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Supplemental Fig 1. Funnel plot for assessment of publication bias in meta-analysis of bioprosthetic versus mechanical prostheses for surgical aortic valve replacement in patients aged 50-70 years.The logit event rate for outcomes (horizontal axis) is presented against the standard error(SE) of the log of logit event rate (vertical axis). SE inversely corresponds to study size.Asymmetry of the plot may indicate publication bias. RR, risk ratio.Supplemental Fig 2. Forest plot of overall long-term freedom from cardiac mortality comparing BV vs MV following AVR.BV, bioprosthetic valve; MV, mechanical valve; AVR, aortic valve replacement; SE, standard error; IV, inverse variance; Random, random effects model; CI, confidence intervalSupplemental Fig 3. Forest plot of overall long-term freedom from stroke comparing BV vs MV following AVR.BV, bioprosthetic valve; MV, mechanical valve; AVR, aortic valve replacement; SE, standard error; IV, inverse variance; Random, random effects model; CI, confidence interval.Supplemental Table 1. Assessment of quality of included studies in meta-analysisFirst authorClear definition of study populationClear definition of outcomes and outcome assessmentIndependent assessment of outcome parametersSufficientduration offollow-upSufficientsamplesizeNo selectiveloss duringfollow-updImportant confounders and prognostic factors identifiedCarrierYesYesYesYesYesYesYesKulikYesYesYesYesNoYesYesPrasongsukarnYesYesYesYesYesYesYesBrownYesYesYesYesYesYesYesStassanoYesYesYesYesNocYesYesWeberNoaYesYesNobNocYesYesChiangYesYesYesYesYesYesYesNishidaNoaYesYesYesYesYesYesMcClureNoaYesYesYesYesYesYesGlaserYesYesYesYesYesYesYesWangNoaYesYesYesNocYesYesRoumiehYesYesYesYesNocYesYesLimitations in design: a No lower age range, therefore analysis limited to <65 years; b mean length of follow-up less than three years; c total matched sample size is less than 300; d both BV and MV patients were lost during follow-up but acceptable since constant censoring is assumed. ................
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