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HYPERLINK "" Covid-19 vaccine: All you need to knowThe UAE has led the way in coronavirus vaccine trials and immunisations.The UAE, along with Bahrain, were two of the first Arab countries to approve the Sinopharm shot — and were the first countries to grant full approval to use a COVID-19 vaccine. Other countries followed suit. Here’s a closer look into the Sinopharm vaccine and how the UAE leads the world in the fight against the pandemic.Who produces the Sinopharm vaccine?Sinopharm’s China National Biotec Group (CNBG). Sinopharm is a Chinese state-owned biotech company based in Beijing.What is the shot called?BBIBP-CorV.Where is it approved for use?Reuters reported in September that Phase III trials for the Sinopharm shot had been conducted in 10 countries worldwide. The vaccine has been granted authorisation in China, and several other countries, including the UAE.Why was the trial of Sinopharm, a Made-in-China vaccine, not done in China itself?A vaccine trial is best done in places where a pathogen (like SARS-CoV-2) is still most active. In China, the case numbers had dropped significantly in the third quarter of 2020, due to the strict lockdowns. Doing a trial there would have made it difficult to obtain any meaningful data at all.How does the Sinopharm vaccine trigger an immune response?Once inside the body, given through intra-muscular injection, some of the inactivated viruses are swallowed up by a type of immune cell called an “antigen-presenting cell”. The antibodies also attach to viral proteins, such as the so-called spike proteins that populate the viral surface.How is the Sinopharm vaccine made?The journal Cell explains: to create Sinopharm’s BBIBP-CorV shot, the researchers obtained three variants of the coronavirus from patients in Chinese hospitals. They picked one of the variants because it was able to multiply quickly in monkey kidney cells grown in bioreactor tanks.What’s the deal with inactivated virus vaccine?It’s a tried-and-tested platform. Inactivated viruses have been used for over 100 years. Polio vaccine inventor Jonas Salk used them to create his polio vaccine in the 1950s. It’s the same method used to prepare vaccines against other diseases including rabies and hepatitis A. Coronaviruses in BBIBP-CorV are literally killed (inactivated) through a chemical process, so they can be injected into your arm without causing Covid-19.How is the coronavirus used in the vaccine ‘killed’?Yes, they are literally killed. But first, before they’re killed, lab workers produce huge stocks of the coronaviruses in high bio-safety labs. Once the desired quantities are produced, they are doused with a chemical called “beta-propiolactone”.What is the efficacy rate of the Sinopharm shot?The UAE, among the first to approve the Sinopharm shot, said the vaccine was 86 percent effective, based on interim results of Phase 3 trials in the Emirates.Is it safe?Yes. Millions have already received the vaccines in the UAE 5.5 million, most of them were Sinopharm shots, with no reports of severe reactions or adverse effects. Chinese media reported on February 20, 2021 that 43 million doses of Sinopharm Covid-19 vaccine had been administrated worldwide, of which 34 million were in China.What did peer-reviewed journals say about earlier trials of the Sinopharm vaccine?On August 13, 2020, JAMA published the interim results of two randomised Phase 2 clinical trials of the Sinopharm vaccine, and wrote: “This inactivated Covid-19 vaccine had a low rate of adverse reactions and demonstrated immunogenicity.” Following trial review and the results’ publication, the Chinese approved the vaccine, the first formal green light for a Covid-19 vaccine in the world.What is the key advantage of the inactivated platform?Less developed countries with no access to deep-freezing facilities would benefit from this type of vaccine. They can be transported more easily and at normal fridge temperatures. By comparison, Moderna and Pfizer’s vaccines, must be kept very cold — -20 °C to -70 °C. This poses a major logistical challenge, especially in places where power is unreliable or non-existent. Immunisation programmes even in developed countries, like the UK and the US, had been hampered because of the freezing requirement.Does it offer 100 percent protection from moderate and severe forms of Covid-19?Yes, according to Abu Dhabi-based chief research officer Dr Walid Abbas Zaher, vaccine project leader of G42 Healthcare. The jab has an overall efficacy rate is 86 percent. “Think about the vaccine the same way you are taking the flu vaccine. If you are taking the flu vaccine, sometimes you don’t get the flu at all and sometimes you get the flu but in a very mild form. Covid-19 at the end of the day is a flu, a very nasty bad flu. And the vaccine works in the same way. It will either prevent you completely from having the disease or there is a remote chance that you get an infection. Even if you get it (infection) after taking the vaccine, you will not feel it. Even if you feel it, it will be a very mild flu.”Does the Sinopharm vaccination mean 100 percent protection against infection?No. Dr Nawal Al Kaabi explained: “(Though) you are protected 100 per cent against severe infection, there is a chance to acquire the disease. So, it is important for people who have taken the vaccine to continue to wear masks . . . and follow all the precautions.”How long will protection last? What about reinfection?Nature wrote that the durability of protective immune responses remains “unknown”: “Although the preponderance of evidence suggests that adaptive immune responses elicited by SARS-CoV-2 infection are present and might protect against re-infection, experience with seasonal coronaviruses and present experience with SARS-CoV-2 suggest that immunity to natural infection might wane over time, and reinfection has been reported.”I had been diagnosed with COVID-19 in the past. Should I get this vaccine?There are people previously infected a COVID-19 infection who had taken the vaccine, with no issues. Nature said it remains unclear whether previously infected persons would benefit from vaccination. However, the journal states vaccination against SARS-CoV-2 should be made irrespective of infection status (whether someone had been infected or not).What about the quality of every batch of this vaccine produced?This is actually a good question. Quality is of utmost importance. That’s why strict inspections and quality controls every step of the biosafe environment and manufacturing processes must be adhered to. This is because both safety and efficacy can be affected by even minor lapses in quality.How is vaccine quality assured?Random and regular inspection of every part of the manufacturing process and every batch of vaccine produced also form part of quality controls. There are country-specific regulations as well as international standards developed by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH), which forms the basis for ensuring quality in clinical research.The “ICH Q” guidance series, on the other hand, ensures that vaccine quality meets global standards for bio-chemistry, manufacturing and control. It’s known as “GxPs” (that is, Good Clinical Practice, Good Manufacturing Practice and Good Laboratory Practice). Compliance ensures the vaccines being deployed have consistent safety and efficacy. That’s critical to overcome vaccine hesitancy.How many other Covid-19 vaccines have been developed in China?Besides CNBG’s two vaccines, China’s emergency-use programme also includes a shot from Sinovac Biotech. A fourth candidate from CanSino Biologics jointly developed by the Hong Kong-listed CanSino and the Beijing Institute of Biotechnology (part of China’s Academy of Military Medical Sciences), was approved for use in for Chinese military personnel in June 2020. — Gulf News. ................
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