Www.dovepress.com



Supplementary Table S1. CCS codes used to identify relevant diagnoses.Heart Failure00108Congestive heart failure, non hypertensiveDiabetes00049Diabetis mellitus, no complications mentioned00050Diabetis mellitus with complicationsHypertension00098Essential hypertension00099Hypertension with complications and secondary hypertensionChronic Kidney Disease00158Chronic kidney diseaseIschemic Heart Disease00100Acute myocardial infarction00101Coronary atherosclerosisCCS = Clinical Classifications SoftwareSupplementary Table S2. ICD-9-CM codes used to identify relevant diagnoses.Heart Failure398.91Rheumatic heart failure (congestive)402.01Malignant hypertensive heart disease with heart failure 402.11 Benign hypertensive heart disease with heart failure402.91Unspecified hypertensive heart disease with heart failure404.01 Hypertensive heart and chronic kidney disease, malignant, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.03 Hypertensive heart and chronic kidney disease, malignant, with heart failure and with chronic kidney disease stage V or end stage renal disease404.11 Hypertensive heart and chronic kidney disease, benign, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.13 Hypertensive heart and chronic kidney disease, benign, with heart failure and chronic kidney disease stage V or end stage renal disease404.91 Hypertensive heart and chronic kidney disease, unspecified, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.93Hypertensive heart and chronic kidney disease, unspecified, with heart failure and chronic kidney disease stage V or end stage renal disease 428Heart failure428.0Congestive heart failure, unspecified 428.1Left heart failure 428.2, 428.2xSystolic heart failure428.3, 428.3x Diastolic heart failure428.4, 428.4xCombined systolic and diastolic heart failure428.9Heart failure, unspecified Diabetes250Diabetes mellitus250.0, 250.0xDiabetes mellitus without mention of complication250.1, 250.1xDiabetes with ketoacidosis250.2, 250.2xDiabetes with hyperosmolarity250.3, 250.3xDiabetes with other coma250.4, 250.4xDiabetes with renal manifestations250.5, 250.5xDiabetes with ophthalmic manifestations250.6, 250.6xDiabetes with neurological manifestations250.7, 250.7xDiabetes with peripheral circulatory disorders250.8, 250.8xDiabetes with other specified manifestations250.9, 250.9xDiabetes with unspecified complicationHypertension401Essential hypertension401.0Malignant essential hypertension 401.1Benign essential hypertension 401.9Unspecified essential hypertension402Hypertensive heart disease402.0, 402.0xMalignant hypertensive heart disease402.1, 402.1x Benign hypertensive heart disease402.9, 402.9x Unspecified hypertensive heart disease403Hypertensive chronic kidney disease403.0, 403.0xMalignant hypertensive renal disease403.1, 403.1x Benign hypertensive renal disease403.9, 403.9xUnspecified hypertensive renal disease404Hypertensive heart and chronic kidney disease404.0, 404.0x Malignant hypertensive heart and renal disease404.1, 404.1x Benign hypertensive heart and renal disease404.9, 404.9x Unspecified hypertensive heart and renal disease405Secondary hypertension405.0, 405.0x Malignant secondary hypertension405.1, 405.1x Benign secondary hypertension405.9, 405.9x Unspecified secondary hypertensionChronic Kidney Disease403.00 Hypertensive chronic kidney disease, malignant, with chronic kidney disease stage I through stage IV, or unspecified403.01 Hypertensive chronic kidney disease, malignant, with chronic kidney disease stage V or end stage renal disease403.10 Hypertensive chronic kidney disease, benign, with chronic kidney disease stage I through stage IV, or unspecified403.11 Hypertensive chronic kidney disease, benign, with chronic kidney disease stage V or end