIGFzdGhtYTwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5OZXcgRW5nbGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBN
ZWRpY2luZTwvZnVsbC10aXRsZT48YWJici0xPk4uIEVuZ2wuIEouIE1lZC48L2FiYnItMT48YWJi
ci0yPk4gRW5nbCBKIE1lZDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTUyOS0xNTM2PC9w
YWdlcz48dm9sdW1lPjM0NTwvdm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48a2V5d29yZHM+PGtl
eXdvcmQ+YWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5hZHVsdDwva2V5d29yZD48a2V5d29y
ZD5hZ2U8L2tleXdvcmQ+PGtleXdvcmQ+YXJ0aWNsZTwva2V5d29yZD48a2V5d29yZD5hc3RobWEv
ZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+Y2hpbGQ8L2tleXdvcmQ+PGtleXdv
cmQ+Y2xpbmljYWwgZmVhdHVyZTwva2V5d29yZD48a2V5d29yZD5jbGluaWNhbCB0cmlhbDwva2V5
d29yZD48a2V5d29yZD5jb250cm9sbGVkIGNsaW5pY2FsIHRyaWFsPC9rZXl3b3JkPjxrZXl3b3Jk
PmNvbnRyb2xsZWQgc3R1ZHk8L2tleXdvcmQ+PGtleXdvcmQ+Y3Jvc3NvdmVyIHByb2NlZHVyZTwv
a2V5d29yZD48a2V5d29yZD5kaXNlYXNlIGV4YWNlcmJhdGlvbjwva2V5d29yZD48a2V5d29yZD5k
aXNlYXNlIHNldmVyaXR5PC9rZXl3b3JkPjxrZXl3b3JkPmRvdWJsZSBibGluZCBwcm9jZWR1cmU8
L2tleXdvcmQ+PGtleXdvcmQ+ZHJ1ZyBzYWZldHk8L2tleXdvcmQ+PGtleXdvcmQ+ZmVtYWxlPC9r
ZXl3b3JkPjxrZXl3b3JkPmh1bWFuPC9rZXl3b3JkPjxrZXl3b3JkPmluZmx1ZW56YS9kdCBbRHJ1
ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5pbmZsdWVuemEvcGMgW1ByZXZlbnRpb25dPC9r
ZXl3b3JkPjxrZXl3b3JkPmluZmx1ZW56YSB2YWNjaW5hdGlvbjwva2V5d29yZD48a2V5d29yZD5t
YWpvciBjbGluaWNhbCBzdHVkeTwva2V5d29yZD48a2V5d29yZD5tYWxlPC9rZXl3b3JkPjxrZXl3
b3JkPm1vcmJpZGl0eTwva2V5d29yZD48a2V5d29yZD5tdWx0aWNlbnRlciBzdHVkeTwva2V5d29y
ZD48a2V5d29yZD5wYWluL3NpIFtTaWRlIEVmZmVjdF08L2tleXdvcmQ+PGtleXdvcmQ+cGVhayBl
eHBpcmF0b3J5IGZsb3c8L2tleXdvcmQ+PGtleXdvcmQ+cHJpb3JpdHkgam91cm5hbDwva2V5d29y
ZD48a2V5d29yZD5yYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWw8L2tleXdvcmQ+PGtleXdvcmQ+
cmlzayBhc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCBvdXRjb21lPC9rZXl3
b3JkPjxrZXl3b3JkPmFudGlhc3RobWF0aWMgYWdlbnQvZHQgW0RydWcgVGhlcmFweV08L2tleXdv
cmQ+PGtleXdvcmQ+YW50aWFzdGhtYXRpYyBhZ2VudC9paCBbSW5oYWxhdGlvbmFsIERydWcgQWRt
aW5pc3RyYXRpb25dPC9rZXl3b3JkPjxrZXl3b3JkPmFudGlhc3RobWF0aWMgYWdlbnQvcG8gW09y
YWwgRHJ1ZyBBZG1pbmlzdHJhdGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+YnJvbmNob2RpbGF0aW5n
IGFnZW50L2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPmJyb25jaG9kaWxhdGlu
ZyBhZ2VudC9paCBbSW5oYWxhdGlvbmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9rZXl3b3JkPjxr
ZXl3b3JkPmNvcnRpY29zdGVyb2lkL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3Jk
PmNvcnRpY29zdGVyb2lkL3BvIFtPcmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9rZXl3b3JkPjxr
ZXl3b3JkPmluYWN0aXZhdGVkIHZhY2NpbmUvYWUgW0FkdmVyc2UgRHJ1ZyBSZWFjdGlvbl08L2tl
eXdvcmQ+PGtleXdvcmQ+aW5hY3RpdmF0ZWQgdmFjY2luZS9jdCBbQ2xpbmljYWwgVHJpYWxdPC9r
ZXl3b3JkPjxrZXl3b3JkPmluYWN0aXZhdGVkIHZhY2NpbmUvZHQgW0RydWcgVGhlcmFweV08L2tl
eXdvcmQ+PGtleXdvcmQ+aW5mbHVlbnphIHZhY2NpbmUvYWUgW0FkdmVyc2UgRHJ1ZyBSZWFjdGlv
bl08L2tleXdvcmQ+PGtleXdvcmQ+aW5mbHVlbnphIHZhY2NpbmUvY3QgW0NsaW5pY2FsIFRyaWFs
XTwva2V5d29yZD48a2V5d29yZD5pbmZsdWVuemEgdmFjY2luZS9kdCBbRHJ1ZyBUaGVyYXB5XTwv
a2V5d29yZD48a2V5d29yZD5wbGFjZWJvPC9rZXl3b3JkPjxrZXl3b3JkPnNhbGJ1dGFtb2wvZHQg
W0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+c2FsYnV0YW1vbC9paCBbSW5oYWxhdGlv
bmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFy
PjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMiBOb3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9k
YXRlcz48aXNibj4wMDI4LTQ3OTM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjAwMTQzOTE2MzwvYWNj
ZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNv
bS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0
JmFtcDtEPWVtZWQ1JmFtcDtBTj0yMDAxNDM5MTYzPC91cmw+PHVybD5odHRwOi8vb3BlbnVybC5h
Yy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/c2lkPU9WSUQ6RW1i
YXNlJmFtcDtpZD1wbWlkOiZhbXA7aWQ9MTAuMTA1NiUyRk5FSk1vYTAxMTk2MSZhbXA7aXNzbj0w
MDI4LTQ3OTMmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzQ1JmFtcDtpc3N1ZT0yMSZhbXA7c3BhZ2U9
MTUyOSZhbXA7cGFnZXM9MTUyOS0xNTM2JmFtcDtkYXRlPTIwMDEmYW1wO3RpdGxlPU5ldytFbmds
YW5kK0pvdXJuYWwrb2YrTWVkaWNpbmUmYW1wO2F0aXRsZT1UaGUrc2FmZXR5K29mK2luYWN0aXZh
dGVkK2luZmx1ZW56YSt2YWNjaW5lK2luK2FkdWx0cythbmQrY2hpbGRyZW4rd2l0aCthc3RobWEm
YW1wO2F1bGFzdD1DYXN0cm8mYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsv
YXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9y
ZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9p
Lm9yZy8xMC4xMDU2L05FSk1vYTAxMTk2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90
ZS1kYXRhYmFzZS1uYW1lPkVtYmFzZTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRh
YmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy
PjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5CYXh0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxSZWNOdW0+Mzg8L1JlY051bT48cmVj
b3JkPjxyZWMtbnVtYmVyPjM4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9
IjE0ODEyMDgzMTEiPjM4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu
YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5C
YXh0ZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5Ub2JhY2ssIFMuIEwuPC9hdXRob3I+PGF1dGhvcj5T
aWZha2lzLCBGLjwvYXV0aG9yPjxhdXRob3I+SGFuc2VuLCBKLjwvYXV0aG9yPjxhdXRob3I+QmFy
dGxldHQsIEouPC9hdXRob3I+PGF1dGhvcj5BdWtlcywgTC48L2F1dGhvcj48YXV0aG9yPkxld2lz
LCBOLjwvYXV0aG9yPjxhdXRob3I+V3UsIFguPC9hdXRob3I+PGF1dGhvcj5BbWJyb3NlLCBDLiBT
LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkthaXNlciBQ
ZXJtYW5lbnRlIFZhY2NpbmUgU3R1ZHkgQ2VudGVyLCBPYWtsYW5kLCBDQSA5NDYxMiwgVVNBLiBy
b2dlci5iYXh0ZXJAa3Aub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBwb3N0bWFy
a2V0aW5nIGV2YWx1YXRpb24gb2YgdGhlIHNhZmV0eSBvZiBBbm4gQXJib3Igc3RyYWluIGxpdmUg
YXR0ZW51YXRlZCBpbmZsdWVuemEgdmFjY2luZSBpbiBjaGlsZHJlbiA1IHRocm91Z2ggMTcgeWVh
cnMgb2YgYWdlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlZhY2NpbmU8L3NlY29uZGFyeS10aXRs
ZT48YWx0LXRpdGxlPlZhY2NpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5WYWNjaW5lPC9mdWxsLXRpdGxlPjxhYmJyLTE+VmFjY2luZTwvYWJici0xPjxhYmJy
LTI+VmFjY2luZTwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+VmFjY2luZTwvZnVsbC10aXRsZT48YWJici0xPlZhY2NpbmU8L2FiYnItMT48YWJici0yPlZh
Y2NpbmU8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yOTg5LTk4PC9wYWdlcz48dm9s
dW1lPjMwPC92b2x1bWU+PG51bWJlcj4xOTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9s
ZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQ
cmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+KkRydWctUmVsYXRlZCBTaWRlIEVmZmVjdHMgYW5k
IEFkdmVyc2UgUmVhY3Rpb25zL2VwIFtFcGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkZl
bWFsZTwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRpb24vc24gW1N0YXRpc3RpY3MgJmFt
cDsgTnVtZXJpY2FsIERhdGFdPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5
d29yZD5JbmZsdWVuemEgVmFjY2luZXMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08
L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5lcy9hZSBbQWR2ZXJzZSBFZmZlY3Rz
XTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPlByb2R1Y3QgU3VydmVp
bGxhbmNlLCBQb3N0bWFya2V0aW5nPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRp
ZXM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2YWwgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+
VW5pdGVkIFN0YXRlczwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgQXR0ZW51YXRlZC9hZCBb
QWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywg
QXR0ZW51YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD4wIChJbmZs
dWVuemEgVmFjY2luZXMpPC9rZXl3b3JkPjxrZXl3b3JkPjAgKFZhY2NpbmVzLCBBdHRlbnVhdGVk
KTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+QXByIDE5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3My0yNTE4PC9p
c2JuPjxhY2Nlc3Npb24tbnVtPjIyMzg2NzQ2PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVz
ZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxh
dGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1w
O0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjIz
ODY3NDY8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlu
a0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1w
bWlkOjIyMzg2NzQ2JmFtcDtpZD0xMC4xMDE2JTJGai52YWNjaW5lLjIwMTIuMDIuMDM5JmFtcDtp
c3NuPTAyNjQtNDEwWCZhbXA7aXNibj0mYW1wO3ZvbHVtZT0zMCZhbXA7aXNzdWU9MTkmYW1wO3Nw
YWdlPTI5ODkmYW1wO3BhZ2VzPTI5ODktOTgmYW1wO2RhdGU9MjAxMiZhbXA7dGl0bGU9VmFjY2lu
ZSZhbXA7YXRpdGxlPUErcG9zdG1hcmtldGluZytldmFsdWF0aW9uK29mK3RoZStzYWZldHkrb2Yr
QW5uK0FyYm9yK3N0cmFpbitsaXZlK2F0dGVudWF0ZWQraW5mbHVlbnphK3ZhY2NpbmUraW4rY2hp
bGRyZW4rNSt0aHJvdWdoKzE3K3llYXJzK29mK2FnZS4mYW1wO2F1bGFzdD1CYXh0ZXImYW1wO3Bp
ZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0
OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj
dHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDE2L2oudmFjY2luZS4y
MDEyLjAyLjAzOTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1l
Pk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+
T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5n
bGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QW1icm9zZTwvQXV0
aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4yNjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1i
ZXI+MjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhk
eDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwODMxMSI+
MjY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFtYnJvc2UsIEMuIFMu
PC9hdXRob3I+PGF1dGhvcj5EdWJvdnNreSwgRi48L2F1dGhvcj48YXV0aG9yPllpLCBULjwvYXV0
aG9yPjxhdXRob3I+QmVsc2hlLCBSLiBCLjwvYXV0aG9yPjxhdXRob3I+QXNoa2VuYXppLCBTLjwv
YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljYWwgYW5k
IFNjaWVudGlmaWMgQWZmYWlycywgTWVkSW1tdW5lLCBMTEMsIE9uZSBNZWRJbW11bmUgV2F5LCBH
YWl0aGVyc2J1cmcsIE1EIDIwODc4LCBVU0EuIGFtYnJvc2VjQG1lZGltbXVuZS5jb208L2F1dGgt
YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgc2FmZXR5IGFuZCBlZmZpY2FjeSBvZiBsaXZlIGF0
dGVudWF0ZWQgaW5mbHVlbnphIHZhY2NpbmUgaW4geW91bmcgY2hpbGRyZW4gd2l0aCBhc3RobWEg
b3IgcHJpb3Igd2hlZXppbmc8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gSm91cm5h
bCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vj
b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+RXVyIEogQ2xpbiBNaWNyb2Jpb2wgSW5mZWN0IERpczwv
YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJu
YWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxs
LXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBDbGluLiBNaWNyb2Jpb2wuIEluZmVjdC4gRGlzLjwvYWJi
ci0xPjxhYmJyLTI+RXVyIEogQ2xpbiBNaWNyb2Jpb2wgSW5mZWN0IERpczwvYWJici0yPjxhYmJy
LTM+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0
aW91cyBEaXNlYXNlczwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVj
dGlvdXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIEouIENsaW4uIE1pY3JvYmlv
bC4gSW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5FdXIgSiBDbGluIE1pY3JvYmlvbCBJbmZl
Y3QgRGlzPC9hYmJyLTI+PGFiYnItMz5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE1pY3Jv
YmlvbG9neSAmYW1wOyBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNh
bD48cGFnZXM+MjU0OS01NzwvcGFnZXM+PHZvbHVtZT4zMTwvdm9sdW1lPjxudW1iZXI+MTA8L251
bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD4qQXN0
aG1hL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5
d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmZpZGVuY2UgSW50ZXJ2
YWxzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6
YXRpb24vc24gW1N0YXRpc3RpY3MgJmFtcDsgTnVtZXJpY2FsIERhdGFdPC9rZXl3b3JkPjxrZXl3
b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2FkIFtBZG1p
bmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSBWYWNj
aW5lcy9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgVmFj
Y2luZXMvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4v
aW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL3BjIFtQ
cmV2ZW50aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+KlJlc3BpcmF0b3J5IFNvdW5kcy9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtl
eXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luYXRpb24vbXQg
W01ldGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRlbnVhdGVkL2FkIFtBZG1p
bmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRl
bnVhdGVkL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBB
dHRlbnVhdGVkL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5h
Y3RpdmF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdv
cmQ+VmFjY2luZXMsIEluYWN0aXZhdGVkL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxr
ZXl3b3JkPlZhY2NpbmVzLCBJbmFjdGl2YXRlZC9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtl
eXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48a2V5d29yZD4wIChWYWNjaW5l
cywgQXR0ZW51YXRlZCk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoVmFjY2luZXMsIEluYWN0aXZhdGVk
KTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzNS00MzczPC9pc2Ju
PjxhY2Nlc3Npb24tbnVtPjIyNDEwNjQ2PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmFuZG9t
aXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym
YXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Au
b3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1m
dWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjQxMDY0NjwvdXJsPjx1cmw+aHR0cDovL29wZW51
cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklE
Ok92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjI0MTA2NDYmYW1wO2lkPSZhbXA7aXNz
bj0wOTM0LTk3MjMmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzEmYW1wO2lzc3VlPTEwJmFtcDtzcGFn
ZT0yNTQ5JmFtcDtwYWdlcz0yNTQ5LTU3JmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUV1cm9wZWFu
K0pvdXJuYWwrb2YrQ2xpbmljYWwrTWljcm9iaW9sb2d5KyUyNitJbmZlY3Rpb3VzK0Rpc2Vhc2Vz
JmFtcDthdGl0bGU9VGhlK3NhZmV0eSthbmQrZWZmaWNhY3krb2YrbGl2ZSthdHRlbnVhdGVkK2lu
Zmx1ZW56YSt2YWNjaW5lK2luK3lvdW5nK2NoaWxkcmVuK3dpdGgrYXN0aG1hK29yK3ByaW9yK3do
ZWV6aW5nLiZhbXA7YXVsYXN0PUFtYnJvc2UmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUv
Jmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7
PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0NTY5MTE8L2N1c3RvbTI+
PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1v
dGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1w
cm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl
PjxBdXRob3I+R2FnbGFuaTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJlY051bT4zOTwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Mzk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRp
bWVzdGFtcD0iMTQ4MTIwODMxMSI+Mzk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPkdhZ2xhbmksIE0uIEouPC9hdXRob3I+PGF1dGhvcj5QaWVkcmEsIFAuIEEuPC9hdXRo
b3I+PGF1dGhvcj5SaWdncywgTS48L2F1dGhvcj48YXV0aG9yPkhlcnNjaGxlciwgRy48L2F1dGhv
cj48YXV0aG9yPkZld2xhc3MsIEMuPC9hdXRob3I+PGF1dGhvcj5HbGV6ZW4sIFcuIFAuPC9hdXRo
b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2VjdGlvbiBvZiBQZWRp
YXRyaWMgSW5mZWN0aW91cyBEaXNlYXNlcywgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzLCBTY290
dCAmYW1wOyBXaGl0ZSBNZW1vcmlhbCBIb3NwaXRhbCBhbmQgQ2xpbmljLCBUZXhhcyBBJmFtcDtN
IFVuaXZlcnNpdHkgSGVhbHRoIFNjaWVuY2UgQ2VudGVyIENvbGxlZ2Ugb2YgTWVkaWNpbmUsIFRl
bXBsZSwgVFggNzY1MDgsIFVTQS4gbWdhZ2xhbmlAc3dtYWlsLnN3Lm9yZzwvYXV0aC1hZGRyZXNz
Pjx0aXRsZXM+PHRpdGxlPlNhZmV0eSBvZiB0aGUgaW50cmFuYXNhbCwgdHJpdmFsZW50LCBsaXZl
IGF0dGVudWF0ZWQgaW5mbHVlbnphIHZhY2NpbmUgKExBSVYpIGluIGNoaWxkcmVuIHdpdGggaW50
ZXJtaXR0ZW50IHdoZWV6aW5nIGluIGFuIG9wZW4tbGFiZWwgZmllbGQgdHJpYWw8L3RpdGxlPjxz
ZWNvbmRhcnktdGl0bGU+UGVkaWF0cmljIEluZmVjdGlvdXMgRGlzZWFzZSBKb3VybmFsPC9zZWNv
bmRhcnktdGl0bGU+PGFsdC10aXRsZT5QZWRpYXRyIEluZmVjdCBEaXMgSjwvYWx0LXRpdGxlPjwv
dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBlZGlhdHJpYyBJbmZlY3Rpb3VzIERpc2Vh
c2UgSm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPlBlZGlhdHIuIEluZmVjdC4gRGlzLiBKLjwv
YWJici0xPjxhYmJyLTI+UGVkaWF0ciBJbmZlY3QgRGlzIEo8L2FiYnItMj48L3BlcmlvZGljYWw+
PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlBlZGlhdHJpYyBJbmZlY3Rpb3VzIERpc2Vhc2Ug
Sm91cm5hbDwvZnVsbC10aXRsZT48YWJici0xPlBlZGlhdHIuIEluZmVjdC4gRGlzLiBKLjwvYWJi
ci0xPjxhYmJyLTI+UGVkaWF0ciBJbmZlY3QgRGlzIEo8L2FiYnItMj48L2FsdC1wZXJpb2RpY2Fs
PjxwYWdlcz40NDQtNTI8L3BhZ2VzPjx2b2x1bWU+Mjc8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJl
cj48a2V5d29yZHM+PGtleXdvcmQ+QWRtaW5pc3RyYXRpb24sIEludHJhbmFzYWw8L2tleXdvcmQ+
PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD4qQXN0aG1hL2ltIFtJbW11bm9s
b2d5XTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJl
c2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbmZhbnQ8
L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5lcy9hZCBbQWRtaW5pc3RyYXRpb24g
JmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2FlIFtB
ZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL3BjIFtQ
cmV2ZW50aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPlJlc3BpcmF0b3J5IFNv
dW5kcy9ldCBbRXRpb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRlbnVhdGVk
L2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2Np
bmVzLCBBdHRlbnVhdGVkL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPjAg
KEluZmx1ZW56YSBWYWNjaW5lcyk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoVmFjY2luZXMsIEF0dGVu
dWF0ZWQpPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDg8L3llYXI+PHB1Yi1k
YXRlcz48ZGF0ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wODkxLTM2Njg8
L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MDEyODk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5D
b21wYXJhdGl2ZSBTdHVkeSYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFs
JiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVy
bHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/
VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWQ1JmFt
cDtBTj0xODQwMTI4OTwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUv
L2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkm
YW1wO2lkPXBtaWQ6MTg0MDEyODkmYW1wO2lkPTEwLjEwOTclMkZJTkYuMGIwMTNlMzE4MTY2MGMy
ZSZhbXA7aXNzbj0wODkxLTM2NjgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MjcmYW1wO2lzc3VlPTUm
YW1wO3NwYWdlPTQ0NCZhbXA7cGFnZXM9NDQ0LTUyJmFtcDtkYXRlPTIwMDgmYW1wO3RpdGxlPVBl
ZGlhdHJpYytJbmZlY3Rpb3VzK0Rpc2Vhc2UrSm91cm5hbCZhbXA7YXRpdGxlPVNhZmV0eStvZit0
aGUraW50cmFuYXNhbCUyQyt0cml2YWxlbnQlMkMrbGl2ZSthdHRlbnVhdGVkK2luZmx1ZW56YSt2
YWNjaW5lKyUyOExBSVYlMjkraW4rY2hpbGRyZW4rd2l0aCtpbnRlcm1pdHRlbnQrd2hlZXppbmcr
aW4rYW4rb3Blbi1sYWJlbCtmaWVsZCt0cmlhbC4mYW1wO2F1bGFzdD1HYWdsYW5pJmFtcDtwaWQ9
Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsm
bHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTA5Ny9JTkYuMGIwMTNlMzE4
MTY2MGMyZTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1F
RExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3Zp
ZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlz
aDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+QW1icm9zZTwvQXV0aG9y
PjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4yNjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+
MjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1ZXhkeDJk
Zml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwODMxMSI+MjY8
L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwv
cmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFtYnJvc2UsIEMuIFMuPC9h
dXRob3I+PGF1dGhvcj5EdWJvdnNreSwgRi48L2F1dGhvcj48YXV0aG9yPllpLCBULjwvYXV0aG9y
PjxhdXRob3I+QmVsc2hlLCBSLiBCLjwvYXV0aG9yPjxhdXRob3I+QXNoa2VuYXppLCBTLjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPk1lZGljYWwgYW5kIFNj
aWVudGlmaWMgQWZmYWlycywgTWVkSW1tdW5lLCBMTEMsIE9uZSBNZWRJbW11bmUgV2F5LCBHYWl0
aGVyc2J1cmcsIE1EIDIwODc4LCBVU0EuIGFtYnJvc2VjQG1lZGltbXVuZS5jb208L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgc2FmZXR5IGFuZCBlZmZpY2FjeSBvZiBsaXZlIGF0dGVu
dWF0ZWQgaW5mbHVlbnphIHZhY2NpbmUgaW4geW91bmcgY2hpbGRyZW4gd2l0aCBhc3RobWEgb3Ig
cHJpb3Igd2hlZXppbmc8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+RXVyb3BlYW4gSm91cm5hbCBv
ZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91cyBEaXNlYXNlczwvc2Vjb25k
YXJ5LXRpdGxlPjxhbHQtdGl0bGU+RXVyIEogQ2xpbiBNaWNyb2Jpb2wgSW5mZWN0IERpczwvYWx0
LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwg
b2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRp
dGxlPjxhYmJyLTE+RXVyLiBKLiBDbGluLiBNaWNyb2Jpb2wuIEluZmVjdC4gRGlzLjwvYWJici0x
PjxhYmJyLTI+RXVyIEogQ2xpbiBNaWNyb2Jpb2wgSW5mZWN0IERpczwvYWJici0yPjxhYmJyLTM+
RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91
cyBEaXNlYXNlczwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0
bGU+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGluaWNhbCBNaWNyb2Jpb2xvZ3kgYW5kIEluZmVjdGlv
dXMgRGlzZWFzZXM8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIEouIENsaW4uIE1pY3JvYmlvbC4g
SW5mZWN0LiBEaXMuPC9hYmJyLTE+PGFiYnItMj5FdXIgSiBDbGluIE1pY3JvYmlvbCBJbmZlY3Qg
RGlzPC9hYmJyLTI+PGFiYnItMz5FdXJvcGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlv
bG9neSAmYW1wOyBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9hYmJyLTM+PC9hbHQtcGVyaW9kaWNhbD48
cGFnZXM+MjU0OS01NzwvcGFnZXM+PHZvbHVtZT4zMTwvdm9sdW1lPjxudW1iZXI+MTA8L251bWJl
cj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD4qQXN0aG1h
L2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29y
ZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPkNvbmZpZGVuY2UgSW50ZXJ2YWxz
PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRp
b24vc24gW1N0YXRpc3RpY3MgJmFtcDsgTnVtZXJpY2FsIERhdGFdPC9rZXl3b3JkPjxrZXl3b3Jk
Pkh1bWFuczwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphIFZhY2NpbmVzL2FkIFtBZG1pbmlz
dHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSBWYWNjaW5l
cy9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgVmFjY2lu
ZXMvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1ZW56YSwgSHVtYW4vaW0g
W0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEsIEh1bWFuL3BjIFtQcmV2
ZW50aW9uICZhbXA7IENvbnRyb2xdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl
eXdvcmQ+KlJlc3BpcmF0b3J5IFNvdW5kcy9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdv
cmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luYXRpb24vbXQgW01l
dGhvZHNdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRlbnVhdGVkL2FkIFtBZG1pbmlz
dHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRlbnVh
dGVkL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBBdHRl
bnVhdGVkL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3Rp
dmF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdvcmQ+
VmFjY2luZXMsIEluYWN0aXZhdGVkL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3
b3JkPlZhY2NpbmVzLCBJbmFjdGl2YXRlZC9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdv
cmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48a2V5d29yZD4wIChWYWNjaW5lcywg
QXR0ZW51YXRlZCk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoVmFjY2luZXMsIEluYWN0aXZhdGVkKTwv
a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+PGRh
dGU+T2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQzNS00MzczPC9pc2JuPjxh
Y2Nlc3Npb24tbnVtPjIyNDEwNjQ2PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmFuZG9taXpl
ZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBv
czt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3Zp
ZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxs
dGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yMjQxMDY0NjwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwu
YWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92
aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MjI0MTA2NDYmYW1wO2lkPSZhbXA7aXNzbj0w
OTM0LTk3MjMmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzEmYW1wO2lzc3VlPTEwJmFtcDtzcGFnZT0y
NTQ5JmFtcDtwYWdlcz0yNTQ5LTU3JmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPUV1cm9wZWFuK0pv
dXJuYWwrb2YrQ2xpbmljYWwrTWljcm9iaW9sb2d5KyUyNitJbmZlY3Rpb3VzK0Rpc2Vhc2VzJmFt
cDthdGl0bGU9VGhlK3NhZmV0eSthbmQrZWZmaWNhY3krb2YrbGl2ZSthdHRlbnVhdGVkK2luZmx1
ZW56YSt2YWNjaW5lK2luK3lvdW5nK2NoaWxkcmVuK3dpdGgrYXN0aG1hK29yK3ByaW9yK3doZWV6
aW5nLiZhbXA7YXVsYXN0PUFtYnJvc2UmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0
OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91
cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0NTY5MTE8L2N1c3RvbTI+PHJl
bW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUt
ZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92
aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB
dXRob3I+QmF4dGVyPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjM4PC9SZWNOdW0+
PHJlY29yZD48cmVjLW51bWJlcj4zODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0
YW1wPSIxNDgxMjA4MzExIj4zODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK
b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo
b3I+QmF4dGVyLCBSLjwvYXV0aG9yPjxhdXRob3I+VG9iYWNrLCBTLiBMLjwvYXV0aG9yPjxhdXRo
b3I+U2lmYWtpcywgRi48L2F1dGhvcj48YXV0aG9yPkhhbnNlbiwgSi48L2F1dGhvcj48YXV0aG9y
PkJhcnRsZXR0LCBKLjwvYXV0aG9yPjxhdXRob3I+QXVrZXMsIEwuPC9hdXRob3I+PGF1dGhvcj5M
ZXdpcywgTi48L2F1dGhvcj48YXV0aG9yPld1LCBYLjwvYXV0aG9yPjxhdXRob3I+QW1icm9zZSwg
Qy4gUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5LYWlz
ZXIgUGVybWFuZW50ZSBWYWNjaW5lIFN0dWR5IENlbnRlciwgT2FrbGFuZCwgQ0EgOTQ2MTIsIFVT
QS4gcm9nZXIuYmF4dGVyQGtwLm9yZzwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkEgcG9z
dG1hcmtldGluZyBldmFsdWF0aW9uIG9mIHRoZSBzYWZldHkgb2YgQW5uIEFyYm9yIHN0cmFpbiBs
aXZlIGF0dGVudWF0ZWQgaW5mbHVlbnphIHZhY2NpbmUgaW4gY2hpbGRyZW4gNSB0aHJvdWdoIDE3
IHllYXJzIG9mIGFnZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5WYWNjaW5lPC9zZWNvbmRhcnkt
dGl0bGU+PGFsdC10aXRsZT5WYWNjaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+VmFjY2luZTwvZnVsbC10aXRsZT48YWJici0xPlZhY2NpbmU8L2FiYnItMT48
YWJici0yPlZhY2NpbmU8L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxs
LXRpdGxlPlZhY2NpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5WYWNjaW5lPC9hYmJyLTE+PGFiYnIt
Mj5WYWNjaW5lPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+Mjk4OS05ODwvcGFnZXM+
PHZvbHVtZT4zMDwvdm9sdW1lPjxudW1iZXI+MTk8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+
QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5DaGlsZDwva2V5d29yZD48a2V5d29yZD5DaGls
ZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPipEcnVnLVJlbGF0ZWQgU2lkZSBFZmZlY3Rz
IGFuZCBBZHZlcnNlIFJlYWN0aW9ucy9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29y
ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SG9zcGl0YWxpemF0aW9uL3NuIFtTdGF0aXN0aWNz
ICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+
PGtleXdvcmQ+SW5mbHVlbnphIFZhY2NpbmVzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3Nh
Z2VdPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEgVmFjY2luZXMvYWUgW0FkdmVyc2UgRWZm
ZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Qcm9kdWN0IFN1
cnZlaWxsYW5jZSwgUG9zdG1hcmtldGluZzwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBT
dHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZpdmFsIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3
b3JkPlVuaXRlZCBTdGF0ZXM8L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luZXMsIEF0dGVudWF0ZWQv
YWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2lu
ZXMsIEF0dGVudWF0ZWQvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+MCAo
SW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48a2V5d29yZD4wIChWYWNjaW5lcywgQXR0ZW51
YXRlZCk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48cHViLWRh
dGVzPjxkYXRlPkFwciAxOTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzMtMjUx
ODwvaXNibj48YWNjZXNzaW9uLW51bT4yMjM4Njc0NjwvYWNjZXNzaW9uLW51bT48d29yay10eXBl
PlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48
cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpT
JmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FO
PTIyMzg2NzQ2PC91cmw+PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZw
L0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7
aWQ9cG1pZDoyMjM4Njc0NiZhbXA7aWQ9MTAuMTAxNiUyRmoudmFjY2luZS4yMDEyLjAyLjAzOSZh
bXA7aXNzbj0wMjY0LTQxMFgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzAmYW1wO2lzc3VlPTE5JmFt
cDtzcGFnZT0yOTg5JmFtcDtwYWdlcz0yOTg5LTk4JmFtcDtkYXRlPTIwMTImYW1wO3RpdGxlPVZh
Y2NpbmUmYW1wO2F0aXRsZT1BK3Bvc3RtYXJrZXRpbmcrZXZhbHVhdGlvbitvZit0aGUrc2FmZXR5
K29mK0FubitBcmJvcitzdHJhaW4rbGl2ZSthdHRlbnVhdGVkK2luZmx1ZW56YSt2YWNjaW5lK2lu
K2NoaWxkcmVuKzUrdGhyb3VnaCsxNyt5ZWFycytvZithZ2UuJmFtcDthdWxhc3Q9QmF4dGVyJmFt
cDtwaWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtB
TiZndDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAxNi9qLnZhY2Np
bmUuMjAxMi4wMi4wMzk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxyZW1vdGUtZGF0YWJhc2Ut
bmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2UtbmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3Zp
ZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdl
PkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNhc3Rybzwv
QXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4zNzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1u
dW1iZXI+Mzc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1
ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4MTIwODMx
MSI+Mzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNhc3RybywgTS48
L2F1dGhvcj48YXV0aG9yPkRvem9yLCBBLjwvYXV0aG9yPjxhdXRob3I+RmlzaCwgSi48L2F1dGhv
cj48YXV0aG9yPklydmluLCBDLjwvYXV0aG9yPjxhdXRob3I+U2NoYXJmLCBTLjwvYXV0aG9yPjxh
dXRob3I+U2NoZWlwZXRlciwgTS4gRS48L2F1dGhvcj48YXV0aG9yPkhvbGJyb29rLCBKLjwvYXV0
aG9yPjxhdXRob3I+VG9uYXNjaWEsIEouPC9hdXRob3I+PGF1dGhvcj5XaXNlLCBSLjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPihDYXN0cm8sIERvem9yLCBG
aXNoLCBJcnZpbiwgU2NoYXJmLCBTY2hlaXBldGVyLCBIb2xicm9vaywgVG9uYXNjaWEsIFdpc2Up
IFdhc2hpbmd0b24gVW5pdi4gU2Nob29sIG9mIE1lZGljaW5lLCBCb3ggODA1MiwgNjYwIFMuIEV1
Y2xpZCBBdmUuLCBTdC4gTG91aXMsIE1PIDYzMTEwLTEwOTMsIFVuaXRlZCBTdGF0ZXMmI3hEO00u
IENhc3RybywgV2FzaGluZ3RvbiBVbml2LiBTY2hvb2wgb2YgTWVkaWNpbmUsIEJveCA4MDUyLCA2
NjAgUy4gRXVjbGlkIEF2ZS4sIFN0LiBMb3VpcywgTU8gNjMxMTAtMTA5MywgVW5pdGVkIFN0YXRl
cy4gRS1tYWlsOiBtY2FzdHJvQGltLnd1c3RsLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp
dGxlPlRoZSBzYWZldHkgb2YgaW5hY3RpdmF0ZWQgaW5mbHVlbnphIHZhY2NpbmUgaW4gYWR1bHRz
IGFuZCBjaGlsZHJlbiB3aXRoIGFzdGhtYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXcgRW5n
bGFuZCBKb3VybmFsIG9mIE1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+TmV3IEVuZ2xhbmQgSm91cm5hbCBvZiBNZWRpY2luZTwvZnVsbC10
aXRsZT48YWJici0xPk4uIEVuZ2wuIEouIE1lZC48L2FiYnItMT48YWJici0yPk4gRW5nbCBKIE1l
ZDwvYWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+MTUyOS0xNTM2PC9wYWdlcz48dm9sdW1lPjM0
NTwvdm9sdW1lPjxudW1iZXI+MjE8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+YWRvbGVzY2Vu
dDwva2V5d29yZD48a2V5d29yZD5hZHVsdDwva2V5d29yZD48a2V5d29yZD5hZ2U8L2tleXdvcmQ+
PGtleXdvcmQ+YXJ0aWNsZTwva2V5d29yZD48a2V5d29yZD5hc3RobWEvZHQgW0RydWcgVGhlcmFw
eV08L2tleXdvcmQ+PGtleXdvcmQ+Y2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Y2xpbmljYWwgZmVh
dHVyZTwva2V5d29yZD48a2V5d29yZD5jbGluaWNhbCB0cmlhbDwva2V5d29yZD48a2V5d29yZD5j
b250cm9sbGVkIGNsaW5pY2FsIHRyaWFsPC9rZXl3b3JkPjxrZXl3b3JkPmNvbnRyb2xsZWQgc3R1
ZHk8L2tleXdvcmQ+PGtleXdvcmQ+Y3Jvc3NvdmVyIHByb2NlZHVyZTwva2V5d29yZD48a2V5d29y
ZD5kaXNlYXNlIGV4YWNlcmJhdGlvbjwva2V5d29yZD48a2V5d29yZD5kaXNlYXNlIHNldmVyaXR5
PC9rZXl3b3JkPjxrZXl3b3JkPmRvdWJsZSBibGluZCBwcm9jZWR1cmU8L2tleXdvcmQ+PGtleXdv
cmQ+ZHJ1ZyBzYWZldHk8L2tleXdvcmQ+PGtleXdvcmQ+ZmVtYWxlPC9rZXl3b3JkPjxrZXl3b3Jk
Pmh1bWFuPC9rZXl3b3JkPjxrZXl3b3JkPmluZmx1ZW56YS9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5
d29yZD48a2V5d29yZD5pbmZsdWVuemEvcGMgW1ByZXZlbnRpb25dPC9rZXl3b3JkPjxrZXl3b3Jk
PmluZmx1ZW56YSB2YWNjaW5hdGlvbjwva2V5d29yZD48a2V5d29yZD5tYWpvciBjbGluaWNhbCBz
dHVkeTwva2V5d29yZD48a2V5d29yZD5tYWxlPC9rZXl3b3JkPjxrZXl3b3JkPm1vcmJpZGl0eTwv
a2V5d29yZD48a2V5d29yZD5tdWx0aWNlbnRlciBzdHVkeTwva2V5d29yZD48a2V5d29yZD5wYWlu
L3NpIFtTaWRlIEVmZmVjdF08L2tleXdvcmQ+PGtleXdvcmQ+cGVhayBleHBpcmF0b3J5IGZsb3c8
L2tleXdvcmQ+PGtleXdvcmQ+cHJpb3JpdHkgam91cm5hbDwva2V5d29yZD48a2V5d29yZD5yYW5k
b21pemVkIGNvbnRyb2xsZWQgdHJpYWw8L2tleXdvcmQ+PGtleXdvcmQ+cmlzayBhc3Nlc3NtZW50
PC9rZXl3b3JkPjxrZXl3b3JkPnRyZWF0bWVudCBvdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPmFu
dGlhc3RobWF0aWMgYWdlbnQvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+YW50
aWFzdGhtYXRpYyBhZ2VudC9paCBbSW5oYWxhdGlvbmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9r
