The University of Washington / Fred Hutchinson Cancer ...



-619125-52387500University of Washington / Fred HutchCenter for AIDS Research (CFAR)2021 Request for Applications (RFA)Mentored International Investigator AwardRFA Release DateNovember 13, 2020Pre-Application Consultation Deadlines:Required Eligibility Check for ApplicantsJanuary 4, 2021Required Budget ConsultationStrongly Encouraged Biostatistical and Qualitative ConsultationsOptional ConsultationsJanuary 4, 2021January 4, 2021January 4, 2021Application Due DateJanuary 18, 2021Estimated Review DateMarch 2021Earliest Award DateApril 1, 2021Mentored International Investigator Award (MIIA)OverviewPurpose The purpose of this award program is to encourage international junior investigators (at an advanced stage of training or recently independent) to conduct independent research with close mentorship from UW/Fred Hutch CFAR senior faculty. This research should ultimately lead to acquiring preliminary data to obtain funding to continue their HIV/AIDS research careers. Eligibility CriteriaApplicants must:Be stationed in and a citizen or permanent resident of an Eligible Low or Middle Income Country. Eligibility does not extend to individuals who have dual citizenship or permanent residency outside of an Eligible Low or Middle Income Country.Have an MD or PhD or equivalent terminal degree (including an MBChB plus a Master’s Degree).Have not had an NIH R01 or equivalent grant in HIV/AIDS.Have an appropriate appointment, as follows:Junior faculty (including acting positions), OR a scientist completing a fellowship, OR a senior post-doctoral fellow initiating a new area of HIV-related research that will form a basis for their independent program, OR faculty-equivalent investigator at an international community-based organization whose primary mission is research.Have a primary mentor appointed at a US-based UW/Fred Hutch CFAR affiliate (University of Washington, Fred Hutch, Infectious Disease Research Institute, Seattle Children’s, University of Hawai’i at Manoa).Be a UW/Fred Hutch CFAR member, or have applied for membership at the time of submission.UW/Fred Hutch CFAR values diversity and encourages individuals from underrepresented groups to apply. Applicants may submit only one application to this program per cycle. Applicants may resubmit revised proposals for other CFAR award programs. Successful applicants usually have some preliminary data to support their application. Contact cfardev@uw.edu if you have questions about eligibility.Types of Projects HIV-related research is defined broadly and includes basic science, clinical, epidemiological, behavioral, implementation science, and health services research. We can only accept applications in the NIH’s HIV/AIDS research high or medium priority areas. We cannot fund research with investigational drugs or clinical trials (see NIH’s definition of a Clinical Trial). If you are considering a study involving approved drugs and/or standard-of-care, please contact cfardev@uw.edu) to determine whether your proposed project would be eligible for funding through CFAR.Funding AvailableOne award of up to $20,000/year (direct costs). Applicants may apply for up to 2 years of funding. Funding cannot be applied to alterations or renovations of any facilities. Budget Development Guidelines and RestrictionsPlease note the following regarding institutional indirect (F&A) costs. The CFAR has negotiated indirect cost waivers from our partners Fred Hutch, Seattle Children’s and University of Hawaii; therefore, proposals with subcontracts to these institutions should not include indirect costs. If the proposal requires a subcontract to an international institution, the maximum allowable indirect cost (F&A) rate is 8%. Indirect costs to international institutions may be added on top of the direct cost budget of $20,000/year and should be kept separate from direct costs in the project budget. Requested support for project collaborators who are NOT at the same institution as the awardee should be listed as consultant costs. If the collaborator cannot accept consultancy fees, a subcontract must be issued to their institution. These costs must be listed in the detailed budget as consortium costs with applicable indirect costs. Please note that the CFAR has negotiated indirect cost waivers with several U.S.-based partner institutions as described above.Requested support for equipment and technology, including computers, must be fully justified in the budget justification with a clear connection to the scientific aspects of the project and not for general office use. Be sure to read our Equipment Policy if you would like to budget for a computer. General office supplies are not allowed.All costs must conform to the NIH Grants Policy Statement (NIHGPS) and applicable U.S. Office of Management and Budget OMB circulars for necessity and reasonability, allocability, conformance and consistency, as well as allowability. Please refer to Section 7.2 The Cost Principles of the NIHGPS.Pre-Submission ProcessRequired of all applicants:Eligibility Checks: All applicants are required obtain approval that they are eligible to apply prior to development of their proposal. They should send a current NIH format biosketch or curriculum vitae for review to cfardev@uw.edu) no later than January 4, 2021.Budget Consultation: Applicants are required to consult with Linh Nguyen about their budgets to clarify budgetary issues. Please send a draft copy of your budget and budget justification to Linh Newcomb, CFAR Grant and Finance Manager, at ltn128@uw.edu no later than January 4, 2021.CFAR Membership: All applicants are required to be UW/Fred Hutch CFAR Members or have applied for membership at the time of submission. Visit for membership information, or contact cfar@uw.edu with any membership questions.Institutional Approval: Applicants should include a Letter of Intent from their institution with their application.Mentoring and Mentoring Plan: All