CV-module



ARYA MITRA SHARMA

MD, PhD, FRCPC

BUSINESS ADDRESS: McMaster University, Hamilton General Hospital, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada, Tel: 905-527-4322 x46806, Fax: 905-525-2260, sharma@cardio.on.ca

PERSONAL DATA: Nationality: German, Status: Permanent Resident of Canada,

DOB: Nov 22, 1959, Wife: Christine, Daughters: Linnie (1982), Kamala (1994), Rashmi (1986)

Areas of Expertise: Obesity, hypertension, insulin resistance, renin-angiotensin system, sympathetic nervous system, adipose-tissue biology, gene-expression analysis, genetics, electrolyte and acid-base homeostasis, dietary interventions, pharmacology

CURRENT POSITIONS

01/2006 - present Scientific Director, Canadian Obesity Network (Network of Centres of Excellence)

06/2003 - present Director, Centre for Obesity Research and Management (Hamilton Health Sciences, Hamilton, ON)

09/2002 - present Professor of Medicine, Michael G. DeGroote School of Medicine, McMaster University (Hamilton, ON)

PREVIOUS POSITIONS

06/2000-08/2002 Research Group Leader "Cardiovascular and Obesity Genetics", Max Delbrück Center for Molecular Medicine, Berlin, Germany

04/2000-08/2002 Professor of Medicine, Assoc. Director, Division of Nephrology and Hypertension, Humboldt University of Berlin, Germany

10/1995-05/2000 Professor of Medicine, Division of Nephrology and Endocrinology, Free University of Berlin, Germany

11/1986-09/1995 Physician, Division of Internal Medicine, University Clinic Benjamin Franklin, Free University Berlin, Germany

EDUCATION

02/1995 Professorial thesis (Habilitation) in Internal Medicine, Freie Universität Berlin: “Studies on Salt Sensitivity on Normotensive Men”

02/1994-02/1995 Visiting Researcher: (Deutsche Forschungsgemeinschaft): J.-M. Lalouel, Eccles Institute of Genetics, Salt Lake City, Utah, USA

1.7-1.8-1992 Visiting Researcher: DC Batlle, Northwestern University Medical School and Lakeside Veterans Administration Research, Chicago, Illinois, USA

5.10-16.11.1990 Visiting Researcher: DC Batlle, Northwestern University Medical School and Lakeside Veterans Administration Research, Chicago, Illinois, USA

18.8-31.8.1990 Fellow at the ‘23rd International Teaching Seminar on Cardiovascular Epidemiology and Prevention’, Council on Epidemiology and Prevention of the International Society and Federation of Cardiology (J. Stamler, R. Stamler, G. Rose et al.), Ziegenhals, GDR

08/1987 Ph.D. - Doctoral thesis: “Effect of Angiotensin-Converting Enzyme Inhibition on Norepinephrine Reactivity and Catecholamine Metabolism” (magna cum laude), Faculty of Medicine, Free University of Berlin, Germany

1986. MD, Freie Universität Berlin, Germany

Post-Graduate Qualifications and Licenses

09/2002- Active Member (The College of Physicians and Surgeons of Ontario)

06/2002- Certification Internal Medicine and Nephrology (Fellow of the Royal College of Physicians and Surgeons of Canada)

10/1998- Board Certification "Nephrology" (Ärztekammer Berlin)

09/1993- Board certification "Internal Medicine" (Ärztekammer Berlin)

Honours and Awards:

2005 Rick Gallop Award for Research Excellence, Heart & Stroke Foundation of Ontario

2002 RD Wright Lecture, High Blood Pressure Research Council of Australia

2002 Canada Research Chair: Cardiovascular Obesity Research and Management, McMaster University, Hamilton, Ontario

1995 Young Investigator Travel Award (German Society of Hypertension)

1994 Young Investigator Travel Award (DFG Sh 35/3)

1994-1996 Habilitationsstipendium (DFG Sh 35/2)