ZXl3b3JkPjxrZXl3b3JkPmFudGlhc3RobWF0aWMgYWdlbnQvcG8gW09yYWwgRHJ1ZyBBZG1pbmlz
dHJhdGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+YnJvbmNob2RpbGF0aW5nIGFnZW50L2R0IFtEcnVn
IFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPmJyb25jaG9kaWxhdGluZyBhZ2VudC9paCBbSW5o
YWxhdGlvbmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9rZXl3b3JkPjxrZXl3b3JkPmNvcnRpY29z
dGVyb2lkL2R0IFtEcnVnIFRoZXJhcHldPC9rZXl3b3JkPjxrZXl3b3JkPmNvcnRpY29zdGVyb2lk
L3BvIFtPcmFsIERydWcgQWRtaW5pc3RyYXRpb25dPC9rZXl3b3JkPjxrZXl3b3JkPmluYWN0aXZh
dGVkIHZhY2NpbmUvYWUgW0FkdmVyc2UgRHJ1ZyBSZWFjdGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+
aW5hY3RpdmF0ZWQgdmFjY2luZS9jdCBbQ2xpbmljYWwgVHJpYWxdPC9rZXl3b3JkPjxrZXl3b3Jk
PmluYWN0aXZhdGVkIHZhY2NpbmUvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+
aW5mbHVlbnphIHZhY2NpbmUvYWUgW0FkdmVyc2UgRHJ1ZyBSZWFjdGlvbl08L2tleXdvcmQ+PGtl
eXdvcmQ+aW5mbHVlbnphIHZhY2NpbmUvY3QgW0NsaW5pY2FsIFRyaWFsXTwva2V5d29yZD48a2V5
d29yZD5pbmZsdWVuemEgdmFjY2luZS9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29y
ZD5wbGFjZWJvPC9rZXl3b3JkPjxrZXl3b3JkPnNhbGJ1dGFtb2wvZHQgW0RydWcgVGhlcmFweV08
L2tleXdvcmQ+PGtleXdvcmQ+c2FsYnV0YW1vbC9paCBbSW5oYWxhdGlvbmFsIERydWcgQWRtaW5p
c3RyYXRpb25dPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT4yMiBOb3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDI4
LTQ3OTM8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjAwMTQzOTE2MzwvYWNjZXNzaW9uLW51bT48dXJs
cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9U
PUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPWVtZWQ1JmFt
cDtBTj0yMDAxNDM5MTYzPC91cmw+PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2Vk
dS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/c2lkPU9WSUQ6RW1iYXNlJmFtcDtpZD1wbWlk
OiZhbXA7aWQ9MTAuMTA1NiUyRk5FSk1vYTAxMTk2MSZhbXA7aXNzbj0wMDI4LTQ3OTMmYW1wO2lz
Ym49JmFtcDt2b2x1bWU9MzQ1JmFtcDtpc3N1ZT0yMSZhbXA7c3BhZ2U9MTUyOSZhbXA7cGFnZXM9
MTUyOS0xNTM2JmFtcDtkYXRlPTIwMDEmYW1wO3RpdGxlPU5ldytFbmdsYW5kK0pvdXJuYWwrb2Yr
TWVkaWNpbmUmYW1wO2F0aXRsZT1UaGUrc2FmZXR5K29mK2luYWN0aXZhdGVkK2luZmx1ZW56YSt2
YWNjaW5lK2luK2FkdWx0cythbmQrY2hpbGRyZW4rd2l0aCthc3RobWEmYW1wO2F1bGFzdD1DYXN0
cm8mYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7
Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91
cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDU2L05F
Sk1vYTAxMTk2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1l
PkVtYmFzZTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5P
dmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5Fbmds
aXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5HYWdsYW5pPC9BdXRo
b3I+PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjM5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl
cj4zOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVleGR4
MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIxNDgxMjA4MzExIj4z
OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3
PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R2FnbGFuaSwgTS4gSi48
L2F1dGhvcj48YXV0aG9yPlBpZWRyYSwgUC4gQS48L2F1dGhvcj48YXV0aG9yPlJpZ2dzLCBNLjwv
YXV0aG9yPjxhdXRob3I+SGVyc2NobGVyLCBHLjwvYXV0aG9yPjxhdXRob3I+RmV3bGFzcywgQy48
L2F1dGhvcj48YXV0aG9yPkdsZXplbiwgVy4gUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5TZWN0aW9uIG9mIFBlZGlhdHJpYyBJbmZlY3Rpb3VzIERpc2Vh
c2VzLCBEZXBhcnRtZW50IG9mIFBlZGlhdHJpY3MsIFNjb3R0ICZhbXA7IFdoaXRlIE1lbW9yaWFs
IEhvc3BpdGFsIGFuZCBDbGluaWMsIFRleGFzIEEmYW1wO00gVW5pdmVyc2l0eSBIZWFsdGggU2Np
ZW5jZSBDZW50ZXIgQ29sbGVnZSBvZiBNZWRpY2luZSwgVGVtcGxlLCBUWCA3NjUwOCwgVVNBLiBt
Z2FnbGFuaUBzd21haWwuc3cub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U2FmZXR5
IG9mIHRoZSBpbnRyYW5hc2FsLCB0cml2YWxlbnQsIGxpdmUgYXR0ZW51YXRlZCBpbmZsdWVuemEg
dmFjY2luZSAoTEFJVikgaW4gY2hpbGRyZW4gd2l0aCBpbnRlcm1pdHRlbnQgd2hlZXppbmcgaW4g
YW4gb3Blbi1sYWJlbCBmaWVsZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5QZWRpYXRy
aWMgSW5mZWN0aW91cyBEaXNlYXNlIEpvdXJuYWw8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PlBlZGlhdHIgSW5mZWN0IERpcyBKPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+UGVkaWF0cmljIEluZmVjdGlvdXMgRGlzZWFzZSBKb3VybmFsPC9mdWxsLXRpdGxl
PjxhYmJyLTE+UGVkaWF0ci4gSW5mZWN0LiBEaXMuIEouPC9hYmJyLTE+PGFiYnItMj5QZWRpYXRy
IEluZmVjdCBEaXMgSjwvYWJici0yPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwt
dGl0bGU+UGVkaWF0cmljIEluZmVjdGlvdXMgRGlzZWFzZSBKb3VybmFsPC9mdWxsLXRpdGxlPjxh
YmJyLTE+UGVkaWF0ci4gSW5mZWN0LiBEaXMuIEouPC9hYmJyLTE+PGFiYnItMj5QZWRpYXRyIElu
ZmVjdCBEaXMgSjwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ0NC01MjwvcGFnZXM+
PHZvbHVtZT4yNzwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5B
ZG1pbmlzdHJhdGlvbiwgSW50cmFuYXNhbDwva2V5d29yZD48a2V5d29yZD5BZG9sZXNjZW50PC9r
ZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3Jk
PkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdv
cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD4qSW5m
bHVlbnphIFZhY2NpbmVzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3Jk
PjxrZXl3b3JkPipJbmZsdWVuemEgVmFjY2luZXMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdv
cmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJv
bF08L2tleXdvcmQ+PGtleXdvcmQ+UmVzcGlyYXRvcnkgU291bmRzL2V0IFtFdGlvbG9neV08L2tl
eXdvcmQ+PGtleXdvcmQ+VmFjY2luZXMsIEF0dGVudWF0ZWQvYWQgW0FkbWluaXN0cmF0aW9uICZh
bXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdvcmQ+VmFjY2luZXMsIEF0dGVudWF0ZWQvYWUgW0Fk
dmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwv
a2V5d29yZD48a2V5d29yZD4wIChWYWNjaW5lcywgQXR0ZW51YXRlZCk8L2tleXdvcmQ+PC9rZXl3
b3Jkcz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48
L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjA4OTEtMzY2ODwvaXNibj48YWNjZXNzaW9uLW51bT4x
ODQwMTI4OTwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNvbXBhcmF0aXZlIFN0dWR5JiN4RDtS
ZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQs
IE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+
aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVX
Uz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDUmYW1wO0FOPTE4NDAxMjg5PC91cmw+PHVy
bD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rp
c3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoxODQwMTI4OSZh
bXA7aWQ9MTAuMTA5NyUyRklORi4wYjAxM2UzMTgxNjYwYzJlJmFtcDtpc3NuPTA4OTEtMzY2OCZh
bXA7aXNibj0mYW1wO3ZvbHVtZT0yNyZhbXA7aXNzdWU9NSZhbXA7c3BhZ2U9NDQ0JmFtcDtwYWdl
cz00NDQtNTImYW1wO2RhdGU9MjAwOCZhbXA7dGl0bGU9UGVkaWF0cmljK0luZmVjdGlvdXMrRGlz
ZWFzZStKb3VybmFsJmFtcDthdGl0bGU9U2FmZXR5K29mK3RoZStpbnRyYW5hc2FsJTJDK3RyaXZh
bGVudCUyQytsaXZlK2F0dGVudWF0ZWQraW5mbHVlbnphK3ZhY2NpbmUrJTI4TEFJViUyOStpbitj
aGlsZHJlbit3aXRoK2ludGVybWl0dGVudCt3aGVlemluZytpbithbitvcGVuLWxhYmVsK2ZpZWxk
K3RyaWFsLiZhbXA7YXVsYXN0PUdhZ2xhbmkmYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUv
Jmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7
PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRw
Oi8vZHguZG9pLm9yZy8xMC4xMDk3L0lORi4wYjAxM2UzMTgxNjYwYzJlPC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFiYXNl
LW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVtb3Rl
LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29yZD48
L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXN0cm88L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (125, 134-136). In these studies, vaccinated patients did not have more frequent asthma exacerbations than unvaccinated patients, and no other adverse event was more common in asthmatics. A study of adult asthma patients who reported bronchospasm after influenza vaccination, indicated that these symptoms were not related to vaccine hypersensitivity PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (137).A common concern is the safety of egg-derived influenza vaccines in patients with egg-allergy, a frequent co-morbidity in children with asthma. The last case of anaphylaxis after influenza vaccination occurred more than 25 years ago at a time when the egg content of vaccines was much higher. The ovalbumin content of most current vaccines is less than 1.2 μg/mL, and an egg-free influenza vaccine is also available. Several studies demonstrated that influenza vaccines containing low levels of egg protein (≤1.2mμg/mL) were safe even in egg-allergic patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHVuZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DaHVuZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJl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ADDIN EN.CITE.DATA (137-143). This also seemed to be true in egg-allergic patients with associated asthma. The recent SNIFFLE studies of LAIV in egg allergic children, including 634 children with asthma/recurrent wheeze (79.7% on daily inhaled corticosteroid treatment), found no immediate systemic allergic reactions PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXJuZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS
ZWNOdW0+MjE5PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNDQsIDE0NSk8L0Rpc3BsYXlUZXh0Pjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MjE5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9
IkVOIiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3Rh
bXA9IjE0ODEyMTAyNDciPjIxOTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK
b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo
b3I+VHVybmVyLCBQYXVsIEouPC9hdXRob3I+PGF1dGhvcj5Tb3V0aGVybiwgSm88L2F1dGhvcj48
YXV0aG9yPkFuZHJld3MsIE5pY2sgSi48L2F1dGhvcj48YXV0aG9yPk1pbGxlciwgRWxpemFiZXRo
PC9hdXRob3I+PGF1dGhvcj5Fcmxld3luLUxhamV1bmVzc2UsIE1pY2hlbDwvYXV0aG9yPjwvYXV0
aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5TYWZldHkgb2YgbGl2ZSBhdHRlbnVh
dGVkIGluZmx1ZW56YSB2YWNjaW5lIGluIHlvdW5nIHBlb3BsZSB3aXRoIGVnZyBhbGxlcmd5OiBt
dWx0aWNlbnRyZSBwcm9zcGVjdGl2ZSBjb2hvcnQgc3R1ZHk8L3RpdGxlPjxzZWNvbmRhcnktdGl0
bGU+Qk1KPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
Qk1KPC9mdWxsLXRpdGxlPjxhYmJyLTE+Qk1KPC9hYmJyLTE+PGFiYnItMj5CTUo8L2FiYnItMj48
L3BlcmlvZGljYWw+PHBhZ2VzPmg2MjkxPC9wYWdlcz48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48
cHViLWRhdGVzPjxkYXRlPjIwMTUvMTIvMDg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVi
bGlzaGVyPkJNSjwvcHVibGlzaGVyPjxpc2JuPjE3NTYtMTgzMzwvaXNibj48dXJscz48cmVsYXRl
ZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTEzNi9ibWouaDYyOTE8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjExMzYvYm1qLmg2
MjkxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5UdXJuZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNOdW0+NDE8L1JlY051bT48cmVj
b3JkPjxyZWMtbnVtYmVyPjQxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9
IjE0ODEyMDgzMTEiPjQxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu
YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5U
dXJuZXIsIFBhdWwgSjwvYXV0aG9yPjxhdXRob3I+U291dGhlcm4sIEpvPC9hdXRob3I+PGF1dGhv
cj5BbmRyZXdzLCBOaWNrIEo8L2F1dGhvcj48YXV0aG9yPk1pbGxlciwgRWxpemFiZXRoPC9hdXRo
b3I+PGF1dGhvcj5Fcmxld3luLUxhamV1bmVzc2UsIE1pY2hlbDwvYXV0aG9yPjxhdXRob3I+U05J
RkZMRSBTdHVkeSBJbnZlc3RpZ2F0b3JzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
Pjx0aXRsZXM+PHRpdGxlPlNhZmV0eSBvZiBsaXZlIGF0dGVudWF0ZWQgaW5mbHVlbnphIHZhY2Np
bmUgaW4gYXRvcGljIGNoaWxkcmVuIHdpdGggZWdnIGFsbGVyZ3k8L3RpdGxlPjxzZWNvbmRhcnkt
dGl0bGU+Sm91cm5hbCBvZiBBbGxlcmd5IGFuZCBDbGluaWNhbCBJbW11bm9sb2d5PC9zZWNvbmRh
cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBBbGxl
cmd5IGFuZCBDbGluaWNhbCBJbW11bm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQWxsZXJn
eSBDbGluLiBJbW11bm9sLjwvYWJici0xPjxhYmJyLTI+SiBBbGxlcmd5IENsaW4gSW1tdW5vbDwv
YWJici0yPjxhYmJyLTM+Sm91cm5hbCBvZiBBbGxlcmd5ICZhbXA7IENsaW5pY2FsIEltbXVub2xv
Z3k8L2FiYnItMz48L3BlcmlvZGljYWw+PHBhZ2VzPjM3Ni04MTwvcGFnZXM+PHZvbHVtZT4xMzY8
L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48L2RhdGVz
Pjxpc2JuPjAwOTEtNjc0OTwvaXNibj48dXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k
Tm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UdXJuZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (144, 145). For 6.6% of children with asthma/recurrent wheeze, the parents reported wheeze within 72 hours of LAIV, but most wheeze episodes only required routine treatment; there was no hospitalization and no increase in respiratory symptoms in the four weeks after LAIV. Based on the robust evidence that influenza vaccines are safe in asthma patients with and without egg allergy, British immunization guidelines ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>238</RecNum><DisplayText>(146)</DisplayText><record><rec-number>238</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481284864">238</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>The Green Book- Immunisation against infectious disease. Chapter 19 – Influenza, 2014. ;(146) now recommend administration of LAIV in the community to children from 2 years of age, including those with asthma, irrespective of egg allergy, unless they have severe or acutely exacerbated asthma (regardless of the egg-allergy status?). US and Canadian guidelines remain more conservative and still suggest that vaccines containing egg proteins (e.g. LAIV) should not be used in children with egg allergy and/or asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9oc2tvcGY8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hcm9oc2tvcGY8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE.DATA (147-149).8. Antiviral treatment against influenza in patients with asthmaFor asthma patients with suspected influenza infection, treatment with antiviral medication as early as possible, prior to laboratory confirmation of influenza, is currently recommended PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRoYW48L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXRoYW48L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (150-154). Since amantadine and rimantadine are limited by drug resistance, they have been replaced by neuraminidase inhibitors (NI). The currently marketed NIs are zanamivir and oseltamivir. However, post-marketing surveillance has revealed bronchospasm and worsening of lung function in a few cases when asthma patients were treated with zanamivir inhalation PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY05pY2hvbGw8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NY05pY2hvbGw8L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFy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 EN.CITE.DATA (155). Therefore, the manufacturer does now not recommend zanamivir for patients with chronic respiratory disease, including asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bb2tpPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bb2tpPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (151, 152). Oseltamivir was not associated with any significant respiratory adverse effects and is recommended for treatment and chemoprophylaxis of influenza in children and adults with high-risk chronic conditions, including asthma PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNO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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNO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 EN.CITE.DATA (156-158). However, large-scale telephone surveys in the USA showed that having asthma, in contrast to diabetes, was not associated with increased rates of antiviral treatment of influenza cases PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaWdnZXJzdGFmZjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaWdnZXJzdGFmZjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE.DATA (159). Data on the efficacy of NI in asthma patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (156, 160-162) are limited. A benefit of oseltamivir treatment was found in children in an RCT that showed significantly improved pulmonary function and fewer AAEs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE.DATA (162). A meta-analysis, based on a single RCT, reported improved FEV1 after oral oseltamivir given to children with asthma and influenza infection, but no effects on peak flow or AAEs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaHVuLVNoaW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaHVuLVNoaW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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 EN.CITE.DATA (163). Two recent systematic reviews found that oseltamivir relieved influenza symptoms in otherwise healthy children, but had no effect on children with asthma who have influenza-like illness PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy
PjxSZWNOdW0+MTQ8L1JlY051bT48RGlzcGxheVRleHQ+KDE2NCwgMTY1KTwvRGlzcGxheVRleHQ+
PHJlY29yZD48cmVjLW51bWJlcj4xNDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0
YW1wPSIxNDgxMjA4MzExIj4xNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK
b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo
b3I+SmVmZmVyc29uLCBULjwvYXV0aG9yPjxhdXRob3I+Sm9uZXMsIE0uPC9hdXRob3I+PGF1dGhv
cj5Eb3NoaSwgUC48L2F1dGhvcj48YXV0aG9yPlNwZW5jZXIsIEUuIEEuPC9hdXRob3I+PGF1dGhv
cj5PbmFrcG95YSwgSS48L2F1dGhvcj48YXV0aG9yPkhlbmVnaGFuLCBDLiBKLjwvYXV0aG9yPjwv
YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPihKZWZmZXJzb24pIENvY2hyYW5l
IEFjdXRlIFJlc3BpcmF0b3J5IEluZmVjdGlvbnMgR3JvdXAsIFZpYSBQdWdsaWUgMjMsIDAwMTg3
IFJvbWUsIEl0YWx5IChKb25lcykgU2Nob29sIG9mIFBvcHVsYXRpb24gSGVhbHRoLCBVbml2ZXJz
aXR5IG9mIFF1ZWVuc2xhbmQsIEJyaXNiYW5lLCBBdXN0cmFsaWEgKERvc2hpKSBEZXBhcnRtZW50
IG9mIFBoYXJtYWNldXRpY2FsIEhlYWx0aCBTZXJ2aWNlcyBSZXNlYXJjaCwgVW5pdmVyc2l0eSBv
ZiBNYXJ5bGFuZCBTY2hvb2wgb2YgUGhhcm1hY3ksIEJhbHRpbW9yZSwgTUQgMjEyMDEsIFVuaXRl
ZCBTdGF0ZXMgKFNwZW5jZXIsIE9uYWtwb3lhLCBIZW5lZ2hhbikgTnVmZmllbGQgRGVwYXJ0bWVu
dCBvZiBQcmltYXJ5IENhcmUgSGVhbHRoIFNjaWVuY2VzLCBVbml2ZXJzaXR5IG9mIE94Zm9yZCwg
T3hmb3JkLCBVbml0ZWQgS2luZ2RvbSYjeEQ7VC4gSmVmZmVyc29uLCBDb2NocmFuZSBBY3V0ZSBS
ZXNwaXJhdG9yeSBJbmZlY3Rpb25zIEdyb3VwLCBWaWEgUHVnbGllIDIzLCAwMDE4NyBSb21lLCBJ
dGFseS4gRS1tYWlsOiB0b21AZ21haWwuY29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+
T3NlbHRhbWl2aXIgZm9yIGluZmx1ZW56YSBpbiBhZHVsdHMgYW5kIGNoaWxkcmVuOiBTeXN0ZW1h
dGljIHJldmlldyBvZiBjbGluaWNhbCBzdHVkeSByZXBvcnRzIGFuZCBzdW1tYXJ5IG9mIHJlZ3Vs
YXRvcnkgY29tbWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Qk1KIChPbmxpbmUpPC9zZWNv
bmRhcnktdGl0bGU+PC90aXRsZXM+PHZvbHVtZT4zNDg8L3ZvbHVtZT48bnVtYmVyPmcyNTQ1PC9u
dW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPmFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPmFydGljbGU8
L2tleXdvcmQ+PGtleXdvcmQ+YnJvbmNoaXRpcy9jbyBbQ29tcGxpY2F0aW9uXTwva2V5d29yZD48
a2V5d29yZD5jYXJkaW92YXNjdWxhciBkaXNlYXNlL3NpIFtTaWRlIEVmZmVjdF08L2tleXdvcmQ+
PGtleXdvcmQ+Y2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+ZGlhcnJoZWEvc2kgW1NpZGUgRWZmZWN0
XTwva2V5d29yZD48a2V5d29yZD5kcnVnIGZhdGFsaXR5L3NpIFtTaWRlIEVmZmVjdF08L2tleXdv
cmQ+PGtleXdvcmQ+ZHJ1ZyBtZWdhZG9zZTwva2V5d29yZD48a2V5d29yZD5oZWFkYWNoZS9zaSBb
U2lkZSBFZmZlY3RdPC9rZXl3b3JkPjxrZXl3b3JkPmhvc3BpdGFsIGFkbWlzc2lvbjwva2V5d29y
ZD48a2V5d29yZD5odW1hbjwva2V5d29yZD48a2V5d29yZD5pbmZlY3Rpb24gcHJldmVudGlvbjwv
a2V5d29yZD48a2V5d29yZD5pbmZsdWVuemEvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtl
eXdvcmQ+aW5mbHVlbnphL3BjIFtQcmV2ZW50aW9uXTwva2V5d29yZD48a2V5d29yZD5pbnRlbnRp
b24gdG8gdHJlYXQgYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+a2lkbmV5IGRpc2Vhc2Uvc2kg
W1NpZGUgRWZmZWN0XTwva2V5d29yZD48a2V5d29yZD5tZWRpY2FsIGRlY2lzaW9uIG1ha2luZzwv
a2V5d29yZD48a2V5d29yZD5tZWRpY2FsIGxpdGVyYXR1cmU8L2tleXdvcmQ+PGtleXdvcmQ+bWVu
dGFsIGRpc2Vhc2Uvc2kgW1NpZGUgRWZmZWN0XTwva2V5d29yZD48a2V5d29yZD5uYXVzZWEvc2kg
W1NpZGUgRWZmZWN0XTwva2V5d29yZD48a2V5d29yZD5vdGl0aXMgbWVkaWEvY28gW0NvbXBsaWNh
dGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+b3V0Y29tZSBhc3Nlc3NtZW50PC9rZXl3b3JkPjxrZXl3
b3JkPnBoYXNlIDEgY2xpbmljYWwgdHJpYWw8L2tleXdvcmQ+PGtleXdvcmQ+cGhhc2UgMiBjbGlu
aWNhbCB0cmlhbDwva2V5d29yZD48a2V5d29yZD5wbmV1bW9uaWEvZHQgW0RydWcgVGhlcmFweV08
L2tleXdvcmQ+PGtleXdvcmQ+cG5ldW1vbmlhL3BjIFtQcmV2ZW50aW9uXTwva2V5d29yZD48a2V5
d29yZD5wcmlvcml0eSBqb3VybmFsPC9rZXl3b3JkPjxrZXl3b3JkPnJhbmRvbWl6ZWQgY29udHJv
bGxlZCB0cmlhbCAodG9waWMpPC9rZXl3b3JkPjxrZXl3b3JkPnJpc2sgYmVuZWZpdCBhbmFseXNp
czwva2V5d29yZD48a2V5d29yZD5yaXNrIHJlZHVjdGlvbjwva2V5d29yZD48a2V5d29yZD5zaW51
c2l0aXMvY28gW0NvbXBsaWNhdGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+c3lzdGVtYXRpYyByZXZp
ZXc8L2tleXdvcmQ+PGtleXdvcmQ+dGltZSB0byB0cmVhdG1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+
dmlydXMgdHJhbnNtaXNzaW9uPC9rZXl3b3JkPjxrZXl3b3JkPnZvbWl0aW5nL3NpIFtTaWRlIEVm
ZmVjdF08L2tleXdvcmQ+PGtleXdvcmQ+b3NlbHRhbWl2aXIvYWUgW0FkdmVyc2UgRHJ1ZyBSZWFj
dGlvbl08L2tleXdvcmQ+PGtleXdvcmQ+b3NlbHRhbWl2aXIvY3QgW0NsaW5pY2FsIFRyaWFsXTwv
a2V5d29yZD48a2V5d29yZD5vc2VsdGFtaXZpci9kbyBbRHJ1ZyBEb3NlXTwva2V5d29yZD48a2V5
d29yZD5vc2VsdGFtaXZpci9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD5wbGFj
ZWJvPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRl
cz48ZGF0ZT4xMCBBcHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNzU2LTE4MzM8
L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjAxNDI2MDU3NDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs
YXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5ibWouY29tL2hpZ2h3aXJlL2ZpbGVzdHJlYW0vNjkz
NzkyL2ZpZWxkX2hpZ2h3aXJlX2FydGljbGVfcGRmLzAvYm1qLmcyNTQ1PC91cmw+PHVybD5odHRw
Oi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4m
YW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9ZW1lZDExJmFtcDtBTj0yMDE0MjYwNTc0PC91cmw+PHVy
bD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rp
c3BsYXk/c2lkPU9WSUQ6RW1iYXNlJmFtcDtpZD1wbWlkOiZhbXA7aWQ9MTAuMTEzNiUyRmJtai5n
MjU0NSZhbXA7aXNzbj0xNzU2LTE4MzMmYW1wO2lzYm49JmFtcDt2b2x1bWU9MzQ4JmFtcDtpc3N1
ZT0wOSZhbXA7c3BhZ2U9JmFtcDtwYWdlcz0mYW1wO2RhdGU9MjAxNCZhbXA7dGl0bGU9Qk1KKyUy
OE9ubGluZSUyOSZhbXA7YXRpdGxlPU9zZWx0YW1pdmlyK2ZvcitpbmZsdWVuemEraW4rYWR1bHRz
K2FuZCtjaGlsZHJlbiUzQStTeXN0ZW1hdGljK3JldmlldytvZitjbGluaWNhbCtzdHVkeStyZXBv
cnRzK2FuZCtzdW1tYXJ5K29mK3JlZ3VsYXRvcnkrY29tbWVudHMmYW1wO2F1bGFzdD1KZWZmZXJz
b24mYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9yJmd0OyZhbXA7
Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVkLXVybHM+PC91
cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8xMC4xMTM2L2Jt
ai5nMjU0NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPkVt
YmFzZTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5Pdmlk
IFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNo
PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhv
cj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+MTU8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy
PjE1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNWV4ZHgy
ZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEyMDgzMTEiPjE1
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KZWZmZXJzb24sIFQuPC9h
dXRob3I+PGF1dGhvcj5Kb25lcywgTS4gQS48L2F1dGhvcj48YXV0aG9yPkRvc2hpLCBQLjwvYXV0
aG9yPjxhdXRob3I+RGVsIE1hciwgQy4gQi48L2F1dGhvcj48YXV0aG9yPkhhbWEsIFIuPC9hdXRo
b3I+PGF1dGhvcj5UaG9tcHNvbiwgTS4gSi48L2F1dGhvcj48YXV0aG9yPlNwZW5jZXIsIEUuIEEu
PC9hdXRob3I+PGF1dGhvcj5PbmFrcG95YSwgSS48L2F1dGhvcj48YXV0aG9yPk1haHRhbmksIEsu
IFIuPC9hdXRob3I+PGF1dGhvcj5OdW5hbiwgRC48L2F1dGhvcj48YXV0aG9yPkhvd2ljaywgSi48
L2F1dGhvcj48YXV0aG9yPkhlbmVnaGFuLCBDLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy
aWJ1dG9ycz48YXV0aC1hZGRyZXNzPkplZmZlcnNvbixUb20uIFRoZSBDb2NocmFuZSBDb2xsYWJv
cmF0aW9uLCBWaWEgUHVnbGllIDIzLCBSb21hLCBJdGFseSwgMDAxODcuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+TmV1cmFtaW5pZGFzZSBpbmhpYml0b3JzIGZvciBwcmV2ZW50aW5nIGFu
ZCB0cmVhdGluZyBpbmZsdWVuemEgaW4gaGVhbHRoeSBhZHVsdHMgYW5kIGNoaWxkcmVuPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkNvY2hyYW5lIERhdGFiYXNlIG9mIFN5c3RlbWF0aWMgUmV2aWV3
czwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q29jaHJhbmUgRGF0YWJhc2UgU3lzdCBSZXY8
L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+Q0QwMDg5NjU8L3BhZ2VzPjx2b2x1bWU+NDwvdm9s
dW1lPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbnRpdmlyYWwg
QWdlbnRzL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3JkPipBbnRpdmlyYWwg
QWdlbnRzL3R1IFtUaGVyYXBldXRpYyBVc2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3
b3JkPjxrZXl3b3JkPkRydWcgRXZhbHVhdGlvbjwva2V5d29yZD48a2V5d29yZD5Fbnp5bWUgSW5o
aWJpdG9ycy9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD4qRW56eW1lIElu
aGliaXRvcnMvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+RXVyb3BlPC9r
ZXl3b3JkPjxrZXl3b3JkPkdyZWF0IEJyaXRhaW48L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFN0
YXR1czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56
YSwgSHVtYW4vZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwg
SHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+SmFw
YW48L2tleXdvcmQ+PGtleXdvcmQ+TGVnaXNsYXRpb24sIERydWc8L2tleXdvcmQ+PGtleXdvcmQ+
Kk5ldXJhbWluaWRhc2UvYWkgW0FudGFnb25pc3RzICZhbXA7IEluaGliaXRvcnNdPC9rZXl3b3Jk
PjxrZXl3b3JkPk9zZWx0YW1pdmlyL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3
b3JkPipPc2VsdGFtaXZpci90dSBbVGhlcmFwZXV0aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD5Q
bmV1bW9uaWEvcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+
UHVibGljYXRpb24gQmlhczwva2V5d29yZD48a2V5d29yZD5SYW5kb21pemVkIENvbnRyb2xsZWQg
VHJpYWxzIGFzIFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXM8L2tleXdvcmQ+
PGtleXdvcmQ+WmFuYW1pdmlyL2FlIFtBZHZlcnNlIEVmZmVjdHNdPC9rZXl3b3JkPjxrZXl3b3Jk
PipaYW5hbWl2aXIvdHUgW1RoZXJhcGV1dGljIFVzZV08L2tleXdvcmQ+PGtleXdvcmQ+MCAoQW50
aXZpcmFsIEFnZW50cyk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoRW56eW1lIEluaGliaXRvcnMpPC9r
ZXl3b3JkPjxrZXl3b3JkPjIwTzkzTDZGOUggKE9zZWx0YW1pdmlyKTwva2V5d29yZD48a2V5d29y
ZD5FQyAzLTItMS0xOCAoTmV1cmFtaW5pZGFzZSk8L2tleXdvcmQ+PGtleXdvcmQ+TDZPM1hJNzc3
SSAoWmFuYW1pdmlyKTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFy
PjwvZGF0ZXM+PGlzYm4+MTQ2OS00OTNYPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NzE4OTIzPC9h
Y2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+TWV0YS1BbmFseXNpcyYjeEQ7UmVzZWFyY2ggU3VwcG9y
dCwgTm9uLVUuUy4gR292JmFwb3M7dCYjeEQ7UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0
ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5jb20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7
Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4dCZhbXA7RD1tZWRsJmFtcDtBTj0yNDcx
ODkyMzwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMudWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5r
RmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQrTUVETElORSUyOFIlMjkmYW1wO2lkPXBt
aWQ6MjQ3MTg5MjMmYW1wO2lkPTEwLjEwMDIlMkYxNDY1MTg1OC5DRDAwODk2NS5wdWI0JmFtcDtp
c3NuPTEzNjEtNjEzNyZhbXA7aXNibj0mYW1wO3ZvbHVtZT00JmFtcDtpc3N1ZT0mYW1wO3NwYWdl
PUNEMDA4OTY1JmFtcDtwYWdlcz1DRDAwODk2NSZhbXA7ZGF0ZT0yMDE0JmFtcDt0aXRsZT1Db2No
cmFuZStEYXRhYmFzZStvZitTeXN0ZW1hdGljK1Jldmlld3MmYW1wO2F0aXRsZT1OZXVyYW1pbmlk
YXNlK2luaGliaXRvcnMrZm9yK3ByZXZlbnRpbmcrYW5kK3RyZWF0aW5nK2luZmx1ZW56YStpbito
ZWFsdGh5K2FkdWx0cythbmQrY2hpbGRyZW4uJmFtcDthdWxhc3Q9SmVmZmVyc29uJmFtcDtwaWQ9
Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsm
bHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi8xNDY1MTg1OC5DRDAw
ODk2NS5wdWI0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLW5hbWU+
TUVETElORTwvcmVtb3RlLWRhdGFiYXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5P
dmlkIFRlY2hub2xvZ2llczwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5Fbmds
aXNoPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (164, 165), a finding that is currently controversial. As high rates of resistance limit the effectiveness of the currently available antiviral drugs, new NI (laninamivir, peramivir) and an RNA-dependent RNA polymerase inhibitor (favipiravir) are currently undergoing clinical trials ADDIN EN.CITE <EndNote><Cite><Author>Kohno</Author><Year>2011</Year><RecNum>229</RecNum><DisplayText>(166)</DisplayText><record><rec-number>229</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">229</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kohno, S.</author><author>Kida, H.</author><author>Mizuguchi, M.</author><author>Hirotsu, N.</author><author>Ishida, T.</author><author>Kadota, J.</author><author>Shimada, J.</author></authors></contributors><titles><title>Intravenous Peramivir for Treatment of Influenza A and B Virus Infection in High-Risk Patients</title><secondary-title>Antimicrobial Agents and Chemotherapy</secondary-title></titles><periodical><full-title>Antimicrobial Agents and Chemotherapy</full-title><abbr-1>Antimicrob. Agents Chemother.</abbr-1><abbr-2>Antimicrob Agents Chemother</abbr-2><abbr-3>Antimicrobial Agents & Chemotherapy</abbr-3></periodical><pages>2803-2812</pages><volume>55</volume><number>6</number><dates><year>2011</year><pub-dates><date>2011/04/04</date></pub-dates></dates><publisher>American Society for Microbiology</publisher><isbn>0066-4804