applicants must identify a mentor and include a mentoring plan in their proposal. A statement from the applicant’s primary mentor that they have read and discussed the application with the applicant must also accompany the application (should be included in the letter of support from the mentor). The mentoring plan should include specific competencies the mentee will develop through the mentoring relationship, frequency/type of communication, outputs and objectives for the mentoring relationship, and how this mentoring plan supports a pathway to independence for the investigator. Please note that a Mentoring Committee will be formed for the successful applicant to provide career development guidance and assess progress. A separate agreement with the committee will be required for the successful applicant after the award is made.Human Subjects and Animal Care Approvals (if applicable): Animal Care and Institutional Review Board approvals, if applicable, must be obtained prior to receipt of award funding, but are not required to submit an application. Strongly Encouraged ConsultationsWe encourage all applicants to use or contact CFAR Cores or link to Scientific Working Groups (see Consultation Information below). Information about other CFAR Cores and services can be found at Consultation: All applicants are strongly encouraged to discuss their proposal with a CFAR biostatistician prior to/during the preparation of their application, with limited exceptions for those with prior biostatistical involvement or project review. This consultation is best done early in the preparation process but must occur before January 4, 2021. In order to receive this consultation, applicants must send a copy of your draft aims and methods to cfardev@uw.edu in order to arrange a consultation.Qualitative Methods Consultation: Applicants whose projects include behavioral research are strongly encouraged to obtain a consultation from the Behavioral Science Core consult with them regarding methods and study design. In order to receive this consultation, applicants must send a copy of your draft aims and methods to cfardev@uw.edu by January 4, 2021 in order to arrange a consultation.Consultation InformationWe encourage you to utilize services from the CFAR Cores and/or Scientific Working Groups early in the preparation of your application. The Cores and Scientific Working Groups have explicitly offered their consultations services (see list below). More information about CFAR Cores and services can be found at . Behavioral Science Core: Provides resources to catalyze new behavioral science research that will contribute to curbing the global HIV epidemic and improve outcomes along the continuum of HIV prevention and care. Applicants proposing a study involving behavioral or qualitative research should contact Danielle Terrill (cfar@uw.edu) to have an expert consult with them regarding their study.Clinical Cohort and Comorbidity Research Core: Helps researchers access and interpret the comprehensive database of the UW HIV Cohort Study. Applicants proposing a study involving longitudinal data from the UW HIV Clinical Cohort or research datasets from the UW HIV Information System should contact Stephen Van Rompaey (kelpie@uw.edu) to have an expert consult with them regarding their study.Translational Research Science Sub-Core: The Translational Research Subcore (formerly the Clinical Retrovirology & Research Core) helps investigators perform clinical studies by supporting enrollment of HIV-infected patients, prospective collections of samples, facilitating use of repository specimens, and assisting with overall study logistics and implementation. Applicants proposing clinical, translational, sociobehavioral or basic research projects that require access to research space, local research subjects, and/or clinical specimens/procedures should contact Kate Thanel (kthanel@uw.edu) to have a professional consult with them regarding their study.HIV-Associated Malignancies Core: Provides assays and data instruments to enable studies of HIV-associated malignancies. Applicants proposing a study involving HIV-associated malignancies should contact Katie Maggard (kmaggard@) to have an expert consult with them regarding their study.Immunology Core: Provides advanced tools and training for evaluating humoral and cellular responses to HIV infection. Applicants proposing a study involving immunology should contact Stephen De Rosa and Ana Gervassi (sderosa@ and ana.gervassi@) to have an expert consult with them regarding their study.Implementation Science Core: Provides resources to develop implementation science expertise within the CFAR community. Applicants proposing a study in the field of implementation science should contact Danielle Terrill (cfar@uw.edu) to have an expert consult with them regarding their study. Retrovirology and Molecular Data Science Core: Assists researchers in viral sequence analysis. Facilities use of frozen blood-derived specimens and data from the Seattle Infection Clinic Cohort. Applicants proposing a study involving sequence-based assays should contact James Mullins (mullspt+cfar@uw.edu) to have an expert consult with them regarding their study.CFAR Scientific Working Group (SWG) ConsultationsAdolescent Health SWG: Catalyzes innovative research by bringing together investigators with interest and experience in addressing the unique issues facing adolescents in HIV treatment, cure, and prevention, including development of biomedical HIV prevention approaches, optimized models for care and treatment, and relevant behavioral and laboratory science. Applicants proposing a study involving adolescent health should contact Renee Heffron (rheffron@uw.edu) to have an expert consult with them regarding their study.Cure SWG: Provides infrastructure that fosters new ideas, engages the community, and promotes the development of novel curative treatments for HIV and develops new intra-/inter-CFAR projects and funding applications on