Template for Electronic Submission to ACS Journals
Quantifying Solvophobic Effects in Non-polar Cohesive InteractionsLixu Yang, Catherine Adam, Scott L. Cockroft*EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK.Supporting Information PlaceholderABSTRACT:The hydrophobic effect plays a central role in determining the structure, activity and properties of biomolecules and materials. In contrast, the general manifestation of this phenomenon in other solvents -the solvophobic effect- although widely invoked, is currently poorly defined due to the lack of a universally accepted descriptor. Here we have used synthetic molecular balances to measure solvent effects on aromatic, aliphatic and fluorous non-polar interactions. Our solvent screening data combined with independent experimental measurements of supramolecular association, single-molecule folding and bulk phase transfer energies were all found to correlate well with the cohesive energy density of the solvent. Meanwhile, other measures of solvent cohesion, such as surface tension and internal pressure, gave inferior correlations. Thus, we establish cohesive energy density as a readily accessible, quantitative descriptor of solvophobic association in a range of chemical contexts.The hydrophobic association of non-polar solutes in aqueous solution demonstrates the intrinsic role that a solvent can play in driving self-assembly processes.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkdy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkdy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ADDIN EN.CITE.DATA 1 Though the origins and defining characteristics of the hydrophobic effect are long-standing subjects of debate,PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJp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 EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJp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 EN.CITE.DATA 1b,2 the minimization of solvent-exposed non-polar surface area can be most simply rationalized as arising from the out-competition of solvent-solute interactions by cohesive solute-solute interactions.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkh1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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkh1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ADDIN EN.CITE.DATA 1,3 The general manifestation of this phenomenon in other solvents can be referred to as the solvophobic effect, with solvent cohesion having both electrostatic and van der Waals dispersion contributions.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkRh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkRh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ADDIN EN.CITE.DATA 4 The solvophobic effect has been invoked as governing the rate and outcome of chemical reactions,PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlNj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlNj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ADDIN EN.CITE.DATA 5 while also being exploited in supramolecular folding, self-assembly,PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJl
Y2VycmlsPC9BdXRob3I+PFllYXI+MjAwMzwvWWVhcj48UmVjTnVtPjU0MzU8L1JlY051bT48RGlz
cGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij42PC9zdHlsZT48L0Rpc3BsYXlUZXh0
PjxyZWNvcmQ+PHJlYy1udW1iZXI+NTQzNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1ZCI+NTQz
NTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3
PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmVjZXJyaWwsIEpvcmdl
PC9hdXRob3I+PGF1dGhvcj5Cb2x0ZSwgTWljaGFlbDwvYXV0aG9yPjxhdXRob3I+QnVyZ3VldGUs
IE0uIElzYWJlbDwvYXV0aG9yPjxhdXRob3I+R2FsaW5kbywgRnJhbmNpc2NvPC9hdXRob3I+PGF1
dGhvcj5HYXJjw61hLUVzcGHDsWEsIEVucmlxdWU8L2F1dGhvcj48YXV0aG9yPkx1aXMsIFNhbnRp
YWdvIFYuPC9hdXRob3I+PGF1dGhvcj5NaXJhdmV0LCBKdWFuIEYuPC9hdXRob3I+PC9hdXRob3Jz
PjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkVmZmljaWVudCBNYWNyb2N5Y2xpemF0aW9u
IG9mIFUtVHVybiBQcmVvcmdhbml6ZWQgUGVwdGlkb21pbWV0aWNzOuKAiSBUaGUgUm9sZSBvZiBJ
bnRyYW1vbGVjdWxhciBILUJvbmQgYW5kIFNvbHZvcGhvYmljIEVmZmVjdHM8L3RpdGxlPjxzZWNv
bmRhcnktdGl0bGU+Si4gQW0uIENoZW0uIFNvYy48L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KLiBBTS4gQ0hFTS4gU09DLjwvZnVsbC10aXRsZT48L3Bl
cmlvZGljYWw+PHBhZ2VzPjY2NzctNjY4NjwvcGFnZXM+PHZvbHVtZT4xMjU8L3ZvbHVtZT48bnVt
YmVyPjIyPC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMDM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4y
MDAzLzA2LzAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5BbWVyaWNhbiBD
aGVtaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAwMi03ODYzPC9pc2JuPjx1cmxzPjxy
ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDIxL2phMDI4NDc1OTwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAyMS9q
YTAyODQ3NTk8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBF
eGNsdWRlQXV0aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+Q29ycmVhPC9BdXRob3I+PFll
YXI+MjAxMjwvWWVhcj48UmVjTnVtPjU0Mzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0
Mzg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBh
NXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQiPjU0Mzg8L2tleT48L2ZvcmVpZ24ta2V5cz48
cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9y
cz48YXV0aG9ycz48YXV0aG9yPkNvcnJlYSwgTi4gTWFyaWFubzwvYXV0aG9yPjxhdXRob3I+U2ls
YmVyLCBKdWFuYSBKLjwvYXV0aG9yPjxhdXRob3I+Uml0ZXIsIFJ1dGggRS48L2F1dGhvcj48YXV0
aG9yPkxldmluZ2VyLCBOYW5jeSBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48
dGl0bGVzPjx0aXRsZT5Ob25hcXVlb3VzIFBvbGFyIFNvbHZlbnRzIGluIFJldmVyc2UgTWljZWxs
ZSBTeXN0ZW1zPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNoZW0uIFJldi48L3NlY29uZGFyeS10
aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaGVtLiBSZXYuPC9mdWxsLXRp
dGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDU2OS00NjAyPC9wYWdlcz48dm9sdW1lPjExMjwvdm9s
dW1lPjxudW1iZXI+ODwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+MjAxMi8wOC8wODwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxwdWJsaXNoZXI+QW1l
cmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2JuPjAwMDktMjY2NTwvaXNibj48
dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAyMS9jcjIwMDI1
NHE8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw
LjEwMjEvY3IyMDAyNTRxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+
PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkxhaGlyaTwvQXV0
aG9yPjxZZWFyPjIwMDA8L1llYXI+PFJlY051bT41NDQ5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51
bWJlcj41NDQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i
NXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDQ5PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MYWhpcmksIFNocmV5YXNpPC9hdXRob3I+PGF1dGhv
cj5UaG9tcHNvbiwgSnVsaWUgTC48L2F1dGhvcj48YXV0aG9yPk1vb3JlLCBKZWZmcmV5IFMuPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlNvbHZvcGhvYmlj
YWxseSBEcml2ZW4gz4AtU3RhY2tpbmcgb2YgUGhlbnlsZW5lIEV0aHlueWxlbmUgTWFjcm9jeWNs
ZXMgYW5kIE9saWdvbWVyczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBBbS4gQ2hlbS4gU29j
Ljwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkouIEFN
LiBDSEVNLiBTT0MuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTEzMTUtMTEzMTk8
L3BhZ2VzPjx2b2x1bWU+MTIyPC92b2x1bWU+PG51bWJlcj40NjwvbnVtYmVyPjxkYXRlcz48eWVh
cj4yMDAwPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAwMC8xMS8wMTwvZGF0ZT48L3B1Yi1kYXRl
cz48L2RhdGVzPjxwdWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVy
Pjxpc2JuPjAwMDItNzg2MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4
LmRvaS5vcmcvMTAuMTAyMS9qYTAwMjEyOWU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs
ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMjEvamEwMDIxMjllPC9lbGVjdHJvbmljLXJlc291
cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFy
PSIxIj48QXV0aG9yPlNjaG5laWRlcjwvQXV0aG9yPjxZZWFyPjIwMDk8L1llYXI+PFJlY051bT42
PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj42PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+
PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVk
Ij42PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+
MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TY2huZWlkZXIsIEhh
bnMtSsO2cmc8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+
QmluZGluZyBNZWNoYW5pc21zIGluIFN1cHJhbW9sZWN1bGFyIENvbXBsZXhlczwvdGl0bGU+PHNl
Y29uZGFyeS10aXRsZT5Bbmdldy4gQ2hlbS4gSW50LiBFZDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFuZ2V3LiBDaGVtLiBJbnQuIEVkPC9mdWxsLXRp
dGxlPjxhYmJyLTE+QW5nZXcuIENoZW0uIEludC4gRWQuPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxw
YWdlcz4zOTI0LTM5Nzc8L3BhZ2VzPjx2b2x1bWU+NDg8L3ZvbHVtZT48a2V5d29yZHM+PGtleXdv
cmQ+ZHJ1ZyBkZXNpZ24gwrcgaG9zdOKAk2d1ZXN0IHN5c3RlbXMgwrc8L2tleXdvcmQ+PGtleXdv
cmQ+bm9uY292YWxlbnQgaW50ZXJhY3Rpb25zIMK3PC9rZXl3b3JkPjxrZXl3b3JkPnJlYWN0aW9u
IG1lY2hhbmlzbXMgwrc8L2tleXdvcmQ+PGtleXdvcmQ+c3VwcmFtb2xlY3VsYXI8L2tleXdvcmQ+
PGtleXdvcmQ+Y2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDk8
L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw
MDIvYW5pZS4yMDA4MDI5NDc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0
ZT48Q2l0ZSBFeGNsdWRlQXV0aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+WmhhbzwvQXV0
aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT41NDc4PC9SZWNOdW0+PHJlY29yZD48cmVjLW51
bWJlcj41NDc4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0i
NXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDc4PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5aaGFvLCBZYW48L2F1dGhvcj48YXV0aG9yPlpob25n
LCBaaGVucWk8L2F1dGhvcj48YXV0aG9yPlJ5dSwgRXVpLUh5dW48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PHRpdGxlcz48dGl0bGU+UHJlZmVyZW50aWFsIFNvbHZhdGlvbiB3aXRo
aW4gSHlkcm9waGlsaWMgTmFub2Nhdml0aWVzIGFuZCBJdHMgRWZmZWN0IG9uIHRoZSBGb2xkaW5n
IG9mIENob2xhdGUgRm9sZGFtZXJzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkouIEFtLiBDaGVt
LiBTb2MuPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
Si4gQU0uIENIRU0uIFNPQy48L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4yMTgtMjI1
PC9wYWdlcz48dm9sdW1lPjEyOTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxkYXRlcz48eWVh
cj4yMDA3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAwNy8wMS8wMTwvZGF0ZT48L3B1Yi1kYXRl
cz48L2RhdGVzPjxwdWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVy
Pjxpc2JuPjAwMDItNzg2MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4
LmRvaS5vcmcvMTAuMTAyMS9qYTA2NzExNTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs
ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMjEvamEwNjcxMTU5PC9lbGVjdHJvbmljLXJlc291
cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFy
PSIxIj48QXV0aG9yPkNyYW08L0F1dGhvcj48WWVhcj4xOTkyPC9ZZWFyPjxSZWNOdW0+NTQ2MDwv
UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTQ2MDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz
PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1
ZCI+NTQ2MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGlj
bGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q3JhbSwgRG9u
YWxkIEouPC9hdXRob3I+PGF1dGhvcj5DaG9pLCBIZXVuZyBKaW48L2F1dGhvcj48YXV0aG9yPkJy
eWFudCwgSnVkaSBBLjwvYXV0aG9yPjxhdXRob3I+S25vYmxlciwgQ2Fyb2x5biBCLjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Ib3N0LWd1ZXN0IGNvbXBs
ZXhhdGlvbi4gNjIuIFNvbHZvcGhvYmljIGFuZCBlbnRyb3BpYyBkcml2aW5nIGZvcmNlcyBmb3Ig