1098-6596</isbn><urls><related-urls><url>;(166). Laninamivir showed similar efficacy and safety to oseltamivir in the treatment of influenza in asthma patients ADDIN EN.CITE <EndNote><Cite><Author>Watanabe</Author><Year>2013</Year><RecNum>16</RecNum><DisplayText>(167)</DisplayText><record><rec-number>16</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">16</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Watanabe, A.</author></authors></contributors><titles><title>A randomized double-blind controlled study of laninamivir compared with oseltamivir for the treatment of influenza in patients with chronic respiratory diseases</title><secondary-title>Journal of Infection and Chemotherapy</secondary-title></titles><pages>89-97</pages><volume>19</volume><number>1</number><keywords><keyword>Antiviral Agents [adverse effects] [therapeutic use]</keyword><keyword>Asthma [complications]</keyword><keyword>Chronic Disease</keyword><keyword>Double-Blind Method</keyword><keyword>Enzyme Inhibitors [therapeutic use]</keyword><keyword>Influenza A Virus, H1N1 Subtype [drug effects]</keyword><keyword>Influenza, Human [drug therapy] [virology]</keyword><keyword>Neuraminidase [antagonists & inhibitors]</keyword><keyword>Oseltamivir [adverse effects] [therapeutic use]</keyword><keyword>Treatment Outcome</keyword><keyword>Zanamivir [adverse effects] [analogs & derivatives] [therapeutic use]</keyword><keyword>Adult[checkword]</keyword><keyword>Aged[checkword]</keyword><keyword>Female[checkword]</keyword><keyword>Humans[checkword]</keyword><keyword>Male[checkword]</keyword><keyword>Middle Aged[checkword]</keyword><keyword>Sr-airways</keyword></keywords><dates><year>2013</year></dates><accession-num>CN-00844191</accession-num><work-type>Randomized Controlled Trial; Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url> 22907567</custom3><electronic-resource-num>10.1007/s10156-012-0460-1</electronic-resource-num></record></Cite></EndNote>(167).9. ConclusionsWe observed significant variation in the reported rates of influenza detection among AAE episodes in both children and adults, with higher rates observed in the latter age group. This may be attributed to major differences in inclusion criteria, disease definitions, virus detection methodology, small population sizes and the limited number of available studies. Therefore, it is presently unclear to what degree influenza causes exacerbation of underlying asthma. All European Union countries currently recommend influenza vaccination of people with asthma, with TIV being the most widely used vaccine. Nonetheless, vaccination coverage varies between regions, and is significantly lower among children with asthma. Several factors and misbeliefs have been shown to predict non-adherence to influenza vaccination, while healthcare worker endorsement highly promotes vaccination. Major policy shifts and health campaigns may help in raising awareness and improve guideline implementation.The limited immunogenicity data suggest that good seroprotection and seroconversion can be achieved in children and adults with asthma. However, higher vaccine doses may be required in elderly patients. Available studies suggest increased efficacy of LAIV in reducing influenza illness in children/adolescents with asthma compared to TIV, but do not provide evidence of efficacy of TIV in reducing influenza illness in asthmatics concurring with a recent systematic review PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXRlczwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJl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ADDIN EN.CITE.DATA (12). There are some limited data to suggest that influenza vaccination reduces asthma-related morbidity in children in real-life settings, as has been concluded in another recent systematic review ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>248</RecNum><DisplayText>(133)</DisplayText><record><rec-number>248</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1496656515">248</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title><style face="normal" font="default" size="100%">Vasiliou E. et al Effectiveness of influenza vaccines in asthma: a systematic review and meta-analysis. Clin Infect Dis. </style><style face="italic" font="default" size="100%">In press</style></title></titles><dates></dates><urls></urls></record></Cite></EndNote>(133). The only data to suggest that vaccination may have a beneficial impact in adults with asthma are from studies of patients with long-term or high-risk conditions, not just asthma. The effectiveness outcomes of these studies are difficult to interpret due to lack of an agreed definition for asthma and/or influenza, and insufficient information on the type of vaccination used. Lack of randomization is also a limitation, as differences in the characteristics of those who do and do not receive the vaccine, such as disease severity and socioeconomic status, may independently impact on the likelihood of asthma morbidity, and analyses may not control for all these differences. Despite these limitations, population-based effectiveness studies are the only way to assess the impact of vaccination in real-life healthcare settings. Inactivated influenza vaccines appear to be safe for people with asthma, and, provided they have low egg protein content (≤1.2 μg/mL), also for those with egg allergy. LAIV is also safe in asthma and egg allergy with the exception of severe or acutely exacerbated asthma, where LAIV cannot be given. Oseltamivir is the NI that is currently used in asthma. Although it has moderately beneficial effects on influenza illness in healthy people, there are insufficient data to determine its efficacy and effectiveness in people with asthma. However, novel NIs are currently in development. 10. Recommendations and future needsPeople with asthma are at high risk of more severe forms of influenza, with increased hospitalization and admission at healthcare facilities, therefore:Education campaigns for both the general population and healthcare providers are needed to promote an increase in annual influenza vaccination, early case recognition and consideration of early empirical antiviral therapy, and to reduce influenza-attributable healthcare utilization among asthmatics.Large cohort and case control studies using standardized definitions (for AAE), sensitive influenza detection methods, such as PCR, and comprehensive assessment of respiratory pathogens are necessary in both children and adults with asthma. There is a need to develop more internationally co-ordinated registries, e.g. for Europe, that accurately collate vaccination status along with medical and socio-demographic details to assess the impact of public health interventions over time. Multiple sources of data must be used to record vaccination status (e.g. self-reported as well as medical notes, vaccination card or billing data). Targeted vaccination of children and at risk groups is needed.Further studies of influenza vaccine immunogenicity, comparing healthy and asthmatic populations, are required to determine if people with asthma have normal influenza vaccine responses or if they require influenza vaccines with enhanced immunogenicity. The discovery and development of improved immune correlates of protection against influenza will enable more meaningful testing of vaccine immunogenicity. In view of the uncertainty around the degree of protection that influenza vaccination affords in people of all ages with asthma, further efficacy data need to be collected in this population. Data should be stratified by age and asthma severity, using adequately powered, randomised, placebo-controlled trials that compare both TIV and LAIV to non-vaccinated controls. Further studies are needed to evaluate the effectiveness of influenza vaccination in patients with asthma, but must be designed to minimize any risk of bias. Safety data in asthma with and without egg allergy are required for new influenza vaccines, and, depending on egg protein content, for new LAIV batches.There is a need to collect more safety data on zanamivir in patients with chronic respiratory disease, and efficacy data on oseltamivir in children with asthma. Development and testing of new anti-influenza drugs among asthmatics is needed. References ADDIN EN.REFLIST 1.Global Atlas of Asthma. Published by the European Academy of Allergy and Clinical Immunology. Editors: Cezmi A. Akdis, Ioana Agache, 2013.2.ERS: The European Lung White Book 2003.3.Darveaux JI, Lemanske RF. Infection-Related Asthma. Journal of Allergy and Clinical Immunology: In Practice 2014;2(6):658-663.4.Edwards MR, Bartlett NW, Hussell T, Openshaw P, Johnston SL. The microbiology of asthma. Nature Reviews Microbiology 2012; 10(7):459-471.5.Gern JE. The ABCs of rhinoviruses, wheezing, and asthma. J Virol 2010;84(15):7418-7426.6.Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Pappas TE, Lee W-M, et al. Evidence for a Causal Relationship between Allergic Sensitization and Rhinovirus Wheezing in Early Life. Am J Respir Crit Care Med 2012;185(3):281-285.7.Papadopoulos NG, Christodoulou I, Rohde G, Agache I, Almqvist C, Bruno A, et al. Viruses and bacteria in acute asthma exacerbations - A GA2LEN-DARE* systematic review. Allergy 2010;66(4):458-468.8.Simonsen L, Spreeuwenberg P, Lustig R, Taylor RJ, Fleming DM, Kroneman M, et al. Global mortality estimates for the 2009 influenza pandemic from the GLaMOR project: a modeling study. PLoS Med 2013;10(11):e1001558.9.Thompson WW. Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States. JAMA 2003;289(2):179.10.Poehling KA, Edwards KM, Weinberg GA, Szilagyi P, Staat MA, Iwane MK, et al. The underrecognized burden of influenza in young children. N Engl J Med 2006;355(1):31-40.11.Neuzil KM, Mellen BG, Wright PF, Mitchel Jr EF, Griffin MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med 2000;342(4):225-231.12.Cates CJ, Rowe BH. Vaccines for preventing influenza in people with asthma. Cochrane Database of Systematic Reviews 2013;2:CD000364.13.Bassetti M, Parisini A, Calzi A, Pallavicini FM, Cassola G, Artioli S, et al. Risk factors for severe complications of the novel influenza A (H1N1): analysis of patients hospitalized in Italy. Clin Microbiol Infect 2011;17(2):247-250.14.Canak G, Kovacevic N, Vukadinov J, Turkulov V, Sevic S, Doder R, et al. Clinical features, treatments and outcomes of influenza A (H1N1) 2009 among the hospitalized patients in the Clinic for Infectious Diseases in Novi Sad. Vojnosanit Pregl 2013;70(2):155-162.15.Celjuska-Tosev E, Kuzman I, Drazenovic V, Knezovic I, Civljak R. Clinical and epidemiological characteristics of hospitalized patients with pandemic a(H1N1) 2009 influenza. Infektoloski Glasnik 2010;30(4):149-159.16.Cutter JL, Ang LW, Lai FYL, Subramony H, Ma S, James L. Outbreak of pandemic influenza a (H1N1-2009) in Singapore, May to September 2009. Annals of the Academy of Medicine Singapore 2010;39(4):273-282.17.Al-Khuwaitir TS, Al-Abdulkarim AS, Abba AA, Yousef AM, El-Din MA, Rahman KT, et al. H1N1 influenza A: Preliminary evaluation in hospitalized patients in a secondary care facility in Saudi Arabia. Saudi Med J 2009;30(12):1532-1536.18.Fleege L, Hallberg E, Morin C, Danila R, Lynfield R. Novel H1N1 influenza hospitalizations: Minneapolis-St. Paul metropolitan area, 2008-2009. Minn Med 2009;92(11):38-42.19.Gonzalez-Velez AE, Diaz-Agero-Perez C, Robustillo-Rodela A, Cornejo-Gutierrez AM, Pita-Lopez MJ, Oliva-Iniguez L, et al. Factors associated to admission to Intensive Care in patients hospitalized due to pandemic Influenza A/H1N1 2009. Med Intensiva 2011;35(8):463-469.20.Jain S, Kamimoto L, Bramley AM, Schmitz AM, Benoit SR, Louie J, et al. Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009. N Engl J Med 2009;361(20):1935-1944.21.Lucker LM, Kherad O, Iten A, Wagner N, Descombes M, Camus V, et al. Clinical features and outcome of hospitalised adults and children with the 2009 influenza A H1N1 infection at Geneva's University Hospital. Swiss Med Wkly 2011;141:w13177.22.Myles P, Nguyen-Van-Tam JS, Semple MG, Brett SJ, Bannister B, Read RC, et al. Differences between asthmatics and nonasthmatics hospitalised with influenza A infection. Eur Respir J 2013;41(4):824-831.23.Nguyen-Van-Tam JS, Openshaw PJM, Hashim A, Gadd EM, Lim WS, Semple MG, et al. Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax 2010;65(7):645-651.24.Pecavar B, Nadrah K, Papst L, Cec V, Kotar T, Maticic M, et al. Clinical characteristics of adult patients with influenza-like illness hospitalized in general ward during Influenza A H1N1 pandemic 2009/2010. Wiener Klinische Wochenschrift 2011;123(21-22):662-667.25.Rodriguez-Rieiro C, Carrasco-Garrido P, Hernandez-Barrera V, Lopez de Andres A, Jimenez-Trujillo I, Gil de Miguel A, et al. Pandemic influenza hospitalization in Spain (2009): incidence, in-hospital mortality, comorbidities and costs. Hum Vaccin Immunother 2012;8(4):443-447.26.Zarogoulidis P, Kouliatsis G, Papanas N, Spyratos D, Constantinidis TC, Kouroumichakis I, et al. Long-term respiratory follow-up of H1N1 infection. Virol J 2011;8:319.27.McKenna JJ, Bramley AM, Skarbinski J, Fry AM, Finelli L, Jain S, et al. Asthma in patients hospitalized with pandemic influenza A(H1N1)pdm09 virus infection-United States, 2009. BMC Infect Dis 2013;13:57.28.Djordjevic Z, Canovic P, Todorovic Z, Gajovic O, Mijailovic Z, Popovska B. Characteristics of influenza a (H1N1): Analysis of the cases treated in clinical centre "kragujevac" in Kragujeva. Medicinski Casopis 2011;45(4):15-20.29.Centers for Disease C, Prevention. Patients hospitalized with 2009 pandemic influenza A (H1N1) - New York City, May 2009. MMWR - Morbidity & Mortality Weekly Report 2010;58(51):1436-1440.30.Dawood FS, Fiore A, Kamimoto L, Bramley A, Reingold A, Gershman K, et al. Burden of seasonal influenza hospitalization in children, United States, 2003 to 2008. J Pediatr 2010;157(5):808-814.31.Desmoulins C, Michard-Lenoir AP, Naud J, Claudet I, Nouyrigat V, Cheron G. Clinical features and outcome of 2009 H1N1 influenza in the pediatric setting. Multicenter prospective study in the ED. Arch Pediatr 2011;18(5):505-511.32.Bue M, Chevallier J, Pigeon Kherchiche P. Clinical study of a cohort of 94 children with influenza A(H1N1) on the Reunion Island. Bull Soc Pathol Exot 2011;104(2):135-141.33.Chiu SS, Chan KH, Chen H, Young BW, Lim W, Wong WH, et al. Virologically confirmed population-based burden of hospitalization caused by influenza A and B among children in Hong Kong. Clin Infect Dis 2009;49(7):1016-1021.34.Chiu SS, Lau YL, Chan KH, Wong WH, Peiris JS. Influenza-related hospitalizations among children in Hong Kong. N Engl J Med 2002;347(26):2097-2103.35.Weigl JA, Puppe W, Schmitt HJ. The incidence of influenza-associated hospitalizations in children in Germany. Epidemiol Infect 2002;129(3):525-533.36.Katsunuma T, Matsui T, Iwata T, Nambu M, Kondo N. Hospitalizations associated with pandemic influenza A (H1N1) 2009 in asthmatic children in Japan. Allergology International 2012;61(1):75-82.37.Al Subaie SS, Al Saadi MA. Features associated with severe disease in hospitalized children with 2009 influenza A (H1N1) infection at a university hospital in Riyadh, Saudi Arabia. Ann Saudi Med 2012;32(1):53-58.38.Chong CY, Tan NW, Menon A, Thoon KC, Tee NW, Fu S. Risk Factors for Complicated Influenza A (H1N1) 2009 Disease in Children. Ann Acad Med Singapore 2013;42(5):232-236.39.Mansour MM, Al Hadidib KM. 2009 H1N1 influenza A in children: a descriptive clinical study. Ann Saudi Med 2012;32(1):59-63.40.Silvennoinen H, Peltola V, Vainionpaa R, Ruuskanen O, Heikkinen T. Admission diagnoses of children 0-16 years of age hospitalized with influenza. Eur J Clin Microbiol Infect Dis 2012;31(3):225-231.41.Tasar MA, Dallar Y, Soyer OU, Yildirim S, Tasar M, Arikan FI. Risk factors and prognosis in children hospitalized due to pandemic H1N1 influenza A virus infection in Ankara, Turkey. Turkish Journal of Medical Sciences 2012;42(3):433-440.42.Izurieta HS, Thompson WW, Kramarz P, Shay DK, Davis RL, DeStefano F, et al. Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000;342(4):232-239.43.Dawood FS, Chaves SS, Perez A, Reingold A, Meek J, Farley MM, et al. Complications and associated bacterial coinfections among children hospitalized with seasonal or pandemic influenza, United States, 2003-2010. J Infect Dis 2014;209(5):686-694.44.Dawood FS, Kamimoto L, D'Mello TA, Reingold A, Gershman K, Meek J, et al. Children with asthma hospitalized with seasonal or pandemic influenza, 2003-2009. Pediatrics 2011;128(1):e27-e32.45.O'Riordan S, Barton M, Yau Y, Read SE, Allen U, Tran D. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza. CMAJ Canadian Medical Association Journal 2010;182(1):39-44.46.Chiu SS, Chan KH, Wong WH, Chan EL, Peiris JS. Age-matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2. PLoS ONE [Electronic Resource] 2011;6(7):e21837.47.Song X, DeBiasi RL, Campos JM, Fagbuyi DB, Jacobs BR, Singh N. Comparison of pandemic and seasonal influenza A infections in pediatric patients: were they different? Influenza Other Respi Viruses 2012;6(1):25-27.48.Miller AC, Safi F, Hussain S, Subramanian RA, Elamin EM, Sinert R. Novel influenza A(H1N1) virus among gravid admissions. Arch Intern Med 2010;170(10):868-873.49.Miller AC, Subramanian RA, Safi F, Sinert R, Zehtabchi S, Elamin EM. Influenza A 2009 (H1N1) virus in admitted and critically ill patients. J Intensive Care Med 2012;27(1):25-31.50.Michaan N, Amzallag S, Laskov I, Cohen Y, Fried M, Lessing JB, et al. Maternal and neonatal outcome of pregnant women infected with H1N1 influenza virus (swine flu). J Matern Fetal Neonatal Med 2012;25(2):130-132.51.Taha I. Characteristics of pregnant Women admitted with 2009 H1N1 Influenza in a referral maternity hospital at Al-Madinah, Saudi Arabia. Egyptian Journal of Hospital Medicine (July 2013) 2014;52:650-657.52.Cullen G, Martin J, O'Donnell J, Boland M, Canny M, Keane E, et al. Surveillance of the first 205 confirmed hospitalised cases of pandemic H1N1 influenza in Ireland, 28 April - 3 October 2009. Euro surveillance: European communicable disease bulletin 2009;14(44):429-433.53.Gilca R, De Serres G, Boulianne N, Ouhoummane N, Papenburg J, Douville-Fradet M, et al. Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec, Canada. Influenza Other Respi Viruses 2011;5(4):247-255.54.Lee TC, Taggart LR, Mater B, Katz K, McGeer A. Predictors of pandemic influenza infection in adults presenting to two urban emergency departments, Toronto, 2009. CJEM Canadian Journal of Emergency Medical Care 2011;13(1):7-12.55.Shimoni Z, Niven M, Kama N, Dusseldorp N, Froom P. Increased complaints of fever in the emergency room can identify influenza epidemics. Eur J Intern Med 2008;19(7):494-498.56.Crisinel PA, Barazzone C, Kaiser L, L'Huillier AG, Taguebue J, Wagner N, et al. Comparison of clinical presentation of respiratory tract infections in H1N1/09-positive and H1N1/09-negative patients. Eur J Pediatr 2012;171(1):159-166.57.Miller EK, Griffin MR, Edwards KM, Weinberg GA, Szilagyi PG, Staat MA, et al. Influenza burden for children with asthma. Pediatrics 2008;121(1):1-8.58.Leckerman KH, Sherman E, Knorr J, Zaoutis TE, Coffin SE. Risk factors for healthcare-associated, laboratory-confirmed influenza in hospitalized pediatric patients: a case-control study. Infect Control Hosp Epidemiol 2010;31(4):421-424.59.Libster R, Coviello S, Cavalieri ML, Morosi A, Alabart N, Alvarez L, et al. Pediatric hospitalizations due to influenza in 2010 in Argentina. N Engl J Med 2010;363(25):2472-2473.60.Lee MC, Kim HY, Kong SG, Kim YM, Park SE, Im YT, et al. Cinical characteristics of pandemic influenza A (H1N1) 2009 pediatric infection in Busan and Gyeongsangnam-do: One institution. Tuberculosis and Respiratory Diseases 2012;72(6):493-500.61.Hassan F, Lewis TC, Davis MM, Gebremariam A, Dombkowski K. Hospital utilization and costs among children with influenza, 2003. Am J Prev Med 2009;36(4):292-296.62.Torres SF, Iolster T, Schnitzler EJ, Farias JA, Bordogna AC, Rufach D, et al. High mortality in patients with influenza A pH1N1 2009 admitted to a pediatric intensive care unit: a predictive model of mortality. Pediatr Crit Care Med 2012;13(2):e78-83.63.Libster R, Bugna J, Coviello S, Hijano DR, Dunaiewsky M, Reynoso N, et al. Pediatric hospitalizations associated with 2009 pandemic influenza A (H1N1) in Argentina. N Engl J Med 2010;362(1):45-55.64.Okada T, Morozumi M, Matsubara K, Komiyama O, Ubukata K, Takahashi T, et al. Characteristic findings of pediatric inpatients with pandemic (H1N1) 2009 virus infection among severe and nonsevere illnesses. Journal of Infection and Chemotherapy 2011;17(2):238-245.65.Jiang H, Yu D, Ruan F, Xu W, Huang T, Li L, et al. Clinical characteristics of adult influenza inpatients in ten provinces in China and analysis of severe risk factors. Zhonghua liuxingbingxue zazhi 2015;36(3):216-221.66.Wark PAB, Johnston SL, Moric I, Simpson JL, Hensley MJ, Gibson PG. Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma. Eur Respir J 2001;19(1):68-75.67.Atmar RL, Guy E, Guntupalli KK, Zimmerman JL, Bandi VD, Baxter BD, et al. Respiratory Tract Viral Infections in Inner-City Asthmatic Adults. Arch Intern Med 1998;158(22):2453.68.Simpson JL, Moric I, Wark PA, Johnston SL, Gibson PG. Use of induced sputum for the diagnosis of influenza and infections in asthma: a comparison of diagnostic techniques. J Clin Virol 2003;26(3):339-346.69.Azevedo AM, Durigon EL, Okasima V, Queiroz DA, de Moraes-Vasconcelos D, Duarte AJ, et al. Detection of influenza, parainfluenza, adenovirus and respiratory syncytial virus during asthma attacks in children older than 2 years old. Allergol Immunopathol (Madr) 2003;31(6):311-317.70.Iikura M, Hojo M, Koketsu R, Watanabe S, Sato A, Chino H, et al. The importance of bacterial and viral infections associated with adult asthma exacerbations in clinical practice. PLoS One 2015;10(4):e0123584.71.Teichtahl H, Buckmaster N, Pertnikovs E. The Incidence of Respiratory Tract Infection in Adults Requiring Hospitalization for Asthma. Chest 1997;112(3):591-596.72.Tan WC, Xiang X, Qiu D, Ng TP, Lam SF, Hegele RG. Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. The American Journal of Medicine 2003;115(4):272-277.73.Johnston NW, Johnston SL, Duncan JM, Greene JM, Kebadze T, Keith PK, et al. The September epidemic of asthma exacerbations in children: A search for etiology. J Allergy Clin Immunol 2005;115(1):132-138.74.Khetsuriani N, Kazerouni NN, Erdman DD, Lu X, Redd SC, Anderson LJ, et al. Prevalence of viral respiratory tract infections in children with asthma. J Allergy Clin Immunol 2007;119(2):314-321.75.Bueving HJ, Bernsen RMD, de Jongste JC, van Suijlekom-Smit LWA, Rimmelzwaan GF, Osterhaus ADM, et al. Influenza vaccination in children with asthma: randomized double-blind placebo-controlled trial. Am J Respir Crit Care Med 2004;169(4):488-493.76.Mandelcwajg A, Moulin F, Menager C, Rozenberg F, Lebon P, Gendrel D. Underestimation of influenza viral infection in childhood asthma exacerbations. J Pediatr 2010;157(3):505-506.77.Thumerelle C, Deschildre A, Bouquillon C, Santos C, Sardet A, Scalbert M, et al. Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: A prospective study in the Nord-Pas de Calais region (France). Pediatr Pulmonol 2003;35(2):75-82.78.Vallet C, Pons-Catalano C, Mandelcwajg A, Wang A, Raymond J, Lebon P, et al. Human Bocavirus: A Cause of Severe Asthma Exacerbation in Children. J Pediatr 2009;155(2):286-288.79.Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, et al. Increased H1N1 Infection Rate in Children with Asthma. Am J Respir Crit Care Med 2012;185(12):1275-1279.80.Biscardi S, Lorrot M, Marc E, Moulin F, Boutonnat-Faucher B, Heilbronner C, et al. Mycoplasma pneumoniae and Asthma in Children. Clin Infect Dis 2004;38(10):1341-1346.81.Greenhawt MJ. Influenza vaccination in asthmatic patients. J Allergy Clin Immunol 2014;133(4):1233-1234.e1233.82.O’Flanagan, D, Cotter, S, Mereckiene, J. Seasonal influenza vaccination in EU / EEA, influenza season 2011-12, VENICE II Consortium. 1–67, 2013.83.Centre for Disease Control and Prevention. Prevention and Control of Seasonal Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices — United States 2013–2014. MMWR 2014;62:1-48.84.Public Health England. Influenza: the green book. Immun. against Infect. Dis. 185–218. Public Health England, 2014.85.Esposito S, Marchisio P, Droghetti R, Lambertini L, Faelli N, Bosis S, et al. Influenza vaccination coverage among children with high-risk medical conditions. Vaccine 2006;24(24):5251-5255.86.Jiménez-García R, Hernández-Barrera V, Carrasco-Garrido P, de Andrés AL, de Miguel Diez J, de Miguel ?G. Coverage and Predictors of Adherence to Influenza Vaccination among Spanish Children and Adults with Asthma. Infection 2009;38(1):52-57.87.Lopez-de-Andres A, Carrasco-Garrido P, Hernandez-Barrera V, de Miguel AG, Jimenez-Garcia R. Coverages and factors associated with influenza vaccination among subjects with chronic respiratory diseases in Spain. Eur J Public Health 2008;18(2):173-177.88.Mayo Montero E, Hernández-Barrera V, Carrasco-Garrido P, Gil de Miguel ?, Jiménez-García R. Influenza vaccination among persons with chronic respiratory diseases: Coverage, related factors and time-trend, 1993–2001. Public Health 2007;121(2):113-121.89.Santos-Sancho JM, López-de Andrés A, Jimenez-Trujillo I, Hernández-Barrera V, Carrasco-Garrido P, Astasio-Arbiza P, et al. Adherence and factors associated with influenza vaccination among subjects with asthma in Spain. Infection 2013;41(2):465-471.90.Keenan H, Campbell J, Evans PH. Influenza vaccination in patients with asthma: why is the uptake so low? Br J Gen Pract 2007;57(538):359-363.91.Leo HL, Clark SJ, Butchart AT, Singer DC, Clark NM, Davis MM. 2009 Seasonal and H1N1 influenza vaccination compliance in asthmatic children and adults. J Allergy Clin Immunol 2010;126(1):166-168.92.Vázquez-Fernández del Pozo S, Hernández-Barrera V, Carrasco-Garrido P, Alvarez-Martín E, López-de Andrés A, Gil de Miguel A, et al. Influenza vaccination coverage and related factors among Spanish children. J Infect 2007;54(5):483-489.93.Rance F, Chave C, De Blic J, Deschildre A, Donato L, Dubus J, et al. Low influenza vaccination coverage in asthmatic children in France in 2006-7. Euro Surveillance: European Communicable Disease Bulletin 2008;13(43):23.94.Centre for Disease Control and Prevention. Vaccination Coverage Among Persons with Asthma — United States 2010–2011 Influenza Season. MMWR 2013;62:973–978.95.Dower J, Donald M, Begum N, Vlack S, Ozolins I. Patterns and determinants of influenza and pneumococcal immunisation among adults with chronic disease living in Queensland, Australia. Vaccine 2011;29(16):3031-3037.96.Figaro MK, Belue R. Prevalence of Influenza Vaccination in a High-risk Population. J Ambul Care Manage 2005;28(1):24-29.97.Foty RG, Guttmann A, Kwong JC, Maaten S, Manuel D, Stieb DM, et al. Predictors of universal influenza vaccination uptake in grades 1 and 2 Toronto school children: Effective vaccination strategies should not end with at risk children. Vaccine 2010;28(39):6518-6522.98.Lu P-j, Callahan DB, Ding H, Euler GL. Influenza A (H1N1) 2009 Monovalent Vaccination Among Adults with Asthma, U.S., 2010. Am J Prev Med 2011;41(6):619-626.99.Lu P-j, Euler GL, Callahan DB. Influenza Vaccination Among Adults with Asthma. Am J Prev Med 2009;37(2):109-115.100.Tuppin P, Samson S, Weill A, Ricordeau P, Allemand H. Seasonal influenza vaccination coverage in France during two influenza seasons (2007 and 2008) and during a context of pandemic influenza A(H1N1) in 2009. Vaccine 2011;29(28):4632-4637.101.Vozoris NT, Lougheed MD. Influenza vaccination among Canadians with chronic respiratory disease. Respir Med 2009;103(1):50-58.102.Walter EB, Hellkamp AS, Goldberg KC, Montgomery D, Patterson B, Dolor R. Improving influenza vaccine coverage among asthmatics: a practice-based research network study. JCOM 2008;15(5):227-234.103.Buyuktiryaki B, Soyer OU, Erkocoglu M, Dogan A, Azkur D, Kocabas CN, et al. What a pandemic teaches us about vaccination attitudes of parents of children with asthma. Vaccine 2014;32(20):2275-2280.104.Gnanasekaran SK, Finkelstein JA, Lozano P, Farber HJ, Chi FW, Lieu TA. Influenza Vaccination Among Children With Asthma in Medicaid Managed Care. Ambul Pediatr 2006;6(1):1-7.105.Lyn-Cook R, Halm EA, Wisnivesky JP. Determinants of adherence to influenza vaccination among inner-city adults with persistent asthma. Primary Care Respiratory Journal 2007;16(4):229-235.106.Soyer OU, Hudaverdiyev S, Civelek E, Isik E, Karabulut E, Kocabas C, et al. Parental perspectives on influenza vaccination in children with asthma. Pediatr Pulmonol 2010;46(2):139-144.107.Bueving HJ, Thomas S, Wouden JCvd. Is influenza vaccination in asthma helpful? Curr Opin Allergy Clin Immunol 2005;5(1):65-70.108.Fleming DM, Monto AS. Influenza Vaccination in Children with Asthma. Am J Respir Crit Care Med 2005;171(8):931-931.109.Clark SJ, Cowan AE, Wortley PM. Perspectives of Allergists/Immunologists on the 2009–2010 H1N1 Vaccination Effort. J Asthma 2012;49(2):184-189.110.Dombkowski KJ, Leung SW, Clark SJ. Physician Perspectives Regarding Annual Influenza Vaccination Among Children With Asthma. Ambul Pediatr 2008;8(5):294-299.111.Lopez-de-Andres A, Hernández-Barrera V, Carrasco-Garrido P, Gil-de-Miguel ?, Jiménez-García R. Influenza vaccination coverage among Spanish children, 2006. Public Health 2009;123(7):465-469.112.Paul IM, Eleoff SB, Shaffer ML, Bucher RM, Moyer KM, Gusic ME. Improving Influenza Vaccination Rates for Children Through Year-round Scheduling. Ambul Pediatr 2006;6(4):230-234.113.Teufel RJ, Basco WT, Simpson KN. Cost effectiveness of an inpatient influenza immunization assessment and delivery program for children with asthma. J Hosp Med 2008;3(2):134-141.114.Trogdon JG, Nurmagambetov TA, Thompson HF. The Economic Implications of Influenza Vaccination for Adults with Asthma. Am J Prev Med 2010;39(5):403-410.115.Bae EY, Choi UY, Kwon HJ, Jeong DC, Rhim JW, Ma SH, et al. Immunogenicity and safety of an inactivated trivalent split influenza virus vaccine in young children with recurrent wheezing. Clinical & Vaccine Immunology: CVI 2013;20(6):811-817.116.Pedroza A, Huerta JG, de la Luz Garcia M, Rojas A, López-Martínez I, Penagos M, et al. The safety and immunogenicity of influenza vaccine in children with asthma in Mexico. Int J Infect Dis 2009;13(4):469-475.117.Zuccotti G, Amendola A, Vigano A, Pariani E, Zappa A, Pogliani L, et al. Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma. Vaccine 2007;25(37-38):6692-6698.118.Busse WW, Peters SP, Fenton MJ, Mitchell H, Bleecker ER, Castro M, et al. Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine. J Allergy Clin Immunol 2011;127(1):130-137, 137.e131-133.119.Abadoglu O, Mungan D, Pasaoglu G, Celik G, Misirligil Z. Influenza vaccination in patients with asthma: effect on the frequency of upper respiratory tract infections and exacerbations. J Asthma 2004;41(3):279-283.120.Bueving HJ, van der Wouden JC, Raat H, Bernsen RM, de Jongste JC, van Suijlekom-Smit LW, et al. Influenza vaccination in asthmatic children: effects on quality of life and symptoms. Eur Respir J 2004;24(6):925-931.121.Fayyaz Jahani F, Karramyyar M, Ahmadnezhad E. Inactivated-trivalent influenza vaccination in asthmatic under-5 children: A randomized double-blind placebo trial. Arch Dis Child 2012;97:A516.122.Fleming DM, Crovari P, Wahn U, Klemola T, Schlesinger Y, Langussis A, et al. Comparison of the efficacy and safety of live attenuated cold-adapted influenza vaccine, trivalent, with trivalent inactivated influenza virus vaccine in children and adolescents with asthma. Pediatr Infect Dis J 2006;25(10):860-869.123.Ashkenazi S, Vertruyen A, Aristegui J, Esposito S, McKeith DD, Klemola T, et al. Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. Pediatr Infect Dis J 2006;25(10):870-879.124.Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, et al. Live attenuated versus inactivated influenza vaccine in infants and young children. N Engl J Med 2007;356(7):685-696.125.Ambrose CS, Dubovsky F, Yi T, Belshe RB, Ashkenazi S. The safety and efficacy of live attenuated influenza vaccine in young children with asthma or prior wheezing. Eur J Clin Microbiol Infect Dis 2012;31(10):2549-2557.126.Koshio N, Hasegawa T, Suzuki K, Tanabe Y, Koya T, Sakagami T, et al. Analysis of the influenza A (H1N1) 2009 pandemic infection in Japanese asthmatic patients: using a questionnaire-based survey. Allergology International 2014;63(1):67-74.127.Kramarz P, Destefano F, Gargiullo PM, Chen RT, Lieu TA, Davis RL, et al. Does influenza vaccination prevent asthma exacerbations in children? J Pediatr 2001;138(3):306-310.128.Smits AJ, Hak E, Stalman WAB, van Essen GA, Hoes AW, Verheij TJM. Clinical effectiveness of conventional influenza vaccination in asthmatic children. Epidemiol Infect 2002;128(2):205-211.129.Ong BA, Forester J, Fallot A. Does influenza vaccination improve pediatric asthma outcomes? J Asthma 2009;46(5):477-480.130.Hak E. Clinical Effectiveness of Influenza Vaccination in Persons Younger Than 65 Years With High-Risk Medical Conditions. Arch Intern Med 2005;165(3):274.131.Christy C, Aligne C, Auinger P, Pulcino T, Weitzman M. Effectiveness of influenza vaccine for the prevention of asthma exacerbations. Arch Dis Child 2004;89(8):734-735.132.Herrera GA, Iwane MK, Cortese M, Brown C, Gershman K, Shupe A, et al. Influenza vaccine effectiveness among 50–64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003–2004. Vaccine 2007;25(1):154-160.133.Vasiliou E. et al Effectiveness of influenza vaccines in asthma: a systematic review and meta-analysis. Clin Infect Dis. In press.134.Castro M, Dozor A, Fish J, Irvin C, Scharf S, Scheipeter ME, et al. The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med 2001;345(21):1529-1536.135.Baxter R, Toback SL, Sifakis F, Hansen J, Bartlett J, Aukes L, et al. A postmarketing evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 5 through 17 years of age. Vaccine 2012;30(19):2989-2998.136.Gaglani MJ, Piedra PA, Riggs M, Herschler G, Fewlass C, Glezen WP. Safety of the intranasal, trivalent, live attenuated influenza vaccine (LAIV) in children with intermittent wheezing in an open-label field trial. Pediatr Infect Dis J 2008;27(5):444-452.137.Miller RL, Cheng M, DiMango EA, Geromanos K, Rothman PB, American Lung Association Asthma Clinical Research C. T-cell responses and hypersensitivity to influenza and egg antigens among adults with asthma immunized with the influenza vaccine. J Allergy Clin Immunol 2003;112(3):606-608.138.Chung EY, Huang L, Schneider L. Safety of influenza vaccine administration in egg-allergic patients. Pediatrics 2010;125(5):e1024-e1030.139.Gagnon R, Primeau MN, Des Roches A, Lemire C, Kagan R, Carr S, et al. Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine. J Allergy Clin Immunol 2010;126(2):317-323.140.Greenhawt MJ, Spergel JM, Rank MA, Green TD, Masnoor D, Sharma H, et al. Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy. Annals of Allergy, Asthma & Immunology 2012;109(6):426-430.141.Howe LE, Conlon ASC, Greenhawt MJ, Sanders GM. Safe administration of seasonal influenza vaccine to children with egg allergy of all severities. Annals of Allergy, Asthma and Immunology 2011;106(5):446-447.142.Esposito S, Gasparini C, Martelli A, Zenga A, Tremolati E, Varin E, et al. Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy. Vaccine 2008;26(36):4664-4668.143.Greenhawt MJ, Chernin AS, Howe L, Li JT, Sanders G. The safety of the H1N1 influenza A vaccine in egg allergic individuals. Annals of Allergy, Asthma & Immunology 2010;105(5):387-393.144.Turner PJ, Southern J, Andrews NJ, Miller E, Erlewyn-Lajeunesse M. Safety of live attenuated influenza vaccine in young people with egg allergy: multicentre prospective cohort study. BMJ 2015:h6291.145.Turner PJ, Southern J, Andrews NJ, Miller E, Erlewyn-Lajeunesse M, Investigators SS. Safety of live attenuated influenza vaccine in atopic children with egg allergy. J Allergy Clin Immunol 2015;136(2):376-381.146.The Green Book- Immunisation against infectious disease. Chapter 19 – Influenza, 2014. LA, Sokolow LZ, Olsen SJ, Bresee JS, Broder KR, Karron RA. Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on immunization practices, United States, 2015-16 influenza season. MMWR Morb Mortal Wkly Rep 2015;64(30):818-825.148.An Advisory Committee Statement (ACS) National Advisory Committee on Immunization (NACI). Statement on Seasonal Influenza Vaccine for 2014-2015. 's flu vaccine. National Health System (NHS) website: RA, Geddes D, Woodhead M. Management of influenza in patients with asthma or chronic obstructive pulmonary disease. Annals of Allergy, Asthma & Immunology 2001;87(6):447-454.151.Aoki FY, Allen UD, Stiver HG, Evans GA. The use of antiviral drugs for influenza: A foundation document for practitioners. Canadian Journal of Infectious Diseases and Medical Microbiology 2013;24(3):1C-15C.152.Aoki FY, Allen UD, Stiver HG, Evans GA. The Use of Antiviral Drugs for Influenza: Guidance for Practitioners 2012/2013. Canadian Journal of Infectious Diseases and Medical Microbiology 2012;23(4):e79-e92.153.Rank MA, Li JT. Clinical pearls for preventing, diagnosing, and treating seasonal and 2009 H1N1 influenza infection in patients with asthma. J Allergy Clin Immunol 2009;124(5):1123-1126.154.Sandrock CE, Norris A. Infection in Severe Asthma Exacerbations and Critical Asthma Syndrome. Clin Rev Allergy Immunol 2014;48(1):104-113.155.McNicholl IR, McNicholl JJ. Neuraminidase inhibitors: Zanamivir and oseltamivir. Ann Pharmacother 2001;35(1):57-70.156.Lin JT, Yu XZ, Cui DJ, Chen XY, Zhu JH, Wang YZ, et al. A multicentre, randomized, controlled trial of oseltamivir in the treatment of influenza in a high-risk Chinese population. Curr Med Res Opin 2006;22(1):75-82.157.Williamson JC, Pegram PS. Neuraminidase inhibitors in patients with underlying airways disease. Am J Respir Med 2002;1(2):85-90.158.Dutkowski R. Oseltamivir in seasonal influenza: cumulative experience in low- and high-risk patients. J Antimicrob Chemother 2010;65(Supplement 2):ii11-ii24.159.Biggerstaff M, Jhung MA, Reed C, Fry AM, Balluz L, Finelli L. Influenza-like illness, the time to seek healthcare, and influenza antiviral receipt during the 2010-2011 influenza season-United States. J Infect Dis 2014;210(4):535-544.160.Cass LM, Gunawardena KA, Macmahon MM, Bye A. Pulmonary function and airway responsiveness in mild to moderate asthmatics given repeated inhaled doses of zanamivir. Respir Med 2000;94(2):166-173.161.Gravenstein S, Johnston SL, Loeschel E, Webster A. Zanamivir: a review of clinical safety in individuals at high risk of developing influenza-related complications. Drug Saf 2001;24(15):1113-1125.162.Johnston SL, Ferrero F, Garcia ML, Dutkowski R. Oral oseltamivir improves pulmonary function and reduces exacerbation frequency for influenza-infected children with asthma. Pediatr Infect Dis J 2005;24(3):225-232.163.Shun-Shin M, Thompson M, Heneghan C, Perera R, Hamden A, Mant D. Neuraminidase inhibitors for treatment and prophylaxis of influenza in children: Systematic review and meta-analysis of randomised controlled trials. BMJ (Online) 2009;339(7718):449.164.Jefferson T, Jones M, Doshi P, Spencer EA, Onakpoya I, Heneghan CJ. Oseltamivir for influenza in adults and children: Systematic review of clinical study reports and summary of regulatory comments. BMJ (Online) 2014;348(g2545).165.Jefferson T, Jones MA, Doshi P, Del Mar CB, Hama R, Thompson MJ, et al. Neuraminidase inhibitors for preventing and treating influenza in healthy adults and children. Cochrane Database of Systematic Reviews 2014;4:CD008965.166.Kohno S, Kida H, Mizuguchi M, Hirotsu N, Ishida T, Kadota J, et al. Intravenous Peramivir for Treatment of Influenza A and B Virus Infection in High-Risk Patients. Antimicrob Agents Chemother 2011;55(6):2803-2812.167.Watanabe A. A randomized double-blind controlled study of laninamivir compared with oseltamivir for the treatment of influenza in patients with chronic respiratory diseases. Journal of Infection and Chemotherapy 2013;19(1):89-97.168.Chacon R, Mirza S, Rodriguez D, Paredes A, Guzman G, Moreno L, et al. Demographic and clinical characteristics of deaths associated with influenza A (H1N1) pdm09 in Central America and Dominican Republic 2009–2010. BMC Public Health 2015;15(1):734.169.Hagerman A, Posfay Barbe KM, Duppenthaler A, Heininger U, Berger C, The PISG. Clinical characteristics and outcomes in children hospitalised with pandemic influenza A/H1N1/09 virus infection–a nationwide survey by the Pediatric Infectious Diseases Group of Switzerland. Swiss Med Wkly 2015;145:w14171.170.Kwon J-M, Shim JW, Kim DS, Jung HL, Park MS, Shim JY. Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations. Korean J Pediatr 2014;57(1):29-34.171.Park YB, Yoo KHA, Hwang YI, Lee WY, Lee CL. Asthma and severity of the 2009 novel H1N1 influenza: A case-control study. Respirology 2013;18:152.172.Placzek HE, Madoff LC. Association of age and comorbidity on 2009 influenza A pandemic H1N1-related intensive care unit stay in Massachusetts. Am J Public Health 2014;104(11):e118-e125.173.Stripeli F, Logotheti I, Vraila VM, Balta C, Patsioura A, Papaevangelou V, et al. Pandemic influenza A vs seasonal influenza A in hospitalized children in Athens. Paediatrics and International Child Health 2015;35(1):61-64.174.Tam K, Yousey-Hindes K, Hadler JL. Influenza-related hospitalization of adults associated with low census tract socioeconomic status and female sex in New Haven County, Connecticut, 2007-2011. Influenza Other Respir Viruses 2014;8(3):274-281.175.Grohskopf LA, Olsen SJ, Sokolow LZ, Bresee JS, Cox NJ, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP)—United States, 2014–15 influenza season. MMWR Morb Mortal Wkly Rep 2014;63(32):691-697.176.Byington CL, Barnett ED, Davies HD, Edwards KM, Jackson MA, Maldonado YA, et al. Recommendations for Prevention and Control of Influenza in Children, 2014–2015. Pediatrics 2014;134(5):e1503-e1519.177.Pennant KN, Costa JJ, Fuhlbrigge AL, Sax PE, Szent-Gyorgyi LE, Coblyn J, et al. Improving Influenza and Pneumococcal Vaccination Rates in Ambulatory Specialty Practices. In: Open forum infectious diseases; 2015: Oxford University Press; 2015. p. ofv119.178.Gnatiuc L, Buist AS, Kato B, Janson C, Ait-Khaled N, Nielsen R, et al. Gaps in using bronchodilators, inhaled corticosteroids and influenza vaccine among 23 high- and low-income sites. Int J Tuberc Lung Dis 2015;19(1):21-30.179.Vernacchio L, Francis ME, Epstein DM, Santangelo J, Trudell EK, Reynolds ME, et al. Effectiveness of an asthma quality improvement program designed for maintenance of certification. Pediatrics 2014;134(1):e242-e248.180.Blackwell DL. Modeling receipt of influenza A(H1N1)pdm09 vaccinations among US children during the 2009-2010 flu season: Findings from the 2010 National Health Interview Survey. Med Care 2015;53(2):191-198.181.Aigbogun N, Hawker J, Stewart A. Interventions to increase influenza vaccination rates in children with high-risk conditions—A systematic review. Vaccine 2015;33(6):759-770.182.Mazurek JM, White GE, Moorman JE, Storey E. Influenza Vaccination Among Persons with Work-Related Asthma. Am J Prev Med 2014;47(2):203-211.183.O’Halloran AC, Lu P-j, Williams WW, Bridges CB, Singleton JA. Influenza Vaccination Coverage Among People With High-Risk Conditions in the US. Am J Prev Med 2016;50(e15-e26).184.Lin CJ, Nowalk MP, Zimmerman RK, Moehling KK, Conti T, Allred NJ, et al. Reducing Racial Disparities in Influenza Vaccination Among Children With Asthma. J Pediatr Health Care 2016;30(3):208-215.185.Shoup JA, Madrid C, Koehler C, Lamb C, Ellis J, Ritzwoller DP. Effectiveness and cost of influenza vaccine reminders for adults with asthma or chronic obstructive pulmonary disease. Am J Manag Care 2015;21(7):e405-413.186.Skupin MK, Havstad S, Wegienka GR, Nageotte CG. Factors associated with rates of influenza vaccination in allergy and primary care clinics. J Allergy Clin Immunol 2015;1:AB237.187.Hart RJ, Stevenson MD, Levine AJ, Bryant KA, Sikes KL, Paul RI. Assessing Intent and Willingness to Immunize Children Against Influenza in the Pediatric Emergency Department. Presented at the Southern Regional Meeting, New Orleans, 2014.188.Lo H-y. Improving Influenza Vaccination Rates for Asthma Patients Admitted to Pediatric Hospital Medicine. In: 2014 AAP National Conference and Exhibition: American Academy of Pediatrics.189.Regan A. The use of electronic health record data extraction for estimating influenza vaccination coverage and effectiveness. In: The 20th IEA World Congress of Epidemiology (17-21 August 2014, Anchorage, AK); 2014: WCE; 2014.190.Jaiwong C, Ngamphaiboon J. Effects of inactivated influenza vaccine on respiratory illnesses and asthma-related events in children with mild persistent asthma in Asia. Asian Pac J Allergy Immunol 2015;33(1):3.191.Yokouchi Y, Katsumori H, Shirakawa S, Fujiwara M, Kashima K, Kozawa R, et al. Protective effects of influenza A (H1N1) pandemic 2009 vaccination against the onset of influenza-like illness and asthma exacerbation in Japanese children. Journal of Asthma: Official Journal of the Association for the Care of Asthma 2014;51(8):825-831.192.Haber P, Moro PL, Cano M, Lewis P, Stewart B, Shimabukuro TT. Post-licensure surveillance of quadrivalent live attenuated influenza vaccine United States, Vaccine Adverse Event Reporting System (VAERS), July 2013-June 2014. Vaccine 2015;33(16):1987-1992.193.Biggerstaff M, Jhung M, Reed C, Garg S, Balluz L, Fry A, et al. Impact of medical and behavioural factors on influenza-like illness, healthcare-seeking, and antiviral treatment during the 2009 H1N1 pandemic: USA, 2009–2010. Epidemiol Infect 2014;142(01):114-125.AcknowledgementsWe thank Dr Ron Hogg (OmniScience SA, Geneva, Switzerland) for his excellent medical writing services and ADME Osterhaus (affiliation) for his endorsement of this review as the chair of the European Scientific Working group on Influenza (ESWI). The work was supported by the European Academy of Allergy and Clinical Immunology (EAACI).Author contributionsAll authors are members of the EAACI Influenza and Asthma Task Force. Skevaki and Schwarze conceived and designed the study. Aziz Sheikh developed the search protocol. Ather Akhlaq, Ulugbek Nurmatov performed the systematic literature search, reviewed and selected the relevant publications. All authors except the former three performed data extraction, compiled the summary tables, contributed to interpretation of results and contributed to writing the first draft of the manuscript, which was reviewed by Skevaki and Schwarze and then revised by all authors. All authors approved the final version of the manuscript.Table 1. Studies included in the systematic review, by sectionSection 2a. Influenza-attributable health care utilization in asthma patients Authors, YearCountryStudy PeriodType of studyInterventionOutcome measureKey findingPopulation characteristicsLimitations/ commentsChacon et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Chacon</Author><Year>2015</Year><RecNum>1</RecNum><DisplayText>(168)</DisplayText><record><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chacon, Rafael</author><author>Mirza, Sara</author><author>Rodriguez, David</author><author>Paredes, Antonio</author><author>Guzman, Giselle</author><author>Moreno, Lourdes</author><author>Then, Cecilia J</author><author>Jara, Jorge</author><author>Blanco, Natalia</author><author>Bonilla, Luis</author></authors></contributors><titles><title>Demographic and clinical characteristics of deaths associated with influenza A (H1N1) pdm09 in Central America and Dominican Republic 2009–2010</title><secondary-title>BMC public health</secondary-title></titles><periodical><full-title>BMC Public Health</full-title><abbr-1>BMC Public Health</abbr-1><abbr-2>BMC Public Health</abbr-2></periodical><pages>734</pages><volume>15</volume><number>1</number><dates><year>2015</year></dates><isbn>1471-2458</isbn><urls></urls></record></Cite></EndNote>(168)Guatemala May 2009 - June 2010Epidemiological retrospective studyNADemographic and clinical characteristics of deaths associated with influenza A (H1N1) pdm09.History of Asthma in 11% of the 112 dead patients with a pre-existing medical condition (7% children < 5 years, 11% people aged 5-59, 16% people aged 60+ and 18% of the 14 dead pregnant or postpartum women)183 children and adults aged 0-60+ years. SARI decedents who tested positive for influenza.Study performed in seven Central America Countries.Dawood et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXdvb2Q8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXdvb2Q8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (43)USA2003-2009 (seasonal)2009-2010 (H1N1)Epidemiological retrospective, population-based studyNAFrequency and severity of influenza complications in hospitalized children.History of asthma in 31% of children hospitalized for seasonal influenza vs. 42% in children hospitalized for influenza A (H1N1).Asthma exacerbation as a complication in 27% of children with influenza A vs. 18% in children with seasonal influenza (overall, 22% of total).6769 children and adolescents aged <18 years hospitalized for both seasonal and H1N1 influenza.Hagerman et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Hagerman</Author><Year>2015</Year><RecNum>3</RecNum><DisplayText>(169)</DisplayText><record><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">3</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hagerman, Andrés</author><author>Posfay Barbe, Klara Maria</author><author>Duppenthaler, Andrea</author><author>Heininger, Ulrich</author><author>Berger, Christoph</author><author>The, Pigs Influenza Study Group</author></authors></contributors><titles><title>Clinical characteristics and outcomes in children hospitalised with pandemic influenza A/H1N1/09 virus infection–a nationwide survey by the Pediatric Infectious Diseases Group of Switzerland</title><secondary-title>Swiss medical weekly</secondary-title></titles><periodical><full-title>Swiss Medical Weekly</full-title><abbr-1>Swiss Med. Wkly.</abbr-1><abbr-2>Swiss Med Wkly</abbr-2></periodical><pages>w14171</pages><volume>145</volume><dates><year>2015</year></dates><isbn>1424-7860</isbn><urls></urls></record></Cite></EndNote>(169)SwitzerlandJune 2009 - Jan 2010Prospective/ retrospective study performed in 11 hospitalsNAClinical characteristics of the influenza-hospitalized children.Asthma 12% among the comorbidities of the 126 influenza-hospitalized children.326 patients aged ≤18 years (189 <5 years; 126 with comorbidities hospitalized in eleven children’s hospitals in Switzerland with a positive influenza A/H1N1/09 RT-PCR from a nasopharyngeal specimen.Study performed in 11 hospitals in Switzerland.Jiang et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Jiang</Author><Year>2015</Year><RecNum>4</RecNum><DisplayText>(65)</DisplayText><record><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jiang, H</author><author>Yu, D</author><author>Ruan, F</author><author>Xu, W</author><author>Huang, T</author><author>Li, L</author><author>Wang, K</author><author>Liu, S</author><author>Zhang, H</author><author>Jia, P</author></authors></contributors><titles><title>Clinical characteristics of adult influenza inpatients in ten provinces in China and analysis of severe risk factors</title><secondary-title>Zhonghua liuxingbingxue zazhi</secondary-title></titles><pages>216-221</pages><volume>36</volume><number>3</number><dates><year>2015</year></dates><isbn>0254-6450</isbn><urls></urls></record></Cite></EndNote>(65)ChinaDec 2008 - June 2014Epidemiological retrospective studyNAClinical characteristics and severe case risk factors for adult inpatient cases of confirmed influenza. Out of the 240 (7.8%) cases of laboratory-confirmed influenza, (H1N, pdm2009 and H3N2), asthma was the most important risk factor for severe cases (RR = 15.200, 95% CI: 1.157-199.633).240 adults aged ≥15 years consistent with?SARI?case definition who were monitored by?SARI?sentinel hospitals in ten cities in China.Data extrapolated from abstract in English. Study performed in ten provinces of China.Kwon et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Kwon</Author><Year>2014</Year><RecNum>5</RecNum><DisplayText>(170)</DisplayText><record><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kwon, Jang-Mi</author><author>Shim, Jae Won</author><author>Kim, Deok Soo</author><author>Jung, Hye Lim</author><author>Park, Moon Soo</author><author>Shim, Jung Yeon</author></authors></contributors><titles><title>Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations</title><secondary-title>Korean journal of pediatrics</secondary-title></titles><periodical><full-title>Korean Journal of Pediatrics</full-title><abbr-1>Korean J. Pediatr.</abbr-1><abbr-2>Korean J Pediatr</abbr-2></periodical><pages>29-34</pages><volume>57</volume><number>1</number><dates><year>2014</year></dates><isbn>1738-1061</isbn><urls></urls></record></Cite></EndNote>(170)South KoreaMay 2010 -Apr 2011Retrospective studyNAPrevalence of year-round respiratory viral infection in children with LRTI and the relationship between respiratory viral infection and allergen sensitization in exacerbating asthma.Influenza virus was detected in 7 (25%) of the 28 asthma patients hospitalized for asthma exacerbation.18 asthmatics (64.3%) had atopic sensitization.Influenza virus responsible for asthma exacerbations with an OR 11.9 (1.5-90.4) for atopic asthma), 0.9 (0.1-12.3) for non-atopic asthma, 4.0 (1.2-13.8) for asthma in general.309 children (median age 26 months) who were hospitalized for acute LRTIs (pneumonia, bronchitis, bronchiolitis or asthma).Park et al. 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYXJrPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (171)South KoreaJan - Dec 2009Multi-site case-control studyNAAssociation of asthma status and severity of H1N1 influenza in adults.Of the 91 cases, 12(13%) and 3 of 54 controls (5%) were asthmatics (p=NS); of those without other comorbidities except asthma, 8 of 56 cases (14%) and 2 of 49 (4%) controls had asthma (p=NS).91 cases (47.3±21.1 years) with a positive PCR for H1N1 influenza and were admitted to the ICU or general ward with a diagnosis of H1N1 influenza.56 controls (45.0±20.6 years) with a positive PCR for H1N1 influenza, but were not admitted to hospitals.Placzek et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Placzek</Author><Year>2014</Year><RecNum>7</RecNum><DisplayText>(172)</DisplayText><record><rec-number>7</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">7</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Placzek, Hilary ED</author><author>Madoff, Lawrence C</author></authors></contributors><titles><title>Association of age and comorbidity on 2009 influenza A pandemic H1N1-related intensive care unit stay in Massachusetts</title><secondary-title>American journal of public health</secondary-title></titles><periodical><full-title>American Journal of Public Health</full-title><abbr-1>Am. J. Public Health</abbr-1><abbr-2>Am J Public Health</abbr-2></periodical><pages>e118-e125</pages><volume>104</volume><number>11</number><dates><year>2014</year></dates><isbn>1541-0048</isbn><urls></urls></record></Cite></EndNote>(172)USAOct 2008 - Apr 2009 (seasonal influenza)Apr 2009 -Sept 2009 (H1N1)Epidemiological retrospective studyNAAssociation of age and comorbidity on 2008-2009 seasonal influenza and 2009 Influenza A (H1N1)-related ICU stay.Asthma was the most prevalent risk factor for hospitalization, occurring in 28% (n=148) of the pH1N1 population, and 24% (n=174) of those with seasonal influenza.1254 children and adults aged <5-64 years with seasonal and H1N1 influenza admitted to an ICU.Stripeli et al. 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdHJpcGVsaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdHJpcGVsaTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+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ADDIN EN.CITE.DATA (173)GreeceOct 2009 - Feb 2010 andJan 2011 - May 2011 (pH1N1)2002 -2003 and 2004 -2005 (Influenza A)Epidemiological retrospective studyNAEpidemiological and clinical characteristics of children hospitalized with pH1N1 compared with those of children hospitalized with seasonal influenza A in previous years.Asthma was the most common underlying illness in both cohorts, but it was considerably more prevalent in the seasonal influenza group (19% vs. 7%; P=0.048).146 children with pH1N1 aged 0-14 years and 138 children with seasonal influenza aged 6 months-14 years who were hospitalized for both pH1N1 and influenza A.Taha 2014 ADDIN EN.CITE <EndNote><Cite><Author>Taha</Author><Year>2014</Year><RecNum>9</RecNum><DisplayText>(51)</DisplayText><record><rec-number>9</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">9</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Taha, Inass</author></authors></contributors><titles><title>Characteristics of pregnant Women admitted with 2009 H1N1 Influenza in a referral maternity hospital at Al-Madinah, Saudi Arabia</title><secondary-title>Egyptian Journal of Hospital Medicine (July 2013)</secondary-title></titles><pages>650-657</pages><volume>52</volume><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>(51)Saudi ArabiaJune 2009 - Feb 2010Retrospective cohort studyNACharacteristics of pregnant Women admitted with 2009 H1N1 Influenza in a referral maternity hospital.Bronchial asthma was present in 15 (45.5%) of pregnant women admitted with influenza.33 pregnant women; mean age 27.7±5.6 years.Tam et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYW08L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYW08L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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 EN.CITE.DATA (174)USA2007-2011Retrospective population-based study (chart reviews) NAInfluenza-related hospitalization of adults associated with low census tract, socioeconomic status and female sex.Asthma was increasingly prevalent among cases with progressively higher census tract poverty status (16.4% in low poverty vs. 37.7% in high poverty).Females overall and in each age group were more likely to have asthma (overall, 27.6% vs. 16.7%; P<0.001).1094 hospitalized adults aged 18-65+ years with laboratory-confirmed influenza.ICU intensive care unit; NS not significant; LRTI lower respiratory tract infection; RR risk ratio; CI confidence interval; OR odds ratio; RT-PCR reverse transcriptase polymerase chain reaction; SARI severe acute respiratory infection.Section 2b. Influenza-induced acute asthma exacerbationsAuthors, YearCountryStudy PeriodType of studyInterventionOutcome measureKey finding (absolute number of positive samples)Population characteristicsLimitations/ comments*CHILDRENAzevedo et al. 2003 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BemV2ZWRvPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE.DATA (69)BrazilNDRetrospective NALaboratory confirmed IFV/ culture and IFA0.0% (0)36 children aged 2-14 yearsThumerelle et al. 2003 ADDIN EN.CITE <EndNote><Cite><Author>Thumerelle</Author><Year>2003</Year><RecNum>154</RecNum><DisplayText>(77)</DisplayText><record><rec-number>154</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">154</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Thumerelle, C.</author><author>Deschildre, A.</author><author>Bouquillon, C.</author><author>Santos, C.</author><author>Sardet, A.</author><author>Scalbert, M.</author><author>Delbecque, L.</author><author>Debray, P.</author><author>Dewilde, A.</author><author>Turck, D.</author><author>Leclerc, F.</author></authors></contributors><titles><title>Role of viruses and atypical bacteria in exacerbations of asthma in hospitalized children: A prospective study in the Nord-Pas de Calais region (France)</title><secondary-title>Pediatric Pulmonology</secondary-title></titles><periodical><full-title>Pediatric Pulmonology</full-title><abbr-1>Pediatr. Pulmonol.</abbr-1><abbr-2>Pediatr Pulmonol</abbr-2></periodical><pages>75-82</pages><volume>35</volume><number>2</number><dates><year>2003</year><pub-dates><date>2003/01/13</date></pub-dates></dates><publisher>Wiley-Blackwell</publisher><isbn>8755-6863
1099-0496</isbn><urls><related-urls><url>;(77)France 1 Oct 1998 - 30 June 1999ProspectiveNALaboratory confirmed IFV/IFA, serology or both 3.6% (3) 82 inpatients aged 2-16 yearsBiscardi et al. 2004 ADDIN EN.CITE <EndNote><Cite><Author>Biscardi</Author><Year>2004</Year><RecNum>155</RecNum><DisplayText>(80)</DisplayText><record><rec-number>155</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">155</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Biscardi, S.</author><author>Lorrot, M.</author><author>Marc, E.</author><author>Moulin, F.</author><author>Boutonnat-Faucher, B.</author><author>Heilbronner, C.</author><author>Iniguez, J. L.</author><author>Chaussain, M.</author><author>Nicand, E.</author><author>Raymond, J.</author><author>Gendrel, D.</author></authors></contributors><titles><title>Mycoplasma pneumoniae and Asthma in Children</title><secondary-title>Clinical Infectious Diseases</secondary-title></titles><periodical><full-title>Clinical Infectious Diseases</full-title><abbr-1>Clin. Infect. Dis.</abbr-1><abbr-2>Clin Infect Dis</abbr-2></periodical><pages>1341-1346</pages><volume>38</volume><number>10</number><dates><year>2004</year><pub-dates><date>2004/05/15</date></pub-dates></dates><publisher>Oxford University Press (OUP)</publisher><isbn>1058-4838
