Gene knockout and knockin by zinc-finger nucleases: current ...
CCR5 Human chemokine receptors 5 gene CHO Chinese hamster ovary Dat Dopamine transporter DHFR Dihydrofolate reductase DSB Double-strand break ES cells Embryonic stem cells ... in the repaired chromosome [8]. Such mutations can cause a frame-shift resulting in the disruption of a gene, leading to a knockout of the targeted gene. The Cel-I assay ... ................
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