Zm9ybWluZyB2ZWxjcmFwbGV4ZXMsIHdoaWNoIGFyZSA0LWZvbGQsIGxvY2sta2V5IGRpbWVycyBp
biBvcmdhbmljIG1lZGlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkouIEFtLiBDaGVtLiBTb2Mu
PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Si4gQU0u
IENIRU0uIFNPQy48L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43NzQ4LTc3NjU8L3Bh
Z2VzPjx2b2x1bWU+MTE0PC92b2x1bWU+PG51bWJlcj4yMDwvbnVtYmVyPjxkYXRlcz48eWVhcj4x
OTkyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MTk5Mi8wOS8wMTwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxwdWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxp
c2JuPjAwMDItNzg2MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRv
aS5vcmcvMTAuMTAyMS9qYTAwMDQ2YTAyMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAyMS9qYTAwMDQ2YTAyMjwvZWxlY3Ryb25pYy1yZXNv
dXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRlWWVh
cj0iMSI+PEF1dGhvcj5Qb25udXN3YW15PC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVt
PjU0NjM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0NjM8L3JlYy1udW1iZXI+PGZvcmVp
Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBz
ZndyMGF3NWQiPjU0NjM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlBv
bm51c3dhbXksIE5hbmRoaW5pPC9hdXRob3I+PGF1dGhvcj5QYW50b8WfLCBHLiBEYW48L2F1dGhv
cj48YXV0aG9yPlNtdWxkZXJzLCBNYWFydGVuIE0uIEouPC9hdXRob3I+PGF1dGhvcj5TYW5kZXJz
LCBKZXJlbXkgSy4gTS48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48
dGl0bGU+VGhlcm1vZHluYW1pY3Mgb2YgU3VwcmFtb2xlY3VsYXIgTmFwaHRoYWxlbmVkaWltaWRl
IE5hbm90dWJlIEZvcm1hdGlvbjogVGhlIEluZmx1ZW5jZSBvZiBTb2x2ZW50cywgU2lkZSBDaGFp
bnMsIGFuZCBHdWVzdCBUZW1wbGF0ZXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Si4gQW0uIENo
ZW0uIFNvYy48L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRs
ZT5KLiBBTS4gQ0hFTS4gU09DLjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjU2Ni01
NzM8L3BhZ2VzPjx2b2x1bWU+MTM0PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGRhdGVzPjx5
ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDEyLzAxLzExPC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5BbWVyaWNhbiBDaGVtaWNhbCBTb2NpZXR5PC9wdWJsaXNo
ZXI+PGlzYm4+MDAwMi03ODYzPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v
ZHguZG9pLm9yZy8xMC4xMDIxL2phMjA4ODY0NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAyMS9qYTIwODg2NDc8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBFeGNsdWRlQXV0aD0iMSIgRXhjbHVkZVll
YXI9IjEiPjxBdXRob3I+Qmhvc2FsZTwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT41
NDkxPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41NDkxPC9yZWMtbnVtYmVyPjxmb3JlaWdu
LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3
cjBhdzVkIj41NDkxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CaG9z
YWxlLCBTaGVzaGFuYXRoIFYuPC9hdXRob3I+PGF1dGhvcj5BZHN1bCwgTXVrdW5kPC9hdXRob3I+
PGF1dGhvcj5TaGl0cmUsIEdhbmVzaCBWLjwvYXV0aG9yPjxhdXRob3I+Qm9iZSwgU2hhcmFkIFIu
PC9hdXRob3I+PGF1dGhvcj5CaG9zYWxlLCBTaWRoYW5hdGggVi48L2F1dGhvcj48YXV0aG9yPlBy
aXbDqXIsIFN0ZXZlbiBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVz
Pjx0aXRsZT5BIFB5cmlkeWwtTW9ub2FubnVsYXRlZCBOYXBodGhhbGVuZSBEaWltaWRlIE1vdGlm
IFNlbGYtQXNzZW1ibGVzIGludG8gVHVuZWFibGUgTmFub3N0cnVjdHVyZXMgYnkgTWVhbnMgb2Yg
U29sdm9waG9iaWMgQ29udHJvbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DaGVtaXN0cnkg4oCT
IEEgRXVyb3BlYW4gSm91cm5hbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs
PjxmdWxsLXRpdGxlPkNoZW1pc3RyeSDigJMgQSBFdXJvcGVhbiBKb3VybmFsPC9mdWxsLXRpdGxl
PjxhYmJyLTE+Q2hlbS4gRXVyLiBKLjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+NzMxMC03
MzEzPC9wYWdlcz48dm9sdW1lPjE5PC92b2x1bWU+PG51bWJlcj4yMzwvbnVtYmVyPjxrZXl3b3Jk
cz48a2V5d29yZD5uYW5vc3RydWN0dXJlczwva2V5d29yZD48a2V5d29yZD5uYXBodGhhbGVuZSBk
aWltaWRlPC9rZXl3b3JkPjxrZXl3b3JkPnBIIHNlbnNvcnM8L2tleXdvcmQ+PGtleXdvcmQ+c2Vs
Zi1hc3NlbWJseTwva2V5d29yZD48a2V5d29yZD5zb2x2b3Bob2JpYzwva2V5d29yZD48L2tleXdv
cmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+PHB1Ymxpc2hlcj5XSUxFWS1WQ0gg
VmVybGFnPC9wdWJsaXNoZXI+PGlzYm4+MTUyMS0zNzY1PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDAyL2NoZW0uMjAxMzAwMTIwPC91cmw+PC9y
ZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAyL2NoZW0u
MjAxMzAwMTIwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGUg
RXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk5lbHNvbjwvQXV0aG9yPjxZ
ZWFyPjE5OTc8L1llYXI+PFJlY051bT41NDI1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41
NDI1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYw
YTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDI1PC9rZXk+PC9mb3JlaWduLWtleXM+
PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv
cnM+PGF1dGhvcnM+PGF1dGhvcj5OZWxzb24sIEphbWVzIEMuPC9hdXRob3I+PGF1dGhvcj5TYXZl
biwgSmVmZmVyeSBHLjwvYXV0aG9yPjxhdXRob3I+TW9vcmUsIEplZmZyZXkgUy48L2F1dGhvcj48
YXV0aG9yPldvbHluZXMsIFBldGVyIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
Pjx0aXRsZXM+PHRpdGxlPlNvbHZvcGhvYmljYWxseSBEcml2ZW4gRm9sZGluZyBvZiBOb25iaW9s
b2dpY2FsIE9saWdvbWVyczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5TY2llbmNlPC9zZWNvbmRh
cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2NpZW5jZTwvZnVsbC10
aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjE3OTMtMTc5NjwvcGFnZXM+PHZvbHVtZT4yNzc8L3Zv
bHVtZT48bnVtYmVyPjUzMzM8L251bWJlcj48ZGF0ZXM+PHllYXI+MTk5NzwveWVhcj48cHViLWRh
dGVzPjxkYXRlPlNlcHRlbWJlciAxOSwgMTk5NzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3LnNjaWVuY2VtYWcub3JnL2NvbnRlbnQv
Mjc3LzUzMzMvMTc5My5hYnN0cmFjdDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+MTAuMTEyNi9zY2llbmNlLjI3Ny41MzMzLjE3OTM8L2VsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBFeGNsdWRlQXV0aD0iMSIgRXhj
bHVkZVllYXI9IjEiPjxBdXRob3I+Q2hvPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVt
PjU0NjY8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0NjY8L3JlYy1udW1iZXI+PGZvcmVp
Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBz
ZndyMGF3NWQiPjU0NjY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkNo
bywgSG9uZ2t3YW48L2F1dGhvcj48YXV0aG9yPlpoYW8sIFlhbjwvYXV0aG9yPjwvYXV0aG9ycz48
L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5FbnZpcm9ubWVudGFsIEVmZmVjdHMgRG9taW5h
dGUgdGhlIEZvbGRpbmcgb2YgT2xpZ29jaG9sYXRlcyBpbiBTb2x1dGlvbiwgU3VyZmFjdGFudCBN
aWNlbGxlcywgYW5kIExpcGlkIE1lbWJyYW5lczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBB
bS4gQ2hlbS4gU29jLjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs
LXRpdGxlPkouIEFNLiBDSEVNLiBTT0MuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+
OTg5MC05ODk5PC9wYWdlcz48dm9sdW1lPjEzMjwvdm9sdW1lPjxudW1iZXI+Mjg8L251bWJlcj48
ZGF0ZXM+PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTAvMDcvMjE8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPkFtZXJpY2FuIENoZW1pY2FsIFNvY2lldHk8
L3B1Ymxpc2hlcj48aXNibj4wMDAyLTc4NjM8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs
Pmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMjEvamExMDM2OTRwPC91cmw+PC9yZWxhdGVkLXVybHM+
PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDIxL2phMTAzNjk0cDwvZWxlY3Ry
b25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBF
eGNsdWRlWWVhcj0iMSI+PEF1dGhvcj5ZYW48L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxSZWNO
dW0+ODk8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjg5PC9yZWMtbnVtYmVyPjxmb3JlaWdu
LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3
cjBhdzVkIj44OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJCb29rIFNlY3Rp
b24iPjU8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5ZYW4sIFpoYW88
L2F1dGhvcj48YXV0aG9yPkplZmZyZXksIFMuIE1vb3JlPC9hdXRob3I+PC9hdXRob3JzPjxzZWNv
bmRhcnktYXV0aG9ycz48YXV0aG9yPlMuIEhlY2h0LCBJLiBIdWM8L2F1dGhvcj48L3NlY29uZGFy
eS1hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+SHVtYm9sZHQgVW5pdmVyc2l0
eSwgSW5zdGl0dXRlIG9mIENoZW1pc3RyeSwgQnJvb2stVGF5bG9yLVN0ci4gMiwgMTI0ODkgQmVy
bGluLCBHZXJtYW55OyBJbnN0aXR1dCBFdXJvcMOpZW4gZGUgQ2hpbWllIGV0IEJpb2xvZ2llLCAy
IHJ1ZSBSb2JlcnQgRXNjYXJwaXQsIDMzNjA3IFBlc3NhYyBDZWRleCwgRnJhbmNlPC9hdXRoLWFk
ZHJlc3M+PHRpdGxlcz48dGl0bGU+Rm9sZGFtZXJzIEJhc2VkIG9uIFNvbHZvcGhvYmljIEVmZmVj
dHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Rm9sZGFtZXJzPC9zZWNvbmRhcnktdGl0bGU+PC90
aXRsZXM+PHBhZ2VzPjc1LTEwODwvcGFnZXM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PC9kYXRl
cz48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi85Nzgz
NTI3NjExNDc4LmNoMyA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PC9yZWNvcmQ+PC9DaXRl
PjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRlWWVhcj0iMSI+PEF1dGhvcj5BZGFtPC9BdXRo
b3I+PFllYXI+MjAxNTwvWWVhcj48UmVjTnVtPjU0MDE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVt
YmVyPjU0MDE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1
cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQiPjU0MDE8L2tleT48L2ZvcmVpZ24t
a2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRy
aWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFkYW0sIENhdGhlcmluZTwvYXV0aG9yPjxhdXRob3I+
WWFuZywgTGl4dTwvYXV0aG9yPjxhdXRob3I+Q29ja3JvZnQsIFNjb3R0IEwuPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBhcnRpdGlvbmluZyBzb2x2b3Bo
b2JpYyBhbmQgZGlzcGVyc2lvbiBmb3JjZXMgaW4gYWxreWwgYW5kIHBlcmZsdW9yb2Fsa3lsIGNv
aGVzaW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFuZ2V3LiBDaGVtLiBJbnQuIEVkLjwvc2Vj
b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkFuZ2V3LiBDaGVt
LiBJbnQuIEVkLjwvZnVsbC10aXRsZT48YWJici0xPkFuZ2V3LiBDaGVtLiBJbnQuIEVkLjwvYWJi
ci0xPjwvcGVyaW9kaWNhbD48cGFnZXM+MTE2NC0xMTY3PC9wYWdlcz48dm9sdW1lPjU0PC92b2x1
bWU+PG51bWJlcj40PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PC9kYXRlcz48dXJs
cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDIvYW5pZS4yMDE0MDg5ODI8
L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBFeGNsdWRlQXV0
aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+WWFuZzwvQXV0aG9yPjxZZWFyPjIwMTM8L1ll
YXI+PFJlY051bT41Mzc0PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41Mzc0PC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZm
M3Yyd3NvOTJwc2Z3cjBhdzVkIj41Mzc0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5h
bWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+
PGF1dGhvcj5ZYW5nLCBMLjwvYXV0aG9yPjxhdXRob3I+QWRhbSwgQy48L2F1dGhvcj48YXV0aG9y
Pk5pY2hvbCwgRy4gUy48L2F1dGhvcj48YXV0aG9yPkNvY2tyb2Z0LCBTLiBMLjwvYXV0aG9yPjwv
YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Ib3cgbXVjaCBkbyB2YW4gZGVy
IFdhYWxzIGRpc3BlcnNpb24gZm9yY2VzIGNvbnRyaWJ1dGUgdG8gbW9sZWN1bGFyIHJlY29nbml0
aW9uIGluIHNvbHV0aW9uPzwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OYXQuIENoZW0uPC9zZWNv
bmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmF0LiBDaGVtLjwv
ZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjEwMDYtMTAxMDwvcGFnZXM+PHZvbHVtZT41
PC92b2x1bWU+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48dXJscz48L3VybHM+PC9y
ZWNvcmQ+PC9DaXRlPjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRlWWVhcj0iMSI+PEF1dGhv
cj5CaGF5YW5hPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48UmVjTnVtPjI3MDwvUmVjTnVtPjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MjcwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9
IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj4yNzA8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJoYXlhbmEsIEJyaWplc2g8L2F1
dGhvcj48YXV0aG9yPldpbGNveCwgQ3JhaWfigIVTPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp
YnV0b3JzPjx0aXRsZXM+PHRpdGxlPkEgTWluaW1hbCBQcm90ZWluIEZvbGRpbmcgTW9kZWwgVG8g
TWVhc3VyZSBIeWRyb3Bob2JpYyBhbmQgQ0jigJPPgCBFZmZlY3RzIG9uIEludGVyYWN0aW9ucyBi