stage renal disease403.90 Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage I through stage IV, or unspecified403.91Hypertensive chronic kidney disease, unspecified, with chronic kidney disease stage V or end stage renal disease404.00 Hypertensive heart and chronic kidney disease, malignant, without heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.01 Hypertensive heart and chronic kidney disease, malignant, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.02Hypertensive heart and chronic kidney disease, malignant, without heart failure and with chronic kidney disease stage V or end stage renal disease 404.03Hypertensive heart and chronic kidney disease, malignant, with heart failure and with chronic kidney disease stage V or end stage renal disease 404.10 Hypertensive heart and chronic kidney disease, benign, without heart failure and with chronic kidney disease stage I through stage IV, or unspecified404.11Hypertensive heart and chronic kidney disease, benign, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified 404.12 Hypertensive heart and chronic kidney disease, benign, without heart failure and with chronic kidney disease stage V or end stage renal disease404.13 Hypertensive heart and chronic kidney disease, benign, with heart failure and chronic kidney disease stage V or end stage renal disease404.90Hypertensive heart and chronic kidney disease, unspecified, without heart failure and with chronic kidney disease stage I through stage IV, or unspecified 404.91Hypertensive heart and chronic kidney disease, unspecified, with heart failure and with chronic kidney disease stage I through stage IV, or unspecified 404.92Hypertensive heart and chronic kidney disease, unspecified, without heart failure and with chronic kidney disease stage V or end stage renal disease 404.93Hypertensive heart and chronic kidney disease, unspecified, with heart failure and chronic kidney disease stage V or end stage renal disease582.xxChronic glomerulonephritis585 Chronic kidney disease585.1 Chronic kidney disease, Stage I585.2 Chronic kidney disease, Stage II (mild)585.3 Chronic kidney disease, Stage III (moderate)585.4 Chronic kidney disease, Stage IV (severe)585.5 Chronic kidney disease, Stage V585.6End stage renal disease 585.9Chronic kidney disease, unspecified458.21 Hypotension of hemodialysis792.5 Cloudy (hemodialysis) (peritoneal) dialysis effluent996.81 Complications of transplanted kidney996.73Other complications due to renal dialysis device, implant, and graft996.56 Mechanical complication due to peritoneal dialysis catheterV42.0 Kidney replaced by transplantV45.1xRenal dialysis statusV56.xxEncounter for extracorporeal dialysisIschemic Heart Disease410Acute myocardial infarction410.0, 410.0xAcute myocardial infarction of anterolateral wall410.1, 410.1xAcute myocardial infarction of other anterior wall410.2, 410.2x Acute myocardial infarction of inferolateral wall410.3, 410.3x Acute myocardial infarction of inferoposterior wall410.4, 410.4x Acute myocardial infarction of other inferior wall410.5, 410.5x Acute myocardial infarction of other lateral wall410.6, 410.6x True posterior wall infarction410.7, 410.7xSubendocardial infarction410.8, 410.8xAcute myocardial infarction of other specified sites410.9, 410.9xAcute myocardial infarction of unspecified site411 Other acute and subacute forms of ischemic heart disease411.0Postmyocardial infarction syndrome 411.1 Intermediate coronary syndrome411.8, 411.8x Other acute and subacute forms of ischemic heart disease412Old myocardial infarction413Angina pectoris413.0 Angina decubitus413.1 Prinzmetal angina413.9Other and unspecified angina pectoris 414Other forms of chronic ischemic heart disease414.0, 414.0x Coronary atherosclerosis414.1, 414.1x