RESUME .sa



Peer reviewed International Publications:

1. Nadeem A, Al-Harbi NO, Ansari MA, Al-Harbi MM, El-Sherbeeny AM,. Zoheir KM, Attia SM, Hafez MM, Al-Shabanah OA, Ahmad SF. Psoriatic inflammation enhances allergic airway inflammation through IL-23/STAT3 signaling in a murine model. Biochem Pharmacol, October 2016, ISSN 0006-2952, , in press. [ISI Impact factor- 5].

2. Nadeem A, Siddiqui N, Al-Harbi NO, Al-Harbi MM, Ahmad SF. TLR-7 agonist attenuates airway reactivity and inflammation through Nrf2-mediated antioxidant protection in a murine model of allergic asthma. Int J Biochem Cell Biol. 2016 73:53-62. [ISI Impact factor- 4].

3. Bakheet SA, Alzahrani MZ, Ansari MA, Nadeem A, Zoheir KM, Attia SM, Al-Ayadhi LY, Ahmad SF. Resveratrol Ameliorates Dysregulation of Th1, Th2, Th17, and T Regulatory Cell-Related Transcription Factor Signaling in a BTBR T + tf/J Mouse Model of Autism. Mol Neurobiol. 2016 Aug 30. [Epub ahead of print]. [ISI Impact factor- 5.1].

4. Ahmad SF, Zoheir KM, Ansari MA, Nadeem A, Bakheet SA, Al-Ayadhi LY, Alzahrani MZ, Al-Shabanah OA, Al-Harbi MM, Attia SM. Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism. Mol Neurobiol. 2016 Jun 25. [Epub ahead of print]. [ISI Impact factor- 5.1].

5. Bakheet SA, Alzahrani MZ, Nadeem A, Ansari MA, Zoheir KM, Attia SM, Al-Ayadhi LY, Ahmad SF. Resveratrol treatment attenuates chemokine receptor expression in the BTBR T+tf/J mouse model of autism. Mol Cell Neurosci. 2016;77:1-10. [ISI Impact factor- 3.7].

6. Al-Harbi NO, Nadeem A, Al-Harbi MM, Zoheir KM, Ansari MA, El-Sherbeeny AM, Alanazi KM, Alotaibi MR, Ahmad SF. Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model. Immunobiology. 2016 Oct 18. pii: S0171-2985(16)30420-X. doi: 10.1016/j.imbio.2016.10.013. [Epub ahead of print]. [ISI Impact factor-2.7].

7. Ahmad SF, Ansari MA, Nadeem A, Zoheir KM, Bakheet SA, Al-Shabanah OA, Al Rikabi AC, Attia SM. The tyrosine kinase inhibitor tyrphostin AG126 reduces activation of inflammatory cells and increases Foxp3+ regulatory T cells during pathogenesis of rheumatoid arthritis. Mol Immunol. 2016;78:65-78. [ISI Impact factor- 3.4].

8. Attia SM, Ahmad SF, Ansari MA, Nadeem A, Al-Shabanah OA, Al-Harbi MM, Bakheet SA. Utility of Dexrazoxane for the Attenuation of Epirubicin-Induced Genetic Alterations in Mouse Germ Cells. PLoS One. 2016;11(10):e0165854. doi: 10.1371/journal.pone.0165854. [ISI Impact factor- 3.3].

9. Ahmad SF, Ansari MA, Nadeem A, Zoheir KM, Bakheet SA, Alsaad AM, Al-Shabanah OA, Attia SM. STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis. Immunobiology. 2016 Oct 3. pii: S0171-2985(16)30388-6. doi: 10.1016/j.imbio.2016.10.001. [ISI Impact factor- 2.7].

10. Bakheet SA, Attia SM, Alwetaid MY, Ansari MA, Zoheir KM, Nadeem A, Al-Shabanah OA, Al-Harbi MM, Ahmad SF. β-1,3-Glucan reverses aflatoxin B1-mediated suppression of immune responses in mice. Life Sci. 2016;152:1-13. [ISI Impact factor- 2.7].

