Connect the dots…DNA to Disease, Oltmann



Name: ___________________________________

Connect the dots…DNA to DISEASE Project

Introduction

We’ve learned that DNA is the genetic material that organisms inherit from their parents, and that DNA encodes how to make the proteins that comes together to make life forms. We have also learned the types of mutations that may occur when the DNA produces errors in replication or when exposed to mutagens and that these mutated DNA sequences will continue to encode for proteins. When made, these proteins are shaped differently than the “normal” proteins made from non-mutated DNA and a different shape leads to different functioning. These different proteins may lead to different and non-normal traits of organisms. When these traits threaten the everyday health of an organism, humans call the complications they cause diseases.

Materials

DNA sequence from teacher

DNA to DISEASE Project Answer Sheet

Computer with an internet connection

White paper

No notebook paper!

Pictures for visual

Procedure

Part 1 (Complete in Class 2/27)

Place all answers on the separate answer sheet for turn in. Do not turn in this document.

1. Obtain your DNA sequence from your teacher. DNA sequence #:_________________

2. Write the sequence carefully in the boxes below. There should be no extra boxes.

3. Convert your DNA sequence into a complementary mRNA sequence. Write the sequence carefully in the boxes below.

EXAMPLE: DNA: T A C G G C T A G

↓

mRNA: A U G C C G A U C

Your DNA sequence:

| |

mRNA sequence:

| | |

|Alanine |A |

|Arginine |R |

|Asparagine |N |

|Aspartic acid |D |

|Cysteine |C |

|Glutamine |Q |

|Glutamic acid |E |

|Glycine |G |

|Histidine |H |

|Isoleucine |I |

|Leucine |L |

|Lysine |K |

|Methionine |M |

|Phenylalanine |F |

|Proline |P |

|Serine |S |

|Threonine |T |

|Tryptophan |W |

|Tyrosine |Y |

|Valine |V |

| | |

| | |

-----------------------

|List of Possible Proteins |

|Presenilin 2 |

|Synuclein |

|Laforin |

|Leptin |

|BRCA 2 |

|Dystrophin |

|Apolipoprotein E |

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