Aneurysm and dissection of heart414.2 Chronic total occlusion of coronary artery414.3 Coronary atherosclerosis due to lipid rich plaque414.4 Coronary atherosclerosis due to calcified coronary lesion414.8 Other specified forms of chronic ischemic heart disease414.9Chronic ischemic heart disease, unspecified996.03Mechanical complication due to coronary bypass graftV45.81 Aortocoronary bypass statusV45.82Percutaneous transluminal coronary angioplasty statusICD-9-CM = International Classification of Diseases, 9th Revision, Clinical ModificationSupplementary Table S3. ICD-10 codes used to identify relevant diagnoses.Heart FailureI09.9Rheumatic heart disease, unspecifiedI11.0Hypertensive heart disease with (congestive) heart failureI13.0Hypertensive heart and renal disease with (congestive) heart failureI13.2Hypertensive heart and renal disease with both (congestive) heart failure and renal failureI50.0Congestive heart failureI50.1Left ventricular failureI50.9Heart failure, unespecifiedDiabetesE10Type 1 diabetes mellitusE11Type 2 diabetes mellitusE12Malnutrition-related diabetes mellitusE13Other specified diabetes mellitusE14Unspecified diabetes mellitusHypertensionI10Essential (primary) hypertensionI11.0Hypertensive heart disease with (congestive) heart failureI11.9Hypertensive heart disease without (congestive) heart failureI12.0Hypertensive renal disease with renal failureI12.9Hypertensive renal disease without renal failureI13.0Hypertensive heart and renal disease with (congestive) heart failureI13.1Hypertensive heart and renal disease with renal failureI13.2Hypertensive heart and renal disease with both (congestive) heart failure and renal failureI13.9Hypertensive heart and renal disease, unspecifiedI15.0Renovascular hypertensionI15.1Hypertension secondary to other renal disordersI15.2Hypertension secondary to endocrine disordersI15.8Other secondary hypertensionI15.9Secondary hypertension, unspecifiedChronic Kidney DiseaseI12.0Hypertensive renal disease with renal failureI13.0Hypertensive heart and renal disease with (congestive) heart failureI13.1Hypertensive heart and renal disease with renal failureI13.2Hypertensive heart and renal disease with both (congestive) heart failure and renal failureI13.9Hypertensive heart and renal disease, unspecifiedN18.1Chronic kidney disease, stage 1N18.2Chronic kidney disease, stage 2N18.3Chronic kidney disease, stage 3N18.4Chronic kidney disease, stage 4N18.5Chronic kidney disease, stage 5N18.9Chronic kidney disease, unspecifiedT82.4Mechanical complication of vascular dialysis catheterT86.1Kidney transplant failure and rejectionY84.1Kidney dialysisZ49Care involving dialysisZ94.0Kidney transplant statusZ99.2Dependence on renal dialysisIschemic Heart DiseaseI20.0Unstable anginaI20.1Angina pectoris with documented spasmI20.8Other forms of angina pectorisI20.9Angina pectoris, unspecifiedI21.0Acute transmural myocardial infarction of anterior wallI21.1Acute transmural myocardial infarction of inferior wallI21.2Acute transmural myocardial infarction of other sitesI21.3Acute transmural myocardial infarction of unspecified siteI21.4Acute subendocardial myocardial infarctionI21.9Acute myocardial infarction, unspecifiedI22.0Subsequent myocardial infarction of anterior wallI22.1Subsequent myocardial infarction of inferior wallI22.8Subsequent myocardial infarction of other sitesI22.9Subsequent myocardial infarction of unspecified siteI23.0Haemopericardium as current complication following acute myocardial infarctionI23.1Atrial septal defect as current complication following acute myocardial infarctionI23.2Ventricular septal defect as current complication following acute myocardial infarctionI23.3Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarctionI23.4Rupture of