11. Al-Harbi NO, Nadeem A, Al-Harbi MM, Ansari MA, AlSharari SD, Bahashwan SA, Attia SM, Al-Hosaini KA, Al Hoshani AR, Ahmad SF. Airway oxidative stress causes vascular and hepatic inflammation via upregulation of IL-17A in a murine model of allergic asthma. Int Immunopharmacol. 2016;34:173-82. [ISI Impact factor- 2.5].

12. Nadeem A, Al-Harbi NO, Al-Harbi MM, El-Sherbeeny AM, Ahmad SF, Siddiqui N, Ansari MA, Zoheir KM, Attia SM, Al-Hosaini KA, Al-Sharary SD. Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation. Pharmacol Res. 2015 Sep;99:248-57. [ISI Impact factor- 4.8].

13. Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H. Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation. Clin Exp Allergy. 2015;45(12):1844-55. [ISI Impact factor- 4.7].

14. Al-Harbi NO, Nadeem A, Al-Harbi MM, Imam F, Al-Shabanah OA, Ahmad SF, Sayed-Ahmed MM, Bahashwan SA. Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma. Int Immunopharmacol. 2015 May;26(1):237-45. [ISI Impact factor- 2.7].

15. Nadeem A, Alharbi NO, Vliagoftis H, Tyagi M, Ahmad SF, Sayed-Ahmed MM. Protease activated receptor-2 mediated dual oxidase-2 upregulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma. Immunology 2015;doi: 10.1111/imm.12453. [ISI Impact factor- 4].

16. Ahmad SF, Zoheir KM, Ansari MA, Nadeem A, Bakheet SA, Al-Hoshani AR, Al-Shabanah OA, Al-Harbi MM, Attia SM. Histamine 4 receptor promotes expression of costimulatory B7.1/B7.2 molecules, CD28 signaling and cytokine production in stress-induced immune responses. J Neuroimmunol. 2015 Dec 15;289:30-42. [ISI Impact factor- 3].

17. Bhat MA, Al-Omar MA, Ansari MA, Zoheir KM, Imam F, Attia SM, Bakheet SA, Nadeem A, Korashy HM, Voronkov A, Berishvili V, Ahmad SF. Design and Synthesis of N-Arylphthalimides as Inhibitors of Glucocorticoid-Induced TNF Receptor-Related Protein, Proinflammatory Mediators, and Cytokines in Carrageenan-Induced Lung Inflammation. J Med Chem. 2015;58(22):8850-67. [ISI Impact factor- 5.4].

18. Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Korashy HM, Sayed-Ahmed MM, Hafez MM, Al-Shabanah OA, Nagi MN, Bahashwan S. Riboflavin attenuates lipopolysaccharide-induced lung injury in rats. Toxicol Mech Methods. 2015;25(5):417-23. [ISI Impact factor- 1.5].

19. Ahmad SF, Ansari MA, Zoheir KM, Bakheet SA, Korashy HM, Nadeem A, et al. Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation. Immunobiology 2015:doi: 10.1016/j.imbio.2015.01.008. [ISI Impact factor- 3.3].

20. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM, Imam F, Sayed-Ahmed MM. Glutathione modulation during sensitization as well as challenge phase regulates airway reactivity and inflammation in mouse model of allergic asthma. Biochimie. 2014 Aug;103:61-70 [ISI Impact factor- 3.4].

21. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM, Imam F. Acute glutathione depletion leads to enhancement of airway reactivity and inflammation via p38MAPK-iNOS pathway in allergic mice. Int Immunopharmacol. 2014;22(1):222-9 [ISI Impact factor- 2.4].

