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Antipsychotics and Lithium1. Regarding lithiuma. It is responsible for inducing type II diabetes – D insipidusb. It requires no treatment in overdosec. It is metabolised by first pass effects in the liverd. Dosing does not need to be reduced in renal impairmente. It is excreted almost entirely in the urine <=2. Haloperidola. Is more sedative than chlorpromazineb. May lower the convulsive threshold <=c. Is a potent dopamine agonist – dompamine receptor blocker (D2>D1=D4>alpha>5HT2)d. Has potent anti-cholinergic effects – extra pyramidale. Has a low incidence of extra-pyramidal reactions3. Regarding chlorpromazine which is NOT true?a. It is more than 80% protein bound – 95-98%b. Is has a plasma half life of approximately 6 hoursc. It is excreted in urine and faeces d. It induces hepatic microsomal enzymes <=e. Plasma levels are increased by concomitant administration of anticholinergic antiparkinson agents4. Haloperidola. Can cause significant nauseab. Has low extrapyramidal toxicityc. Has a high clinical potency <=d. Acts primarily at GABA receptorse. Belongs to the thienobenzodiazepam drug family5. The drug used as an antipsychotic most likely to cause extrapyramidal effects isa. Chlorpromazineb. Lorazepamc. Risperidoned. Haloperidol <=e. Clozapine ................
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