chordae tendineae as current complication following acute myocardial infarctionI23.5Rupture of papillary muscle as current complication following acute myocardial infarctionI23.6Thrombosis of atrium, auricular appendage, and ventricle as current complications following acute myocardial infarctionI23.8Other current complications following acute myocardial infarctionI24.0Coronary thrombosis not resulting in myocardial infarctionI24.1Dressler syndromeI24.8Other forms of acute ischaemic heart diseaseI24.9Acute ischaemic heart disease, unspecifiedI25.0Atherosclerotic cardiovascular disease, so describedI25.1Atherosclerotic heart diseaseI25.2Old myocardial infarctionI25.3Aneurysm of heartI25.4Coronary artery aneurysm and dissectionI25.5Ischaemic cardiomyopathyI25.6Silent myocardial ischaemiaI25.8Other forms of chronic ischaemic heart diseaseI25.9Chronic ischaemic heart disease, unspecifiedT82.2Mechanical complication of coronary artery bypass and valve graftsZ95.1Presence of aortocoronary bypass graftV45.82Percutaneous transluminal coronary angioplasty statusICD-10 = International Classification of Diseases, 10th RevisionSupplementary Table S4. ATC codes used to identify RAASI medications.ACEIs (plain, or in combination)captoprilC09AA01, C09BA01enalaprilC09AA02, C09AA02, C09BA02, C09BB02, C09BB06lisinoprilC09AA03, C09BB03, C09BA03, C10BX07perindoprilC10BX15, C10BX12, C10BX11, C09AA04, C09BB04, C09BX02, C09BA04, C09BX01, C10BX14, C10BX13ramiprilC10BX06, C09AA05, C09BB07, C09BA05, C09BB05, C09BX03, C10BX04quinaprilC09AA06, C09AA06, C09BA06benazeprilC09AA07, C09BA07cilazaprilC09AA08, C09BA08fosinoprilC09AA09, C09BA09trandolaprilC09AA10, C09BB10spiraprilC09AA11delaprilC09AA12, C09BA12, C09BB12moexiprilC09AA13, C09BA13temocaprilC09AA14zofenoprilC09AA15, C09BA15imidaprilC09AA16ARBs (plain, or in combination)losartanC09CA01, C09DB06, C09DA01eprosartanC09CA02, C09DA02valsartan*C10BX10, C09CA03, C09DX02, C09DB01, C09DA03, C09DB08, C09DX04, C09DX01irbesartanC09CA04, C09DB05, C09DA04tasosartanC09CA05candesartanC09CA06, C09DB07, C09DA06telmisartanC09CA07, C09DB04, C09DA07olmesartanC09CA08, C09DB02, C09DA08, C09DX03azilsartan C09CA09, C09DA09fimasartanC09CA10, C09DA10Rennin inhibitorsremikirenC09XA01aliskirenC09XA02, C09XA53, C09XA52, C09XA54, C09DX02Aldosterone inhibitors (potassium-sparing diuretics)spironolactoneC03DA01eplerenoneC03DA04*Includes the combination valsartan/sacubitril (code C09DX04)ACEI = angiotensin converting enzyme inhibitor; ARB = angiotensin-receptor blocker; ATC = Anatomical Therapeutic Chemical; RAASI = renin-angiotensin-aldosterone system inhibitionSupplementary Table S5. Prevalence of CKD and of DM among adults ≥55 years of age, MetroSud area, Catalonia, January 1st, 2015 to January 1st, 2017.CHF + CKDCHF + DM2015 No. cases4,2374,341 Prevalence1.21.2 Proportion among CHF cases (N= 8,140)52.153.32016 No. cases5,6105,341 Prevalence1.51.4 Proportion among CHF cases (N = 10,507)53.450.82017 No. cases6,5386,003 Prevalence1.71.6 Proportion among CHF cases (N = 12,062)54.249.8Data presented as number of cases or prevalence (in %). For each year, prevalent diagnoses were assessed using all historical information available in the database as of January 1st (e.g., for 2015, prevalent diagnoses were identified using all cumulative information available as of January 1st, 2015), among individuals included in the study population for each study period. Abbreviations: CHF = chronic heart failure; CKD = chronic kidney disease; DM = diabetes mellitus; No. = numberSupplementary Table S6. Prevalence of hiperkalemia and of hypokalemia among adults ≥55 years of age with CHF and CKD, MetroSud area, Catalonia, January 1st, 2015 to January 1st, 2017.Total NHyperKHypoKHyperK or HypoKRecurrent HyperK20165,610 