1537-6591</isbn><urls><related-urls><url>;(80)France1 Jan 1999 - 30 June 2001ProspectiveNALaboratory confirmed IFV/culture and IFA 3.4% (4)119 inpatients aged 2-15 years0.0% (0)51 first episode (initial asthma)Bueving et al. 2004 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (75)Netherlands1999-2001Double-blind, randomized, placebo-controlled trialInactivated influenza vaccine vs placeboLaboratory confirmed IFV/ culture, IFA and RT-PCR 7.2% (17)235 children aged 6-18 yearsLow number of IFV positive samples in first season-compensated by recruitment of higher number of subjects in second seasonJohnston et al. 2005 ADDIN EN.CITE <EndNote><Cite><Author>Johnston</Author><Year>2005</Year><RecNum>157</RecNum><DisplayText>(73)</DisplayText><record><rec-number>157</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">157</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Johnston, Neil W.</author><author>Johnston, Sebastian L.</author><author>Duncan, Joanne M.</author><author>Greene, Justina M.</author><author>Kebadze, Tatiana</author><author>Keith, Paul K.</author><author>Roy, Madan</author><author>Waserman, Susan</author><author>Sears, Malcolm R.</author></authors></contributors><titles><title>The September epidemic of asthma exacerbations in children: A search for etiology</title><secondary-title>Journal of Allergy and Clinical Immunology</secondary-title></titles><periodical><full-title>Journal of Allergy and Clinical Immunology</full-title><abbr-1>J. Allergy Clin. Immunol.</abbr-1><abbr-2>J Allergy Clin Immunol</abbr-2><abbr-3>Journal of Allergy & Clinical Immunology</abbr-3></periodical><pages>132-138</pages><volume>115</volume><number>1</number><dates><year>2005</year><pub-dates><date>2005/01</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0091-6749</isbn><urls><related-urls><url>;(73)Canada10-30 Sept 2001ProspectiveNALaboratory confirmed IFV/PCR 0.0% (0) 52 children aged 5-15 yearsKetsuriani et al. 2007 ADDIN EN.CITE <EndNote><Cite><Author>Khetsuriani</Author><Year>2007</Year><RecNum>158</RecNum><DisplayText>(74)</DisplayText><record><rec-number>158</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">158</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Khetsuriani, Nino</author><author>Kazerouni, N. Neely</author><author>Erdman, Dean D.</author><author>Lu, Xiaoyan</author><author>Redd, Stephen C.</author><author>Anderson, Larry J.</author><author>Teague, W. Gerald</author></authors></contributors><titles><title>Prevalence of viral respiratory tract infections in children with asthma</title><secondary-title>Journal of Allergy and Clinical Immunology</secondary-title></titles><periodical><full-title>Journal of Allergy and Clinical Immunology</full-title><abbr-1>J. Allergy Clin. Immunol.</abbr-1><abbr-2>J Allergy Clin Immunol</abbr-2><abbr-3>Journal of Allergy & Clinical Immunology</abbr-3></periodical><pages>314-321</pages><volume>119</volume><number>2</number><dates><year>2007</year><pub-dates><date>2007/02</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0091-6749</isbn><urls><related-urls><url>;(74)USAMar 2003 - Feb 2004 ProspectiveNALaboratory confirmed IFV/PCR 0.0% (0) 65 children aged 2-17 yearsModest sample sizeMiller et al. 2008 ADDIN EN.CITE <EndNote><Cite><Author>Miller</Author><Year>2008</Year><RecNum>116</RecNum><DisplayText>(57)</DisplayText><record><rec-number>116</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209720">116</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Miller, E Kathryn</author><author>Griffin, Marie R</author><author>Edwards, Kathryn M</author><author>Weinberg, Geoffrey A</author><author>Szilagyi, Peter G</author><author>Staat, Mary A</author><author>Iwane, Marika K</author><author>Zhu, Yuwei</author><author>Hall, Caroline B</author><author>Fairbrother, Gerry</author></authors></contributors><titles><title>Influenza burden for children with asthma</title><secondary-title>Pediatrics</secondary-title></titles><periodical><full-title>Pediatrics</full-title><abbr-1>Pediatrics</abbr-1><abbr-2>Pediatrics</abbr-2></periodical><pages>1-8</pages><volume>121</volume><number>1</number><dates><year>2008</year></dates><isbn>0031-4005</isbn><urls></urls></record></Cite></EndNote>(57)USA2002-2004Prospective NALaboratory confirmed IFV/PCR or culture15.5% (38) 245 outpatients3.7% (19) 513 inpatients aged 6-59 months Vallet et al. 2009 ADDIN EN.CITE <EndNote><Cite><Author>Vallet</Author><Year>2009</Year><RecNum>160</RecNum><DisplayText>(78)</DisplayText><record><rec-number>160</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">160</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vallet, Christelle</author><author>Pons-Catalano, Charlotte</author><author>Mandelcwajg, Alexis</author><author>Wang, Andrew</author><author>Raymond, Josette</author><author>Lebon, Pierre</author><author>Gendrel, Dominique</author></authors></contributors><titles><title>Human Bocavirus: A Cause of Severe Asthma Exacerbation in Children</title><secondary-title>Journal of Pediatrics</secondary-title></titles><periodical><full-title>Journal of Pediatrics</full-title><abbr-1>J. Pediatr.</abbr-1><abbr-2>J Pediatr</abbr-2></periodical><pages>286-288</pages><volume>155</volume><number>2</number><dates><year>2009</year><pub-dates><date>2009/08</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0022-3476</isbn><urls><related-urls><url>;(78)France1 Oct 2005 - 30 Nov 2007ProspectiveNALaboratory confirmed IFV/IFA 2.4% (4) 166 inpatients aged 2-15 yearsKwon et al. 2013 ADDIN EN.CITE <EndNote><Cite><Author>Kwon</Author><Year>2014</Year><RecNum>5</RecNum><DisplayText>(170)</DisplayText><record><rec-number>5</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">5</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kwon, Jang-Mi</author><author>Shim, Jae Won</author><author>Kim, Deok Soo</author><author>Jung, Hye Lim</author><author>Park, Moon Soo</author><author>Shim, Jung Yeon</author></authors></contributors><titles><title>Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations</title><secondary-title>Korean journal of pediatrics</secondary-title></titles><periodical><full-title>Korean Journal of Pediatrics</full-title><abbr-1>Korean J. Pediatr.</abbr-1><abbr-2>Korean J Pediatr</abbr-2></periodical><pages>29-34</pages><volume>57</volume><number>1</number><dates><year>2014</year></dates><isbn>1738-1061</isbn><urls></urls></record></Cite></EndNote>(170)KoreaApr 2010 -Apr 2011ProspectiveNALaboratory confirmed IFV/RT-PCR25.0% (7)28 inpatients aged 60±34 months (Mean±SD)Modest sample size, selection of the study population, short duration (1 year) of the study, single medical center, and subjects were limited to children with LRTIs severe enough to require hospitalization.Mandelcwajg et al. 2010 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYW5kZWxjd2FqZzwvQXV0aG9yPjxZZWFyPjIwMTA8L1ll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ADDIN EN.CITE.DATA (76)FranceNov 2005 -Mar 2009RetrospectiveNALaboratory confirmed IFV/ IFA14.0% (15) 107 outpatients2.6% (6) 232 inpatients aged 1.5-15 yearsADULTSWark et al. 2001 ADDIN EN.CITE <EndNote><Cite><Author>Wark</Author><Year>2001</Year><RecNum>162</RecNum><DisplayText>(66)</DisplayText><record><rec-number>162</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">162</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wark, P. A. B.</author><author>Johnston, S. L.</author><author>Moric, I.</author><author>Simpson, J. L.</author><author>Hensley, M. J.</author><author>Gibson, P. G.</author></authors></contributors><titles><title>Neutrophil degranulation and cell lysis is associated with clinical severity in virus-induced asthma</title><secondary-title>European Respiratory Journal</secondary-title></titles><periodical><full-title>European Respiratory Journal</full-title><abbr-1>Eur. Respir. J.</abbr-1><abbr-2>Eur Respir J</abbr-2></periodical><pages>68-75</pages><volume>19</volume><number>1</number><dates><year>2001</year><pub-dates><date>2001/01/01</date></pub-dates></dates><publisher>European Respiratory Society (ERS)</publisher><isbn>0903-1936
1399-3003</isbn><urls><related-urls><url>;(66) Australia/UK2 Feb - 1 Dec 1998ProspectiveNALaboratory confirmed IFV/RT-PCR, serology, culture and IFA24% (12)49 outpatients aged 16-74 years Simpson et al. 2003 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1wc29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1wc29uPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48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ADDIN EN.CITE.DATA (68)Australia/UKNDProspectiveNALaboratory confirmed IFV/PCR or serology or IFA PCR screening: 24.0% (12) Serology screening: 18.4% (9) IFA screening: 2.0% (1) 49 inpatients aged 16-74 yearsTan et al. 2003 ADDIN EN.CITE <EndNote><Cite><Author>Tan</Author><Year>2003</Year><RecNum>115</RecNum><DisplayText>(72)</DisplayText><record><rec-number>115</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481209720">115</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tan, Wan C</author><author>Xiang, Xueyu</author><author>Qiu, Diwen</author><author>Ng, Tze Pin</author><author>Lam, Sin F</author><author>Hegele, Richard G</author></authors></contributors><titles><title>Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease</title><secondary-title>The American Journal of Medicine</secondary-title></titles><pages>272-277</pages><volume>115</volume><number>4</number><dates><year>2003</year></dates><isbn>0002-9343</isbn><urls></urls></record></Cite></EndNote>(72)SingaporeNDProspectiveNALaboratory confirmed IFV/RT-PCR, dot blot and DIG-probe hybridization20.7% (6)29 inpatients aged 42±15 years (Mean±SD)Uneven sex distribution (prevalence of females in acute asthma group).Iikura et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JaWt1cmE8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS
ZWNOdW0+MjQ2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig3MCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MjQ2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
OTI1OTMwMTAiPjI0Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SWlr
dXJhLCBNLjwvYXV0aG9yPjxhdXRob3I+SG9qbywgTS48L2F1dGhvcj48YXV0aG9yPktva2V0c3Us
IFIuPC9hdXRob3I+PGF1dGhvcj5XYXRhbmFiZSwgUy48L2F1dGhvcj48YXV0aG9yPlNhdG8sIEEu
PC9hdXRob3I+PGF1dGhvcj5DaGlubywgSC48L2F1dGhvcj48YXV0aG9yPlJvLCBTLjwvYXV0aG9y
PjxhdXRob3I+TWFzYWtpLCBILjwvYXV0aG9yPjxhdXRob3I+SGlyYXNoaW1hLCBKLjwvYXV0aG9y
PjxhdXRob3I+SXNoaWksIFMuPC9hdXRob3I+PGF1dGhvcj5OYWthLCBHLjwvYXV0aG9yPjxhdXRo
b3I+VGFrYXNha2ksIEouPC9hdXRob3I+PGF1dGhvcj5JenVtaSwgUy48L2F1dGhvcj48YXV0aG9y
PktvYmF5YXNoaSwgTi48L2F1dGhvcj48YXV0aG9yPllhbWFndWNoaSwgUy48L2F1dGhvcj48YXV0
aG9yPk5ha2FlLCBTLjwvYXV0aG9yPjxhdXRob3I+U3VnaXlhbWEsIEguPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBSZXNwaXJhdG9y
eSBNZWRpY2luZSwgTmF0aW9uYWwgQ2VudGVyIGZvciBHbG9iYWwgSGVhbHRoIGFuZCBNZWRpY2lu
ZSwgVG9reW8sIEphcGFuLiYjeEQ7TGFib3JhdG9yeSBvZiBTeXN0ZW1zIEJpb2xvZ3ksIENlbnRl
ciBmb3IgRXhwZXJpbWVudGFsIE1lZGljaW5lIGFuZCBTeXN0ZW1zIEJpb2xvZ3ksIFRoZSBJbnN0
aXR1dGUgb2YgTWVkaWNhbCBTY2llbmNlLCBUaGUgVW5pdmVyc2l0eSBvZiBUb2t5bywgVG9reW8s
IEphcGFuLiYjeEQ7TGFib3JhdG9yeSBvZiBTeXN0ZW1zIEJpb2xvZ3ksIENlbnRlciBmb3IgRXhw
ZXJpbWVudGFsIE1lZGljaW5lIGFuZCBTeXN0ZW1zIEJpb2xvZ3ksIFRoZSBJbnN0aXR1dGUgb2Yg
TWVkaWNhbCBTY2llbmNlLCBUaGUgVW5pdmVyc2l0eSBvZiBUb2t5bywgVG9reW8sIEphcGFuOyBQ
cmVjdXJzb3J5IFJlc2VhcmNoIGZvciBFbWJyeW9uaWMgU2NpZW5jZSBhbmQgVGVjaG5vbG9neSwg
SmFwYW4gU2NpZW5jZSBhbmQgVGVjaG5vbG9neSBBZ2VuY3ksIFNhaXRhbWEsIEphcGFuLjwvYXV0
aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRoZSBpbXBvcnRhbmNlIG9mIGJhY3RlcmlhbCBhbmQg
dmlyYWwgaW5mZWN0aW9ucyBhc3NvY2lhdGVkIHdpdGggYWR1bHQgYXN0aG1hIGV4YWNlcmJhdGlv
bnMgaW4gY2xpbmljYWwgcHJhY3RpY2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+UExvUyBPbmU8
L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5QbG9TIE9u
ZTwvZnVsbC10aXRsZT48YWJici0xPlBMb1MgT25lPC9hYmJyLTE+PGFiYnItMj5QTG9TIE9uZTwv
YWJici0yPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAxMjM1ODQ8L3BhZ2VzPjx2b2x1bWU+MTA8L3Zv
bHVtZT48bnVtYmVyPjQ8L251bWJlcj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+
PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2VkLCA4MCBhbmQgb3Zlcjwva2V5d29y
ZD48a2V5d29yZD5Bc3RobWEvY29tcGxpY2F0aW9ucy9lcGlkZW1pb2xvZ3kvKm1pY3JvYmlvbG9n
eS8qdmlyb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QmFjdGVyaWFsIEluZmVjdGlvbnMvKmNvbXBs
aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+Q29tb3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+
RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9r
ZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk5hc29waGFyeW54
L21pY3JvYmlvbG9neS92aXJvbG9neTwva2V5d29yZD48a2V5d29yZD5QbmV1bW9uaWEvZXBpZGVt
aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlB1bG1vbmFyeSBEaXNlYXNlLCBDaHJvbmljIE9ic3Ry
dWN0aXZlL2VwaWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5WaXJ1cyBEaXNlYXNlcy8qY29t
cGxpY2F0aW9uczwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE1PC95ZWFyPjwv
ZGF0ZXM+PGlzYm4+MTkzMi02MjAzIChFbGVjdHJvbmljKSYjeEQ7MTkzMi02MjAzIChMaW5raW5n
KTwvaXNibj48YWNjZXNzaW9uLW51bT4yNTkwMTc5NzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs
YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU5MDE3
OTc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+UE1DNDQwNjY4OTwvY3VzdG9t
Mj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTM3MS9qb3VybmFsLnBvbmUuMDEyMzU4NDwv
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JaWt1cmE8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (70)JapanMay 2011-Dec 2012ProspectiveNALaboratory confirmed IFV/RT-PCR10.0% (5)50 inpatients aged 28-92 yearsAlthough 98% of patients had a common cold history receding their AAE, a pathogen was detected from nasopharyngeal swabs in only 70% of cases. Overall, 15 major viruses and 6 major bacteria were evaluated by multiplex PCR analysis. It is possible that other minor pathogens may be involved in AAE. Other potential reasons for the low yield include inappropriate timing of sampling, lower respiratory tract infections, misinterpretation of allergic rhinitis symptoms, and single testing upon admission.Teichtal et al. 1997 ADDIN EN.CITE <EndNote><Cite><Author>Teichtahl</Author><Year>1997</Year><RecNum>164</RecNum><DisplayText>(71)</DisplayText><record><rec-number>164</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">164</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Teichtahl, Harry</author><author>Buckmaster, Nicholas</author><author>Pertnikovs, Eric</author></authors></contributors><titles><title>The Incidence of Respiratory Tract Infection in Adults Requiring Hospitalization for Asthma</title><secondary-title>Chest</secondary-title></titles><periodical><full-title>Chest</full-title><abbr-1>Chest</abbr-1><abbr-2>Chest</abbr-2></periodical><pages>591-596</pages><volume>112</volume><number>3</number><dates><year>1997</year><pub-dates><date>1997/09</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0012-3692</isbn><urls><related-urls><url>;(71)AustraliaAug 1993-July 1994ProspectiveNALaboratory confirmed IFV/Culture and serology 19.0% (15)79 inpatients aged 16-66 yearsAtmar et al. 1998 ADDIN EN.CITE <EndNote><Cite><Author>Atmar</Author><Year>1998</Year><RecNum>165</RecNum><DisplayText>(67)</DisplayText><record><rec-number>165</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">165</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Atmar, Robert L.</author><author>Guy, Elizabeth</author><author>Guntupalli, Kalpalatha K.</author><author>Zimmerman, Janice L.</author><author>Bandi, Venkata D.</author><author>Baxter, Barbara D.</author><author>Greenberg, Stephen B.</author></authors></contributors><titles><title>Respiratory Tract Viral Infections in Inner-City Asthmatic Adults</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>2453</pages><volume>158</volume><number>22</number><dates><year>1998</year><pub-dates><date>1998/12/07</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(67)USA6 Dec 1991-3 May 1994Prospective NALaboratory confirmed IFV/Culture, serology and RT-PCR 37.9% (11)29 inpatients aged 19-50 years9 Dec 1992-31 May 1993Cross-sectional9.8% (12)122 outpatients aged 17-77 years*as reported in the original article3a. Current influenza vaccine recommendations for people with asthmaAuthors, yearCountryStudy PeriodType of studyInterventionOutcome measureKey findingsPopulation characteristicsLimitations/commentsGrohskopf et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Grohskopf</Author><Year>2014</Year><RecNum>56</RecNum><DisplayText>(175)</DisplayText><record><rec-number>56</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">56</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Grohskopf, Lisa A</author><author>Olsen, Sonja J</author><author>Sokolow, Leslie Z</author><author>Bresee, Joseph S</author><author>Cox, Nancy J</author><author>Broder, Karen R</author><author>Karron, Ruth A</author><author>Walter, Emmanuel B</author></authors></contributors><titles><title>Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP)—United States, 2014–15 influenza season</title><secondary-title>MMWR Morb Mortal Wkly Rep</secondary-title></titles><periodical><full-title>MMWR: Morbidity and Mortality Weekly Report</full-title><abbr-1>MMWR Morb. Mortal. Wkly. Rep.</abbr-1><abbr-2>MMWR Morb Mortal Wkly Rep</abbr-2><abbr-3>MMWR: Morbidity & Mortality Weekly Report</abbr-3></periodical><pages>691-7</pages><volume>63</volume><number>32</number><dates><year>2014</year></dates><urls></urls></record></Cite></EndNote>(175)USA2013-2014National Recommendations after reviewing literature based on GRADE approachLAIV and IIV in asthmaEfficacy and safetyAdvise that children between 2-4 years who have asthma or wheezing in previous 12 months should not be given LAIV.Adults and children including those with asthma. Population size unavailable.Grohskopf et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Grohskopf</Author><Year>2015</Year><RecNum>57</RecNum><DisplayText>(147)</DisplayText><record><rec-number>57</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">57</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Grohskopf, Lisa A</author><author>Sokolow, Leslie Z</author><author>Olsen, Sonja J</author><author>Bresee, Joseph S</author><author>Broder, Karen R</author><author>Karron, Ruth A</author></authors></contributors><titles><title>Prevention and control of influenza with vaccines: Recommendations of the Advisory Committee on immunization practices, United States, 2015-16 influenza season</title><secondary-title>MMWR Morb Mortal Wkly Rep</secondary-title></titles><periodical><full-title>MMWR: Morbidity and Mortality Weekly Report</full-title><abbr-1>MMWR Morb. Mortal. Wkly. Rep.</abbr-1><abbr-2>MMWR Morb Mortal Wkly Rep</abbr-2><abbr-3>MMWR: Morbidity & Mortality Weekly Report</abbr-3></periodical><pages>818-825</pages><volume>64</volume><number>30</number><dates><year>2015</year></dates><urls></urls></record></Cite></EndNote>(147)USA2014 - 2015National Recommendations after reviewing literature based on GRADE approachLAIV and IIV in asthmaEfficacy and safety-All adults and children including those with asthma. Population size unavailable.No change from 2014 -2015Byington et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Byington</Author><Year>2014</Year><RecNum>58</RecNum><DisplayText>(176)</DisplayText><record><rec-number>58</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">58</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Byington, Carrie L</author><author>Barnett, Elizabeth D</author><author>Davies, H Dele</author><author>Edwards, Kathryn M</author><author>Jackson, Mary Anne</author><author>Maldonado, Yvonne A</author><author>Murray, Dennis L</author><author>Rathore, Mobeen H</author><author>Sawyer, Mark H</author><author>Schutze, Gordon E</author></authors></contributors><titles><title>Recommendations for Prevention and Control of Influenza in Children, 2014–2015</title><secondary-title>Pediatrics</secondary-title></titles><periodical><full-title>Pediatrics</full-title><abbr-1>Pediatrics</abbr-1><abbr-2>Pediatrics</abbr-2></periodical><pages>e1503-e1519</pages><volume>134</volume><number>5</number><dates><year>2014</year></dates><isbn>0031-4005</isbn><urls></urls></record></Cite></EndNote>(176)USA2013 - 2014National Recommendations from American Academy of PaediatricsLAIV and IIV in asthmaEfficacy and safetyAnnual vaccination (trivalent or quadrivalent) recommended for everyone with special effort made towards asthmatics.Asthma present in 26% hospitalized children with confirmed influenza during the 2013-14 season.All children aged >6 months including those with asthma. Population size unavailable.LAIV live attenuated influenza vaccine; IIV inactivated influenza vaccineSection 3b. Current influenza vaccine coverage for people with asthmaAuthors, yearCountryStudy PeriodType of studyInterventionOutcome measureKey findingsPopulation CharacteristicsLimitations/commentsKoshio et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (126)JapanSept-Oct 2010Questionnaire-based cross-sectional survey NAReceipt of H1N1 vaccine and infection status as well as recording of ACT score.Incidence of H1N1 pdm09 infection 6.7% (95% CI 5.7–7.6).Vaccine receipt in 63.9% (95% CI 62.1-65.8%).Infected patients (n=170) had significantly lower rates of vaccination, were younger and had experienced more night symptoms and sleep disturbance in the preceding 2 weeks.2,555 asthma patients, aged ≥16 years.Good characterization of asthmatics but no objective definition of influenza infection.Pennant et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Pennant</Author><Year>2015</Year><RecNum>43</RecNum><DisplayText>(177)</DisplayText><record><rec-number>43</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">43</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Pennant, Keyana N</author><author>Costa, John J</author><author>Fuhlbrigge, Anne L</author><author>Sax, Paul E</author><author>Szent-Gyorgyi, Lara E</author><author>Coblyn, Jonathan</author><author>Desai, Sonali P</author></authors></contributors><titles><title>Improving Influenza and Pneumococcal Vaccination Rates in Ambulatory Specialty Practices</title><secondary-title>Open forum infectious diseases</secondary-title></titles><pages>ofv119</pages><volume>2</volume><number>4</number><dates><year>2015</year></dates><publisher>Oxford University Press</publisher><isbn>2328-8957</isbn><urls></urls></record></Cite></EndNote>(177)USA2009-2015Prospective interventional quality improvement studyPhysician reminders, patient letters, nurse-drivenChange in vaccination uptake rate.Vaccine receipt improved from 59% to 64% between 2011 and 2014 influenza seasons.1142 asthma patients in an allergy clinic aged ≥13 years (85 declined vaccine). Gnatiuc et al. 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbmF0aXVjPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjQ0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNzgpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjQ0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjQ0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5HbmF0
aXVjLCBMLjwvYXV0aG9yPjxhdXRob3I+QnVpc3QsIEEuIFMuPC9hdXRob3I+PGF1dGhvcj5LYXRv
LCBCLjwvYXV0aG9yPjxhdXRob3I+SmFuc29uLCBDLjwvYXV0aG9yPjxhdXRob3I+QWl0LUtoYWxl
ZCwgTi48L2F1dGhvcj48YXV0aG9yPk5pZWxzZW4sIFIuPC9hdXRob3I+PGF1dGhvcj5Lb3VsLCBQ
LiBBLjwvYXV0aG9yPjxhdXRob3I+Tml6YW5rb3dza2EtTW9naWxuaWNrYSwgRS48L2F1dGhvcj48
YXV0aG9yPk9iYXNla2ksIEQuPC9hdXRob3I+PGF1dGhvcj5JZG9sb3IsIEwuIEYuPC9hdXRob3I+
PGF1dGhvcj5IYXJyYWJpLCBJLjwvYXV0aG9yPjxhdXRob3I+QnVybmV5LCBQLiBHLjwvYXV0aG9y
PjxhdXRob3I+Qm9sZCBDb2xsYWJvcmF0aW9uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+R25hdGl1YyxMLiBOYXRpb25hbCBIZWFydCBhbmQgTHVuZyBJbnN0
aXR1dGUsIEltcGVyaWFsIENvbGxlZ2UsIExvbmRvbiwgVUsuIEJ1aXN0LEEgUy4gT3JlZ29uIEhl
YWx0aCAmYW1wOyBTY2llbmNlIFVuaXZlcnNpdHksIFBvcnRsYW5kLCBPcmVnb24sIFVTQS4gS2F0
byxCLiBOYXRpb25hbCBIZWFydCBhbmQgTHVuZyBJbnN0aXR1dGUsIEltcGVyaWFsIENvbGxlZ2Us
IExvbmRvbiwgVUsuIEphbnNvbixDLiBSZXNwaXJhdG9yeSBNZWRpY2luZSAmYW1wOyBBbGxlcmdv
bG9neSwgRGVwYXJ0bWVudCBvZiBNZWRpY2FsIFNjaWVuY2VzLCBVcHBzYWxhIFVuaXZlcnNpdHks
IFVwcHNhbGEsIFN3ZWRlbi4gQWl0LUtoYWxlZCxOLiBJbnRlcm5hdGlvbmFsIFVuaW9uIEFnYWlu
c3QgVHViZXJjdWxvc2lzIGFuZCBMdW5nIERpc2Vhc2UsIFBhcmlzLCBGcmFuY2UuIE5pZWxzZW4s
Ui4gSW5zdGl0dXRlIG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIEJlcmdlbiwgQmVyZ2VuLCBO
b3J3YXk7IERlcGFydG1lbnQgb2YgVGhvcmFjaWMgTWVkaWNpbmUsIEhhdWtlbGFuZCBVbml2ZXJz
aXR5IEhvc3BpdGFsLCBCZXJnZW4sIE5vcndheS4gS291bCxQIEEuIFNoZXJpIEthc2htaXIgSW5z
dGl0dXRlIG9mIE1lZGljYWwgU2NpZW5jZXMsIFNyaW5hZ2FyLCBJbmRpYS4gTml6YW5rb3dza2Et
TW9naWxuaWNrYSxFLiBEZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lLCBKYWdpZWxsb25p
YW4gVW5pdmVyc2l0eSBTY2hvb2wgb2YgTWVkaWNpbmUsIEtyYWtvdywgUG9sYW5kLiBPYmFzZWtp
LEQuIE9iYWZlbWkgQXdvbG93byBVbml2ZXJzaXR5LCBJbGUtSWZlLCBOaWdlcmlhLiBJZG9sb3Is
TCBGLiBEZXBhcnRtZW50IG9mIFB1bG1vbmFyeSBNZWRpY2luZSwgTHVuZyBDZW50cmUgb2YgdGhl
IFBoaWxpcHBpbmVzLCBRdWV6b24gQ2l0eSwgVGhlIFBoaWxpcHBpbmVzLiBIYXJyYWJpLEkuIEZh
Y3VsdHkgb2YgTWVkaWNpbmUsIFNvdXNzZSwgVHVuaXNpYS4gQnVybmV5LFAgRyBKLiBOYXRpb25h
bCBIZWFydCBhbmQgTHVuZyBJbnN0aXR1dGUsIEltcGVyaWFsIENvbGxlZ2UsIExvbmRvbiwgVUsu
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+R2FwcyBpbiB1c2luZyBicm9uY2hvZGlsYXRv
cnMsIGluaGFsZWQgY29ydGljb3N0ZXJvaWRzIGFuZCBpbmZsdWVuemEgdmFjY2luZSBhbW9uZyAy
MyBoaWdoLSBhbmQgbG93LWluY29tZSBzaXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnRl
cm5hdGlvbmFsIEpvdXJuYWwgb2YgVHViZXJjdWxvc2lzICZhbXA7IEx1bmcgRGlzZWFzZTwvc2Vj
b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+SW50IEogVHViZXJjIEx1bmcgRGlzPC9hbHQtdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9m
IFR1YmVyY3Vsb3NpcyBhbmQgTHVuZyBEaXNlYXNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50LiBK
LiBUdWJlcmMuIEx1bmcgRGlzLjwvYWJici0xPjxhYmJyLTI+SW50IEogVHViZXJjIEx1bmcgRGlz
PC9hYmJyLTI+PGFiYnItMz5JbnRlcm5hdGlvbmFsIEpvdXJuYWwgb2YgVHViZXJjdWxvc2lzICZh
bXA7IEx1bmcgRGlzZWFzZTwvYWJici0zPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+SW50ZXJuYXRpb25hbCBKb3VybmFsIG9mIFR1YmVyY3Vsb3NpcyBhbmQgTHVuZyBE
aXNlYXNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+SW50LiBKLiBUdWJlcmMuIEx1bmcgRGlzLjwvYWJi
ci0xPjxhYmJyLTI+SW50IEogVHViZXJjIEx1bmcgRGlzPC9hYmJyLTI+PGFiYnItMz5JbnRlcm5h
dGlvbmFsIEpvdXJuYWwgb2YgVHViZXJjdWxvc2lzICZhbXA7IEx1bmcgRGlzZWFzZTwvYWJici0z
PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjIxLTMwPC9wYWdlcz48dm9sdW1lPjE5PC92b2x1bWU+
PG51bWJlcj4xPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkcmVuYWwgQ29ydGV4IEhvcm1v
bmVzL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPipB
ZHJlbmFsIENvcnRleCBIb3Jtb25lcy90dSBbVGhlcmFwZXV0aWMgVXNlXTwva2V5d29yZD48a2V5
d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFzdGhtYS9kaSBbRGlhZ25vc2lzXTwva2V5d29y
ZD48a2V5d29yZD5Bc3RobWEvZHQgW0RydWcgVGhlcmFweV08L2tleXdvcmQ+PGtleXdvcmQ+KkFz
dGhtYS9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qQnJvbmNob2RpbGF0b3Ig
QWdlbnRzL3R1IFtUaGVyYXBldXRpYyBVc2VdPC9rZXl3b3JkPjxrZXl3b3JkPkNyb3NzLVNlY3Rp
b25hbCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5I
dW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5lcy90dSBbVGhlcmFwZXV0
aWMgVXNlXTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB
Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBvdmVydHk8L2tleXdvcmQ+PGtleXdvcmQ+UHJldmFsZW5j
ZTwva2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgRGlzZWFzZSwgQ2hyb25pYyBPYnN0cnVjdGl2
ZS9kaSBbRGlhZ25vc2lzXTwva2V5d29yZD48a2V5d29yZD5QdWxtb25hcnkgRGlzZWFzZSwgQ2hy
b25pYyBPYnN0cnVjdGl2ZS9kdCBbRHJ1ZyBUaGVyYXB5XTwva2V5d29yZD48a2V5d29yZD4qUHVs
bW9uYXJ5IERpc2Vhc2UsIENocm9uaWMgT2JzdHJ1Y3RpdmUvZXAgW0VwaWRlbWlvbG9neV08L2tl
eXdvcmQ+PGtleXdvcmQ+UXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+U29jaW9lY29u
b21pYyBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmF0aW9uL3NuIFtTdGF0aXN0aWNz
ICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5d29yZD48a2V5d29yZD4wIChBZHJlbmFsIENvcnRl
eCBIb3Jtb25lcyk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoQnJvbmNob2RpbGF0b3IgQWdlbnRzKTwv
a2V5d29yZD48a2V5d29yZD4wIChJbmZsdWVuemEgVmFjY2luZXMpPC9rZXl3b3JkPjwva2V5d29y
ZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW48L2RhdGU+PC9w
dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODE1LTc5MjA8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjU1
MTk3ODY8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5NdWx0aWNlbnRlciBTdHVkeSYjeEQ7UmVz
ZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxh
dGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1w
O0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkYyZhbXA7QU49MjU1
MTk3ODY8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlu
a0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5K0NvcnJlY3Rp
b25zJmFtcDtpZD1wbWlkOjI1NTE5Nzg2JmFtcDtpZD0xMC41NTg4JTJGaWp0bGQuMTQuMDI2MyZh
bXA7aXNzbj0xMDI3LTM3MTkmYW1wO2lzYm49JmFtcDt2b2x1bWU9MTkmYW1wO2lzc3VlPTEmYW1w
O3NwYWdlPTIxJmFtcDtwYWdlcz0yMS0zMCZhbXA7ZGF0ZT0yMDE1JmFtcDt0aXRsZT1JbnRlcm5h
dGlvbmFsK0pvdXJuYWwrb2YrVHViZXJjdWxvc2lzKyUyNitMdW5nK0Rpc2Vhc2UmYW1wO2F0aXRs
ZT1HYXBzK2luK3VzaW5nK2Jyb25jaG9kaWxhdG9ycyUyQytpbmhhbGVkK2NvcnRpY29zdGVyb2lk
cythbmQraW5mbHVlbnphK3ZhY2NpbmUrYW1vbmcrMjMraGlnaC0rYW5kK2xvdy1pbmNvbWUrc2l0
ZXMuJmFtcDthdWxhc3Q9R25hdGl1YyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7
Jmx0Oy9hdXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3Vy
bD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+RU1TNjQ0NTcmI3hEO1BNQzQ1MzEzMDY8
L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPmh0dHA6Ly9keC5kb2kub3JnLzEwLjU1
ODgvaWp0bGQuMTQuMDI2MzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFz
ZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJv
dmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3Vh
Z2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HbmF0aXVjPC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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 EN.CITE.DATA (178)Global (23 countries)2008 onwardInternational cross sectional survey comparing high income and low-middle income countriesParticipants with doctor diagnosed asthma underwent reversibility testing with salbutamolUse of respiratory medicines and uptake of influenza vaccine in preceding 12 months.Overall influenza vaccination uptake rates: 1.4% in LMIC vs. 28.4% in HIC (P = 0.0001).15,590 adults with asthma and COPD, aged ≥40 years (unclear what proportion are asthmatic).Rare example of research comparing multiple countries from across the income spectrumThe age criteria for the study likely excluded a large proportion of asthmatics Vernacchio et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Vernacchio</Author><Year>2014</Year><RecNum>45</RecNum><DisplayText>(179)</DisplayText><record><rec-number>45</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">45</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Vernacchio, Louis</author><author>Francis, Mary E</author><author>Epstein, Daniel M</author><author>Santangelo, Jean</author><author>Trudell, Emily K</author><author>Reynolds, Meghan E</author><author>Risko, Wanessa</author></authors></contributors><titles><title>Effectiveness of an asthma quality improvement program designed for maintenance of certification</title><secondary-title>Pediatrics</secondary-title></titles><periodical><full-title>Pediatrics</full-title><abbr-1>Pediatrics</abbr-1><abbr-2>Pediatrics</abbr-2></periodical><pages>e242-e248</pages><volume>134</volume><number>1</number><dates><year>2014</year></dates><isbn>0031-4005</isbn><urls></urls></record></Cite></EndNote>(179)USA2009-2012Learning collaborative modelRegular face to face meetings and electronic communication between healthcare teamsUptake of influenza seasonal vaccination. Uptake of asthma action plans.Inconsistent improvements in rates of vaccine uptake. Significant increase in implementation of asthma action plans.594 patients with persistent asthma, aged 5-17 years.Blackwell et al. 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbGFja3dlbGw8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CbGFja3dlbGw8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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==
