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Supplementary Table 1.Search query and resultsEmbaseSearch Query(asthma OR “bronchial asthma” OR “asthma, bronchial”) AND (predictive OR prediction) AND ((symptoms) OR (medical history OR comorbidity) OR (diagnosis OR diagnoses))Search Date26-Dec-16Total No. of Hits3423PubMedSearch Query(asthma OR “bronchial asthma” OR “asthma, bronchial”) AND (predictive OR prediction) AND ((symptoms) OR (medical history OR comorbidity) OR (diagnosis OR diagnoses))Search Date26-Dec-16Total No. of Hits2611Cochrane LibrarySearch Query(asthma OR “bronchial asthma” OR “asthma, bronchial”) AND (predictive OR prediction) AND ((symptoms) OR (medical history OR comorbidity) OR (diagnosis OR diagnoses))Search Date26-Dec-16Total No. of Hits143Google ScholarSearch Query? (asthma OR “bronchial asthma” OR “asthma, bronchial”) AND (predictive OR prediction) AND ((symptoms) OR (medical history OR comorbidity) OR (diagnosis OR diagnoses))Search Date26-Dec-16Total No. of Hits300Total number of Unique Hits4939Supplementary Table 2.List of combinations reportedCombinationSymptoms in bi. 1wheezing + breathlessness + chest tightness + coughCombi. 2bronchial hyperresponsivenessCombi. 3wheezingCombi. 4wheezing + coughCombi. 5wheezing + breathlessness + coughCombi. 6wheezing + breathlessness + chest tightness + cough + asthma exacerbationCombi. 7wheezing + breathlessness + chest tightness + cough + bronchial hyperresponsivenessCombi. 8sneezing + running nose/rhinorrhea + nasal congestionCombi. 9coughCombi. 10sneezingCombi. 11breathlessness + cough + sinusitisCombi. 12breathlessness + coughCombi. 13running nose/rhinorrhea + nasal congestionCombi. 14wheezing + sleep disturbancesCombi. 15sinusitisCombi. 16wheezing + breathlessness + cough + sleep disturbancesCombi. 17wheezing + breathlessness + chest tightness + cough + sneezing + running nose/rhinorrhea + sleep disturbances + bronchial hyperresponsiveness + sinusitisCombi. 18wheezing + breathlessness + exercise induced bronchoconstriction + sleep disturbances + asthma exacerbationCombi. 19wheezing + breathlessness + cough + exercise induced bronchoconstriction + asthma exacerbationCombi. 20wheezing + breathlessness + chest tightness + cough + exercise induced bronchoconstriction + sleep disturbances + asthma exacerbations + bronchial hyperresponsivenessCombi. 21exercise induced bronchoconstrictionCombi. 22wheezing + cough + bronchial hyperresponsivenessCombi. 23wheezing + breathlessness + chest tightness + cough + sleep disturbances + asthma exacerbationCombi. 24wheezing + breathlessness + chest tightness + sleep disturbancesCombi. 25asthma exacerbation + sinusitisCombi. 26wheezing + breathlessness + chest tightness + cough + sneezing + running nose/rhinorrhea + nasal congestion + exercise induced bronchoconstrictionCombi. 27wheezing + breathlessness + cough + exercise induced bronchoconstriction + sleep disturbances + bronchial hyperresponsivenessCombi. 28wheezing + breathlessness + chest tightness + cough + exercise induced bronchoconstriction + sleep disturbancesCombi. 29wheezing + breathlessness + chest tightness + cough + exercise induced bronchoconstriction + bronchial hyperresponsivenessCombi. 