No. cases1,3071051,405375 Prevalence23.31.925.06.720176,538 No. cases1,6101401,741522 Prevalence24.62.126.68.0Data presented as number of cases, or prevalence (in %). For each year, prevalence was assessed between January 1st of the preceding year, and January 1st of the corresponding year (e.g., for 2016, prevalence of hyperkalemia was assessed between January 1st, 2015 and January 1st, 2016), among individuals from the study population with recorded evidence of at least one of the conditions of interest and using each RAASI medication (regardless of whether they had their K+ levels assessed during the relevant study period). Serum K+ levels were not recorded before January 1st, 2015.Abbreviations: CHF = chronic heart failure; CKD = chronic kidney disease; HyperK = hyperkalemia; hypoK = hypokalemia; N = number; No. = numberSupplementary Table S7. Prevalence of potassium derangements among adults ≥55 years of age with at least one relevant condition (CHF, CKD, DM, IHD, HTN) and taking at least one relevant drug (ACEIs, ARBs, MRAs, RIs), by age group.NHyperKHypoKHyperK or HypoKRecurrent HyperK2016152,180 55-64y34,8048.11.09.11.1 65-74y53,30110.91.111.91.8 75-84y44,73713.81.114.82.7 85y +19,33814.21.215.32.82017156,411 55-64y35,1608.51.09.51.5 65-74y54,67711.51.112.62.4 75-84y45,68414.21.215.33.2 85y +20,89014.71.215.93.1Data presented as number of individuals, or prevalence (in %). For each year, prevalence was assessed between January 1st of the preceding year, and January 1st of the corresponding year (e.g., for 2016, prevalence of hyperkalemia was assessed between January 1st, 2015 and January 1st, 2016), among individuals from the study population with recorded evidence of at least one of the conditions of interest and using at least one RAASI medication (regardless of whether they had their K assessed during the relevant study period). Serum K+ levels were not recorded before January 1st, 2015.Abbreviations: ACEIs = angiotensin converting enzyme inhibitor(s); ARBs = angiotensin receptor blocker(s); CHF = chronic heart failure; CKD = chronic kidney disease; DM = diabetes mellitus; HTN = hypertension; hyperK = hyperkalemia; hypoK = hypokalemia; IHD = ischaemic heart disease; MRAs = mineralocorticoid receptor antagonist; N = number; RIs = rennin inhibitorsSupplementary Table S8. Sensitivity analysis: prevalence of hyperkalemia (defined as ≥5.5 meq/L) among adults ≥55 years of age with at least one relevant condition (CHF, CKD, DM, IHD, HTN) and taking ACEIs, ARBs, MRAs, or any RAASI medication.ACEIsARBsMRAsAny2016 Total N110,37163,3966,116152,180 No. cases2,4001,2782.723,071 Prevalence2.22.04.42.02017 Total N116,25565,5256,518156,411 No. cases2,5481,4293243,296 Prevalence2.22.25.02.1Data presented as number of cases, or prevalence (in %). For each year, prevalence was assessed between January 1st of the preceding year, and January 1st of the corresponding year (e.g., for 2016, prevalence of hyperkalemia was assessed between January 1st, 2015 and January 1st, 2016), among individuals from the study population with recorded evidence of at least one of the conditions of interest and using each RAASI medication (regardless of whether they had their K+ levels assessed during the relevant study period). Serum K+ levels were not recorded before January 1st, 2015.Abbreviations: ACEIs = angiotensin converting enzyme inhibitor(s); ARBs = angiotensin receptor blocker(s); CHF = chronic heart failure; CKD = chronic kidney disease; DM = diabetes mellitus; HTN = hypertension; hyperK = hyperkalemia; IHD = ischaemic heart disease; K+ = potassium; MRAs = mineralocorticoid receptor antagonist; N = number; RAASI = renin-angiotensin-aldosterone system inhibitors ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download