ADDIN EN.CITE.DATA (180)USA2009-2010Cross-sectional surveyTelephone surveyReceipt of vaccine in previous 12 months.Asthmatics receiving H1N1 vaccine: OR 1.13 (CI 0.97-1.33).667 children, aged 4 months to 17 years, including asthmatics.Aigbogun et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Aigbogun</Author><Year>2015</Year><RecNum>47</RecNum><DisplayText>(181)</DisplayText><record><rec-number>47</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">47</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aigbogun, NW</author><author>Hawker, JI</author><author>Stewart, A</author></authors></contributors><titles><title>Interventions to increase influenza vaccination rates in children with high-risk conditions—A systematic review</title><secondary-title>Vaccine</secondary-title></titles><periodical><full-title>Vaccine</full-title><abbr-1>Vaccine</abbr-1><abbr-2>Vaccine</abbr-2></periodical><pages>759-770</pages><volume>33</volume><number>6</number><dates><year>2015</year></dates><isbn>0264-410X</isbn><urls></urls></record></Cite></EndNote>(181)Global2014Systematic reviewNAUptake of vaccination rates in high-risk children.Reminder letters useful in improving uptake but less evidence for telephone recall.9 studies in children with asthma, aged 6 months to 19 years.Mazurek et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Mazurek</Author><Year>2014</Year><RecNum>48</RecNum><DisplayText>(182)</DisplayText><record><rec-number>48</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">48</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mazurek, Jacek M</author><author>White, Gretchen E</author><author>Moorman, Jeanne E</author><author>Storey, Eileen</author></authors></contributors><titles><title>Influenza Vaccination Among Persons with Work-Related Asthma</title><secondary-title>American journal of preventive medicine</secondary-title></titles><periodical><full-title>American Journal of Preventive Medicine</full-title><abbr-1>Am. J. Prev. Med.</abbr-1><abbr-2>Am J Prev Med</abbr-2></periodical><pages>203-211</pages><volume>47</volume><number>2</number><dates><year>2014</year></dates><isbn>0749-3797</isbn><urls></urls></record></Cite></EndNote>(182)USA2006-2009Cross-sectional surveyTelephone surveyInfluenza vaccination uptake in the preceding 12 months.42.7% uptake rate. Higher rates in those aged 50-64 years, unemployment and in those requiring urgent treatment for worsening symptoms.28,809 adults aged 18-64 years with work-related asthma.O’Halloran, 2015 ADDIN EN.CITE <EndNote><Cite><Author>O’Halloran</Author><Year>2016</Year><RecNum>49</RecNum><DisplayText>(183)</DisplayText><record><rec-number>49</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">49</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>O’Halloran, Alissa C</author><author>Lu, Peng-jun</author><author>Williams, Walter W</author><author>Bridges, Carolyn B</author><author>Singleton, James A</author></authors></contributors><titles><title>Influenza Vaccination Coverage Among People With High-Risk Conditions in the US</title><secondary-title>American journal of preventive medicine</secondary-title></titles><periodical><full-title>American Journal of Preventive Medicine</full-title><abbr-1>Am. J. Prev. Med.</abbr-1><abbr-2>Am J Prev Med</abbr-2></periodical><volume>50</volume><number>e15-e26</number><dates><year>2016</year></dates><isbn>0749-3797</isbn><urls></urls></record></Cite></EndNote>(183)USA2012-2013Cross-sectional surveyTelephone surveyInfluenza vaccination uptake in the preceding 12 months.Uptake rate of 29% (95% CI 26.5-31.7%).8,831 adults, aged 18-64 years with “pulmonary disease”.Lin et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Lin</Author><Year>2016</Year><RecNum>50</RecNum><DisplayText>(184)</DisplayText><record><rec-number>50</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">50</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lin, Chyongchiou Jeng</author><author>Nowalk, Mary Patricia</author><author>Zimmerman, Richard K</author><author>Moehling, Krissy K</author><author>Conti, Tracey</author><author>Allred, Norma J</author><author>Reis, Evelyn C</author></authors></contributors><titles><title>Reducing Racial Disparities in Influenza Vaccination Among Children With Asthma</title><secondary-title>Journal of Pediatric Health Care</secondary-title></titles><periodical><full-title>Journal of Pediatric Health Care</full-title><abbr-1>J. Pediatr. Health Care</abbr-1><abbr-2>J Pediatr Health Care</abbr-2></periodical><pages>208-215</pages><volume>30</volume><number>3</number><dates><year>2016</year></dates><isbn>0891-5245</isbn><urls></urls></record></Cite></EndNote>(184)USA2010-2013Prospective interventional quality improvement studyUtilized the “4 pillars immunization toolkit”Influenza vaccination rates pre and post intervention.Uptake rates increased between 2010-11 to 2012-2013 seasons in: Non-White children: 46% to 61%; White children: 58% to 65%.8,250 asthmatic children aged 6 months-18 years.This intervention reduced the racial disparity seen in vaccination uptake rates.Shoup et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Shoup</Author><Year>2015</Year><RecNum>51</RecNum><DisplayText>(185)</DisplayText><record><rec-number>51</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">51</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Shoup, J. A.</author><author>Madrid, C.</author><author>Koehler, C.</author><author>Lamb, C.</author><author>Ellis, J.</author><author>Ritzwoller, D. P.</author></authors></contributors><titles><title>Effectiveness and cost of influenza vaccine reminders for adults with asthma or chronic obstructive pulmonary disease</title><secondary-title>American Journal of Managed Care</secondary-title></titles><periodical><full-title>American Journal of Managed Care</full-title><abbr-1>Am. J. Manag. Care</abbr-1><abbr-2>Am J Manag Care</abbr-2></periodical><pages>e405-13</pages><volume>21</volume><number>7</number><keywords><keyword>Sr-airways</keyword></keywords><dates><year>2015</year></dates><accession-num>CN-01087206</accession-num><urls><related-urls><url> 26295268</custom3><electronic-resource-num>86255 [pii]</electronic-resource-num></record></Cite></EndNote>(185)USA2012-2013Pragmatic 3-arm randomized control trialThree arms:1. Postcard reminder2. Telephone reminder3. Postcard & telephone reminderChange in influenza vaccination rate.No difference in intervention groups.Telephone (interactive voice response) calls were most cost-effective.12,285 adults aged 19-64 years with asthma or COPD.Buyuktiryaki et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXl1a3Rpcnlha2k8L0F1dGhvcj48WWVhcj4yMDE0PC9Z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ADDIN EN.CITE.DATA (103)Turkey2010Cross-sectional survey of parentsQuestionnaireH1N1 and seasonal influenza vaccination rates with analysis of demographic factors, asthma control parameters and parental attitudes towards vaccination.16.8 % received H1N1 vaccine; 45.7% received seasonal vaccine.Significant factors influencing uptake included low educational background of parents, previous vaccination with seasonal influenza and having a family member vaccinated against Influenza A/H1N1.Asthma control parameters had no influence on uptake of the vaccine and physician recommendation (84.8%) was important in the decision-making process for immunization.625 children and adolescents aged 6-18 years with asthma.Skupin et al. 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ta3VwaW48L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ta3VwaW48L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (186)USA2013Cross-sectional surveyQuestionnaireInfluenza vaccination uptake in preceding year.Black patients had much lower vaccination rates (62.1%) than White (83.8%) or Asian (93.3%) patients.Belief in efficacy in vaccine and physicians recommendation important determinants in higher vaccination rates.472 adults attending internal medicine and allergy clinics.Hart et al. 2014 ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><RecNum>247</RecNum><DisplayText>(187)</DisplayText><record><rec-number>247</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1496333345">247</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors></contributors><titles><title>Hart RJ, Stevenson MD, Levine AJ, Bryant KA, Sikes KL, Paul RI. Assessing Intent and Willingness to Immunize Children Against Influenza in the Pediatric Emergency Department. Presented at the Southern Regional Meeting, New Orleans, 2014.</title></titles><dates></dates><urls></urls></record></Cite></EndNote>(187)USA2013Cross-sectional surveyStructured interviewVaccination uptake in previous year and parental intent to vaccinate in upcoming flu season.64% (95% CI 59-70%) received vaccine in previous year.37% of those parents with intent to vaccinate did not actually do so.224 children, aged 6 months-17 years, attending paediatric emergency department.Unclear what proportion are asthmatic at baseline.Lo, 2014 ADDIN EN.CITE <EndNote><Cite><Author>Lo</Author><RecNum>54</RecNum><DisplayText>(188)</DisplayText><record><rec-number>54</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">54</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Lo, Huay-ying</author></authors></contributors><titles><title>Improving Influenza Vaccination Rates for Asthma Patients Admitted to Pediatric Hospital Medicine</title><secondary-title>2014 AAP National Conference and Exhibition</secondary-title></titles><dates></dates><publisher>American Academy of Pediatrics</publisher><urls></urls></record></Cite></EndNote>(188)USA2013-2014Prospective interventional quality improvement studyImplementation of influenza immunization bundleVaccination rate pre- and post-intervention.Vaccination rate improvement from 19% (6-26%) to 39% (9-55%).117 children attending hospital with asthma exacerbation.Regan, 2014 ADDIN EN.CITE <EndNote><Cite><Author>Regan</Author><Year>2014</Year><RecNum>55</RecNum><DisplayText>(189)</DisplayText><record><rec-number>55</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">55</key></foreign-keys><ref-type name="Conference Proceedings">10</ref-type><contributors><authors><author>Regan, Annette</author></authors></contributors><titles><title>The use of electronic health record data extraction for estimating influenza vaccination coverage and effectiveness</title><secondary-title>The 20th IEA World Congress of Epidemiology (17-21 August 2014, Anchorage, AK)</secondary-title></titles><dates><year>2014</year></dates><publisher>WCE</publisher><urls></urls></record></Cite></EndNote>(189)Australia2013Cross-sectional survey of electronic outpatient recordsNAAssessment of proportion of people immunized and estimate of vaccine effectiveness.29.7% vaccination rate in asthmatics vs. 52.2% in those with coronary heart disease.In all patients, combined clinical and pathological data suggested vaccination had effectiveness of 56% in preventing infection: OR 0.44 (95% CI 0.24-0.79).2731 general practice patients with clinical and pathological data.ACT asthma control test; LMIC low-middle income countries; HIC high-income companies; COPD chronic obstructive pulmonary disease OR odds ration; CI confidence interval; NA not available; Section 4. Immunogenicity of influenza vaccines in asthma Authors, yearCountryStudy periodType of studyInterventionOutcome measureKey findingPopulation characteristicsLimitations/commentsBae et al. 2013 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWU8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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==
ADDIN EN.CITE.DATA (115)Korea2011-2012 influenza seasonPhase 4, multi-center, open label studyTIV (H1N1, H3N2, B) (7.5 μg per strain) Two doses in vaccine na?ve children; one dose in previously vaccinated Interval between first and second dose not stated.Short-term seroconversion rates, seroprotection rates, GMT, and GMT ratio; HI assay Safety: local and systemic adverse events.Seroconversion and seroprotection rates in wheezers were similar to healthy children and significant for all 3 strains. The GMT was higher in the one dose-group vs. the two-dose group both in healthy children and in wheezers. The GMT ratio was significantly higher in healthy children than wheezers for the H1N1, H3N2 strains. No difference between steroid-treated and non-treated wheezers.68 healthy children and 62 recurrent wheezers aged 6 months to 3 years. Chronic and high dose ICS excluded. No adjustment for ICS dose. Age significantly lower in healthy controls (1-2 y) than in wheezers (2-3 y). Busse et al. 2011 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNzZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXNzZTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (118)US2009 influenza autumn seasonRandomized, open-label studyMonovalent H1N1 tested at two doses (15 vs. 30 μg) twice at 21 days intervalShort term rates and GMT of seroconversion and seroprotection; HI assay and microneutralization.The 2 dosing groups did not differ in seroconversion rates. In mild-to-moderate asthma the two doses offered equal seroprotection. In severe asthma seroprotection was significantly higher with the 30 μg dose In severe asthmatics >60 years old the seroprotection was achieved only with the 30 μg dose The second dose provided no additional benefit. Atopy, BMI, systemic corticosteroid or ICS dose had no influence on HI GMTs or on seroprotection rates.Adolescents and adults (12-79) with asthma; special subgroup > 60 years with mild-to-moderate and severe asthma (including use of OCS).No healthy controls for comparison.Pedrosa et al. 2009 ADDIN EN.CITE <EndNote><Cite><Author>Pedroza</Author><Year>2009</Year><RecNum>198</RecNum><DisplayText>(116)</DisplayText><record><rec-number>198</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">198</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Pedroza, Alvaro</author><author>Huerta, José G.</author><author>de la Luz Garcia, Maria</author><author>Rojas, Arsheli</author><author>López-Martínez, Irma</author><author>Penagos, Martín</author><author>Franco-Paredes, Carlos</author><author>Deroche, Christele</author><author>Mascare?as, Cesar</author></authors></contributors><titles><title>The safety and immunogenicity of influenza vaccine in children with asthma in Mexico</title><secondary-title>International Journal of Infectious Diseases</secondary-title></titles><periodical><full-title>International Journal of Infectious Diseases</full-title><abbr-1>Int. J. Infect. Dis.</abbr-1><abbr-2>Int J Infect Dis</abbr-2></periodical><pages>469-475</pages><volume>13</volume><number>4</number><dates><year>2009</year><pub-dates><date>2009/07</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>1201-9712</isbn><urls><related-urls><url>;(116)Mexico2001-2002 influenza seasonDouble-blind, placebo controlled, randomized study Inactivated TIV (H1N1, H3N2,B); dose 15 μg per strain; twice at 28 days intervalSafety: local and systemic adverse events; lung function; short-term rate of seroconversion; HI assay.Significant rate of seroconversion after the first and second dose for all 3 strains.Children 5-9 years with mild intermittent and moderate asthma.No healthy controls for comparison. Study funded by industry.Asthma severity assessed only as LF; no data on exacerbations. Subjects with a history of allergy to egg protein excluded. Previous influenza vaccination status not reported.Zuccotti, et al. 2007 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5adWNjb3R0aTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+
PFJlY051bT4yMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTE3KTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj4yMDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjVleGR4MmRmaXpkemZpZXdzdjhwMjk1ejUwejlkNXp2djB6dCIgdGltZXN0YW1wPSIx
NDgxMjA4MzExIj4yMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+WnVj
Y290dGksIEcuPC9hdXRob3I+PGF1dGhvcj5BbWVuZG9sYSwgQS48L2F1dGhvcj48YXV0aG9yPlZp
Z2FubywgQS48L2F1dGhvcj48YXV0aG9yPlBhcmlhbmksIEUuPC9hdXRob3I+PGF1dGhvcj5aYXBw
YSwgQS48L2F1dGhvcj48YXV0aG9yPlBvZ2xpYW5pLCBMLjwvYXV0aG9yPjxhdXRob3I+R2lhY29t
ZXQsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXZhcmlubywgQS48L2F1dGhvcj48YXV0aG9yPlBvZGVz
dGEsIEEuPC9hdXRob3I+PGF1dGhvcj5Sb3R0b2xpLCBBLjwvYXV0aG9yPjxhdXRob3I+VGFuemks
IEUuPC9hdXRob3I+PGF1dGhvcj5aYW5ldHRpLCBBLjwvYXV0aG9yPjxhdXRob3I+UmFkYWVsbGks
IEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0
bWVudCBvZiBQZWRpYXRyaWNzLCBVbml2ZXJzaXR5IG9mIE1pbGFuLCBMdWlnaSBTYWNjbyBIb3Nw
aXRhbCwgVmlhIEdCIEdyYXNzaSA3NCwgMjAxNTcgTWlsYW4sIEl0YWx5LiBnaWFudmluY2Vuem8u
enVjY290dGlAdW5pbWkuaXQ8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Mb25nLXRlcm0g
aW1tdW5vZ2VuaWNpdHkgb2YgYSB2aXJvc29tYWwgc3VidW5pdCBpbmFjdGl2YXRlZCBpbmZsdWVu
emEgdmFjY2luZSBpbiBjaGlsZHJlbiB3aXRoIGFzdGhtYTwvdGl0bGU+PHNlY29uZGFyeS10aXRs
ZT5WYWNjaW5lPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5WYWNjaW5lPC9hbHQtdGl0bGU+
PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+VmFjY2luZTwvZnVsbC10aXRsZT48YWJi
ci0xPlZhY2NpbmU8L2FiYnItMT48YWJici0yPlZhY2NpbmU8L2FiYnItMj48L3BlcmlvZGljYWw+
PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlZhY2NpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5W
YWNjaW5lPC9hYmJyLTE+PGFiYnItMj5WYWNjaW5lPC9hYmJyLTI+PC9hbHQtcGVyaW9kaWNhbD48
cGFnZXM+NjY5Mi04PC9wYWdlcz48dm9sdW1lPjI1PC92b2x1bWU+PG51bWJlcj4zNy0zODwvbnVt
YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BY3V0ZSBEaXNlYXNlPC9rZXl3b3JkPjxrZXl3b3JkPkFu
dGlib2RpZXMsIFZpcmFsL2JsIFtCbG9vZF08L2tleXdvcmQ+PGtleXdvcmQ+QW50aWJvZGllcywg
VmlyYWwvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvaW0gW0ltbXVu
b2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQ
cmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmx1
ZW56YSBBIFZpcnVzLCBIMU4xIFN1YnR5cGUvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3
b3JkPkluZmx1ZW56YSBBIFZpcnVzLCBIM04yIFN1YnR5cGUvaW0gW0ltbXVub2xvZ3ldPC9rZXl3
b3JkPjxrZXl3b3JkPkluZmx1ZW56YSBCIHZpcnVzL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48
a2V5d29yZD5JbmZsdWVuemEgVmFjY2luZXMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+
PGtleXdvcmQ+SW5mbHVlbnphIFZhY2NpbmVzL2NoIFtDaGVtaXN0cnldPC9rZXl3b3JkPjxrZXl3
b3JkPipJbmZsdWVuemEgVmFjY2luZXMvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3Jk
PlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3
b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2NpbmVz
LCBJbmFjdGl2YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD4qVmFj
Y2luZXMsIEluYWN0aXZhdGVkL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5WYWNj
aW5lcywgU3VidW5pdC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD4qVmFj
Y2luZXMsIFN1YnVuaXQvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipWaXJvc29t
ZXMvaW0gW0ltbXVub2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPjAgKEFudGlib2RpZXMsIFZpcmFs
KTwva2V5d29yZD48a2V5d29yZD4wIChJbmZsdWVuemEgVmFjY2luZXMpPC9rZXl3b3JkPjxrZXl3
b3JkPjAgKFZhY2NpbmVzLCBJbmFjdGl2YXRlZCk8L2tleXdvcmQ+PGtleXdvcmQ+MCAoVmFjY2lu
ZXMsIFN1YnVuaXQpPC9rZXl3b3JkPjxrZXl3b3JkPjAgKFZpcm9zb21lcyk8L2tleXdvcmQ+PC9r
ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPlNlcCAxNzwv
ZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAyNjQtNDEwWDwvaXNibj48YWNjZXNzaW9u
LW51bT4xNzY5NzczMDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPk11bHRpY2VudGVyIFN0dWR5
PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9vdmlkc3Aub3ZpZC5j
b20vb3ZpZHdlYi5jZ2k/VD1KUyZhbXA7Q1NDPVkmYW1wO05FV1M9TiZhbXA7UEFHRT1mdWxsdGV4
dCZhbXA7RD1tZWQ1JmFtcDtBTj0xNzY5NzczMDwvdXJsPjx1cmw+aHR0cDovL29wZW51cmwuYWMu
dWsvYXRoZW5zOl9lZHUvL2xmcC9MaW5rRmluZGVyUGx1cy9EaXNwbGF5P3NpZD1PVklEOk92aWQr
TUVETElORSUyOFIlMjkmYW1wO2lkPXBtaWQ6MTc2OTc3MzAmYW1wO2lkPSZhbXA7aXNzbj0wMjY0
LTQxMFgmYW1wO2lzYm49JmFtcDt2b2x1bWU9MjUmYW1wO2lzc3VlPTM3JmFtcDtzcGFnZT02Njky
JmFtcDtwYWdlcz02NjkyLTgmYW1wO2RhdGU9MjAwNyZhbXA7dGl0bGU9VmFjY2luZSZhbXA7YXRp
dGxlPUxvbmctdGVybStpbW11bm9nZW5pY2l0eStvZithK3Zpcm9zb21hbCtzdWJ1bml0K2luYWN0
aXZhdGVkK2luZmx1ZW56YSt2YWNjaW5lK2luK2NoaWxkcmVuK3dpdGgrYXN0aG1hLiZhbXA7YXVs
YXN0PVp1Y2NvdHRpJmFtcDtwaWQ9Jmx0O2F1dGhvciZndDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhv
ciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsmbHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRl
ZC11cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLW5hbWU+TUVETElORTwvcmVtb3RlLWRhdGFi
YXNlLW5hbWU+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5PdmlkIFRlY2hub2xvZ2llczwvcmVt
b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5FbmdsaXNoPC9sYW5ndWFnZT48L3JlY29y
ZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5adWNjb3R0aTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+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ADDIN EN.CITE.DATA (117)Italy2005-2006 influenza seasonObservational prospective open label multi-centre studyVirosomal-adjuvanted TIV (H1N1, H3N2,B); dose 15 μg per strain; single dose Short (at one month) and long-term (at 6 months) seroconversion (≥1:40) and seroprotection (≥1:10); HI assay; both rate and fold-increase in GMT. Seroconversion and seroprotection in relation to pre-existing antibodies. Safety: local and systemic adverse events.Seroconversion: Both rates and GMT significantly high at both 1 and 6 months for all 3 strains Better GMT increase for the B strain in children 6-9 years compared to 3-5 years. Seroprotection: At one month satisfactory in both age groups, decreased seroprotection for H3N2 for children aged 6-9 years. At 6 months: >80% in children aged 6-9 years; significantly lower (<70%) in children aged 3-5 years. Both seroconversion and seroprotection to any specific strain significantly lower without pre-existing antibodies.Children with asthma aged 3-9 years (subgroups 3-5 years and 6-9 years). No data on asthma severity. No healthy controls. More than 50% of children had pre-existing antibodies at baseline. Baseline GMTs were relatively high for all 3 strains. Subjects with history of egg allergy and/or severe atopy were excluded. BMI body mass index; ICS inhaled corticosteroids; LF lung function; GMT geometric mean titer; HI hemagglutinin inhibition; OCS oral corticosteroids; SPT skin prick test; TIV trivalent influenza vaccines Section 5. Efficacy of influenza vaccines in asthmaAuthors, yearCountryStudy PeriodType of studyIntervention Outcome measureKey findingPopulation characteristicsLimitations/ commentsAbadoglu et al. 2004 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmFkb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BYmFkb2dsdTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+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 EN.CITE.DATA (119)TurkeyRecruitment: Sept -Nov 2001.Follow-up until Mar 2002Randomized, controlled trialTIV vs. no vaccineFrequency of URTI infections and asthma exacerbations during the winter following vaccination.URTI and asthma exacerbation rates similar between vaccinated and non-vaccinated groups = no protective effect.Asthmatic adults aged 22-84 years. In total: 128 Vaccination: 86 Nothing: 42.Lack of knowledge on rate of influenza epidemic in tested period or on the cause of URTI. Relatively low number of subjects enrolled.Bueving et al. 2004 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48
UmVjTnVtPjIyPC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMjApPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjIyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjIyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CdWV2
aW5nLCBILiBKLjwvYXV0aG9yPjxhdXRob3I+dmFuIGRlciBXb3VkZW4sIEouIEMuPC9hdXRob3I+
PGF1dGhvcj5SYWF0LCBILjwvYXV0aG9yPjxhdXRob3I+QmVybnNlbiwgUi4gTS48L2F1dGhvcj48
YXV0aG9yPmRlIEpvbmdzdGUsIEouIEMuPC9hdXRob3I+PGF1dGhvcj52YW4gU3Vpamxla29tLVNt
aXQsIEwuIFcuPC9hdXRob3I+PGF1dGhvcj5Pc3RlcmhhdXMsIEEuIEQuPC9hdXRob3I+PGF1dGhv
cj5SaW1tZWx6d2FhbiwgRy4gRi48L2F1dGhvcj48YXV0aG9yPk1vbGtlbiwgTS4gUi48L2F1dGhv
cj48YXV0aG9yPlRob21hcywgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1
dGgtYWRkcmVzcz5EZXB0IG9mIEdlbmVyYWwgUHJhY3RpY2UsIHJvb20gRmYzMDUsIEVyYXNtdXMg
TUMgLSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyIFJvdHRlcmRhbSwgUE8gQm94LCAxNzM4LCBU
aGUgTmV0aGVybGFuZHMuIGoudmFuZGVyd291ZGVuQGVyYXNtdXNtYy5ubDwvYXV0aC1hZGRyZXNz
Pjx0aXRsZXM+PHRpdGxlPkluZmx1ZW56YSB2YWNjaW5hdGlvbiBpbiBhc3RobWF0aWMgY2hpbGRy
ZW46IGVmZmVjdHMgb24gcXVhbGl0eSBvZiBsaWZlIGFuZCBzeW1wdG9tczwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9zZWNvbmRhcnktdGl0bGU+
PGFsdC10aXRsZT5FdXIgUmVzcGlyIEo8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5FdXJvcGVhbiBSZXNwaXJhdG9yeSBKb3VybmFsPC9mdWxsLXRpdGxlPjxhYmJy
LTE+RXVyLiBSZXNwaXIuIEouPC9hYmJyLTE+PGFiYnItMj5FdXIgUmVzcGlyIEo8L2FiYnItMj48
L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIFJlc3BpcmF0
b3J5IEpvdXJuYWw8L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXIuIFJlc3Bpci4gSi48L2FiYnItMT48
YWJici0yPkV1ciBSZXNwaXIgSjwvYWJici0yPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjkyNS0z
MTwvcGFnZXM+PHZvbHVtZT4yNDwvdm9sdW1lPjxudW1iZXI+NjwvbnVtYmVyPjxrZXl3b3Jkcz48
a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFuYWx5c2lzIG9mIFZhcmlhbmNl
PC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvcHAgW1BoeXNpb3BhdGhvbG9neV08L2tleXdvcmQ+
PGtleXdvcmQ+QXN0aG1hL3ZpIFtWaXJvbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tl
eXdvcmQ+PGtleXdvcmQ+RG91YmxlLUJsaW5kIE1ldGhvZDwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbmZsdWVuemEg
VmFjY2luZXMvYWQgW0FkbWluaXN0cmF0aW9uICZhbXA7IERvc2FnZV08L2tleXdvcmQ+PGtleXdv
cmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBbQ29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+
KkluZmx1ZW56YSwgSHVtYW4vcGMgW1ByZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+
PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5OZXRoZXJsYW5kczwva2V5d29yZD48a2V5
d29yZD4qUXVhbGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxrZXl3b3JkPlNwaXJvbWV0cnk8L2tleXdv
cmQ+PGtleXdvcmQ+MCAoSW5mbHVlbnphIFZhY2NpbmVzKTwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PGlzYm4+MDkwMy0xOTM2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1NTcyNTMz
PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1JhbmRvbWl6ZWQg
Q29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7
dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vb3ZpZHNwLm92aWQu
Y29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4mYW1wO1BBR0U9ZnVsbHRl
eHQmYW1wO0Q9bWVkNSZhbXA7QU49MTU1NzI1MzM8L3VybD48dXJsPmh0dHA6Ly9vcGVudXJsLmFj
LnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxheT9zaWQ9T1ZJRDpPdmlk
K01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjE1NTcyNTMzJmFtcDtpZD0mYW1wO2lzc249MDkw
My0xOTM2JmFtcDtpc2JuPSZhbXA7dm9sdW1lPTI0JmFtcDtpc3N1ZT02JmFtcDtzcGFnZT05MjUm
YW1wO3BhZ2VzPTkyNS0zMSZhbXA7ZGF0ZT0yMDA0JmFtcDt0aXRsZT1FdXJvcGVhbitSZXNwaXJh
dG9yeStKb3VybmFsJmFtcDthdGl0bGU9SW5mbHVlbnphK3ZhY2NpbmF0aW9uK2luK2FzdGhtYXRp
YytjaGlsZHJlbiUzQStlZmZlY3RzK29uK3F1YWxpdHkrb2YrbGlmZSthbmQrc3ltcHRvbXMuJmFt
cDthdWxhc3Q9QnVldmluZyZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9h
dXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1k
YXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8
L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9y
ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (120)The Netherlands1999-2000 2000-2001Double-blind, placebo controlled, randomized study TIV vs. placeboSymptom scores (to detect infection); pharyngeal swab and spirometry; quality of life (QoL).In in?uenza-positive weeks of illness: - no effect was found for respiratory symptoms recorded in the diaries - moderately bene?cial effect on QoL throughout the seasons: No differences for respiratory symptoms and QoL.Asthmatic children aged 6-18 yrs.In total: 696 (296 in 1999 -2000 and 400 in 2000 -2001) 347: in?uenza vaccine and 349 placebo. Relatively few in?uenza- positive weeks of illness. Bueving et al. 2004 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdWV2aW5nPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48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ADDIN EN.CITE.DATA (75)The Netherlands1999-20002000-2001Double-blind, placebo controlled, randomized study TIV vs. placeboSymptom scores (to detect infection) Pharyngeal swab. Blood samples for in?uenza virus -speci?c antibodies (immunogenicity).Influenza vaccination did not result in a significant reduction of the number, severity, or duration of asthma exacerbations caused by influenza.696 asthmatic children aged 618 years.Fayyaz Jahani et al. 2012 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXl5YXogSmFoYW5pPC9BdXRob3I+PFllYXI+MjAxMjwv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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GYXl5YXogSmFoYW5pPC9BdXRob3I+PFllYXI+MjAxMjwv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ADDIN EN.CITE.DATA (121)IranNDRandomized, placebo-controlled studyTIVAsthma exacerbations.Lower asthma exacerbation rates following TIV (13%) than after placebo (53%).140 asthmatic children aged 6 to 60 months.Conference abstract, thus limited information.Fleming et al. 2006 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GbGVtaW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GbGVtaW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48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ADDIN EN.CITE.DATA (122)Multicenter (UK & Europe)Oct 2002 - May 2003Reactive-CT to examine relative efficacy of CAIV-T vs. TIVCAIV-T vs. TIVSurveillance for in?uenza-like symptoms. Nasal swab viral culture culture-con?rmed in?uenza illness. Primary efficacy endpoint: incidence of culture-con?rmed in?uenza illness caused by a community-acquired subtype antigenically similar to that in the vaccine.CAIV-T had a signi?cantly greater relative ef?cacy of 35% compared with TIV. There was no evidence of a signi?cant increase in adverse pulmonary outcomes for CAIV-T compared with TIV. CAIV-T was well tolerated in children and adolescents with asthma. Asthmatic children aged 6 to 17 years.CAIV-T (n=1114) TIV (n=1115).No placebo group, therefore the absolute ef?cacy of each vaccine cannot be calculated.Ambrose et al. 2012 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48
UmVjTnVtPjI2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMjUpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjI2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjI2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BbWJy
b3NlLCBDLiBTLjwvYXV0aG9yPjxhdXRob3I+RHVib3Zza3ksIEYuPC9hdXRob3I+PGF1dGhvcj5Z
aSwgVC48L2F1dGhvcj48YXV0aG9yPkJlbHNoZSwgUi4gQi48L2F1dGhvcj48YXV0aG9yPkFzaGtl
bmF6aSwgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5N
ZWRpY2FsIGFuZCBTY2llbnRpZmljIEFmZmFpcnMsIE1lZEltbXVuZSwgTExDLCBPbmUgTWVkSW1t
dW5lIFdheSwgR2FpdGhlcnNidXJnLCBNRCAyMDg3OCwgVVNBLiBhbWJyb3NlY0BtZWRpbW11bmUu
Y29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIHNhZmV0eSBhbmQgZWZmaWNhY3kg
b2YgbGl2ZSBhdHRlbnVhdGVkIGluZmx1ZW56YSB2YWNjaW5lIGluIHlvdW5nIGNoaWxkcmVuIHdp
dGggYXN0aG1hIG9yIHByaW9yIHdoZWV6aW5nPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9w
ZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5ICZhbXA7IEluZmVjdGlvdXMgRGlz
ZWFzZXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1ciBKIENsaW4gTWljcm9iaW9sIElu
ZmVjdCBEaXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJv
cGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW91cyBEaXNl
YXNlczwvZnVsbC10aXRsZT48YWJici0xPkV1ci4gSi4gQ2xpbi4gTWljcm9iaW9sLiBJbmZlY3Qu
IERpcy48L2FiYnItMT48YWJici0yPkV1ciBKIENsaW4gTWljcm9iaW9sIEluZmVjdCBEaXM8L2Fi
YnItMj48YWJici0zPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5ICZh
bXA7IEluZmVjdGlvdXMgRGlzZWFzZXM8L2FiYnItMz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5
IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBDbGlu
LiBNaWNyb2Jpb2wuIEluZmVjdC4gRGlzLjwvYWJici0xPjxhYmJyLTI+RXVyIEogQ2xpbiBNaWNy
b2Jpb2wgSW5mZWN0IERpczwvYWJici0yPjxhYmJyLTM+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGlu
aWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91cyBEaXNlYXNlczwvYWJici0zPjwvYWx0
LXBlcmlvZGljYWw+PHBhZ2VzPjI1NDktNTc8L3BhZ2VzPjx2b2x1bWU+MzE8L3ZvbHVtZT48bnVt
YmVyPjEwPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtl
eXdvcmQ+KkFzdGhtYS9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tl
eXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5Db25maWRl
bmNlIEludGVydmFsczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+
SG9zcGl0YWxpemF0aW9uL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5
d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5l
cy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5JbmZs
dWVuemEgVmFjY2luZXMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+SW5m
bHVlbnphIFZhY2NpbmVzL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVu
emEsIEh1bWFuL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBI
dW1hbi9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXTwva2V5d29yZD48a2V5d29yZD5NYWxl
PC9rZXl3b3JkPjxrZXl3b3JkPipSZXNwaXJhdG9yeSBTb3VuZHMvaW0gW0ltbXVub2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2Np
bmF0aW9uL210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgQXR0ZW51YXRl
ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5WYWNj
aW5lcywgQXR0ZW51YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD5W
YWNjaW5lcywgQXR0ZW51YXRlZC9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+VmFj
Y2luZXMsIEluYWN0aXZhdGVkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3
b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBJbmFjdGl2YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwv
a2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3RpdmF0ZWQvaW0gW0ltbXVub2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPjAgKEluZmx1ZW56YSBWYWNjaW5lcyk8L2tleXdvcmQ+PGtleXdvcmQ+
MCAoVmFjY2luZXMsIEF0dGVudWF0ZWQpPC9rZXl3b3JkPjxrZXl3b3JkPjAgKFZhY2NpbmVzLCBJ
bmFjdGl2YXRlZCk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48
cHViLWRhdGVzPjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzUt
NDM3MzwvaXNibj48YWNjZXNzaW9uLW51bT4yMjQxMDY0NjwvYWNjZXNzaW9uLW51bT48d29yay10
eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9u
LVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw
Oi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4m
YW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjI0MTA2NDY8L3VybD48dXJsPmh0
dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxh
eT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjIyNDEwNjQ2JmFtcDtp
ZD0mYW1wO2lzc249MDkzNC05NzIzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxJmFtcDtpc3N1ZT0x
MCZhbXA7c3BhZ2U9MjU0OSZhbXA7cGFnZXM9MjU0OS01NyZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRs
ZT1FdXJvcGVhbitKb3VybmFsK29mK0NsaW5pY2FsK01pY3JvYmlvbG9neSslMjYrSW5mZWN0aW91
cytEaXNlYXNlcyZhbXA7YXRpdGxlPVRoZStzYWZldHkrYW5kK2VmZmljYWN5K29mK2xpdmUrYXR0
ZW51YXRlZCtpbmZsdWVuemErdmFjY2luZStpbit5b3VuZytjaGlsZHJlbit3aXRoK2FzdGhtYStv
citwcmlvcit3aGVlemluZy4mYW1wO2F1bGFzdD1BbWJyb3NlJmFtcDtwaWQ9Jmx0O2F1dGhvciZn
dDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsm
bHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNDU2OTEx
PC9jdXN0b20yPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2Ut
bmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUt
ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwv
Q2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE.DATA (125)Meta-analysis of two randomized, multinational trialsCAIV-T vs. TIVCulture confirmed influenza illness during the influenza surveillance period. Rate of wheezing, hospitalization, adverse events.Children receiving LAIV had fewer cases of culture-confirmed influenza illness than TIV recipients.1940 children aged 2-5 years with asthma or prior wheezing.Post hoc definition of study cohorts, but this is in part addressed by the sub-population analysis. Identification of subjects asthma or history of wheezing relied on investigator judgment without validation. TIV trivalent influenza vaccines; URTI upper respiratory tract infection; QoL quality of life; CAIV-T trivalent, cold-adapted influenza vaccine; LAIV live attenuated influenza vaccineSection 6. Effectiveness of influenza vaccination in asthmaAuthors, yearCountryStudy PeriodType of studyInterventionOutcome measureKey findingPopulation characteristicsLimitations/ commentsChristy et al. 2004 ADDIN EN.CITE <EndNote><Cite><Author>Christy</Author><Year>2004</Year><RecNum>27</RecNum><DisplayText>(131)</DisplayText><record><rec-number>27</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">27</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Christy, C</author><author>Aligne, CA</author><author>Auinger, P</author><author>Pulcino, T</author><author>Weitzman, M</author></authors></contributors><titles><title>Effectiveness of influenza vaccine for the prevention of asthma exacerbations</title><secondary-title>Archives of disease in childhood</secondary-title></titles><periodical><full-title>Archives of Disease in Childhood</full-title><abbr-1>Arch. Dis. Child.</abbr-1><abbr-2>Arch Dis Child</abbr-2></periodical><pages>734-735</pages><volume>89</volume><number>8</number><dates><year>2004</year></dates><isbn>1468-2044</isbn><urls></urls></record></Cite></EndNote>(131)USA1996-1997Retrospective nested case control studyInfluenza vaccineAsthma-related hospitalization, clinic and emergency department visits.Adjusted OR (95% CI) associated with vaccine for asthma related: Hospitalization 1.9 (0.9-3.9).Clinic visit 2.9 (2.0-4.1).Emergency department visits 2.0 (1.2-3.1).Primary care cohort. 400 randomly selected children with asthma who had been vaccinated, and 400 who had not. Age range 1-19 years. Two groups were not balanced in terms of ethnicity and likelihood of receiving vaccine in previous year, but this was taken into account in adjusted analysis.Study suggests that vaccine associated with worse outcomes. Patients with more severe asthma or those more likely to present may be more likely to have been vaccinated although controlling for these did not alter the results. Hak 2005 ADDIN EN.CITE <EndNote><Cite><Author>Hak</Author><Year>2005</Year><RecNum>208</RecNum><DisplayText>(130)</DisplayText><record><rec-number>208</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">208</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hak, Eelko</author></authors></contributors><titles><title>Clinical Effectiveness of Influenza Vaccination in Persons Younger Than 65 Years With High-Risk Medical Conditions</title><secondary-title>Archives of Internal Medicine</secondary-title></titles><periodical><full-title>Archives of Internal Medicine</full-title><abbr-1>Arch. Intern. Med.</abbr-1><abbr-2>Arch Intern Med</abbr-2></periodical><pages>274</pages><volume>165</volume><number>3</number><dates><year>2005</year><pub-dates><date>2005/02/14</date></pub-dates></dates><publisher>American Medical Association (AMA)</publisher><isbn>0003-9926</isbn><urls><related-urls><url>;(130)Netherlands1999-2000Nested case control study Influenza vaccinationAll cause mortality, hospitalization, general practice visits for influenza, pneumonia and other acute respiratory problems.High-risk children <18 years, 43% (10%-64%) of visits were prevented by vaccination after adjustment. High-risk adults (18-64 years) 78% of deaths (39-92%), 87% of hospitalizations (39-97%), and 26% of GP visits (7-47%) were prevented. Elderly persons vaccine prevented 50% of deaths (95% CI, 23-68%) and 48% of hospitalization (7- 71%) were prevented. All age groups with long term medical conditions. >75,000 patients in primary care cohort.No separate analysis for asthma. Adjusted for previous medical utilisation and comorbidities. Herrera et al. 2007 ADDIN EN.CITE <EndNote><Cite><Author>Herrera</Author><Year>2007</Year><RecNum>207</RecNum><DisplayText>(132)</DisplayText><record><rec-number>207</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">207</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Herrera, Guillermo A.</author><author>Iwane, Marika K.</author><author>Cortese, Margaret</author><author>Brown, Cedric</author><author>Gershman, Ken</author><author>Shupe, Alyson</author><author>Averhoff, Francisco</author><author>Chaves, Sandra S.</author><author>Gargiullo, Paul</author><author>Bridges, Carolyn B.</author></authors></contributors><titles><title>Influenza vaccine effectiveness among 50–64-year-old persons during a season of poor antigenic match between vaccine and circulating influenza virus strains: Colorado, United States, 2003–2004</title><secondary-title>Vaccine</secondary-title></titles><periodical><full-title>Vaccine</full-title><abbr-1>Vaccine</abbr-1><abbr-2>Vaccine</abbr-2></periodical><pages>154-160</pages><volume>25</volume><number>1</number><dates><year>2007</year><pub-dates><date>2007/01</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>0264-410X</isbn><urls><related-urls><url>;(132)USA2003-2004Case-control studyInfluenza vaccineLaboratory confirmed influenza report.Influenza: vaccine “efficacy” was 60% (43 -72%) and 48% (21 -66%) among those without and with high-risk medical conditions.Influenza-related hospitalization: vaccine “efficacy” was 90% (68 -97%) and 36% (0 -63%) against for persons without and with high-risk conditions.330 cases, 1055 randomly recruited controls. Age range 50-64 years.No separate data for asthma. Apparent effectiveness may be inflated by potential tendency to not test vaccinated people and miss an influenza diagnosis on a vaccinated patient. Authors say “efficacy” but study set up as an effectiveness study. Vaccine strains did not closely match circulating influenza strains.Koshio et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb3NoaW88L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (126)JapanSept-Oct 2010Survey Vaccination against “ new type of influenza”: H1N1 pdm09.Report of a “new type of influenza”: H1N1 pdm09.For influenza, OR (95% CI) for previous vaccination was 0.62 (0.42-0.90) for younger patients ≤61 years); among older patients OR was 1.38 (0.66-2.89) For infection-induced asthma exacerbation, OR (95% CI) for previous vaccination was 1.67 (0.60-4.66) for younger patients and 1.71 (0.50-5.83) for older ones.2555 adults with asthma.There may have been other differences between vaccinated and non-vaccinated patients that explained the difference in risk of influenza. Influenza cases were not laboratory proven. This study looked at pandemic rather than ordinary influenza. Kramarz et al. 2001 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmFtYXJ6PC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48
UmVjTnVtPjI4PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMjcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjI4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjI4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5LcmFt
YXJ6LCBQLjwvYXV0aG9yPjxhdXRob3I+RGVzdGVmYW5vLCBGLjwvYXV0aG9yPjxhdXRob3I+R2Fy
Z2l1bGxvLCBQLiBNLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgUi4gVC48L2F1dGhvcj48YXV0aG9y
PkxpZXUsIFQuIEEuPC9hdXRob3I+PGF1dGhvcj5EYXZpcywgUi4gTC48L2F1dGhvcj48YXV0aG9y
Pk11bGxvb2x5LCBKLiBQLjwvYXV0aG9yPjxhdXRob3I+QmxhY2ssIFMuIEIuPC9hdXRob3I+PGF1
dGhvcj5TaGluZWZpZWxkLCBILiBSLjwvYXV0aG9yPjxhdXRob3I+Qm9obGtlLCBLLjwvYXV0aG9y
PjxhdXRob3I+V2FyZCwgSi4gSS48L2F1dGhvcj48YXV0aG9yPk1hcmN5LCBTLiBNLjwvYXV0aG9y
PjxhdXRob3I+VmFjY2luZSBTYWZldHkgRGF0YWxpbmssIHRlYW08L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5DZW50ZXJzIGZvciBEaXNlYXNlIENvbnRyb2wg
YW5kIFByZXZlbnRpb24sIEF0bGFudGEsIEdlb3JnaWEgMzAzMzMsIFVTQS48L2F1dGgtYWRkcmVz
cz48dGl0bGVzPjx0aXRsZT5Eb2VzIGluZmx1ZW56YSB2YWNjaW5hdGlvbiBwcmV2ZW50IGFzdGht
YSBleGFjZXJiYXRpb25zIGluIGNoaWxkcmVuPzwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Kb3Vy
bmFsIG9mIFBlZGlhdHJpY3M8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkogUGVkaWF0cjwv
YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgUGVk
aWF0cmljczwvZnVsbC10aXRsZT48YWJici0xPkouIFBlZGlhdHIuPC9hYmJyLTE+PGFiYnItMj5K
IFBlZGlhdHI8L2FiYnItMj48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkpvdXJuYWwgb2YgUGVkaWF0cmljczwvZnVsbC10aXRsZT48YWJici0xPkouIFBlZGlhdHIuPC9h
YmJyLTE+PGFiYnItMj5KIFBlZGlhdHI8L2FiYnItMj48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4z
MDYtMTA8L3BhZ2VzPjx2b2x1bWU+MTM4PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGtleXdv
cmRzPjxrZXl3b3JkPkFjdXRlIERpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+QXN0aG1hL2VwIFtF
cGlkZW1pb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPipBc3RobWEvcGMgW1ByZXZlbnRpb24gJmFt
cDsgQ29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+KkFzdGhtYS92aSBbVmlyb2xvZ3ldPC9rZXl3
b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tl
eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48
a2V5d29yZD4qSW1tdW5pemF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkluY2lkZW5jZTwva2V5d29y
ZD48a2V5d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1hbi9jbyBb
Q29tcGxpY2F0aW9uc108L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSwgSHVtYW4vcGMgW1By
ZXZlbnRpb24gJmFtcDsgQ29udHJvbF08L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48
a2V5d29yZD5SZWdyZXNzaW9uIEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPlJldHJvc3BlY3Rp
dmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5SaXNrPC9rZXl3b3JkPjxrZXl3b3JkPlNldmVy
aXR5IG9mIElsbG5lc3MgSW5kZXg8L2tleXdvcmQ+PGtleXdvcmQ+VW5pdGVkIFN0YXRlcy9lcCBb
RXBpZGVtaW9sb2d5XTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDAxPC95ZWFy
PjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAy
Mi0zNDc2PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjExMjQxMDM0PC9hY2Nlc3Npb24tbnVtPjx3b3Jr
LXR5cGU+TXVsdGljZW50ZXIgU3R1ZHk8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1
cmw+aHR0cDovL292aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7
TkVXUz1OJmFtcDtQQUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZDQmYW1wO0FOPTExMjQxMDM0PC91cmw+
PHVybD5odHRwOi8vb3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVz
L0Rpc3BsYXk/c2lkPU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoxMTI0MTAz
NCZhbXA7aWQ9JmFtcDtpc3NuPTAwMjItMzQ3NiZhbXA7aXNibj0mYW1wO3ZvbHVtZT0xMzgmYW1w
O2lzc3VlPTMmYW1wO3NwYWdlPTMwNiZhbXA7cGFnZXM9MzA2LTEwJmFtcDtkYXRlPTIwMDEmYW1w
O3RpdGxlPUpvdXJuYWwrb2YrUGVkaWF0cmljcyZhbXA7YXRpdGxlPURvZXMraW5mbHVlbnphK3Zh
Y2NpbmF0aW9uK3ByZXZlbnQrYXN0aG1hK2V4YWNlcmJhdGlvbnMraW4rY2hpbGRyZW4lM0YuJmFt
cDthdWxhc3Q9S3JhbWFyeiZhbXA7cGlkPSZsdDthdXRob3ImZ3Q7Jmx0O3AxNS8mZ3Q7Jmx0Oy9h
dXRob3ImZ3Q7JmFtcDsmbHQ7QU4mZ3Q7Jmx0O3AxNi8mZ3Q7Jmx0Oy9BTiZndDs8L3VybD48L3Jl
bGF0ZWQtdXJscz48L3VybHM+PHJlbW90ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1k
YXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8
L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9y
ZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmFtYXJ6PC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48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ADDIN EN.CITE.DATA (127)USA1993-1996Population based, retrospective cohort study Influenza vaccineExacerbation of asthma.Adjusted incidence rate ratios of asthma exacerbations after vaccination were 0.78 (0.55-1.10), 0.59 (0.43-0.81), and 0.65 (0.52-0.80) compared with the period before vaccination during the 3 influenza seasons.Children aged 1-6 years with asthma in 4 large health maintenance organizations. (>70,000 patients).As a database-based analysis, the asthma diagnostic labelling and recording of asthma exacerbations may not be completely accurate.Differences in patients receiving vaccination may have explained the difference in exacerbations.Adjusted for asthma severity. Ong et al. 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pbmc8L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (129)USASurveyInfluenza vaccineExacerbation of asthma defined by oral corticosteroid, hospital visit or emergency department visit.In the multivariate analyses, current influenza vaccination status was independently associated with significantly decreased OR of using oral steroids in the previous 12 months (0.29, 0.10-0.84). There was no association with hospitalization (1.39; 0.340 -5.67) nor emergency department visits.80 children with asthma in a paediatric clinic.Retrospective approach may have introduced recall bias. Factors influencing likelihood of vaccination may have influenced likelihood of exacerbation, confounding the results.Triggers other than influenza may have been responsibly for the exacerbation. Smits et al. 2002 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjIwMDI8L1llYXI+PFJl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ADDIN EN.CITE.DATA (128)Netherlands1995-1997Retrospective cohort study Inactive influenza vaccinationPhysician diagnosed acute respiratory illness.Vaccine effectiveness was 27% (-7 to 51%) after adjustments. For those <6 years, it was 55% (20 to 75%) compared with -5% (-81 to 39%) in older ones. Children with asthma aged 0-12 years in primary care. Over 300 patients in each season.Patients vaccinated may have been different to others and these factors may have impacted on likelihood of developing respiratory illness. Adjusted for previous healthy utilizationJaiwong et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Jaiwong</Author><Year>2015</Year><RecNum>30</RecNum><DisplayText>(190)</DisplayText><record><rec-number>30</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">30</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jaiwong, C</author><author>Ngamphaiboon, J</author></authors></contributors><titles><title>Effects of inactivated influenza vaccine on respiratory illnesses and asthma-related events in children with mild persistent asthma in Asia</title><secondary-title>Asian Pacific Journal of Allergy and Immunology</secondary-title></titles><periodical><full-title>Asian Pacific Journal of Allergy and Immunology</full-title><abbr-1>Asian Pac. J. Allergy Immunol.</abbr-1><abbr-2>Asian Pac J Allergy Immunol</abbr-2><abbr-3>Asian Pacific Journal of Allergy & Immunology</abbr-3></periodical><pages>3</pages><volume>33</volume><number>1</number><dates><year>2015</year></dates><isbn>0125-877X</isbn><urls></urls></record></Cite></EndNote>(190)ThailandJune 2012 - Aug 2013Cross-sectional non-randomized studyTIV vs. no vaccineRespiratory illnesses and asthma-related events.The immunized group had significantly reduced: acute respiratory tract illnesses; asthma exacerbations; ER visits; bronchodilator usage and systemic steroid administrations; number of hospitalizations (p<0.001) and their duration (p <0.034).93 mild persistent asthmatic children aged 1-14 years (48 patients: 2 doses of inactivated influenza).Non-randomized study. Small sample size. Lack of info related to other confounding factors in asthmatic exacerbations such as compliance and controller usage, other virus and bacterial infections, pollution, emotional conditions of the patient.Yokoushi et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb2tvdWNoaTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Zb2tvdWNoaTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (191)JapanMay 2009 -Feb 2010Retrospective, cross-sectional, questionnaire-based surveyInactivated, split-virus, non-adjuvanted monovalent vs. no vaccineVaccination rates. Vaccine effectiveness against physician-diagnosed influenza A infection, and consecutive. asthma parison of positive influenza diagnosis rates between vaccinated and unvaccinated children with and without asthma showed that: Unvaccinated children with asthma had an elevated odds ratio (13.235; 95% CI; 5.564-32.134).Treatment for asthma exacerbations was needed in a larger proportion of unvaccinated children.Vaccine effectiveness against physician diagnosed influenza was 87% (95% CI, 78-93%) overall, 92% (95% CI, 81-96%) in children with asthma and 81% (95% CI, 63-91%) in children without asthma, respectively.460 children with (n=144) and without asthma (n=316).Other environmental factors that may cause asthma exacerbation were not considered. No data on atopic comorbidities.Retrospective study. Physician diagnosed influenza infection with or without a positive rapid antigen test result for influenza A during the pandemic period.ER emergency room; OR odds ratio; GP general practitioner; TIV trivalent influenza vaccine; CI confidence intervalSection 7. Safety of influenza vaccines in asthma Authors, yearCountryStudy PeriodType of studyInterventionOutcome measureKey findingsPopulation characteristicsLimitations/ comments Greenhawt et al, 2012 ADDIN EN.CITE <EndNote><Cite><Author>Greenhawt</Author><Year>2012</Year><RecNum>210</RecNum><DisplayText>(140)</DisplayText><record><rec-number>210</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">210</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greenhawt, Matthew J.</author><author>Spergel, Jonathan M.</author><author>Rank, Matthew A.</author><author>Green, Todd D.</author><author>Masnoor, Darlene</author><author>Sharma, Hemant</author><author>Bird, J. Andrew</author><author>Chang, Jinny E.</author><author>Sinh, Divya</author><author>Teich, Esther</author><author>Kelso, John M.</author><author>Sanders, Georgiana M.</author></authors></contributors><titles><title>Safe administration of the seasonal trivalent influenza vaccine to children with severe egg allergy</title><secondary-title>Annals of Allergy, Asthma & Immunology</secondary-title></titles><pages>426-430</pages><volume>109</volume><number>6</number><dates><year>2012</year><pub-dates><date>2012/12</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>1081-1206</isbn><urls><related-urls><url>;(140)USAOct 2010 - Mar 2012Phase 1: randomized, controlled trial. Phase 2: retrospective, observational trialPhase 1: Group A: graded 2 dose TIV challenge Group B: sham (saline) 1st dose followed by full TIV dose Phase 2: participants who declined study and received TIV from their allergist or had already received TIV in primary care.Safety of TIV in egg-allergic children with severe allergy.No allergic reactions were recorded.Egg-allergic children with severe allergy (mean age 12 years). All patients had previous confirmed severe allergic reactions to egg.Howe et al. 2011 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib3dlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ib3dlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (141)USAPhase 1: Oct 2004- Feb 2009 Phase 2: 2009-2010Phase 1: Retrospective, observational study. Phase 2: Prospective observational study.TIVSafety of TIV in egg-allergic and non-allergic patients.No severe allergic reactions have been recorded.ChildrenMiller et al. 2003 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaWxsZXI8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (137)USADouble-blind, placebo controlled trial.Influenza vaccineT-cell immune response to vaccine components in patients with asthma who experience bronchospasm.Increased influenza (but not egg) antigen-induced mononuclear cell proliferation, unrelated to asthma exacerbations after vaccine. No differences in cytokine production in response to either influenza or egg antigen in association with asthma exacerbations. Bronchospasm after immunization is not related to vaccination.Adults, mean age 43 years.Chung et al. 2010 ADDIN EN.CITE <EndNote><Cite><Author>Chung</Author><Year>2010</Year><RecNum>34</RecNum><DisplayText>(138)</DisplayText><record><rec-number>34</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">34</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Chung, Erica Y</author><author>Huang, Lin</author><author>Schneider, Lynda</author></authors></contributors><titles><title>Safety of influenza vaccine administration in egg-allergic patients</title><secondary-title>Pediatrics</secondary-title></titles><periodical><full-title>Pediatrics</full-title><abbr-1>Pediatrics</abbr-1><abbr-2>Pediatrics</abbr-2></periodical><pages>e1024-e1030</pages><volume>125</volume><number>5</number><dates><year>2010</year></dates><isbn>0031-4005</isbn><urls></urls></record></Cite></EndNote>(138)USA2002-2009Retrospective, observational studyInfluenza vaccineTolerability of the vaccine, defined as the lack of localized or systemic adverse reactions, in egg-allergic and non-allergic patients.95% of egg-allergic patients who received the vaccine skin test tolerated the influenza vaccine without any serious adverse reactions.Children, 6 months - 18 years.Gagnon et al. 2010 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWdub248L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWdub248L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS
ZWNOdW0+MzU8L1JlY051bT48RGlzcGxheVRleHQ+KDEzOSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MzU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1ZXhkeDJkZml6ZHpmaWV3c3Y4cDI5NXo1MHo5ZDV6dnYwenQiIHRpbWVzdGFtcD0iMTQ4
MTIwODMxMSI+MzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkdhZ25v
biwgUi48L2F1dGhvcj48YXV0aG9yPlByaW1lYXUsIE0uIE4uPC9hdXRob3I+PGF1dGhvcj5EZXMg
Um9jaGVzLCBBLjwvYXV0aG9yPjxhdXRob3I+TGVtaXJlLCBDLjwvYXV0aG9yPjxhdXRob3I+S2Fn
YW4sIFIuPC9hdXRob3I+PGF1dGhvcj5DYXJyLCBTLjwvYXV0aG9yPjxhdXRob3I+T3Vha2tpLCBN
LjwvYXV0aG9yPjxhdXRob3I+QmVub2l0LCBNLjwvYXV0aG9yPjxhdXRob3I+RGUgU2VycmVzLCBH
LjwvYXV0aG9yPjxhdXRob3I+UGhhYy1DaWhyIEluZmx1ZW56YSBSZXNlYXJjaCBOZXR3b3JrPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2VudHJlIGhvc3Bp
dGFsaWVyIHVuaXZlcnNpdGFpcmUgZGUgUXVlYmVjLCBMYXZhbCBVbml2ZXJzaXR5LCBRdWViZWMg
Q2l0eSwgUXVlYmVjLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U2FmZSB2
YWNjaW5hdGlvbiBvZiBwYXRpZW50cyB3aXRoIGVnZyBhbGxlcmd5IHdpdGggYW4gYWRqdXZhbnRl
ZCBwYW5kZW1pYyBIMU4xIHZhY2NpbmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBv
ZiBBbGxlcmd5ICZhbXA7IENsaW5pY2FsIEltbXVub2xvZ3k8L3NlY29uZGFyeS10aXRsZT48YWx0
LXRpdGxlPkogQWxsZXJneSBDbGluIEltbXVub2w8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k
aWNhbD48ZnVsbC10aXRsZT5Kb3VybmFsIG9mIEFsbGVyZ3kgYW5kIENsaW5pY2FsIEltbXVub2xv
Z3k8L2Z1bGwtdGl0bGU+PGFiYnItMT5KLiBBbGxlcmd5IENsaW4uIEltbXVub2wuPC9hYmJyLTE+
PGFiYnItMj5KIEFsbGVyZ3kgQ2xpbiBJbW11bm9sPC9hYmJyLTI+PGFiYnItMz5Kb3VybmFsIG9m
IEFsbGVyZ3kgJmFtcDsgQ2xpbmljYWwgSW1tdW5vbG9neTwvYWJici0zPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBBbGxlcmd5IGFuZCBDbGluaWNh
bCBJbW11bm9sb2d5PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQWxsZXJneSBDbGluLiBJbW11bm9s
LjwvYWJici0xPjxhYmJyLTI+SiBBbGxlcmd5IENsaW4gSW1tdW5vbDwvYWJici0yPjxhYmJyLTM+
Sm91cm5hbCBvZiBBbGxlcmd5ICZhbXA7IENsaW5pY2FsIEltbXVub2xvZ3k8L2FiYnItMz48L2Fs
dC1wZXJpb2RpY2FsPjxwYWdlcz4zMTctMjM8L3BhZ2VzPjx2b2x1bWU+MTI2PC92b2x1bWU+PG51
bWJlcj4yPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPipBZGp1dmFudHMsIEltbXVub2xvZ2lj
L2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3b3JkPjxrZXl3b3JkPkFkanV2
YW50cywgSW1tdW5vbG9naWMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+
QWRvbGVzY2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbmFw
aHlsYXhpcy9jaSBbQ2hlbWljYWxseSBJbmR1Y2VkXTwva2V5d29yZD48a2V5d29yZD5DaGlsZDwv
a2V5d29yZD48a2V5d29yZD5DaGlsZCwgUHJlc2Nob29sPC9rZXl3b3JkPjxrZXl3b3JkPipEaXNl
YXNlIE91dGJyZWFrczwva2V5d29yZD48a2V5d29yZD4qRWdnIEh5cGVyc2Vuc2l0aXZpdHk8L2tl
eXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48
a2V5d29yZD5JbmZhbnQ8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBBIFZpcnVzLCBIMU4x
IFN1YnR5cGU8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5lcy9hZCBbQWRtaW5p
c3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVuemEgVmFjY2lu
ZXMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+SW5mbHVlbnphLCBIdW1h
bi9lcCBbRXBpZGVtaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBIdW1hbi9w
YyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPipWYWNjaW5hdGlvbjwva2V5d29yZD48a2V5d29yZD4wIChBZGp1dmFudHMs
IEltbXVub2xvZ2ljKTwva2V5d29yZD48a2V5d29yZD4wIChJbmZsdWVuemEgVmFjY2luZXMpPC9r
ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0
ZT5BdWc8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk3LTY4MjU8L2lzYm4+PGFj
Y2Vzc2lvbi1udW0+MjA1Nzk3MjA8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBU
cmlhbCYjeEQ7TXVsdGljZW50ZXIgU3R1ZHkmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMu
IEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL292
aWRzcC5vdmlkLmNvbS9vdmlkd2ViLmNnaT9UPUpTJmFtcDtDU0M9WSZhbXA7TkVXUz1OJmFtcDtQ
QUdFPWZ1bGx0ZXh0JmFtcDtEPW1lZGwmYW1wO0FOPTIwNTc5NzIwPC91cmw+PHVybD5odHRwOi8v
b3BlbnVybC5hYy51ay9hdGhlbnM6X2VkdS8vbGZwL0xpbmtGaW5kZXJQbHVzL0Rpc3BsYXk/c2lk
PU9WSUQ6T3ZpZCtNRURMSU5FJTI4UiUyOSZhbXA7aWQ9cG1pZDoyMDU3OTcyMCZhbXA7aWQ9MTAu
MTAxNiUyRmouamFjaS4yMDEwLjA1LjAzNyZhbXA7aXNzbj0wMDkxLTY3NDkmYW1wO2lzYm49JmFt
cDt2b2x1bWU9MTI2JmFtcDtpc3N1ZT0yJmFtcDtzcGFnZT0zMTcmYW1wO3BhZ2VzPTMxNy0yMyZh
bXA7ZGF0ZT0yMDEwJmFtcDt0aXRsZT1Kb3VybmFsK29mK0FsbGVyZ3krJTI2K0NsaW5pY2FsK0lt
bXVub2xvZ3kmYW1wO2F0aXRsZT1TYWZlK3ZhY2NpbmF0aW9uK29mK3BhdGllbnRzK3dpdGgrZWdn
K2FsbGVyZ3krd2l0aCthbithZGp1dmFudGVkK3BhbmRlbWljK0gxTjErdmFjY2luZS4mYW1wO2F1
bGFzdD1HYWdub24mYW1wO3BpZD0mbHQ7YXV0aG9yJmd0OyZsdDtwMTUvJmd0OyZsdDsvYXV0aG9y
Jmd0OyZhbXA7Jmx0O0FOJmd0OyZsdDtwMTYvJmd0OyZsdDsvQU4mZ3Q7PC91cmw+PC9yZWxhdGVk
LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT5odHRwOi8vZHguZG9pLm9yZy8x
MC4xMDE2L2ouamFjaS4yMDEwLjA1LjAzNzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90
ZS1kYXRhYmFzZS1uYW1lPk1FRExJTkU8L3JlbW90ZS1kYXRhYmFzZS1uYW1lPjxyZW1vdGUtZGF0
YWJhc2UtcHJvdmlkZXI+T3ZpZCBUZWNobm9sb2dpZXM8L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRl
cj48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA (139)CanadaOct-Dec 2009Prospective, observational studyAdjuvanted monovalent 2009 pandemic influenza A/H1N1 influenza vaccineRisk of anaphylaxis in children with egg allergy administered an adjuvanted monovalent 2009 pandemic influenza A/H1N1 influenza vaccine.No patient had an anaphylactic reaction.Children and adults.Greenhawt et al. 2010 ADDIN EN.CITE <EndNote><Cite><Author>Greenhawt</Author><Year>2010</Year><RecNum>213</RecNum><DisplayText>(143)</DisplayText><record><rec-number>213</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">213</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greenhawt, Matthew J.</author><author>Chernin, Anna S.</author><author>Howe, Laura</author><author>Li, James T.</author><author>Sanders, Georgiana</author></authors></contributors><titles><title>The safety of the H1N1 influenza A vaccine in egg allergic individuals</title><secondary-title>Annals of Allergy, Asthma & Immunology</secondary-title></titles><pages>387-393</pages><volume>105</volume><number>5</number><dates><year>2010</year><pub-dates><date>2010/11</date></pub-dates></dates><publisher>Elsevier BV</publisher><isbn>1081-1206</isbn><urls><related-urls><url>;(143)USAOct 2009- Feb 2010Controlled, prospective trialH1N1 influenza vaccineSafety of administering H1N1 to egg-allergic patients compared with non-egg-allergic, paediatric, control patients.No significant allergic reactions were recorded.Children and adults aged 6 months to 24 years.Esposito et al. 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3Bvc2l0bzwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+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 EN.CITE.DATA (142)ItalyNov-Dec 2007Prospective studyVirosomal adjuvanted influenza vaccineTo evaluate whether the virosomal adjuvanted influenza vaccine that has been shown to have the lowest egg protein content could be administered to children with even severe egg allergy without any risk of allergic reactions.Administration of the whole vaccine was safe and well tolerated by all of the children, with no differences between those with and without egg allergy, or between those with egg allergy of different severity.Children >3 years.Castro et al. 2001 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXN0cm88L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXN0cm88L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (134)USASep-Nov 2000Multicenter, randomized, double blind, placebo-controlled, crossover trialTIV or placeboSafety of TIV in adults and children with asthma.The frequency of asthma exacerbations was similar in the two weeks after the TIV or placebo injection. The exacerbation rates were similar in subgroups defined according to age, severity of asthma, and other factors.Children and adults aged 3-64 years.Baxter et al. 2012 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXh0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXh0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (135)USAOct 2003 - March 2008Prospective observational post-marketing studyLAIV, TIV or placebo.Safety of LAIV, compared to TIV and placebo in children.Asthma/wheezing major adverse events were not statistically increased in LAIV recipients. No anaphylaxis events occurred.Children aged 5-17 years.Ambrose et al. 2012 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbWJyb3NlPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48
UmVjTnVtPjI2PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxMjUpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjI2PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0
ODEyMDgzMTEiPjI2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5BbWJy
b3NlLCBDLiBTLjwvYXV0aG9yPjxhdXRob3I+RHVib3Zza3ksIEYuPC9hdXRob3I+PGF1dGhvcj5Z
aSwgVC48L2F1dGhvcj48YXV0aG9yPkJlbHNoZSwgUi4gQi48L2F1dGhvcj48YXV0aG9yPkFzaGtl
bmF6aSwgUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5N
ZWRpY2FsIGFuZCBTY2llbnRpZmljIEFmZmFpcnMsIE1lZEltbXVuZSwgTExDLCBPbmUgTWVkSW1t
dW5lIFdheSwgR2FpdGhlcnNidXJnLCBNRCAyMDg3OCwgVVNBLiBhbWJyb3NlY0BtZWRpbW11bmUu
Y29tPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VGhlIHNhZmV0eSBhbmQgZWZmaWNhY3kg