ZXR3ZWVuIE5vbnBvbGFyIFN1cmZhY2VzIGluIFdhdGVyPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PkFuZ2V3LiBDaGVtLiBJbnQuIEVkLjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkFuZ2V3LiBDaGVtLiBJbnQuIEVkLjwvZnVsbC10aXRsZT48YWJici0x
PkFuZ2V3LiBDaGVtLiBJbnQuIEVkLjwvYWJici0xPjwvcGVyaW9kaWNhbD48cGFnZXM+NjgzMy02
ODM2PC9wYWdlcz48dm9sdW1lPjQ2PC92b2x1bWU+PG51bWJlcj4zNjwvbnVtYmVyPjxrZXl3b3Jk
cz48a2V5d29yZD5jb25mb3JtYXRpb24gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+R2liYnMg
ZW5lcmd5PC9rZXl3b3JkPjxrZXl3b3JkPmh5ZHJvcGhvYmljIGludGVyYWN0aW9uczwva2V5d29y
ZD48a2V5d29yZD5wcm90ZWluIGZvbGRpbmc8L2tleXdvcmQ+PGtleXdvcmQ+c29sdmVudCBlZmZl
Y3RzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDc8L3llYXI+PC9kYXRlcz48
cHVibGlzaGVyPldJTEVZLVZDSCBWZXJsYWc8L3B1Ymxpc2hlcj48dXJscz48cmVsYXRlZC11cmxz
Pjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAwMi9hbmllLjIwMDcwMDkzMjwvdXJsPjwvcmVs
YXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4
Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkxpPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVjTnVt
PjU0NjI8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0NjI8L3JlYy1udW1iZXI+PGZvcmVp
Z24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBz
ZndyMGF3NWQiPjU0NjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h
bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxp
LCBJc2FhYyBULiBTLjwvYXV0aG9yPjxhdXRob3I+V2Fsa2VyLCBHaWxiZXJ0IEMuPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkludGVyZmFjaWFsIEZyZWUg
RW5lcmd5IEdvdmVybnMgU2luZ2xlIFBvbHlzdHlyZW5lIENoYWluIENvbGxhcHNlIGluIFdhdGVy
IGFuZCBBcXVlb3VzIFNvbHV0aW9uczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBBbS4gQ2hl
bS4gU29jLjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl
PkouIEFNLiBDSEVNLiBTT0MuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NjUzMC02
NTQwPC9wYWdlcz48dm9sdW1lPjEzMjwvdm9sdW1lPjxudW1iZXI+MTg8L251bWJlcj48ZGF0ZXM+
PHllYXI+MjAxMDwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTAvMDUvMTI8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPkFtZXJpY2FuIENoZW1pY2FsIFNvY2lldHk8L3B1Ymxp
c2hlcj48aXNibj4wMDAyLTc4NjM8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6
Ly9keC5kb2kub3JnLzEwLjEwMjEvamExMDExNTVoPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDIxL2phMTAxMTU1aDwvZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRl
WWVhcj0iMSI+PEF1dGhvcj5OZXdjb21iPC9BdXRob3I+PFllYXI+MTk5NDwvWWVhcj48UmVjTnVt
PjE4NjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MTg2PC9yZWMtbnVtYmVyPjxmb3JlaWdu
LWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3
cjBhdzVkIj4xODY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk5ld2Nv
bWIsIExpc2EgRi48L2F1dGhvcj48YXV0aG9yPkdlbGxtYW4sIFNhbXVlbCBILjwvYXV0aG9yPjwv
YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Bcm9tYXRpYyBTdGFja2luZyBJ
bnRlcmFjdGlvbnMgaW4gQXF1ZW91cyBTb2x1dGlvbjogRXZpZGVuY2UgVGhhdCBuZWl0aGVyIENs
YXNzaWNhbCBIeWRyb3Bob2JpYyBFZmZlY3RzIG5vciBEaXNwZXJzaW9uIEZvcmNlcyBBcmUgSW1w
b3J0YW50PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkouIEFtLiBDaGVtLiBTb2MuPC9zZWNvbmRh
cnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Si4gQU0uIENIRU0uIFNP
Qy48L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz40OTkzLTQ5OTQ8L3BhZ2VzPjx2b2x1
bWU+MTE2PC92b2x1bWU+PG51bWJlcj4xMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4xOTk0PC95ZWFy
PjwvZGF0ZXM+PHB1Ymxpc2hlcj5BbWVyaWNhbiBDaGVtaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+
PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9keC5kb2kub3JnLzEwLjEwMjEvamEwMDA5
MGEwNTcgPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBF
eGNsdWRlQXV0aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+R2FyZG5lcjwvQXV0aG9yPjxZ
ZWFyPjE5OTc8L1llYXI+PFJlY051bT41NDk1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41
NDk1PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYw
YTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDk1PC9rZXk+PC9mb3JlaWduLWtleXM+
PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv
cnM+PGF1dGhvcnM+PGF1dGhvcj5HYXJkbmVyLCBSb2JiIFIuPC9hdXRob3I+PGF1dGhvcj5DaHJp
c3RpYW5zb24sIExhdXJpZSBBLjwvYXV0aG9yPjxhdXRob3I+R2VsbG1hbiwgU2FtdWVsIEguPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlF1YW50aXRhdGl2
ZSBBbmFseXNpcyBvZiBIeWRyb3Bob2JpY2FsbHkgSW5kdWNlZCBGb2xkaW5nIGluIGEgTWluaW1h
bCBNb2RlbCBTeXN0ZW08L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Sm91cm5hbCBvZiB0aGUgQW1l
cmljYW4gQ2hlbWljYWwgU29jaWV0eTwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2Rp
Y2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIENoZW1pY2FsIFNvY2lldHkg
PC9mdWxsLXRpdGxlPjxhYmJyLTE+Si4gQW0uIENoZW0uIFNvYy48L2FiYnItMT48L3BlcmlvZGlj
YWw+PHBhZ2VzPjUwNDEtNTA0MjwvcGFnZXM+PHZvbHVtZT4xMTk8L3ZvbHVtZT48bnVtYmVyPjIx
PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjE5OTc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT4xOTk3LzA1
LzAxPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxpc2hlcj5BbWVyaWNhbiBDaGVtaWNh
bCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAwMi03ODYzPC9pc2JuPjx1cmxzPjxyZWxhdGVk
LXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDIxL2phOTcwNTMxdzwvdXJsPjwvcmVs
YXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAyMS9qYTk3MDUz
MXc8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZSBFeGNsdWRl
QXV0aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+Q29yYmV0dDwvQXV0aG9yPjxZZWFyPjIw
MDY8L1llYXI+PFJlY051bT41NDM5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41NDM5PC9y
ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0
NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDM5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10
eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1
dGhvcnM+PGF1dGhvcj5Db3JiZXR0LCBQZXRlciBULjwvYXV0aG9yPjxhdXRob3I+TGVjbGFpcmUs
IEp1bGllbjwvYXV0aG9yPjxhdXRob3I+VmlhbCwgTGF1cmVudDwvYXV0aG9yPjxhdXRob3I+V2Vz
dCwgS2V2aW4gUi48L2F1dGhvcj48YXV0aG9yPldpZXRvciwgSmVhbi1MdWM8L2F1dGhvcj48YXV0
aG9yPlNhbmRlcnMsIEplcmVteSBLLiBNLjwvYXV0aG9yPjxhdXRob3I+T3R0bywgU2lqYnJlbjwv
YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5EeW5hbWljIENv
bWJpbmF0b3JpYWwgQ2hlbWlzdHJ5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNoZW0uIFJldi48
L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaGVtLiBS
ZXYuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MzY1Mi0zNzExPC9wYWdlcz48dm9s
dW1lPjEwNjwvdm9sdW1lPjxudW1iZXI+OTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA2PC95ZWFy
PjxwdWItZGF0ZXM+PGRhdGU+MjAwNi8wOS8wMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxw
dWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2JuPjAwMDkt
MjY2NTwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAu
MTAyMS9jcjAyMDQ1MnA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjEwLjEwMjEvY3IwMjA0NTJwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3Jl
Y29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9y
PlNhZm9udC1TZW1wZXJlPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVjTnVtPjU0NDE8L1Jl
Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0NDE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48
a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQi
PjU0NDE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNhZm9udC1TZW1w
ZXJlLCBNYXJpbmEgTS48L2F1dGhvcj48YXV0aG9yPkZlcm7DoW5kZXosIEd1c3Rhdm88L2F1dGhv
cj48YXV0aG9yPlfDvHJ0aG5lciwgRnJhbms8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv
cnM+PHRpdGxlcz48dGl0bGU+U2VsZi1Tb3J0aW5nIFBoZW5vbWVuYSBpbiBDb21wbGV4IFN1cHJh
bW9sZWN1bGFyIFN5c3RlbXM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2hlbS4gUmV2Ljwvc2Vj
b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZW0uIFJldi48
L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz41Nzg0LTU4MTQ8L3BhZ2VzPjx2b2x1bWU+
MTExPC92b2x1bWU+PG51bWJlcj45PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTE8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT4yMDExLzA5LzE0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PHB1Ymxp
c2hlcj5BbWVyaWNhbiBDaGVtaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAwOS0yNjY1
PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8xMC4xMDIx
L2NyMTAwMzU3aDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+MTAuMTAyMS9jcjEwMDM1N2g8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3Jk
PjwvQ2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJl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ADDIN EN.CITE.DATA 6 and functional materials.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h
dHN1a2l6b25vPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjU0NDM8L1JlY051bT48
RGlzcGxheVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij43PC9zdHlsZT48L0Rpc3BsYXlU
ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+NTQ0MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1ZCI+
NTQ0Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi
PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWF0c3VraXpvbm8s
IEhpcm95dWtpPC9hdXRob3I+PGF1dGhvcj5LdXJvaXdhLCBLZWl0YTwvYXV0aG9yPjxhdXRob3I+
S2ltaXp1a2EsIE5vYnVvPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+
PHRpdGxlPkxpcGlkLVBhY2thZ2VkIExpbmVhciBJcm9uKElJKSBUcmlhem9sZSBDb21wbGV4ZXMg
aW4gU29sdXRpb246IENvbnRyb2xsZWQgU3BpbiBDb252ZXJzaW9uIHZpYSBTb2x2b3Bob2JpYyBT
ZWxmLUFzc2VtYmx5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkouIEFtLiBDaGVtLiBTb2MuPC9z
ZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Si4gQU0uIENI
RU0uIFNPQy48L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz41NjIyLTU2MjM8L3BhZ2Vz
Pjx2b2x1bWU+MTMwPC92b2x1bWU+PG51bWJlcj4xNzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA4
PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAwOC8wNC8wMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxwdWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2Ju
PjAwMDItNzg2MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5v
cmcvMTAuMTAyMS9qYTcxMTM1NWo8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjEwLjEwMjEvamE3MTEzNTVqPC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48
QXV0aG9yPk1pbmFrYXRhPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVjTnVtPjU0NDQ8L1Jl
Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0NDQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48
a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQi
PjU0NDQ8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1pbmFrYXRhLCBT
YXRvc2hpPC9hdXRob3I+PGF1dGhvcj5Uc3VydW9rYSwgUnlvamk8L2F1dGhvcj48YXV0aG9yPktv
bWF0c3UsIE1pdHN1bzwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0
aXRsZT5JbmNsdXNpb24gb2YgQzYwIGludG8gTUNNLTQxIGJ5IFNvbHZvcGhvYmljIE5hdHVyZTwv
dGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBBbS4gQ2hlbS4gU29jLjwvc2Vjb25kYXJ5LXRpdGxl
PjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkouIEFNLiBDSEVNLiBTT0MuPC9mdWxs
LXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTUzNi0xNTM3PC9wYWdlcz48dm9sdW1lPjEzMDwv
dm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+MjAwOC8wMi8wMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxwdWJsaXNoZXI+
QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2JuPjAwMDItNzg2MzwvaXNi
bj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAyMS9qYTA3
NzExNHc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjEwLjEwMjEvamEwNzcxMTR3PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0Np
dGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlpodWFuZzwv
QXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJlY051bT41NDcyPC9SZWNOdW0+PHJlY29yZD48cmVj
LW51bWJlcj41NDcyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDcyPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5aaHVhbmcsIEppYXFpPC9hdXRob3I+PGF1dGhv
cj5XdSwgSHVpbWVuZzwvYXV0aG9yPjxhdXRob3I+WWFuZywgWW9uZ2FuPC9hdXRob3I+PGF1dGhv
cj5DYW8sIFkuIENoYXJsZXM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxl
cz48dGl0bGU+U3VwZXJjcnlzdGFsbGluZSBDb2xsb2lkYWwgUGFydGljbGVzIGZyb20gQXJ0aWZp
Y2lhbCBBdG9tczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBBbS4gQ2hlbS4gU29jLjwvc2Vj
b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkouIEFNLiBDSEVN
LiBTT0MuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTQxNjYtMTQxNjc8L3BhZ2Vz
Pjx2b2x1bWU+MTI5PC92b2x1bWU+PG51bWJlcj40NjwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDA3
PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+MjAwNy8xMS8wMTwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxwdWJsaXNoZXI+QW1lcmljYW4gQ2hlbWljYWwgU29jaWV0eTwvcHVibGlzaGVyPjxpc2Ju
PjAwMDItNzg2MzwvaXNibj48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5v
cmcvMTAuMTAyMS9qYTA3NjQ5NGk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjEwLjEwMjEvamEwNzY0OTRpPC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48
QXV0aG9yPkJlcm5hPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjU0ODE8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjU0ODE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQiPjU0
ODE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJlcm5hLCBKb3NlPC9h
dXRob3I+PGF1dGhvcj5MZWlnaCwgRGF2aWQgQS48L2F1dGhvcj48YXV0aG9yPkx1Ym9tc2thLCBN
b25pa2E8L2F1dGhvcj48YXV0aG9yPk1lbmRvemEsIFNhbmRyYSBNLjwvYXV0aG9yPjxhdXRob3I+
UGVyZXosIEVtaWxpbyBNLjwvYXV0aG9yPjxhdXRob3I+UnVkb2xmLCBQZXRyYTwvYXV0aG9yPjxh
dXRob3I+VGVvYmFsZGksIEdpbGJlcnRvPC9hdXRob3I+PGF1dGhvcj5aZXJiZXR0bywgRnJhbmNl
c2NvPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPk1hY3Jv
c2NvcGljIHRyYW5zcG9ydCBieSBzeW50aGV0aWMgbW9sZWN1bGFyIG1hY2hpbmVzPC90aXRsZT48
c2Vjb25kYXJ5LXRpdGxlPk5hdC4gTWF0ZXIuPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBl
cmlvZGljYWw+PGZ1bGwtdGl0bGU+TmF0LiBNYXRlci48L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2Fs
PjxwYWdlcz43MDQtNzEwPC9wYWdlcz48dm9sdW1lPjQ8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJl
cj48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPjA5Ly9wcmludDwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NzYtMTEyMjwvaXNibj48d29yay10eXBlPjEw
LjEwMzgvbm1hdDE0NTU8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDov
L2R4LmRvaS5vcmcvMTAuMTAzOC9ubWF0MTQ1NTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+aHR0cDovL3d3dy5uYXR1cmUuY29tL25tYXQvam91cm5h
bC92NC9uOS9zdXBwaW5mby9ubWF0MTQ1NV9TMS5odG1sPC9lbGVjdHJvbmljLXJlc291cmNlLW51
bT48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48
QXV0aG9yPkFyZHVpbmk8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NTQ2NDwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTQ2NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1ZCI+
NTQ2NDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi
PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QXJkdWluaSwgQXJ0
dXJvPC9hdXRob3I+PGF1dGhvcj5CdXNzb2xhdGksIFJvY2NvPC9hdXRob3I+PGF1dGhvcj5DcmVk
aSwgQWxiZXJ0bzwvYXV0aG9yPjxhdXRob3I+U2VjY2hpLCBBbmRyZWE8L2F1dGhvcj48YXV0aG9y
PlNpbHZpLCBTZXJlbmE8L2F1dGhvcj48YXV0aG9yPlNlbWVyYXJvLCBNb25pY2E8L2F1dGhvcj48
YXV0aG9yPlZlbnR1cmksIE1hcmdoZXJpdGE8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv
cnM+PHRpdGxlcz48dGl0bGU+VG93YXJkIERpcmVjdGlvbmFsbHkgQ29udHJvbGxlZCBNb2xlY3Vs
YXIgTW90aW9ucyBhbmQgS2luZXRpYyBJbnRyYS0gYW5kIEludGVybW9sZWN1bGFyIFNlbGYtU29y
dGluZzogVGhyZWFkaW5nIFByb2Nlc3NlcyBvZiBOb25zeW1tZXRyaWMgV2hlZWwgYW5kIEF4bGUg
Q29tcG9uZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBBbS4gQ2hlbS4gU29jLjwvc2Vj
b25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkouIEFNLiBDSEVN
LiBTT0MuPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+OTkyNC05OTMwPC9wYWdlcz48
dm9sdW1lPjEzNTwvdm9sdW1lPjxudW1iZXI+MjY8L251bWJlcj48ZGF0ZXM+PHllYXI+MjAxMzwv
eWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTMvMDcvMDM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRl
cz48cHVibGlzaGVyPkFtZXJpY2FuIENoZW1pY2FsIFNvY2lldHk8L3B1Ymxpc2hlcj48aXNibj4w
MDAyLTc4NjM8L2lzYm4+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly9keC5kb2kub3Jn
LzEwLjEwMjEvamE0MDQyNzBjPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj
LXJlc291cmNlLW51bT4xMC4xMDIxL2phNDA0MjcwYzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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ADDIN EN.CITE.DATA 7 Solvophobic effects are of unquestionable importance in certain fluorocarbon/aqueous/organic combinations,PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk15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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk15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ADDIN EN.CITE.DATA 8 and in ionic liquids, ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Greaves</Author><Year>2013</Year><RecNum>5422</RecNum><DisplayText><style face="superscript">9</style></DisplayText><record><rec-number>5422</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5422</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Greaves, Tamar L.</author><author>Drummond, Calum J.</author></authors></contributors><titles><title>Solvent nanostructure, the solvophobic effect and amphiphile self-assembly in ionic liquids</title><secondary-title>Chemical Society Reviews</secondary-title></titles><periodical><full-title>Chemical Society Reviews </full-title><abbr-1>Chem. Soc. Rev.</abbr-1></periodical><pages>1096-1120</pages><volume>42</volume><number>3</number><dates><year>2013</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>0306-0012</isbn><work-type>10.1039/C2CS35339C</work-type><urls><related-urls><url> but their role is less clear away from the immiscible extremes. For example, there have been contrasting views on whether solvophobic self-assembly requires solvents that form hydrogen-bond networks.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlJh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlJh
eTwvQXV0aG9yPjxZZWFyPjE5NzE8L1llYXI+PFJlY051bT41NDIwPC9SZWNOdW0+PERpc3BsYXlU
ZXh0PjxzdHlsZSBmYWNlPSJzdXBlcnNjcmlwdCI+NGIsOS0xMDwvc3R5bGU+PC9EaXNwbGF5VGV4
dD48cmVjb3JkPjxyZWMtbnVtYmVyPjU0MjA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5
IGFwcD0iRU4iIGRiLWlkPSI1cHRwdjBhNXV2YXQ1OWUwZmYzdjJ3c285MnBzZndyMGF3NWQiPjU0
MjA8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJheSwgQXNob2thPC9h
dXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlNvbHZvcGhvYmlj
IEludGVyYWN0aW9ucyBhbmQgTWljZWxsZSBGb3JtYXRpb24gaW4gU3RydWN0dXJlIEZvcm1pbmcg
Tm9uYXF1ZW91cyBTb2x2ZW50czwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OYXR1cmU8L3NlY29u
ZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OYXR1cmU8L2Z1bGwt
dGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4zMTMtMzE1PC9wYWdlcz48dm9sdW1lPjIzMTwvdm9s
dW1lPjxudW1iZXI+NTMwMTwvbnVtYmVyPjxkYXRlcz48eWVhcj4xOTcxPC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+MDYvMDQvcHJpbnQ8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48d29yay10eXBl
PjEwLjEwMzgvMjMxMzEzYTA8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cDovL2R4LmRvaS5vcmcvMTAuMTAzOC8yMzEzMTNhMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs
cz48L3JlY29yZD48L0NpdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48
QXV0aG9yPkdyZWF2ZXM8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NTQyMjwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTQyMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1ZCI+
NTQyMjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUi
PjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+R3JlYXZlcywgVGFt
YXIgTC48L2F1dGhvcj48YXV0aG9yPkRydW1tb25kLCBDYWx1bSBKLjwvYXV0aG9yPjwvYXV0aG9y
cz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5Tb2x2ZW50IG5hbm9zdHJ1Y3R1cmUsIHRo
ZSBzb2x2b3Bob2JpYyBlZmZlY3QgYW5kIGFtcGhpcGhpbGUgc2VsZi1hc3NlbWJseSBpbiBpb25p
YyBsaXF1aWRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNoZW1pY2FsIFNvY2lldHkgUmV2aWV3
czwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNoZW1p
Y2FsIFNvY2lldHkgUmV2aWV3cyA8L2Z1bGwtdGl0bGU+PGFiYnItMT5DaGVtLiBTb2MuIFJldi48
L2FiYnItMT48L3BlcmlvZGljYWw+PHBhZ2VzPjEwOTYtMTEyMDwvcGFnZXM+PHZvbHVtZT40Mjwv
dm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0ZXM+
PHB1Ymxpc2hlcj5UaGUgUm95YWwgU29jaWV0eSBvZiBDaGVtaXN0cnk8L3B1Ymxpc2hlcj48aXNi
bj4wMzA2LTAwMTI8L2lzYm4+PHdvcmstdHlwZT4xMC4xMDM5L0MyQ1MzNTMzOUM8L3dvcmstdHlw
ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL2R4LmRvaS5vcmcvMTAuMTAzOS9DMkNT
MzUzMzlDPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMDM5L0MyQ1MzNTMzOUM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwv
Q2l0ZT48Q2l0ZSBFeGNsdWRlQXV0aD0iMSIgRXhjbHVkZVllYXI9IjEiPjxBdXRob3I+U2Vkb3Y8
L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+NTQ5MjwvUmVjTnVtPjxyZWNvcmQ+PHJl
Yy1udW1iZXI+NTQ5MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVwdHB2MGE1dXZhdDU5ZTBmZjN2MndzbzkycHNmd3IwYXc1ZCI+NTQ5Mjwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2Vkb3YsIEkuIEEuPC9hdXRob3I+PGF1dGhv
cj5Tb2xvbW9ub3YsIEIuIE4uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRs
ZXM+PHRpdGxlPlNvbHZvcGhvYmljIGVmZmVjdHM6IFF1YWxpdGF0aXZlIGRldGVybWluYXRpb24g
YW5kIHF1YW50aXRhdGl2ZSBkZXNjcmlwdGlvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KLiBT
dHJ1Y3QuIENoZW0uPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5KIFN0cnVjdCBDaGVtPC9h
bHQtdGl0bGU+PC90aXRsZXM+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2Yg
U3RydWN0dXJhbCBDaGVtaXN0cnk8L2Z1bGwtdGl0bGU+PGFiYnItMT5KIFN0cnVjdCBDaGVtPC9h
YmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjYyLTI3MDwvcGFnZXM+PHZvbHVtZT41NDwv
dm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5zb2x2b3Bob2JpYyBl
ZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPnNlbGYtYXNzb2NpYXRpb248L2tleXdvcmQ+PGtleXdv
cmQ+R2liYnMgZnJlZSBlbmVyZ3k8L2tleXdvcmQ+PGtleXdvcmQ+ZW50aGFscHk8L2tleXdvcmQ+
PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPjIwMTMv
MTIvMDE8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48cHVibGlzaGVyPlNwcmluZ2VyIFVTPC9w
dWJsaXNoZXI+PGlzYm4+MDAyMi00NzY2PC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o
dHRwOi8vZHguZG9pLm9yZy8xMC4xMTM0L1MwMDIyNDc2NjEzMDgwMDc2PC91cmw+PC9yZWxhdGVk
LXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTM0L1MwMDIyNDc2NjEz
MDgwMDc2PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+RW5nbGlzaDwvbGFuZ3Vh
Z2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA 4b,9-10 Furthermore, the role of solvophobic effects may be further obscured by other non-covalent interactions, particularly those whose magnitudes scale with the size of molecular surface area contacts as is the case with dispersion interactions.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkh1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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkh1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=