1993 Dieter Klaus Förderpreis, German Society of Hypertension

1993 Young Scholars Travel Grant (American Society of Hypertension)

1992. "Outstanding Clinical Research Award" of the Free University Berlin

1992 Travel Grant (International Society of Hypertension)

1989 Young Scholars Travel Grant (American Society of Hypertension)

ACADEMIC, PROFESSIONAL & RESEARCH COMMITTEES

2006-present Steering Committee, International Chair on Cardiometabolic Disease

2006 Clinical Co-Chair, Health Technology Utilization Guidelines Committee for Bariatric Surgery in Ontario

2005-present Canadian Shield Ethics Review Board

2005-present Obesity Canada: Obesity Practice Guidelines Committee

2004-present Canadian Institutes of Health Research Peer Review Committee – Nutrition, Food and Health

2004 Ad hoc Committee International Association for the Study of Obesity (IASO) and International Federation of Obesity Surgery (IFSO)

2004 Chair: International Association for the Study of Obesity (IASO): 2010 Site Selection Committee

2000-2002 Independent Research Group Leader at the Max-Delbrück Center for Molecular Medicine "Cardiovascualar Genetics and Obesity"

2001-present Steering Committee and founding faculty, Specialist Certification of Obesity Professionals in Europe (SCOPE)

1996-2000 Elected member of the Fachbereichsrat (ruling body) of the Medical Faculty of the FU Berlin

1999-2000 Elected coordinator of the Cardiovascular Research Programme of the Freie Universität Berlin

1995-2002 Deputy Chairman of the Patient Information Section of the German Hypertension Society

1995-2000 Elected faculty member of the "Institutsrat" of the Dept. of Internal Medicine Freie Universität

1988-1992 Elected deputy representative of the non-faculty medical employees of the Dept. of Internal Medicine in the "Institutsrat" Freie Universität Berlin

1991. Elected member of the Academic Senate of the Freie Universität Berlin

CLINICAL TRIALS

International

2006-present Member, Executive Steering Committee, Aliskiren against Various Athero-metabolic Trial Outcomes in obesity or Risk elevation (AVIATOR Study; Novartis)

2006-present Chairman, Executive Steering Committee, The 5A registry: Awareness of Abdominal Adiposity As A marker of cardiometabolic risk (Sanofi-Aventis)

2006-present National Coordinator, INSPIRE (Sanofi-Aventis)

2005-2006 National Coordinator, International Day for Evaluation of Abdominal obesity (IDEA Study, Sanofi-Aventis)

2006-present Member, Data Safety Monitory Board, A 104-Week, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Assess the Safety and Efficacy of Lorcaserin Hydrochloride in Obese Patients (Behavioral modification and Lorcaserin for Obesity and Overweight Management, BLOOM; ADP356-009, Arena pharmaceuticals)

2004 Global PI: Telmisartan in patients with mild/moderate hypertension and chronic kidney disease (ESPRIT; Boehringer Ingelheim)

2002-2004 Global PI: A prospective, randomised, open-label, blinded end-point, forced-titration trial to compare MICARDIS( PLUS / MICARDIS( HCT (telmisartan combined with hydrochlorothiazide 80 mg/12.5 mg) to DIOVAN HCT( (valsartan combined with hydrochlorothiazide 160 mg/12.5 mg), for the control of mild-to-moderate hypertension in obese patients with type-2 diabetes mellitus using ambulatory blood pressure monitoring. (SMOOTH Study, 502.399, Boehringer Ingelheim)

2000 Local PI: Randomized, Multicenter, Double-Blind, Trial on the Efficacy and Tolerability of TOPIRAMATE in obese patients (PRI/TOP-INT-31, Janssen-Cilag)

2001-present Member, Executive Steering Committee, Sibutramine Cardiovascular OUTcomes Trial (SCOUT Trial, Abbott Laboratories)

2000 National PI: Efficacy and Tolerability of ORLISTAT when used with two different weight loss diets in obese patients (Ro 18-0647, Hofmann-La Roche)

2000 Local PI: A Phase III, Multi-Center, Two-Arm Study to assess the efficacy and sagety of ECOPIPAM (SCH 39166) in the treatment of obesity in subjects with type 2 Diabetes Mellitus (P00741, Schering-Plough)

1998 Local PI: Multi-centre, prospective, randomised, double-blind, placebo-controlled parallel-group study to examine the influence of SIBUTRAMINE 15 mg over 12 weeks on plasma fibrinogen levels in obese patients with a BMI>30 kg/m2 and ................
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