b2YgbGl2ZSBhdHRlbnVhdGVkIGluZmx1ZW56YSB2YWNjaW5lIGluIHlvdW5nIGNoaWxkcmVuIHdp
dGggYXN0aG1hIG9yIHByaW9yIHdoZWV6aW5nPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1cm9w
ZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5ICZhbXA7IEluZmVjdGlvdXMgRGlz
ZWFzZXM8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1ciBKIENsaW4gTWljcm9iaW9sIElu
ZmVjdCBEaXM8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXJv
cGVhbiBKb3VybmFsIG9mIENsaW5pY2FsIE1pY3JvYmlvbG9neSBhbmQgSW5mZWN0aW91cyBEaXNl
YXNlczwvZnVsbC10aXRsZT48YWJici0xPkV1ci4gSi4gQ2xpbi4gTWljcm9iaW9sLiBJbmZlY3Qu
IERpcy48L2FiYnItMT48YWJici0yPkV1ciBKIENsaW4gTWljcm9iaW9sIEluZmVjdCBEaXM8L2Fi
YnItMj48YWJici0zPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5ICZh
bXA7IEluZmVjdGlvdXMgRGlzZWFzZXM8L2FiYnItMz48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkV1cm9wZWFuIEpvdXJuYWwgb2YgQ2xpbmljYWwgTWljcm9iaW9sb2d5
IGFuZCBJbmZlY3Rpb3VzIERpc2Vhc2VzPC9mdWxsLXRpdGxlPjxhYmJyLTE+RXVyLiBKLiBDbGlu
LiBNaWNyb2Jpb2wuIEluZmVjdC4gRGlzLjwvYWJici0xPjxhYmJyLTI+RXVyIEogQ2xpbiBNaWNy
b2Jpb2wgSW5mZWN0IERpczwvYWJici0yPjxhYmJyLTM+RXVyb3BlYW4gSm91cm5hbCBvZiBDbGlu
aWNhbCBNaWNyb2Jpb2xvZ3kgJmFtcDsgSW5mZWN0aW91cyBEaXNlYXNlczwvYWJici0zPjwvYWx0
LXBlcmlvZGljYWw+PHBhZ2VzPjI1NDktNTc8L3BhZ2VzPjx2b2x1bWU+MzE8L3ZvbHVtZT48bnVt
YmVyPjEwPC9udW1iZXI+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtl
eXdvcmQ+KkFzdGhtYS9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tl
eXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNjaG9vbDwva2V5d29yZD48a2V5d29yZD5Db25maWRl
bmNlIEludGVydmFsczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+
SG9zcGl0YWxpemF0aW9uL3NuIFtTdGF0aXN0aWNzICZhbXA7IE51bWVyaWNhbCBEYXRhXTwva2V5
d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkluZmx1ZW56YSBWYWNjaW5l
cy9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5JbmZs
dWVuemEgVmFjY2luZXMvYWUgW0FkdmVyc2UgRWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+SW5m
bHVlbnphIFZhY2NpbmVzL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD5JbmZsdWVu
emEsIEh1bWFuL2ltIFtJbW11bm9sb2d5XTwva2V5d29yZD48a2V5d29yZD4qSW5mbHVlbnphLCBI
dW1hbi9wYyBbUHJldmVudGlvbiAmYW1wOyBDb250cm9sXTwva2V5d29yZD48a2V5d29yZD5NYWxl
PC9rZXl3b3JkPjxrZXl3b3JkPipSZXNwaXJhdG9yeSBTb3VuZHMvaW0gW0ltbXVub2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZhY2Np
bmF0aW9uL210IFtNZXRob2RzXTwva2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgQXR0ZW51YXRl
ZC9hZCBbQWRtaW5pc3RyYXRpb24gJmFtcDsgRG9zYWdlXTwva2V5d29yZD48a2V5d29yZD5WYWNj
aW5lcywgQXR0ZW51YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwva2V5d29yZD48a2V5d29yZD5W
YWNjaW5lcywgQXR0ZW51YXRlZC9pbSBbSW1tdW5vbG9neV08L2tleXdvcmQ+PGtleXdvcmQ+VmFj
Y2luZXMsIEluYWN0aXZhdGVkL2FkIFtBZG1pbmlzdHJhdGlvbiAmYW1wOyBEb3NhZ2VdPC9rZXl3
b3JkPjxrZXl3b3JkPlZhY2NpbmVzLCBJbmFjdGl2YXRlZC9hZSBbQWR2ZXJzZSBFZmZlY3RzXTwv
a2V5d29yZD48a2V5d29yZD5WYWNjaW5lcywgSW5hY3RpdmF0ZWQvaW0gW0ltbXVub2xvZ3ldPC9r
ZXl3b3JkPjxrZXl3b3JkPjAgKEluZmx1ZW56YSBWYWNjaW5lcyk8L2tleXdvcmQ+PGtleXdvcmQ+
MCAoVmFjY2luZXMsIEF0dGVudWF0ZWQpPC9rZXl3b3JkPjxrZXl3b3JkPjAgKFZhY2NpbmVzLCBJ
bmFjdGl2YXRlZCk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMjwveWVhcj48
cHViLWRhdGVzPjxkYXRlPk9jdDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0MzUt
NDM3MzwvaXNibj48YWNjZXNzaW9uLW51bT4yMjQxMDY0NjwvYWNjZXNzaW9uLW51bT48d29yay10
eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9u
LVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRw
Oi8vb3ZpZHNwLm92aWQuY29tL292aWR3ZWIuY2dpP1Q9SlMmYW1wO0NTQz1ZJmFtcDtORVdTPU4m
YW1wO1BBR0U9ZnVsbHRleHQmYW1wO0Q9bWVkbCZhbXA7QU49MjI0MTA2NDY8L3VybD48dXJsPmh0
dHA6Ly9vcGVudXJsLmFjLnVrL2F0aGVuczpfZWR1Ly9sZnAvTGlua0ZpbmRlclBsdXMvRGlzcGxh
eT9zaWQ9T1ZJRDpPdmlkK01FRExJTkUlMjhSJTI5JmFtcDtpZD1wbWlkOjIyNDEwNjQ2JmFtcDtp
ZD0mYW1wO2lzc249MDkzNC05NzIzJmFtcDtpc2JuPSZhbXA7dm9sdW1lPTMxJmFtcDtpc3N1ZT0x
MCZhbXA7c3BhZ2U9MjU0OSZhbXA7cGFnZXM9MjU0OS01NyZhbXA7ZGF0ZT0yMDEyJmFtcDt0aXRs
ZT1FdXJvcGVhbitKb3VybmFsK29mK0NsaW5pY2FsK01pY3JvYmlvbG9neSslMjYrSW5mZWN0aW91
cytEaXNlYXNlcyZhbXA7YXRpdGxlPVRoZStzYWZldHkrYW5kK2VmZmljYWN5K29mK2xpdmUrYXR0
ZW51YXRlZCtpbmZsdWVuemErdmFjY2luZStpbit5b3VuZytjaGlsZHJlbit3aXRoK2FzdGhtYStv
citwcmlvcit3aGVlemluZy4mYW1wO2F1bGFzdD1BbWJyb3NlJmFtcDtwaWQ9Jmx0O2F1dGhvciZn
dDsmbHQ7cDE1LyZndDsmbHQ7L2F1dGhvciZndDsmYW1wOyZsdDtBTiZndDsmbHQ7cDE2LyZndDsm
bHQ7L0FOJmd0OzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMzNDU2OTEx
PC9jdXN0b20yPjxyZW1vdGUtZGF0YWJhc2UtbmFtZT5NRURMSU5FPC9yZW1vdGUtZGF0YWJhc2Ut
bmFtZT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk92aWQgVGVjaG5vbG9naWVzPC9yZW1vdGUt
ZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPkVuZ2xpc2g8L2xhbmd1YWdlPjwvcmVjb3JkPjwv
Q2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE.DATA (125)Study 1: 2004-2005 Study 2: 2002-2003Post-hoc analysis of two randomized, multinational trials of LAIV and TIV in children aged 6 -71 monthsLAIV vs. TIVSafety of LAIV in asthmatic children younger than 6 years.Wheezing, lower respiratory illness, and hospitalization were not significantly increased in children receiving LAIV compared with TIV. Increased upper respiratory symptoms and irritability were observed in LAIV recipients.Children aged 2-5 years.Gaglani et al. 2008 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWdsYW5pPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYWdsYW5pPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA (136)USA1998-2002Open-label field trialTrivalent LAIVSafety of the intranasal LAIV3 in children with intermitted wheezing/asthma.No increased risk for medically-attended acute respiratory illnesses, including asthma exacerbation.Children aged 1.5-18 years.Haber et al. 2015 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWJlcjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYWJlcjwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE.DATA (192)USALAIV4 reports: 2013-2014 LAIV3 reports: 2010-2013Analysis of reports received at the “Vaccine Adverse Event Reporting System”LAIV4 vs. LAIV3Medical records were reviewed for non-manufacturer serious reports (i.e., death, hospitalization, prolonged hospitalization, life-threatening illness, permanent disability) and reports of selected conditions of interest.No new or unexpected safety concerns with LAIV4. The safety pro?le of LAIV4 was similar to LAIV3. Just over 94% of LAIV4 reports were non-serious and the most common adverse events were mild, self-limited conditions (e.g., fever, headache and cough).Children and adults aged 2-49 years. 12.7 million doses of LAIV4 were distributed.General limitations of passive surveillance. Turner et al. 2015 ADDIN EN.CITE <EndNote><Cite><Author>Turner</Author><Year>2015</Year><RecNum>41</RecNum><DisplayText>(145)</DisplayText><record><rec-number>41</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">41</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Turner, Paul J</author><author>Southern, Jo</author><author>Andrews, Nick J</author><author>Miller, Elizabeth</author><author>Erlewyn-Lajeunesse, Michel</author><author>SNIFFLE Study Investigators</author></authors></contributors><titles><title>Safety of live attenuated influenza vaccine in atopic children with egg allergy</title><secondary-title>Journal of Allergy and Clinical Immunology</secondary-title></titles><periodical><full-title>Journal of Allergy and Clinical Immunology</full-title><abbr-1>J. Allergy Clin. Immunol.</abbr-1><abbr-2>J Allergy Clin Immunol</abbr-2><abbr-3>Journal of Allergy & Clinical Immunology</abbr-3></periodical><pages>376-81</pages><volume>136</volume><number>2</number><dates><year>2015</year></dates><isbn>0091-6749</isbn><urls></urls></record></Cite></EndNote>(145)UK Sept 2013 - Jan 2014Prospective, multi-centre, open-label, phase IV intervention studyLAIVClinical symptoms after LAIV administration to estimate incidence of 1. Allergic reaction within 2 hours, 2. Delayed allergic symptoms within 72 hours, 3. Non-allergic adverse events; and change in nasal airway patency (acoustic rhinometry).LAIV appeared to be safe in children with egg allergy and additional asthma or recurrent wheeze. No systemic allergic reactions reported. Eight children had mild, self-limiting, potentially IgE-mediated allergic symptoms. 26 (9.4%; 95% CI for population, 6.2% to 13.4%) children experienced lower respiratory tract symptoms within 72 hours, including 13 with parent-reported wheeze. None of these episodes required medical intervention beyond routine treatment.282 children with egg allergy aged 2-17 years.The egg protein content of LAIV batches may vary, thus data from this study may not be applicable to future LAIV stocks in which egg content may be higher. TIV trivalent influenza vaccine; LAIV live attenuated influenza vaccine; CI confidence intervalSection 8. Antiviral treatment against influenza in patients with atshmaAuthors, yearCountryStudy PeriodType of studyInterventionOutcome measureKey findingPopulation characteristicsLimitations/ comments Johnston et al. 2005 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb2huc3RvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+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ADDIN EN.CITE.DATA (162)Randomized studyOseltamivir (2 mg/kg) or placebo twice daily, as a syrupEffects of oseltamivir among influenza-infected children with asthma. Oseltamivir is safe and well tolerated among asthmatic children, may reduce symptom duration and helps improve lung function and reduce asthma exacerbations during influenza infection.Asthmatic children aged 6-12 years. Analysis was performed for both the intent-to-treat infected (n=179) and per protocol (n=162) populations.Lin et al.2006 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW48L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (156) China 2002-2003Randomized, open-label, controlled trialOseltamivir 7 5 mg twice daily for 5 days (oseltamivir group), or symptomatic treatment (control group) within 48 h after symptom onsetDuration and severity of illness in influenza-infected patients, incidence of complications, antibiotic use, hospitalization and total medical cost.Oseltamivir is effective and well tolerated in high-risk patients with chronic respiratory or cardiac diseases. It can reduce the duration and severity of influenza symptoms and decrease the incidence of secondary complications and antibiotic use, without increasing the total medical cost.118 Chinese patients (mean age 48.1 years) with chronic respiratory diseases (chronic bronchitis, obstructive emphysema, bronchial asthma or bronchiectasis) or chronic cardiac disease. Only 8 patients with bronchial asthma.Cass et al. 2000 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj
TnVtPjEyPC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNjApPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjEyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEy
MDgzMTEiPjEyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXNzLCBM
LiBNLjwvYXV0aG9yPjxhdXRob3I+R3VuYXdhcmRlbmEsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5N
YWNtYWhvbiwgTS4gTS48L2F1dGhvcj48YXV0aG9yPkJ5ZSwgQS48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+UHVsbW9uYXJ5IGZ1bmN0aW9uIGFuZCBhaXJ3
YXkgcmVzcG9uc2l2ZW5lc3MgaW4gbWlsZCB0byBtb2RlcmF0ZSBhc3RobWF0aWNzIGdpdmVuIHJl
cGVhdGVkIGluaGFsZWQgZG9zZXMgb2YgemFuYW1pdmlyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PlJlc3BpcmF0b3J5IG1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj
YWw+PGZ1bGwtdGl0bGU+UmVzcGlyYXRvcnkgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5S
ZXNwaXIuIE1lZC48L2FiYnItMT48YWJici0yPlJlc3BpciBNZWQ8L2FiYnItMj48L3BlcmlvZGlj
YWw+PHBhZ2VzPjE2Ni03MzwvcGFnZXM+PHZvbHVtZT45NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVt
YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG1pbmlzdHJhdGlvbiwgSW5oYWxhdGlvbjwva2V5d29y
ZD48a2V5d29yZD5Bc3RobWEgW2RydWcgdGhlcmFweV0gW3BoeXNpb3BhdGhvbG9neV08L2tleXdv
cmQ+PGtleXdvcmQ+Q3Jvc3MtT3ZlciBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRvdWJsZS1C
bGluZCBNZXRob2Q8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lIEluaGliaXRvcnMgW2FkbWluaXN0
cmF0aW9uICZhbXA7IGRvc2FnZV0gW2FkdmVyc2UgZWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+
Rm9yY2VkIEV4cGlyYXRvcnkgVm9sdW1lIFtwaHlzaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5H
dWFuaWRpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPk5ldXJhbWluaWRhc2UgW2FudGFnb25pc3RzICZh
bXA7IGluaGliaXRvcnNdPC9rZXl3b3JkPjxrZXl3b3JkPlBlYWsgRXhwaXJhdG9yeSBGbG93IFJh
dGUgW3BoeXNpb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlB5cmFuczwva2V5d29yZD48a2V5d29y
ZD5TaWFsaWMgQWNpZHMgW2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZV0gW2FkdmVyc2UgZWZm
ZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+Vml0YWwgQ2FwYWNpdHkgW3BoeXNpb2xvZ3ldPC9rZXl3
b3JkPjxrZXl3b3JkPlphbmFtaXZpcjwva2V5d29yZD48a2V5d29yZD5BZHVsdFtjaGVja3dvcmRd
PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZVtjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPkh1
bWFuc1tjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGVbY2hlY2t3b3JkXTwva2V5d29y
ZD48a2V5d29yZD5NaWRkbGUgQWdlZFtjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPkhzLWhh
bmRzcmNoOiBzci1haXJ3YXlzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8
L3llYXI+PC9kYXRlcz48YWNjZXNzaW9uLW51bT5DTi0wMDI3NjA4NzwvYWNjZXNzaW9uLW51bT48
d29yay10eXBlPkNsaW5pY2FsIFRyaWFsOyBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWw8L3dv
cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL29ubGluZWxpYnJhcnkud2ls
ZXkuY29tL28vY29jaHJhbmUvY2xjZW50cmFsL2FydGljbGVzLzA4Ny9DTi0wMDI3NjA4Ny9mcmFt
ZS5odG1sPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20zPlB1Ym1lZCAxMDcxNDQy
NDwvY3VzdG9tMz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9ybWVkLjE5OTkuMDcx
ODwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNzPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48UmVj
TnVtPjEyPC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNjApPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjEyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNWV4ZHgyZGZpemR6Zmlld3N2OHAyOTV6NTB6OWQ1enZ2MHp0IiB0aW1lc3RhbXA9IjE0ODEy
MDgzMTEiPjEyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXNzLCBM
LiBNLjwvYXV0aG9yPjxhdXRob3I+R3VuYXdhcmRlbmEsIEsuIEEuPC9hdXRob3I+PGF1dGhvcj5N
YWNtYWhvbiwgTS4gTS48L2F1dGhvcj48YXV0aG9yPkJ5ZSwgQS48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+UHVsbW9uYXJ5IGZ1bmN0aW9uIGFuZCBhaXJ3
YXkgcmVzcG9uc2l2ZW5lc3MgaW4gbWlsZCB0byBtb2RlcmF0ZSBhc3RobWF0aWNzIGdpdmVuIHJl
cGVhdGVkIGluaGFsZWQgZG9zZXMgb2YgemFuYW1pdmlyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PlJlc3BpcmF0b3J5IG1lZGljaW5lPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj
YWw+PGZ1bGwtdGl0bGU+UmVzcGlyYXRvcnkgTWVkaWNpbmU8L2Z1bGwtdGl0bGU+PGFiYnItMT5S
ZXNwaXIuIE1lZC48L2FiYnItMT48YWJici0yPlJlc3BpciBNZWQ8L2FiYnItMj48L3BlcmlvZGlj
YWw+PHBhZ2VzPjE2Ni03MzwvcGFnZXM+PHZvbHVtZT45NDwvdm9sdW1lPjxudW1iZXI+MjwvbnVt
YmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZG1pbmlzdHJhdGlvbiwgSW5oYWxhdGlvbjwva2V5d29y
ZD48a2V5d29yZD5Bc3RobWEgW2RydWcgdGhlcmFweV0gW3BoeXNpb3BhdGhvbG9neV08L2tleXdv
cmQ+PGtleXdvcmQ+Q3Jvc3MtT3ZlciBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkRvdWJsZS1C
bGluZCBNZXRob2Q8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lIEluaGliaXRvcnMgW2FkbWluaXN0
cmF0aW9uICZhbXA7IGRvc2FnZV0gW2FkdmVyc2UgZWZmZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+
Rm9yY2VkIEV4cGlyYXRvcnkgVm9sdW1lIFtwaHlzaW9sb2d5XTwva2V5d29yZD48a2V5d29yZD5H
dWFuaWRpbmVzPC9rZXl3b3JkPjxrZXl3b3JkPk5ldXJhbWluaWRhc2UgW2FudGFnb25pc3RzICZh
bXA7IGluaGliaXRvcnNdPC9rZXl3b3JkPjxrZXl3b3JkPlBlYWsgRXhwaXJhdG9yeSBGbG93IFJh
dGUgW3BoeXNpb2xvZ3ldPC9rZXl3b3JkPjxrZXl3b3JkPlB5cmFuczwva2V5d29yZD48a2V5d29y
ZD5TaWFsaWMgQWNpZHMgW2FkbWluaXN0cmF0aW9uICZhbXA7IGRvc2FnZV0gW2FkdmVyc2UgZWZm
ZWN0c108L2tleXdvcmQ+PGtleXdvcmQ+Vml0YWwgQ2FwYWNpdHkgW3BoeXNpb2xvZ3ldPC9rZXl3
b3JkPjxrZXl3b3JkPlphbmFtaXZpcjwva2V5d29yZD48a2V5d29yZD5BZHVsdFtjaGVja3dvcmRd
PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZVtjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPkh1
bWFuc1tjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGVbY2hlY2t3b3JkXTwva2V5d29y
ZD48a2V5d29yZD5NaWRkbGUgQWdlZFtjaGVja3dvcmRdPC9rZXl3b3JkPjxrZXl3b3JkPkhzLWhh
bmRzcmNoOiBzci1haXJ3YXlzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDA8
L3llYXI+PC9kYXRlcz48YWNjZXNzaW9uLW51bT5DTi0wMDI3NjA4NzwvYWNjZXNzaW9uLW51bT48
d29yay10eXBlPkNsaW5pY2FsIFRyaWFsOyBSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWw8L3dv
cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL29ubGluZWxpYnJhcnkud2ls
ZXkuY29tL28vY29jaHJhbmUvY2xjZW50cmFsL2FydGljbGVzLzA4Ny9DTi0wMDI3NjA4Ny9mcmFt
ZS5odG1sPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20zPlB1Ym1lZCAxMDcxNDQy
NDwvY3VzdG9tMz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1My9ybWVkLjE5OTkuMDcx
ODwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA (160)UK2000Double-blind, randomized, placebo controlled, two way cross-over study, 7 day wash out period.10 mg zanamivir as a dry powder (265 mg) or a placebo, twice daily on day 1 and then four times daily from day 2 to day 14.Safety of Zanamivir in asthmatics.Zanamivir inhaled as a dry powder does not significantly affect the pulmonary function and airway responsiveness of subjects with mild/moderate asthma and therefore its use in such patients/subjects is not precluded.13 subjects, aged 19-49 years, with asthma.Shun-Shin et al. 2009 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaHVuLVNoaW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaHVuLVNoaW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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 EN.CITE.DATA (163)Systematic review and meta-analysis of randomized controlled trialsNAEffects of the neuraminidase inhibitors oseltamivir and zanamivir in treatment of children with seasonal influenza and prevention of transmission to children in households.Oseltamivir did not reduce asthma exacerbations or improve peak flow in children with asthma.Children aged ≤12 years in the community (not admitted to hospital) with confirmed or clinically suspected influenza.Based on only one trial.Jefferson et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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ADDIN EN.CITE.DATA (164)Systematic review NAPotential benefit and harm of oseltamivir by reviewing all clinical study reports (or similar document when no clinical study report exists) of randomized placebo controlled trials and regulatory comments.Ozeltamivir had no effect in children with asthma, but there was an effect in otherwise healthy children.Children and adults who either were healthy before exposure to respiratory agents or had a chronic illness (such as asthma, diabetes, hypertension) but excluding people with immune suppression.Jefferson et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KZWZmZXJzb248L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy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==
ADDIN EN.CITE.DATA (165)Cochrane reviewNAPotential benefit and harm of neuraminidase inhibitors for influenza in all age groups by reviewing all clinical study reports of published and unpublished randomized, placebo-controlled trials and regulatory comments.For the treatment of adults, oseltamivir reduced the time to first alleviation of symptoms by 16.8 hours (95% CI 8.4-25.1, p<0.0001). This represents a reduction in the time to first alleviation of symptoms from 7 to 6.3 days. There was no effect in asthmatic children, but in otherwise healthy children there was a reduction by 29 hours (95% CI 12-47 hours, p=0.001). All age groups. 53 trials in Stage 1 and 46 in Stage 2 (formal analysis), including 20 oseltamivir (9623 participants) and 26 zanamivir trials (14,628 participants).Watanabe, 2013 ADDIN EN.CITE <EndNote><Cite><Author>Watanabe</Author><Year>2013</Year><RecNum>16</RecNum><DisplayText>(167)</DisplayText><record><rec-number>16</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481208311">16</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Watanabe, A.</author></authors></contributors><titles><title>A randomized double-blind controlled study of laninamivir compared with oseltamivir for the treatment of influenza in patients with chronic respiratory diseases</title><secondary-title>Journal of Infection and Chemotherapy</secondary-title></titles><pages>89-97</pages><volume>19</volume><number>1</number><keywords><keyword>Antiviral Agents [adverse effects] [therapeutic use]</keyword><keyword>Asthma [complications]</keyword><keyword>Chronic Disease</keyword><keyword>Double-Blind Method</keyword><keyword>Enzyme Inhibitors [therapeutic use]</keyword><keyword>Influenza A Virus, H1N1 Subtype [drug effects]</keyword><keyword>Influenza, Human [drug therapy] [virology]</keyword><keyword>Neuraminidase [antagonists & inhibitors]</keyword><keyword>Oseltamivir [adverse effects] [therapeutic use]</keyword><keyword>Treatment Outcome</keyword><keyword>Zanamivir [adverse effects] [analogs & derivatives] [therapeutic use]</keyword><keyword>Adult[checkword]</keyword><keyword>Aged[checkword]</keyword><keyword>Female[checkword]</keyword><keyword>Humans[checkword]</keyword><keyword>Male[checkword]</keyword><keyword>Middle Aged[checkword]</keyword><keyword>Sr-airways</keyword></keywords><dates><year>2013</year></dates><accession-num>CN-00844191</accession-num><work-type>Randomized Controlled Trial; Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url> 22907567</custom3><electronic-resource-num>10.1007/s10156-012-0460-1</electronic-resource-num></record></Cite></EndNote>(167)Japan2009Double-blind, randomized controlled trialLaninamivir group: singe inhalation of 40 mg laninamivir and placebo oseltamivir capsules twice daily for 5 days. Oseltamivir group: one capsule (75 mg) of oseltamivir orally twice daily for 5 days and laninamivir placebo powder once on day 1.Efficacy and safety of laninamivir octanoate, an inhaled neuraminidase inhibitor for the treatment of influenza patients with chronic respiratory diseases.Laninamivir octanoate showed similar efficacy and safety to oseltamivir in the treatment of influenza, including that caused by influenza A(H1N1)2009, in patients with chronic respiratory diseases.203 patients aged ≥20 years. Most patients had underlying bronchial asthma.Kohno 2011 ADDIN EN.CITE <EndNote><Cite><Author>Kohno</Author><Year>2011</Year><RecNum>229</RecNum><DisplayText>(166)</DisplayText><record><rec-number>229</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481210247">229</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kohno, S.</author><author>Kida, H.</author><author>Mizuguchi, M.</author><author>Hirotsu, N.</author><author>Ishida, T.</author><author>Kadota, J.</author><author>Shimada, J.</author></authors></contributors><titles><title>Intravenous Peramivir for Treatment of Influenza A and B Virus Infection in High-Risk Patients</title><secondary-title>Antimicrobial Agents and Chemotherapy</secondary-title></titles><periodical><full-title>Antimicrobial Agents and Chemotherapy</full-title><abbr-1>Antimicrob. Agents Chemother.</abbr-1><abbr-2>Antimicrob Agents Chemother</abbr-2><abbr-3>Antimicrobial Agents & Chemotherapy</abbr-3></periodical><pages>2803-2812</pages><volume>55</volume><number>6</number><dates><year>2011</year><pub-dates><date>2011/04/04</date></pub-dates></dates><publisher>American Society for Microbiology</publisher><isbn>0066-4804
1098-6596</isbn><urls><related-urls><url>;(166)JapanJan-May 2009Multicenter, uncontrolled, randomized, double-blind studyPeramivir intravenously administered at 300 or 600 mg/day for 1 to 5 days, as neededEfficacy and safety of the novel anti-influenza virus drug peramivir in high-risk patients.In the 600 mg group about 50% shorter duration of illness. In 33% of patients adverse drug reactions, described as “not particularly problematic clinically” with quick recovery in all cases. 37 influenza patients, ≥20 years, with risk factors, including asthma.5 patients with asthma were also taking steroids.Biggerstaff et al. 2014 ADDIN EN.CITE <EndNote><Cite><Author>Biggerstaff</Author><Year>2014</Year><RecNum>241</RecNum><DisplayText>(193)</DisplayText><record><rec-number>241</rec-number><foreign-keys><key app="EN" db-id="5exdx2dfizdzfiewsv8p295z50z9d5zvv0zt" timestamp="1481300306">241</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Biggerstaff, M</author><author>Jhung, MA</author><author>Reed, C</author><author>Garg, S</author><author>Balluz, L</author><author>Fry, AM</author><author>Finelli, L</author></authors></contributors><titles><title>Impact of medical and behavioural factors on influenza-like illness, healthcare-seeking, and antiviral treatment during the 2009 H1N1 pandemic: USA, 2009–2010</title><secondary-title>Epidemiology and infection</secondary-title></titles><periodical><full-title>Epidemiology and Infection</full-title><abbr-1>Epidemiol. Infect.</abbr-1><abbr-2>Epidemiol Infect</abbr-2><abbr-3>Epidemiology & Infection</abbr-3></periodical><pages>114-125</pages><volume>142</volume><number>01</number><dates><year>2014</year></dates><isbn>1469-4409</isbn><urls></urls></record></Cite></EndNote>(193)USA2009-2010USA state-based, random-digit-dialled telephone surveynoneIn?uenza antiviral treatment prescription in influenza like illness (ILI).26% of respondents with ILI received clinical influenza diagnosis. Of these 36% received antiviral treatment. Being younger and employed but not high-risk conditions, including asthma, were associated with antiviral treatment. 216,431 adults ≥18 years, non-institutionalizedData in this study are self-reported and subject to recall and social desirability bias.Diagnosis and treatment are not verified.Biggerstaff et al. 2014 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaWdnZXJzdGFmZjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaWdnZXJzdGFmZjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1ll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ADDIN EN.CITE.DATA (159)USA2010-2011USA state-based, random-digit-dialled telephone survey noneIn?uenza antiviral treatment prescription in influenza like illness (ILI).Among adults with a physician diagnosis of in?uenza, 34% received antiviral treatment. Having asthma was not associated with antiviral treatment.75,088 adults (18->65 years) and 15,649 children (0-17 years) were interviewed.Data in this study are self-reported and subject to recall and social desirability bias. Diagnosis and treatment arte not verified.COPD chronic obstructive pulmonary disease; NAI neuraminidase inhibitor; CI confidence interval.Figure 122225270065500Figure 1. Global seasonal influenza vaccination policies for people with asthma. Source data obtained from following references: Europe1,2; Americas3,4; Africa5,6; Asia2,7-9; Oceania7. The following countries have vaccination policies for chronic disease, which includes asthma in the majority of cases: Argentina, Bahamas, Belize, Bolivia, Brazil, Chile, Colombia, Costa Rica, Cuba, Dominican Republic, Ecuador, Egypt, El Salvador, Fiji, Grenada, Ivory Coast, Mauritius, Mexico, Morocco, Panama, Paraguay, Peru, Philippines, Saint Lucia, Thailand, Trinidad and Tobago, Uruguay and Venezuela. This graphic is licenced by a Creative Commons Attribution-ShareAlike 3.0 Unported License: . 1. O’Flanagan, D et al. Seasonal influenza vaccination in EU / EEA, influenza season 2011-12, VENICE II Consortium. 2013;1–67.2. WHO. Evaluation of seasonal influenza vaccination policies and coverage in the WHO European Region. Results from the 2008/2009 and 2009/2010 influenza seasons Based on a joint VENICE–ECDC–WHO survey. 2010;1–29.3. Ropero-alvarez, AM Influenza Vaccine Use In the Americas Network for Evaluation of Influenza Vaccine Effectiveness REVELAC-i. Pan American Health Organization. 2014. . Ropero-Alvarez, AM et al. Expansion of seasonal influenza vaccination in the Americas. BMC Public Health. 2009;9:361.5. Duque, J et al. Influenza vaccines and influenza antiviral drugs in Africa: are they available and do guidelines for their use exist? BMC Public Health. 2014;14:41.6. Green, RJ et al. Influenza Guideline for South Africa – Update 2008. S. Afr. Med. J. 2008;98:224–230.7. Dwyer, D et al. Seasonal influenza vaccine policies, recommendations and use in the World Health Organization’s Western Pacific Region. West. Pacific Surveill. response J. WPSAR. 2013;4:51–9.8. Gupta, V et al. Influenza vaccination guidelines and vaccine sales in Southeast Asia: 2008-2011. 2012;PLoS One 7:e52842.9. Kang, J. Effectiveness and safety of seasonal influenza vaccination in children with underlying respiratory diseases and allergy. Korean J. Pediatr. 2014;57:164–170.Appendix 1Search strategy: Medline formatRespiratory Hypersensitivity/ or Bronchial Hyperractivity or Asthma/ or Status Asthmaticus/(asthma or asthma exacerbation or asthma attack or acute asthma or acute asthmatic attack or asthmatic children or wheez*).mp.(bronchial disorder or airway reactivity or airway hyperresponsiveness or bronchial hyperreactivity or bronchial hyperresponsiveness or lung function or ventilatory function or FEV or FEF or FVC or PEF).mp.or/1-3Influenza, Human/ or Influenza vaccines/ or Influenza A virus or Influenza B virus or Influenzavirus C/ or Influenza A Virus, H5N1 Subtype/ or Influenza A Virus, H1N1 Subtype/ or Influenza A Virus, H3N2 Subtype/exp Epidemiologic Studies/ or exp Intervention Studies/ or exp Evaluation Studies/ or exp Comparative Studies/ or exp Follow-up Studies/ or exp Prospective Studies/ or exp Cohort Studies/ or exp Case-Control Studies/ or exp Cross-Sectional Studies/(prospectiv* or cohort or birth cohort or analytical stud* or cohort stud* or case-control stud*or cross-sectional stud*).mp.Review literature as Topic/ or systematic review.mp.Clinical trial/ or Controlled Clinical Trial/ or Randomized Controlled Trial/exp Placebos/ or exp Random Allocation/ or exp Double-Blind Method/ or exp Single-Blind Method/(trial or clinical trial or controlled clinical trial or random* or randomi?ed controlled trial or double-blind design or single blind design).mp.exp Survey/ or survey.mp.or/6-124 AND 5 AND 13limit 14 to yr=”2000-2014”limit 15 to human Search Strategy: free-field format(Asthma or acute asthmatic attack or status asthmaticus or wheez* or respiratory hypersensitivity or bronchial hyperreactivity or bronchial hyperresponsiveness or airway hyperreactivity or airway hyperresponsiveness)AND (Influenza, human or influenza vaccin* or influenza A virus or influenza B virus or influenzavirus C or influenza A virus subtype H1N1 or Influenza A virus subtype H3N2 or Influenza A virus subtype H5N1)AND(Analytical stud* or epidemiologic* or compar* or evaluat* or follow-up or observation* or cohort stud* or case-control stud* or cross-sectional stud* or systematic review or intervention* or trial* or RCT or double-blind or single-blind or control* or random* or prospective or retrospective) ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- iris sphincter tear icd 10
- iris synechiae
- iris synechiae icd 10
- abnormal iris icd 10
- iris tear icd 10
- traumatic iris icd 10
- depunere declaratia unica anaf
- depunere declaratie unica 2021
- depunere declaratie unica persoane fizice
- declaratia unica 2020 pdf
- formular declaratie unica 2020
- descarcare declaratie unica 2020