ADDIN EN.CITE.DATA 3b,6d,6f,11 As a result, most attributions of the solvophobic effect are qualitative, and only in a few notable cases are sufficient solvents examined to draw firm conclusions regarding the mechanistic origin of any observed behavior.2b,3b,5d,5e,6f,6l,6m,6o,8a,10,11a,11c,12h,18,20. Even then, there is no general agreement on the parameters that can be reliably used to identify solvophobic effects.Here we examine the utility of different parameters for quantifying solvophobic effects in multiple classes of non-polar molecular contacts. Solvophobic effects in aromatic edge-to-face, aliphatic and fluorous interactions were measured using Wilcox torsion balances (Figures 1 to 3), and the generality of the findings tested in a range of contexts: from the unfolding of single polymer molecules (Figure 4b), to supramolecular aromatic stacking interactions (Figure 4c), and bulk phase transfer energies (Figure 4d).Figure 1. Wilcox molecular torsion balances showing the conformational equilibria used to measure non-covalent interactions between non-polar functional groups. ?Gcontrols is the mean conformational free energy of the control balances.The ambiguity surrounding the significance of solvophobic effects, particularly in organic solvents, can be largely attributed to the scarcity of solvent screening data. For example, in some solvents the interactions between non-polar species such as those shown on the right of Figure 1 may be too weak to overcome the entropic cost associated with bimolecular association, ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Hunter</Author><Year>2004</Year><RecNum>4</RecNum><DisplayText><style face="superscript">1c</style></DisplayText><record><rec-number>4</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">4</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hunter, C. A.</author></authors></contributors><auth-address>Hunter, CA
Univ Sheffield, Dept Chem, Krebs Isnt Biomol Sci, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England
Univ Sheffield, Dept Chem, Krebs Isnt Biomol Sci, Ctr Chem Biol, Sheffield S3 7HF, S Yorkshire, England</auth-address><titles><title>Quantifying intermolecular interactions: Guidelines for the molecular recognition toolbox</title><secondary-title>Angew. Chem. Int. Ed.</secondary-title><alt-title>Angew Chem Int Edit</alt-title></titles><periodical><full-title>Angew. Chem. Int. Ed.</full-title><abbr-1>Angew. Chem. Int. Ed.</abbr-1></periodical><alt-periodical><full-title>Angewandte Chemie-International Edition</full-title><abbr-1>Angew Chem Int Edit</abbr-1></alt-periodical><pages>5310-5324</pages><volume>43</volume><number>40</number><keywords><keyword>formation enthalpy</keyword><keyword>hydrogen bonds</keyword><keyword>molecular recognition</keyword><keyword>solvent effects</keyword><keyword>statistical thermo-dynamics</keyword><keyword>host-guest complexes</keyword><keyword>hydrogen-bonded complexes</keyword><keyword>free-energy relationships</keyword><keyword>cation-pi interaction</keyword><keyword>theoretical prediction</keyword><keyword>protein-ligand</keyword><keyword>solvent size</keyword><keyword>binding</keyword><keyword>basicity</keyword><keyword>associations</keyword></keywords><dates><year>2004</year></dates><isbn>1433-7851</isbn><accession-num>ISI:000224592400005</accession-num><urls><related-urls><url><Go to ISI>://000224592400005</url></related-urls></urls><language>English</language></record></Cite></EndNote>1c while in other cases solvophobic self-association may be so strong that the compounds of interest may not even dissolve. In addition, obtaining high-quality thermodynamic data using titration-based methods in many different solvents can be a particularly time-consuming process. Synthetic molecular torsion balances provide a means of overcoming some of the challenges associated with the measurement of non-covalent interactions.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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 EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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 EN.CITE.DATA 6p,6q,12 Most molecular torsion balances possess defined folded and unfolded conformations in which functional groups are either exposed to the solvent or brought into contact. The structures shown in Figure 1 represent archetypal molecular torsion balances of the type originally derived by Wilcox and co-workers from a Tr?ger’s base scaffold.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlBh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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlBh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==
ADDIN EN.CITE.DATA 13 Since the conformational population is sensitive to the magnitude of the intramolecular interactions and the effects of the solvent, then the position of a conformational equilibrium can be used as a direct measure of non-covalent interactions and solvent effects.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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 EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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 EN.CITE.DATA 12a,14 Furthermore, rotation about the biaryl bond in the compounds shown in Figure 1 is slow on the NMR timescale (but rapid enough for equilibrium to be established in a convenient period of time). This means that the conformational free energy difference between the two conformers can be determined from a single NMR spectrum by integrating the distinct NMR peaks corresponding to each of the conformers, where ?G = ?RT ln[folded]/[unfolded]. Thus, molecular balances are particularly suited to examining the solvent effects on weak non-covalent interactions.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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ADDIN EN.CITE.DATA 6l,6m,12hWe set out to screen for solvophobic effects on the cohesive self-association of the non-polar functional groups depicted in Figure 1. Despite numerous previous studies of aromatic edge-to-face interactions using Wilcox torsion balances, none have involved extensive solvent screens.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlBh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlBh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ADDIN EN.CITE.DATA 6n,13,15 To date, the general finding has been that both direct substituent-aryl and polar CH-aryl interactions make the largest contributions to the interaction energy in organic solvents. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Gardarsson</Author><Year>2014</Year><RecNum>5406</RecNum><DisplayText><style face="superscript">15d</style></DisplayText><record><rec-number>5406</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5406</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Gardarsson, Haraldur</author><author>Schweizer, W. Bernd</author><author>Trapp, Nils</author><author>Diederich, Fran?ois</author></authors></contributors><titles><title>Structures and Properties of Molecular Torsion Balances to Decipher the Nature of Substituent Effects on the Aromatic Edge-to-Face Interaction</title><secondary-title>Chem. Eur. J.</secondary-title></titles><periodical><full-title>Chem. Eur. J.</full-title></periodical><pages>4608-4616</pages><volume>20</volume><number>16</number><keywords><keyword>aromatic edge-to-face interactions</keyword><keyword>dipole–dipole interactions</keyword><keyword>fluorine</keyword><keyword>molecular torsion balance</keyword><keyword>substituent effects</keyword><keyword>Tr?ger base</keyword></keywords><dates><year>2014</year></dates><publisher>WILEY-VCH Verlag</publisher><isbn>1521-3765</isbn><urls><related-urls><url> Thus, the unsubstituted Wilcox balance (±)-1E was used in the present study (Figure 1a), since any investigation of solvophobic effects on aromatic edge-to-face interactions should seek to minimize electrostatic contributions.To account for the multiple factors contributing to the position of the conformational equilibrium in each solvent,PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkNv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 EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkNv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 EN.CITE.DATA 12a,14 the strength of the edge-to-face interaction, ?Gedge was estimated by subtracting the conformational free energy of the control compound (±)-2E (in which the aryl ring was replaced by a methyl group) from that of (±)-1E. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Kim</Author><Year>1998</Year><RecNum>171</RecNum><DisplayText><style face="superscript">13b</style></DisplayText><record><rec-number>171</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">171</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kim, Eun-il</author><author>Paliwal, Sunil</author><author>Wilcox, Craig S.</author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Measurements of Molecular Electrostatic Field Effects in Edge-to-Face Aromatic Interactions and CH-</style><style face="normal" font="default" charset="161" size="100%">π</style><style face="normal" font="default" size="100%"> Interactions with Implications for Protein Folding and Molecular Recognition</style></title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. AM. CHEM. SOC.</full-title></periodical><pages>11192-11193</pages><volume>120</volume><number>43</number><dates><year>1998</year></dates><publisher>American Chemical Society</publisher><isbn>0002-7863</isbn><urls><related-urls><url>, ADDIN EN.CITE <EndNote><Cite><RecNum>0</RecNum><Note> Computational models of this compound support Wilcox’s previous assertion that the methyl group is not large enough to form significant dispersive contact or CH-aryl interactions in the folded conformation, but is still large enough to block solvation of the aromatic face in a similar manner as the phenyl ester in the folded conformation (Figure S2).{#171</Note><DisplayText><style face="superscript">16</style></DisplayText></Cite></EndNote>16 Similarly, non-polar alkyl-alkyl (?Galiphatic) and perfluoroalkyl-perfluoroalkyl interactions (?Gfluorous) were measured in Wilcox balances (±)-1H and (±)-1F against the control compounds shown in Figure 1b-c. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Yang</Author><Year>2013</Year><RecNum>5374</RecNum><DisplayText><style face="superscript">6l,6m</style></DisplayText><record><rec-number>5374</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5374</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yang, L.</author><author>Adam, C.</author><author>Nichol, G. S.</author><author>Cockroft, S. L.</author></authors></contributors><titles><title>How much do van der Waals dispersion forces contribute to molecular recognition in solution?</title><secondary-title>Nat. Chem.</secondary-title></titles><periodical><full-title>Nat. Chem.</full-title></periodical><pages>1006-1010</pages><volume>5</volume><dates><year>2013</year></dates><urls></urls></record></Cite><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Adam</Author><Year>2015</Year><RecNum>5401</RecNum><record><rec-number>5401</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5401</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adam, Catherine</author><author>Yang, Lixu</author><author>Cockroft, Scott L.