MolMed



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Basic Human Genetics course

‘Genetics for dummies’

Wednesday 6 & Thursday 7 November 2019

vs 191014

This 2-day course will explain to you the basic concepts in human genetics. The course will cover real basic genetics with some history, how to perform linkage analysis in families with hereditary diseases, but also a large introduction to “Complex Genetics”. This is the scientific discipline that studies the role of genetic variation in common complex diseases (such as osteoporosis, cardiovascular disease, diabetes, etc.) and traits (such as blood pressure, BMD, glucose level, height, cholesterol level, etc.).

Fuelled by successful applications of Genome Wide Association Studies (GWAS) and High Throughput (HT) Sequencing in various disease areas, this course is meant to give some introductory background for people wanting to start or become involved in such studies, or just want to know what it is all about. Mostly, these will be people who are specialized in the diseases and/or traits of interest, but do not have the necessary genetic background knowledge.

Target audience

The target audience includes -but is not limited to- Master of Science students, technicians, PhD students, post-docs, assistant/associate/full professors with an interest in genetic studies. These may come from various disciplines and from a clinical, basic/biological, epidemiological or public health background.

Students who have followed the Nihes Summer Course (master Health Science and related courses) ESP57 (“Genomics in Molecular Medicine”) do not have to follow this course because the contents are similar.

This short course is also very useful connected with the more advanced MolMed “SNP course” which covers a much wider and deeper range of topics in this rapidly evolving field (see: molmed.nl/courses).

The minimal number of participants is 8, and the total number of participants is limited to 30.

ECTS

This course including self-study is 0,6 ECTS

Course fees

The attendance fee of the course is €400, but certain participants can get a discount. See below for all details.

Program

In “Genetics for Dummies” five experienced lecturers from Erasmus MC will introduce you to basic concepts in complex genetics, laboratory techniques, and statistical analytical issues. The program is built on four half days, each of which is covered by one speaker. After every talk, much time is reserved for Questions and Answers, to get interactivity with the participants.

Basic knowledge, background literature

Basic knowledge of (molecular) biology is expected from the participants. Background literature on the topic can be found in :

- “Genetics for Dummies” (2nd edition, T.R. Robinson, Wiley Publishing, Inc.; ISBN 978-0-470-55174-5)

- "Molecular Biology of the Cell" (6th ed.; editors: Alberts et al.; published by Garland Sciences; ISBN 978-0-815-34432-2);

- "Human Molecular Genetics" (4th ed.; editors Tom Strachan& Andrew Reed.

ISBN 0-471-33061-2; published by Garland Sciences; £40,-).

To this aim, also a series of basic papers is published on our website: molmed.nl on the page of the SNP course. At the start of the course a reader will be issued.

Course organizers

Dr. Robert Kraaij, Dept Internal Medicine, Erasmus MC

Prof.dr. André Uitterlinden, Dept Internal Medicine, Erasmus MC

Dr. Annemieke Verkerk, Dept Internal Medicine, Erasmus MC

Dr. Frank van Vliet, Postgraduate School MolMed

Lecturers

Prof.dr. André Uitterlinden, Dr. Annemieke Verkerk, Dr. Robert Kraaij, and Dr. Linda Broer.

Subscription is open now on: molmed.nl. If you have any questions, please mail or call Frank van Vliet: molmed@erasmusmc.nl (010-70 38 053 or 06-5474 6408).

|First Day, Wednesday 6 November, room OWR-4 |

|Moderators: Annemieke Verkerk & Robert Kraaij |

|Time |Speaker |Subject |

|09.30-09.45 |Registration and coffee |

|09.45-10.30 |Annemieke Verkerk |Basic genetics: history & concepts (1) |

|10.30-10.45 |Coffee break | |

|10.45-11.30 |Annemieke Verkerk |Basic genetics: history & concepts (2) |

|11.30-11.45 |Coffee break |

|11.45-12.30 |Robert Kraaij |Molecular genetics (1) |

|12.30-13.30 |Lunch | |

|13.30-14.15 |Robert Kraaij |Molecular genetics (2) |

|14.15-14.30 |Coffee break |

|14.30-15.15 |André Uitterlinden |Introduction to complex genetics (1) |

|15.15-15.30 |Coffee break |

|15.30-16.15 |André Uitterlinden |Introduction to complex genetics (2) |

|Second Day, Thursday 7 November, room OWR-72 (nb NOT in OWR, but in the Ee building, entrance from the 3rd floor next to the porters loge) |

|Moderators: Annemieke Verkerk & Robert Kraaij |

|Time |Speaker |Subject |

|10.15-11.15 |Linda Broer |Statistics and analytical issues: SNP and haplotype analysis |

|11.15-11.30 |Coffee break |

|11.30-12.30 |Linda Broer |Statistics and analytical issues: SNP and GWAS data |

|12.30-13.15 |Lunch |

|13.15-14.15 |Robert Kraaij |“Next Gen” HT Sequencing: techniques and data analysis (1) |

|14.15-14.30 |Coffee break |

|14.30-15.30 |Robert Kraaij |“Next Gen” HT Sequencing: techniques and data analysis (2) |

|15.30-15.45 |Coffee break | |

|15.45-16.45 |Linda Broer |Applications of DNA Technology in Society |

Attendance fees

The subscription fee of non-commercial participants for the Course is € 400. Discounts are handled as followed:

• PhD students get a discount of 50% and pay €200.

• Only participants from the postgraduate school MolMed get a discount of 100% and pay €0.

• Master students from elsewhere who pay the fee from their personal budget get a discount of 75% and pay €100.

If these financial requirements pose a problem but you wish to attend the Course, please contact Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at: f.vanvliet@erasmusmc.nl.

Invoices

Fees can be paid upon an INVOICE. Shortly after your registration you will receive the INVOICE per mail. Payment per bank can be done together with the number on your INVOICE.

Late participants can also pay in cash upon signing in for the Course.

Cancellations

The fees are for all the days of the Course. There is no discount for partaking only in part of the Course. Our cancellation policy is that cancellation is possible up to one week before the start of the Course. Later cancellation will not be accepted, but you are allowed to send a substitute.

Commercial participants & sponsors

Companies are invited to inquire for participation and sponsoring.

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