22. Al-Harbi NO, Imam F, Al-Harbi MM, Iqbal M, Nadeem A, Sayed-Ahmed MM, Alabidy AD, Almukhallafi AF. Olmesartan attenuates tacrolimus-induced biochemical and ultrastructural changes in rat kidney tissue. Biomed Res Int. 2014;2014:607246. doi: 10.1155/2014/607246. [ISI Impact factor- 2.7].

23. Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Iqbal M, Rahman S, Al-Hosaini KA, Bahashwan S. Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren. Toxicol Mech Methods. 2014; 24(9):697-702. [ISI Impact factor- 1.5].

24. Al-Harbi NO, Imam F, Nadeem A, Al-Harbi MM, Iqbal M, Ahmad SF. Carbon tetrachloride-induced hepatotoxicity in rat is reversed by treatment with riboflavin. Int Immunopharmacol. 2014;21(2):383-8 [ISI Impact factor- 2.4].

25. Lianshu Ding , Chong Zhang, Masood A, Jianxin Li, Jiao Sun, Nadeem A, Han-Ting Zhang3, James M. O’ Donnell, Ying Xu. Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: involvement of antioxidant and anti-apoptotic mechanisms. Behav Brain Res 2014; 268:150-8. [ISI Impact factor- 3.3].

26. Naif O. Al-Harbi, Faisal Imam, Mohamed M. Al-Harbi, Muzaffar Iqbal, Nadeem A, Othman A Al-Shahrah , Hesham M Karashy , Khalid A Al-Hosaini , Mukhtar Ahmed , Saleh Bahashwar. Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats. J Ren Ang Aldos System ;16(4):1329-36. [ISI Impact factor- 2.2].

27. Rievaj J, Davidson C, Nadeem A, Hollenberg M, Duszyk M, Vliagoftis H. Allergic sensitization enhances anion current responsiveness of murine trachea to PAR-2 activation. Pflugers Arch (Eur J Physiology) 2012;463:497-509. [ISI Impact factor- 4.8].

28. Arizmendi NG, Abel M, Mihara K, Davidson C, Polley D, Nadeem A, El Mays T, Gilmore BF, Walker B, Gordon JR, Hollenberg MD, Vliagoftis H. Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and proteinase-activated receptor-2 activation. J Immunol. 2011;186:3164-72 [ISI Impact factor- 5.5].

29. Ponnoth DS, Nadeem A, Tilley SL, Mustafa SJ. Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma. Am J Physiol Heart Circ Physiol. 2010 ;299:H81-87. [ISI Impact factor- 3.8].

30. Ansari HR, Teng B, Nadeem A, et al. A1 adenosine receptor mediated PKC and p42/p44 MAPK signaling in mouse coronary artery smooth muscle cells. Am J Physiol Heart Circ Physiol 2009;297(3):H1032-9. [ISI Impact factor- 3.8].

31. Nadeem A, Ponnoth DS, Ansari HR, Batchelor TP, Dey RD, Ledent C, Mustafa SJ. A2A AR deficiency leads to impaired tracheal relaxation via NADPH oxidase pathway in allergic mice. J Pharmacol Exp Ther 2009 ;330:99-108. [ISI Impact factor- 3.8].

32. Masood A, Nadeem A, Mustafa SJ, O’Donnell JM. Reversal of oxidative stress-induced anxiety by phophodiesterase-2 inhibition. J Pharamcol Exper Ther 2008; 326:369-379. [ISI Impact factor- 3.8].

33. Nadeem A, Raj HG, Chhabra SK. Effect of vitamin E supplementation of standard treatment on oxidant-antioxidant status in Chronic Obstructive Pulmonary Disease. Ind J Med Res 2008; 128:705-711. [ISI Impact factor-1.5].

34. Ponnoth D, Nadeem A, Mustafa SJ. Adenosine-mediated impairment of vascular reactivity and inflammation in a murine model of asthma. Am J Physiol Heart Circ Physiol 2008; H2158-65. [ISI Impact factor- 3.8].