</author></authors></contributors><titles><title>Partitioning solvophobic and dispersion forces in alkyl and perfluoroalkyl cohesion</title><secondary-title>Angew. Chem. Int. Ed.</secondary-title></titles><periodical><full-title>Angew. Chem. Int. Ed.</full-title><abbr-1>Angew. Chem. Int. Ed.</abbr-1></periodical><pages>1164-1167</pages><volume>54</volume><number>4</number><dates><year>2015</year></dates><urls></urls><electronic-resource-num>10.1002/anie.201408982</electronic-resource-num></record></Cite></EndNote>6l,6m ?Gedge, ?Galiphatic, and ?Gfluorous were measured in 23 different solvents (Figure 2).All three classes of non-polar interaction examined were found to be weak, lying in the range of +1 to ?2 kJ mol–1. The aromatic edge-to-face interaction measured in chloroform was similar to that previously determined in other supramolecular model systems.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPk1h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ADDIN EN.CITE.DATA 17 The preference for non-polar association in the aqueous and polar organic solvents compared to the apolar solvents was observed across all three data sets (Figure 2). This qualitative observation points to a role of cohesive solvent-solvent (solvophobic) effects in all three classes of non-polar association examined (aromatic edge-to-face, aliphatic and fluorous cohesion). Thus, it might be expected that parameters describing Figure 2. Bar graph showing non-polar cohesive interactions measured in a range of solvents using the compounds and equations shown in Figure 1. Deuterated solvents were used in place of all protic solvents. Solvent mixtures are quoted in v/v %. All data are tabulated in the SI.Figure 3. Correlations of ?Galiphatic,??Gedge, and ?Gfluorous (colored circles), and the average of all three ?Gnon-polar (black circles) as the cohesive energy density of the solvent is varied. For the purpose of clarity, the plots of ?Gfluorous, ?Gedge, ?Galiphatic are offset by ?2,???, and ?? kJ mol?1, respectively. All data are tabulated in the SI. A version of this graph in which the extrapolated water points (hollow circles) are excluded is shown in Figure S7a.solvent-solvent cohesive interactions may be useful for quantifying solvophobic association. Several different parameters have been proposed as describing cohesive solvent interactions: cohesive tension (?),PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlRh
bmZvcmQ8L0F1dGhvcj48WWVhcj4xOTc5PC9ZZWFyPjxSZWNOdW0+ODE8L1JlY051bT48RGlzcGxh
eVRleHQ+PHN0eWxlIGZhY2U9InN1cGVyc2NyaXB0Ij4zYyw2bzwvc3R5bGU+PC9EaXNwbGF5VGV4
dD48cmVjb3JkPjxyZWMtbnVtYmVyPjgxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh
cHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj44MTwv
a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y
ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGFuZm9yZCwgQy48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5XaGl0ZWhlYWQgTWVkaWNh
bCBSZXNlYXJjaCBJbnN0aXR1dGUgYW5kIHRoZSBEZXBhcnRtZW50IG9mIEJpb2NoZW1pc3RyeSwg
RHVrZSBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEdXJoYW0sIE5vcnRoIENhcm9saW5hIDI3
NzEwLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludGVyZmFjaWFsIGZyZWUgZW5lcmd5
IGFuZCB0aGUgaHlkcm9waG9iaWMgZWZmZWN0PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlByb2Mu
IE5hdGwuIEFjYWQuIFNjaS4gVVNBPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj
YWw+PGZ1bGwtdGl0bGU+UHJvYy4gTmF0bC4gQWNhZC4gU2NpLiBVU0E8L2Z1bGwtdGl0bGU+PC9w
ZXJpb2RpY2FsPjxwYWdlcz40MTc1LTQxNzY8L3BhZ2VzPjx2b2x1bWU+NzY8L3ZvbHVtZT48bnVt
YmVyPjk8L251bWJlcj48ZWRpdGlvbj4xOTc5LzA5LzAxPC9lZGl0aW9uPjxkYXRlcz48eWVhcj4x
OTc5PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+U2VwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+
PGlzYm4+MTA5MS02NDkwIChFbGVjdHJvbmljKSYjeEQ7MDAyNy04NDI0IChMaW5raW5nKTwvaXNi
bj48YWNjZXNzaW9uLW51bT4xNjU5MjY5OTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L2VudHJlei9xdWVyeS5mY2dpP2Nt
ZD1SZXRyaWV2ZSZhbXA7ZGI9UHViTWVkJmFtcDtkb3B0PUNpdGF0aW9uJmFtcDtsaXN0X3VpZHM9
MTY1OTI2OTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPkVuZzwvbGFuZ3Vh
Z2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlIEV4Y2x1ZGVBdXRoPSIxIiBFeGNsdWRlWWVhcj0iMSI+
PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT41NDYyPC9SZWNOdW0+
PHJlY29yZD48cmVjLW51bWJlcj41NDYyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBh
cHA9IkVOIiBkYi1pZD0iNXB0cHYwYTV1dmF0NTllMGZmM3Yyd3NvOTJwc2Z3cjBhdzVkIj41NDYy
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MaSwgSXNhYWMgVC4gUy48
L2F1dGhvcj48YXV0aG9yPldhbGtlciwgR2lsYmVydCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv
bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5JbnRlcmZhY2lhbCBGcmVlIEVuZXJneSBHb3Zlcm5z
IFNpbmdsZSBQb2x5c3R5cmVuZSBDaGFpbiBDb2xsYXBzZSBpbiBXYXRlciBhbmQgQXF1ZW91cyBT
b2x1dGlvbnM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Si4gQW0uIENoZW0uIFNvYy48L3NlY29u
ZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KLiBBTS4gQ0hFTS4g
U09DLjwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjY1MzAtNjU0MDwvcGFnZXM+PHZv
bHVtZT4xMzI8L3ZvbHVtZT48bnVtYmVyPjE4PC9udW1iZXI+PGRhdGVzPjx5ZWFyPjIwMTA8L3ll
YXI+PHB1Yi1kYXRlcz48ZGF0ZT4yMDEwLzA1LzEyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+
PHB1Ymxpc2hlcj5BbWVyaWNhbiBDaGVtaWNhbCBTb2NpZXR5PC9wdWJsaXNoZXI+PGlzYm4+MDAw
Mi03ODYzPC9pc2JuPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vZHguZG9pLm9yZy8x
MC4xMDIxL2phMTAxMTU1aDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTAyMS9qYTEwMTE1NWg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwv
cmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlRh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ADDIN EN.CITE.DATA 3c,6o internal pressure (Pi), ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Dack</Author><Year>1975</Year><RecNum>5378</RecNum><DisplayText><style face="superscript">3b,4a</style></DisplayText><record><rec-number>5378</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5378</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Dack, M. R. J.</author></authors></contributors><titles><title>The importance of solvent internal pressure and cohesion to solution phenomena</title><secondary-title>Chem. Soc. Rev.</secondary-title></titles><periodical><full-title>Chem. Soc. Rev.</full-title></periodical><pages>211-229</pages><volume>4</volume><number>2</number><dates><year>1975</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>0306-0012</isbn><work-type>10.1039/CS9750400211</work-type><urls><related-urls><url> ExcludeAuth="1" ExcludeYear="1"><Author>Otto</Author><Year>2013</Year><RecNum>5373</RecNum><record><rec-number>5373</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5373</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Otto, Sijbren</author></authors></contributors><titles><title>The role of solvent cohesion in nonpolar solvation</title><secondary-title>Chem. Sci.</secondary-title></titles><periodical><full-title>Chem. Sci.</full-title></periodical><pages>2953-2959</pages><volume>4</volume><number>7</number><dates><year>2013</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>2041-6520</isbn><work-type>10.1039/C3SC50740H</work-type><urls><related-urls><url> the enthalpy of vaporization (?Hvap), cohesive energy density (ced),3b, 20 Hildebrand solubility parameter (?H) ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Hildebrand</Author><Year>1964</Year><RecNum>5486</RecNum><DisplayText><style face="superscript">18</style></DisplayText><record><rec-number>5486</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5486</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Hildebrand, J. H.</author><author>Scott, R. L.</author></authors></contributors><titles><title>The Solubility of Nonelectrolytes</title></titles><edition>3rd Ed.</edition><dates><year>1964</year></dates><pub-location>New York</pub-location><publisher>Dover Publications</publisher><urls></urls></record></Cite></EndNote>18 and Abraham’s solvophobicity parameter (Sp). ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Abraham</Author><Year>1988</Year><RecNum>5386</RecNum><DisplayText><style face="superscript">11c</style></DisplayText><record><rec-number>5386</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5386</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abraham, Michael H.</author><author>Grellier, Priscilla L.</author><author>McGill, R. Andrew</author></authors></contributors><titles><title>A quantitative measure of solvent solvophobic effect</title><secondary-title>J. Chem. Soc., Perkin Trans. 2</secondary-title></titles><periodical><full-title>J. Chem. Soc., Perkin Trans. 2</full-title><abbr-1>J. Chem. Soc., Perkin Trans. 2</abbr-1></periodical><pages>339-345</pages><number>3</number><dates><year>1988</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>0300-9580</isbn><work-type>10.1039/P29880000339</work-type><urls><related-urls><url> Several of the parameters are related as follows:?H2 = ced = (?Hvap – RT) / Vmwhere R is the gas constant, T is the temperature and Vm is the molar volume of the solvent.Among the independent parameters describing cohesive solvent-solvent interactions, cohesive energy density provided the best correlations with the non-polar interaction energies measured in the present study (Figure 3, data are offset in 2 kJ mol–1 increments for purposes clarity). This plot comprises over 200 experimental measurements of conformational free energies determined for the nine molecular balances shown in Figure 1 in 23 different solvents. However, these data correlated substantially less well with alternative descriptors of solvent cohesion such as surface tension and internal pressure (Figure S6). The result supports earlier suggestions that surface tension may not be an ideal descriptor for hydrophobic effects.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlRh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPlRh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ADDIN EN.CITE.DATA 3c,19 Internal pressure has been shown to be more important in the solvation of very small solutes such as gases compared to the larger interaction interfaces examined in the present study. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Otto</Author><Year>2013</Year><RecNum>5373</RecNum><DisplayText><style face="superscript">3b</style></DisplayText><record><rec-number>5373</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5373</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Otto, Sijbren</author></authors></contributors><titles><title>The role of solvent cohesion in nonpolar solvation</title><secondary-title>Chem. Sci.</secondary-title></titles><periodical><full-title>Chem. Sci.</full-title></periodical><pages>2953-2959</pages><volume>4</volume><number>7</number><dates><year>2013</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>2041-6520</isbn><work-type>10.1039/C3SC50740H</work-type><urls><related-urls><url> Indeed, the gradients of the correlations in Figure 4a reflect the qualitative ordering of the size of the interaction interfaces. The significant scatter associated with the correlations corresponding to individual interaction classes (colored circles in Figure 3) can be attributed to solvent-specific attenuation of dispersion and electrostatic interactions, in addition to the experimental errors associated with the measurement of very weak non-covalent interactions. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Adam</Author><Year>2015</Year><RecNum>5401</RecNum><DisplayText><style face="superscript">6l</style></DisplayText><record><rec-number>5401</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5401</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Adam, Catherine</author><author>Yang, Lixu</author><author>Cockroft, Scott L.</author></authors></contributors><titles><title>Partitioning solvophobic and dispersion forces in alkyl and perfluoroalkyl cohesion</title><secondary-title>Angew. Chem. Int. Ed.</secondary-title></titles><periodical><full-title>Angew. Chem. Int. Ed.</full-title><abbr-1>Angew. Chem. Int. Ed.</abbr-1></periodical><pages>1164-1167</pages><volume>54</volume><number>4</number><dates><year>2015</year></dates><urls></urls><electronic-resource-num>10.1002/anie.201408982</electronic-resource-num></record></Cite></EndNote>6l Strikingly, taking the mean interaction energy across all three classes of non-polar contact reveals a common solvophobic driving force for non-polar association, providing a correlation with R2 = 0.95 (black circles in Figure 3, and R2 = 0.83 with water points excluded in Figure S7), which arises due to the minimization of errors, and the cancellation of dispersion contributions across the interaction types. Interestingly, the intercepts of the correlations in Figure 3 are close to zero (~0.5 kJ mol–1). Since the intercept corresponds to the situation where there is no solvophobic effect, the observation is consistent with a minimal contribution of electrostatic interactions and the generalized cancellation of dispersion forces in solution in the classes of interaction examined.3b, 6l, 6m, 11a,12kTo test the generality of cohesive energy densities as a scale for describing solvophobic association (Figure 4a), we have replotted experimental data previously obtained in a range of solvents for both the collapse of single polystyrene molecules (Figure 4b) ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Li</Author><Year>2010</Year><RecNum>5462</RecNum><DisplayText><style face="superscript">6o</style></DisplayText><record><rec-number>5462</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5462</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, Isaac T. S.</author><author>Walker, Gilbert C.</author></authors></contributors><titles><title>Interfacial Free Energy Governs Single Polystyrene Chain Collapse in Water and Aqueous Solutions</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. AM. CHEM. SOC.</full-title></periodical><pages>6530-6540</pages><volume>132</volume><number>18</number><dates><year>2010</year><pub-dates><date>2010/05/12</date></pub-dates></dates><publisher>American Chemical Society</publisher><isbn>0002-7863</isbn><urls><related-urls><url> and supramolecular aromatic stacking interactions (Figure 4c). ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Cubberley</Author><Year>2001</Year><RecNum>5279</RecNum><DisplayText><style face="superscript">20</style></DisplayText><record><rec-number>5279</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cubberley, Mark S.</author><author>Iverson, Brent L.</author></authors></contributors><titles><title>1H NMR Investigation of Solvent Effects in Aromatic Stacking Interactions</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. AM. CHEM. SOC.</full-title></periodical><pages>7560-7563</pages><volume>123</volume><number>31</number><dates><year>2001</year><pub-dates><date>2001/08/01</date></pub-dates></dates><publisher>American Chemical Society</publisher><isbn>0002-7863</isbn><urls><related-urls><url> The data shown in Figure 4b represents the plateau force required to unfold a collapsed single polystyrene molecule in solution, which is directly proportional to the solvation free energy per monomer (?G). ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Li</Author><Year>2010</Year><RecNum>5462</RecNum><DisplayText><style face="superscript">6o</style></DisplayText><record><rec-number>5462</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5462</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, Isaac T. S.</author><author>Walker, Gilbert C.</author></authors></contributors><titles><title>Interfacial Free Energy Governs Single Polystyrene Chain Collapse in Water and Aqueous Solutions</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. AM. CHEM. SOC.</full-title></periodical><pages>6530-6540</pages><volume>132</volume><number>18</number><dates><year>2010</year><pub-dates><date>2010/05/12</date></pub-dates></dates><publisher>American Chemical Society</publisher><isbn>0002-7863</isbn><urls><related-urls><url> This data had previously been plotted against solvent surface tension differences, giving a good, but notably lower quality correlation (Figure S8) than that shown in Figure 4b. Figure 4c shows a plot of experimental aromatic stacking interaction energies plotted against the cohesive energy density of the solvents examined. A subset of this data had previously been correlated against the ET(30) solvent polarity scale, ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Wheeler</Author><Year>2014</Year><RecNum>5379</RecNum><DisplayText><style face="superscript">21</style></DisplayText><record><rec-number>5379</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5379</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wheeler, Steven E.</author><author>Bloom, Jacob W. G.</author></authors></contributors><titles><title>Towards a More Complete Understanding of Non-Covalent Interactions Involving Aromatic Rings</title><secondary-title>J. Phys. Chem. A</secondary-title></titles><periodical><full-title>J. Phys. Chem. A</full-title><abbr-1>J. Phys. Chem. A.</abbr-1></periodical><pages>6133–6147</pages><volume>118</volume><dates><year>2014</year></dates><publisher>American Chemical Society</publisher><isbn>1089-5639</isbn><urls><related-urls><url> yielding a correlation with R2 = 0.88 (Figure S9a). However, all three of the original data sets can now correlated against cohesive energy density giving R2 values ranging between 0.94 and 0.97 (Figure 4c). Contrasting with the correlations in Figure 3, the different intercepts in Figure 4c can be attributed to differences in electrostatic/dispersion interactions as the stacked complex was varied. Correlations of this data against Abraham’s solvophobicity parameter, Sp HYPERLINK \l "_ENREF_46" \o "Abraham, 1988 #5386" ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Abraham</Author><Year>1988</Year><RecNum>5386</RecNum><DisplayText><style face="superscript">11c</style></DisplayText><record><rec-number>5386</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5386</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abraham, Michael H.</author><author>Grellier, Priscilla L.</author><author>McGill, R. Andrew</author></authors></contributors><titles><title>A quantitative measure of solvent solvophobic effect</title><secondary-title>J. Chem. Soc., Perkin Trans. 2</secondary-title></titles><periodical><full-title>J. Chem. Soc., Perkin Trans. 2</full-title><abbr-1>J. Chem. Soc., Perkin Trans. 2</abbr-1></periodical><pages>339-345</pages><number>3</number><dates><year>1988</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>0300-9580</isbn><work-type>10.1039/P29880000339</work-type><urls><related-urls><url> yielded equally pleasing correlations with R2 = 0.93-0.97 (Figure S9b). As was the case for the three non-polar contacts measured using Wilcox balances, the data for aromatic stacking did not correlate well with the surface tension nor the internal pressure of the solvent (Figure S9c-d). The general utility of cohesive energy densities in describing solvophobic effects was further demonstrated by the strong correlations with solvophobicity values, Sp (Figure 4d) ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Abraham</Author><Year>1988</Year><RecNum>5386</RecNum><DisplayText><style face="superscript">11c</style></DisplayText><record><rec-number>5386</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5386</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Abraham, Michael H.</author><author>Grellier, Priscilla L.</author><author>McGill, R. Andrew</author></authors></contributors><titles><title>A quantitative measure of solvent solvophobic effect</title><secondary-title>J. Chem. Soc., Perkin Trans. 2</secondary-title></titles><periodical><full-title>J. Chem. Soc., Perkin Trans. 2</full-title><abbr-1>J. Chem. Soc., Perkin Trans. 2</abbr-1></periodical><pages>339-345</pages><number>3</number><dates><year>1988</year></dates><publisher>The Royal Society of Chemistry</publisher><isbn>0300-9580</isbn><work-type>10.1039/P29880000339</work-type><urls><related-urls><url> and phase transfer free energies of hydrocarbons from water (Figure S10a). The quality of these relationships (R2 = 0.94-0.97) are notable given that cohesive energy density is directly related to the enthalpy of vaporization (see equation above),while the phase transfer energies (from which Sp values are determined) are oftenFigure 4. a) Scale of cohesive energy densities (ced) indicating the relative solvophobicities of common solvents. Solvent mixtures are quoted in v/v %. b) Previously reported plateau forces, FN for unfolding single polystyrene molecules,6o and c) aromatic stacking interaction energies, ?Gstack. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Cubberley</Author><Year>2001</Year><RecNum>5279</RecNum><DisplayText><style face="superscript">20</style></DisplayText><record><rec-number>5279</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cubberley, Mark S.</author><author>Iverson, Brent L.</author></authors></contributors><titles><title>1H NMR Investigation of Solvent Effects in Aromatic Stacking Interactions</title><secondary-title>J. Am. Chem. Soc.</secondary-title></titles><periodical><full-title>J. AM. CHEM. SOC.</full-title></periodical><pages>7560-7563</pages><volume>123</volume><number>31</number><dates><year>2001</year><pub-dates><date>2001/08/01</date></pub-dates></dates><publisher>American Chemical Society</publisher><isbn>0002-7863</isbn><urls><related-urls><url> replotted against the cohesive energy density of the solvents in which the measurements were made. d) Abraham’s solvophobicity parameter5e,11c versus cohesive energy density. All plotted data are tabulated in the SI. dominated by entropy. ADDIN EN.CITE <EndNote><Cite ExcludeAuth="1" ExcludeYear="1"><Author>Frank</Author><Year>1945</Year><RecNum>5501</RecNum><DisplayText><style face="superscript">23</style></DisplayText><record><rec-number>5501</rec-number><foreign-keys><key app="EN" db-id="5ptpv0a5uvat59e0ff3v2wso92psfwr0aw5d">5501</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Frank, Henry S.