30wheezing + breathlessness + chest tightness + cough + exercise induced bronchoconstrictionCombi. 31wheezing + breathlessness + chest tightness + cough + sleep disturbancesCombi. 32wheezing + cough + exercise induced bronchoconstrictionCombi. 33wheezing + breathlessness + cough + exercise induced bronchoconstrictionCombi. 34wheezing + cough + exercise induced bronchoconstriction + sleep disturbancesCombi. 35wheezing + breathlessness + bronchial hyperresponsivenessCombi. 36wheezing + breathlessness + chest tightness + exercise induced bronchoconstrictionCombi. 37wheezing + breathlessness + chest tightness + cough + sneezing + running nose/rhinorrhea + nasal congestion + sleep disturbancesSupplementary Table 3.Proportion of patients with different asthma severity and symptomsCombinationNo. of studiesTotal No. of patients, NAvg. % of patients with symptomMild, n (%)Mild-moderate,n (%)Moderate, n (%)Moderate-severe, n (%)Severe, n (%)Intermittent, n (%)Not defined, n (%)Combi. 14120471.2643 (3.57)0 (0)86 (7.14)0 (0)247 (21.53)41 (3.57)787(65.3)Combi. 23108957.73180 (16.53)0 (0)167 (15.33)181 (16.62)154 (14.14)210 (19.28)0 (0)Combi. 3275914.98396 (52.18)0 (0)0 (0)0 (0)0 (0)0 (0)363 (50.48)Combi. 43121735.130 (0)380 (31.22)0 (0)0 (0)837 (68.77)0 (0)0 (0)Combi. 5113254.300 (0)0 (0)0 (0)0 (0)0 (0)0 (0)132 (100)Combi. 62231342.870 (0)0 (0)0 (0)0 (0)0 (0)0 (0)2313 (100)Combi. 7155125.90156 (28)0 (0)41 (7)0 (0)35 (6)0 (0)319 (58)Combi. 8114018.530 (0)0 (0)0 (0)140 (100)0 (0)0 (0)0 (0)Combi. 9185629.7069 (8.10)0 (0)143 (16.70)0 (0)154 (17.99)388 (45.32)0 (0)Combi. 10110962.380 (0)0 (0)0 (0)0 (0)0 (0)0 (0)109 (100)Combi. 11113518.330 (0)0 (0)0 (0)0 (0)0 (0)0 (0)135 (100)Combi. 12177437.920 (0)0 (0)0 (0)0 (0)0 (0)774 (100)0 (0)Combi. 13112465.705 (4.03)0 (0)68 (54.83)0 (0)30 (24.19)21 (16.93)0 (0)Combi. 14110650.330 (0)0 (0)0 (0)0 (0)0 (0)0 (0)106 (100)Combi. 15117363.700 (0)0 (0)0 (0)0 (0)0 (0)0 (0)173 (100)Combi. 16163529.060 (0)0 (0)0 (0)0 (0)0 (0)0 (0)635 (100)Combi. 171659026.030 (0)0 (0)0 (0)0 (0)0 (0)0 (0)6590 (100)Combi. 18112555.8877 (61.60)0 (0)40 (32)0 (0)8 (6.4)0 (0)0 (0)Combi. 19121066.800 (0)0 (0)0 (0)0 (0)0 (0)0 (0)210 (100)Combi. 201152713.360 (0)0 (0)0 (0)0 (0)0 (0)0 (0)1527 (100)Combi. 21123527.070 (0)0 (0)0 (0)0 (0)0 (0)0 (0)235 (100)Combi. 22115062.660 (0)0 (0)0 (0)0 (0)0 (0)0 (0)150 (100)Combi. 23121545.520 (0)0 (0)0 (0)0 (0)0 (0)215 (100)0 (0)Combi. 241168399.400 (0)0 (0)0 (0)0 (0)0 (0)0 (0)1683 (100)Combi. 251203251.00963 (47.40)0 (0)824 (40.55)0 (0)243 (11.96)0 (0)0 (0)Combi. 26121260.070 (0)0 (0)0 (0)0 (0)0 (0)0 (0)212 (100)Combi. 271600918.170 (0)0 (0)0 (0)0 (0)0 (0)0 (0)6009 (100)Combi. 28123942.340 (0)0 (0)0 (0)0 (0)0 (0)0 (0)229 (95.81)Combi. 29178421.750 (0)0 (0)0 (0)0 (0)0 (0)0 (0)784 (100)Combi. 30117647.9851 (28.97)0 (0)34 (19.32)0 (0)9 (5.11)82 (46.59)0 (0)Combi. 311110318.500 (0)0 (0)0 (0)0 (0)0 (0)0 (0)1103 (100)Combi. 32110925.400 (0)0 (0)0 (0)0 (0)0 (0)0 (0)109 (100)Combi. 33116449.850 (0)164 (100)0 (0)0 (0)0 (0)0 (0)0 (0)Combi. 34157516.850 (0)0 (0)0 (0)0 (0)0 (0)0 (0)575 (100)Combi. 35111,29726.930 (0)0 (0)0 (0)0 (0)0 (0)0 (0)11297 (100)Combi. 361162319.370 (0)0 (0)0 (0)0 (0)0 (0)0 (0)1623 (100)Combi. 37176738.45537 (70.01)0 (0)0 (0)232 (30.25)0 (0)0 (0)0 (0) ................
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