35. Ansari HR, Nadeem A, Tilley SL, Mustafa SJ. Evidence for the involvement of COX-1/COX-2 in A3 adenosine receptor-mediated contraction through endothelium in mouse aorta. Am J Physiol Heart Circ Physiol 2007;293: H3448-55. [ISI Impact factor- 3.8].

36. Nadeem A, Fan M, Ansari HR, Ledent C, Mustafa SJ. Enhanced airway reactivity and airway inflammation in A2A adenosine receptor deficient allergic mice. Am J Physiol Lung Cell Mol Physiol 2007;292:L1335-44. [ISI Impact factor- 4].

37. Mustafa SJ, Nadeem A, Fan M, Zhong H, Belardinelli L, Zeng D. Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist, AMP and allergen-induced airway responsiveness and inflammation in a mouse model of asthma. J Pharmacol Exp Ther 2007; 320:1246-51. [ISI Impact factor- 3.8].

38. Ansari HR, Nadeem A, Talukder MAH, Sakhalkar S, Mustafa SJ. Evidence for the involvement of Nitric Oxide in A2B receptor-Mediated Vasorelaxation of Mouse aorta. Am J Physiol Heart Circ Physiol 2007; 292: H719-25. [ISI Impact factor- 3.8].

39. Nadeem A, Obiefuna PCM, Wilson CN, Mustafa SJ. Adenosine A1 Receptor Antagonist versus Montelukast Sodium on Airway Reactivity and Inflammation. Eur J Pharmacol 2006; 551:116-24. [ISI Impact factor- 2.5].

40. Nadeem A, Masood A, Masood N, Gilani RA, Shah ZA. Immobilization stress causes extra-cellular oxidant-antioxidant imbalance in rats: Restoration by L-NAME and vitamin E. Eur Neuropsychopharmacol 2006; 16:260-267. [ISI Impact factor- 4.3].

41. Obiefuna PCM, Batra VK, Nadeem A, Borron O, Wilson CN, Mustafa SJ. A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma. J Pharmacol Exp Ther 2005; 315: 329-336. [ISI Impact factor- 3.8].

42. Nadeem A, Raj HG, Chhabra SK. Increased oxidative stress and altered levels of antioxidants in chronic obstructive pulmonary disease. Inflammation 2005; 29: 23-32. [ISI Impact factor- 2.4].

43. Nadeem A, Chhabra SK, Raj HG. Increased oxidative stress in acute exacerbations of asthma. J Asthma 2005; 42: 45-50. [ISI Impact factor- 1.5].

44. Nadeem A, Chhabra SK, Masood A, Raj HG. Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol 2003; 111; 72-78. [ISI Impact factor- 13].

Reviews/Book chapter

1. Nadeem A, Siddiqui N, Alharbi NO, Alharbi MM. Airway and systemic oxidant-antioxidant dysregulation in asthma: a possible scenario of oxidants spill over from lung into blood. Pulm Pharmacol Ther. 2014 Oct;29(1):31-40.

2. Nadeem A, El-Sherbeeny AM, Al-Harbi MM, Ahmad SF. Pulmonary Oxidant–Antioxidant Dysregulation in Asthma. In: Reactive Oxygen Species in Biology and Human Health. Ed. Shamim Ahmad. pp.189-203. DOI: 10.1201/b20228-19 .: CRC Press.

3. Nadeem A, Mustafa SJ. Adenosine receptor antagonists & asthma. Drug Discovery Today: Therapeutic Strategies 2006; 3: 269-275.

4. Wilson CN, Nadeem A, Spina D, Brown R, Page CP, Mustafa SJ. Adenosine Receptors and Asthma. In, Adenosine receptors in Health and Disease (Wilson CN and Mustafa SJ, eds). Handbook of Experimental Pharmacology. Vol. 193, 2009. pp- 329-362.

5. Nadeem A, Masood A, Siddiqui N. Oxidant--antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options. Ther Adv Respir Dis. 2008;2:215-35.

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