</author><author>Evans, Marjorie W.</author></authors></contributors><titles><title>Free Volume and Entropy in Condensed Systems III. Entropy in Binary Liquid Mixtures; Partial Molal Entropy in Dilute Solutions; Structure and Thermodynamics in Aqueous Electrolytes</title><secondary-title>The Journal of Chemical Physics</secondary-title></titles><periodical><full-title>The Journal of Chemical Physics</full-title></periodical><pages>507-532</pages><volume>13</volume><number>11</number><dates><year>1945</year></dates><urls><related-urls><url> This relationship is likely to be a consequence of enthalpy-entropy compensation, and the existence of a mechanistic continuum between the two thermodynamic extremes of entropically versus enthalpically dominated solvophobic effects. Indeed, the manifestation of the hydrophobic effect at both thermodynamic extremes is well-recognized.PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGUgRXhjbHVkZUF1dGg9IjEiIEV4Y2x1ZGVZZWFyPSIxIj48QXV0aG9yPkJl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ADDIN EN.CITE.DATA 1b,4b,24In summary, we have collated new and previously published experimental measurements of non-polar cohesive interactions to examine the utility of several quantitative solvophobic descriptors. The collated data comprised hundreds of aromatic stacking, aromatic edge-to-face, aliphatic and fluorous interaction energies measured in intramolecular, intermolecular, bulk and single-molecule contexts where solvent effects were systematically examined. All sets of solvent screening data correlated well with cohesive energy densities (the square of the Hildebrand parameter, ?H2), or Abraham’s Sp values.25 In contrast, alternative measures of solvent cohesion, such as surface tension and internal pressure provided substantially lower quality correlations. Thus, we propose that correlations of chemical properties against solvent cohesive energy densities provide a quantitative signature for characterizing solvophobic effects. ASSOCIATED CONTENTSupporting InformationTables of data, additional correlations, synthetic procedures and compound characterization data are provided in the Supporting Information. This material is available free of charge via the Internet at . AUTHOR INFORMATIONCorresponding Authorscott.cockroft@ed.ac.ukNotesThe authors declare no competing financial interests.ACKNOWLEDGMENT We thank Pfizer Ltd. and MTEM Ltd. for studentships to C.A. and L.Y. respectively, and Nicholas Dominelli-Whiteley for assistance with compound characterization.REFERENCES ADDIN EN.REFLIST (1) a) Granick, S.; Bae, S. C. Science 2008, 322, 1477; b) Biedermann, F.; Nau, W. M.; Schneider, H.-J. Angew. Chem. Int. Ed. 2014, 53, 11158; c) Hunter, C. A. Angew. Chem. Int. Ed. 2004, 43, 5310.(2) a) Marmur, A. J. Am. Chem. Soc. 2000, 122, 2120; b) Abraham, M. H.; Blandamer, M. J. J. Am. Chem. Soc. 2002, 124, 7853.(3) a) Lazaridis, T. Acc. Chem. Res. 2001, 34, 931; b) Otto, S. Chem. Sci. 2013, 4, 2953; c) Tanford, C. Proc. Natl. Acad. Sci. USA 1979, 76, 4175.(4) a) Dack, M. R. J. Chem. Soc. Rev. 1975, 4, 211; b) Sedov, I. A.; Solomonov, B. N. J. Struct. Chem. 2013, 54, 262.(5) a) Scherrmann, M. C.; Norsikian, S.; Lubineau, A. In Adv. Org. Synth.; Atta-ur-Rahman, Ed.; Bentham Science Publishers: 2005; Vol. 1, p 341; b) Clark, C. G.; Wenzel, R. J.; Andreitchenko, E. V.; Steffen, W.; Zenobi, R.; Müllen, K. J. Am. Chem. Soc. 2007, 129, 3292; c) Breslow, R. Acc. Chem. Res. 1991, 24, 159; d) Schneider, H.-J.; Sangwan, N. K. Angew. Chem. Int. Ed. Engl. 1987, 26, 896; e) Cativiela, C.; I. Garcia, J.; Gil, J.; M. Martinez, R.; A. Mayoral, J.; Salvatella, L.; S. Urieta, J.; M. Mainar, A.; H. Abraham, M. J. Chem. Soc., Perkin Trans. 2 1997, 653.(6) a) Becerril, J.; Bolte, M.; Burguete, M. I.; Galindo, F.; García-Espa?a, E.; Luis, S. V.; Miravet, J. F. J. Am. Chem. Soc. 2003, 125, 6677; b) Correa, N. M.; Silber, J. J.; Riter, R. E.; Levinger, N. E. Chem. Rev. 2012, 112, 4569; c) Lahiri, S.; Thompson, J. L.; Moore, J. S. J. Am. Chem. Soc. 2000, 122, 11315; d) Schneider, H.-J. Angew. Chem. Int. Ed. 2009, 48, 3924; e) Zhao, Y.; Zhong, Z.; Ryu, E.-H. J. Am. Chem. Soc. 2007, 129, 218; f) Cram, D. J.; Choi, H. J.; Bryant, J. A.; Knobler, C. B. J. Am. Chem. Soc. 1992, 114, 7748; g) Ponnuswamy, N.; Panto?, G. D.; Smulders, M. M. J.; Sanders, J. K. M. J. Am. Chem. Soc. 2012, 134, 566; h) Bhosale, S. V.; Adsul, M.; Shitre, G. V.; Bobe, S. R.; Bhosale, S. V.; Privér, S. H. Chem. Eur. J. 2013, 19, 7310; i) Nelson, J. C.; Saven, J. G.; Moore, J. S.; Wolynes, P. G. Science 1997, 277, 1793; j) Cho, H.; Zhao, Y. J. Am. Chem. Soc. 2010, 132, 9890; k) Yan, Z.; Moore, J. S. In Foldamers; Eds. Hecht, S., Huc, I., Wiley, Weinheim, 2007, p 75,; l) Adam, C.; Yang, L.; Cockroft, S. L. Angew. Chem. Int. Ed. 2015, 54, 1164; m) Yang, L.; Adam, C.; Nichol, G. S.; Cockroft, S. L. Nat. Chem. 2013, 5, 1006; n) Bhayana, B.; Wilcox, C. S. Angew. Chem. Int. Ed. 2007, 46, 6833; o) Li, I. T. S.; Walker, G. C. J. Am. Chem. Soc. 2010, 132, 6530; p) Newcomb, L. F.; Gellman, S. H. J. Am. Chem. Soc. 1994, 116, 4993; q) Gardner, R. R.; Christianson, L. A.; Gellman, S. H. J. Am. Chem. Soc. 1997, 119, 5041; r) Corbett, P. T.; Leclaire, J.; Vial, L.; West, K. R.; Wietor, J.-L.; Sanders, J. K. M.; Otto, S. Chem. Rev. 2006, 106, 3652; s) Safont-Sempere, M. M.; Fernández, G.; Würthner, F. Chem. Rev. 2011, 111, 5784.(7) a) Matsukizono, H.; Kuroiwa, K.; Kimizuka, N. J. Am. Chem. Soc. 2008, 130, 5622; b) Minakata, S.; Tsuruoka, R.; Komatsu, M. J. Am. Chem. Soc. 2008, 130, 1536; c) Zhuang, J.; Wu, H.; Yang, Y.; Cao, Y. C. J. Am. Chem. Soc. 2007, 129, 14166; d) Berna, J.; Leigh, D. A.; Lubomska, M.; Mendoza, S. M.; Perez, E. M.; Rudolf, P.; Teobaldi, G.; Zerbetto, F. Nat. Mater. 2005, 4, 704; e) Arduini, A.; Bussolati, R.; Credi, A.; Secchi, A.; Silvi, S.; Semeraro, M.; Venturi, M. J. Am. Chem. Soc. 2013, 135, 9924.(8) a) Myers, K. E.; Kumar, K. J. Am. Chem. Soc. 2000, 122, 12025; b) Kuwahara, H.; Hamada, M.; Ishikawa, Y.; Kunitake, T. J. Am. Chem. Soc. 1993, 115, 3002.(9) Greaves, T. L.; Drummond, C. J. Chem. Soc. Rev. 2013, 42, 1096.(10) Ray, A. Nature 1971, 231, 313.(11) a) Hunter, C. A. Chem. Sci. 2013, 4, 834; b) Joh, N. H.; Oberai, A.; Yang, D.; Whitelegge, J. P.; Bowie, J. U. J. Am. Chem. Soc. 2009, 131, 10846; c) Abraham, M. H.; Grellier, P. L.; McGill, R. A. J. Chem. Soc., Perkin Trans. 2 1988, 339.(12) a) Mati, I. K.; Cockroft, S. L. Chem. Soc. Rev. 2010, 39, 4195; b) Cozzi, F.; Siegel, J. S. Pure Appl. Chem. 1995, 67, 683; c) Motherwell, W. B.; Mo?se, J.; Aliev, A. E.; Ni?, M.; Coles, S. J.; Horton, P. N.; Hursthouse, M. B.; Chessari, G.; Hunter, C. A.; Vinter, J. G. Angew. Chem. Int. Ed. 2007, 46, 7823; d) Aliev, A. E.; Arendorf, J. R. T.; Pavlakos, I.; Moreno, R. B.; Porter, M. J.; Rzepa, H. S.; Motherwell, W. B. Angew. Chem. Int. Ed. 2015, 127, 561; e) Hwang, J.; Li, P.; Carroll, W. R.; Pellechia, P. J.; Shimizu, K. D. J. Am. Chem. Soc. 2014, 136, 14060; f) Oki, M. Acc. Chem. Res. 1990, 23, 351; g) Muchowska, K. B.; Adam, C.; Mati, I. K.; Cockroft, S. L. J. Am. Chem. Soc. 2013, 135, 9976; h) Mati, I. K.; Adam, C.; Cockroft, S. L. Chem. Sci. 2013, 4, 3965; i) Hwang, J.; Dial, B. E.; Li, P.; Kozik, M. E.; Smith, M. D.; Shimizu, K. D. Chem. Sci. 2015, 6, 4358; j) Pavlakos, I.; Arif, T.; Aliev, A. E.; Motherwell, W. B.; Tizzard, G. J.; Coles, S. J. Angew. Chem. Int. Ed. 2015, 54, 8169. k) Maier, J. M.; Li, P.; Hwang, J.; Smith, M. D.; Shimizu, K. D. J. Am. Chem. Soc. 2015, 137, 8014.(13) a) Paliwal, S.; Geib, S.; Wilcox, C. S. J. Am. Chem. Soc. 1994, 116, 4497; b) Kim, E.-i.; Paliwal, S.; Wilcox, C. S. J. Am. Chem. Soc. 1998, 120, 11192.(14) Cockroft, S. L.; Hunter, C. A. Chem. Soc. Rev. 2007, 36, 172.(15) a) Hof, F.; Scofield, D. M.; Schweizer, W. B.; Diederich, F. Angew. Chem. Int. Ed. 2004, 43, 5056; b) Fischer, F. R.; Schweizer, W. B.; Diederich, F. Angew. Chem. Int. Ed. 2007, 46, 8270; c) Fischer, F. R.; Schweizer, W. B.; Diederich, F. Chem. Commun. 2008, 4031; d) Gardarsson, H.; Schweizer, W. B.; Trapp, N.; Diederich, F. Chem. Eur. J. 2014, 20, 4608; e) Ren, T.; Jin, Y.; Kim, K. S.; Kim, D. H. J. Biomol. Struct. Dyn. 1997, 15, 401; f) Nakamura, K.; Houk, K. N. Org. Lett. 1999, 1, 2049; g) Cockroft, S. L.; Hunter, C. A. Chem. Commun. 2006, 3806; h) Cockroft, S. L.; Hunter, C. A. Chem. Commun. 2009, 3961.(16) Computational models support Wilcox’s previous assertion that the methyl group is not large or polar enough to form significant dispersive contact or CH-aryl interactions in the folded conformation, but is still large enough to block solvation of the aromatic face in a similar manner as the phenyl ester in the folded conformation (Figure S2).13b Furthermore, Figure S5 is consistent with small secondary interaction differences between balances (±)-1E and (±)-2E, paricularly when compared to the variations in the alkyl/perfluoroalkyl control balances. (17) a) Martinez, A. G.; Barcina, J. O.; Cerezo, A. D. Chem. Eur. J. 2001, 7, 1171; b) Carver, F. J.; Hunter, C. A.; Livingstone, D. J.; McCabe, J. F.;Seward, E. M. Chem. Eur. J. 2002, 8, 2847.(18) Hildebrand, J. H.; Scott, R. L. The Solubility of Nonelectrolytes; 3rd Ed.; Dover Publications: New York, 1964.(19) Crothers, D. M.; Ratner, D. I. Biochemistry 1968, 7, 1823.(20) Cubberley, M. S.; Iverson, B. L. J. Am. Chem. Soc. 2001, 123, 7560.(21) Wheeler, S. E.; Bloom, J. W. G. J. Phys. Chem. A. 2014, 118, 6133.(22) Frank, H. S.; Evans, M. W. J. Chem. Phys. 1945, 13, 507.(23) Contrasting with the correlations against Gibbs energy-related properties shown in Figures 4d and S10a, there is no correlation between ced and the enthalpy of phase transfer from water (Figure S10b).(24) a) Ben-Amotz, D.; Underwood, R. Acc. Chem. Res. 2008, 41, 957; b) Biela, A.; Nasief, N. N.; Betz, M.; Heine, A.; Hangauer, D.; Klebe, G. Angew. Chem. Int. Ed. 2013, 52, 1822; c) Meyer, E., A.; Castellano, R. K.; Diederich, F. Angew. Chem. Int. Ed. 2003, 42, 1210; d) Chen, L.-J.; Lin, S.-Y.; Huang, C.-C. J. Phys. Chem. B 1998, 102, 4350. (25) We propose that ced is the most useful parameter for quantifying solvophobic effects since: i. Linear free energy correlations require energies (or parameters that are directly proportional to energies) to be plotted against one another [cf. the Hildebrand parameter, which has units of (energy)1/2]. ii. Comprehensive data for Gibbs energies of phase transfer of standard solutes (from which Sp values are derived) are not easily sourced, while enthalpies of vaporization from which ced values are determined are widely reported (see Tables and associated references in the SI).Table of Contents Graphic ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- fda electronic submission guidance
- fda electronic submission requirements
- electronic submission guidelines
- fda electronic submission guidelines
- how to writing template for first grade
- to do list template for word
- best electronic websites to buy
- how to write journals examples
- electronic submission guidance fda
- free website submission to 1000 search engines
- electronic submission gateway fda
- template for introduction to a research paper