Lymphoma Diagnostic Work-up from a Lab Perspective
Lymphoma Diagnostic Work-up from a Lab Perspective
Mohamed E. Salama M.D.
Mohamed.salama@path.utah.edu
Lymphoproliferative Disorders
Malignant lymphoma 1. Non-Hodgkin lymphoma (NHL) 2. Hodgkin (disease) lymphoma 3. Multiple myeloma
Basic concepts
Lymphomas are solid tumors of the hematopoietic system. Neoplasms of lymphoid origin, typically causing lymphadenopathy
leukemia vs. lymphoma
Leukemias as systemically distributed neoplasms of white cells
Very important concept......
lymphomas and leukemias are clonal expansions of cells at certain developmental stages
Follicle / germinal center (B cell)
Mantle zone (B-cell)
Paracortex (T-cell)
Lymphatic sinus
NORMAL LYMPH NODE
Medullary cord (B-cell)
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