PHARMACOLOGY BASIC PRINCIPLES
Competitive inhibition: drug may bind CP450 heme iron hence preventing CP450 from metabolizing via competitive inhibition (eg. Ketoconazole, cimetidine) Drug may bind CP450 heme iron and render it catalytically inactive (eg. macrolide AB’s) Suicide inhibitors: CP450 may be bound by metabolic substrate of a drug and hence altered (eg. ................
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