curative therapies for HIV. Applicants proposing a study in HIV cure should contact Tom Andrus (tandrus@) to have an expert consult with them regarding their study. eHealth SWG: Promotes multidisciplinary collaborations and provides coordination between CFAR investigators currently working independently in Electronic health (eHealth), mobile health (mHealth), and related digital technologies (“eHealth”). Applicants proposing a study involving eHealth, mHealth, and related technologies should contact Joanne Stekler (jstekler@uw.edu) to have an expert consult with them regarding their study.Post-Award RequirementsHuman Subjects and Animal Care Approvals: If applicable, prior to funding, a copy of all Institutional Biohazard, Animal Care and IRB approvals must be forwarded to cfardev@uw.edu. NIH International and Clinical Clearances: If the project involves human subjects and the institutional IRB has deemed the study “greater than minimal risk”, the awardee must submit a Clinical Research Checklist to Linh Newcomb, CFAR Grant and Finance Manager, at ltn128@uw.edu before funding is released. Proposals involving either international sites or clinical research above minimal risk will require additional clearance from NIH prior to receipt of an award, which requires documenting IRB approval from all participating sites, human subjects training certification for all key personnel, and providing the approved consent form(s). Please note that international projects, especially those involving human subjects, can take several months to obtain all required approvals and therefore applicants should incorporate this into their study timeline.Mentoring Committee and Agreement: The Awardee will work with his or her mentor(s) to develop a brief written agreement identifying members of the mentoring committee and setting terms and expectations for the mentoring process.Reporting and Presentation Requirements: The awardee will be required to submit yearly progress reports to the CFAR. Additionally, we expect awardees to disseminate the results from MIIA projects to the communities relevant to the research, ideally both through scientific and community forums, and where appropriate, shared with public health decision makers.CFAR Support: The UW/Fred Hutch CFAR grant number (P30 AI027757) must be cited in all publications and presentations derived from CFAR funding (see: ).Other Support: In the event that pending other support is funded which overlaps with or reduces your effort on this CFAR project, you must notify cfardev@uw.edu. Your application aims and budget will be reviewed and if it is determined that you are unable to meet the specific aims of your CFAR proposal, the CFAR award will be revoked.Review Process and CriteriaThe evaluation criteria for proposals include:Scientific Merit of the proposal and the likelihood of the project to exert a sustained powerful influence on the field. Will this proposal be likely to provide information that can significantly advance our understanding of HIV and/or provide preliminary data that is likely to lead towards independent research grant funding? Significance – Does the study address an important problem consistent with the objective to advance our understanding of HIV? If the aims are achieved, how will scientific knowledge be advanced? What will be the effect of these studies on the concepts or methods that drive the field of HIV and AIDS?Investigator – Are the PI, mentor(s), collaborators, and other researchers well suited to the project? Does this person have appropriate experience and training? If the project is collaborative, do the investigators/mentors have complementary expertise? Approach – Are the conceptual framework, design methods, and analyses adequately developed, well integrated and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternatives?Innovation – Does the project employ novel concepts, approaches, or methods? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies?Mentorship Plan and Impact of Project on Pathway to Independence – Will the project help prepare the applicant for a career as an independent HIV/AIDS researcher? Will the proposed mentorship aid in the investigator’s career development?-247650-952500UW/Fred Hutch Center for AIDS Research2021 Mentored International Investigator Award Application1. Title of Project FORMTEXT ?????City and Country of Project: FORMTEXT ?????Field Site: FORMTEXT ?????2. Principal Investigator?????Name and Title: FORMTEXT ?????Organization: FORMTEXT ?????Address: FORMTEXT ?????City: FORMTEXT ?????State: FORMTEXT ?????Zip: FORMTEXT ?????Phone: FORMTEXT ?????Fax: FORMTEXT ?????Email: FORMTEXT ??????3. Mentor??Name and Title: FORMTEXT ?????Organization: FORMTEXT ?????Address: FORMTEXT ?????City: FORMTEXT ?????Country: FORMTEXT ?????Phone: FORMTEXT ?????Fax: FORMTEXT ?????Email: FORMTEXT ??????4. Research Plan (Maximum 5 pages for a-e below):?Specific Aims (suggested length ? page)Significance (suggested length 1 page)Innovation (suggested length ? page)Approach (suggested length 2 pages)Mentoring Plan (suggested length 1 page)—include specific competencies the mentoring relationship will develop, frequency/type of communication, outputs and objectives for the mentoring relationship, and how this mentoring plan supports a pathway to independence for the investigator.?? FORMTEXT ?????12. Co-Investigators ???????NameAffiliation??Email?? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ?????DETAILED BUDGET FOR INITIAL BUDGET PERIODDIRECT COSTS ONLYFROMTHROUGH FORMTEXT ????? FORMTEXT ????? List PERSONNEL (Applicant organization only), Use Cal, Acad, or Summer to Enter Months Devoted to Project Enter Dollar Amounts Requested (omit cents) for Salary Requested and Fringe BenefitsNAMEROLE ONPROJECTCal.MnthsAcad.MnthsSummerMnthsINST.BASESALARYSALARYREQUESTEDFRINGEBENEFITSTOTAL FORMTEXT ?????PD/PI FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ????? FORMTEXT ?????274320016890900SUBTOTALS FORMTEXT ????? FORMTEXT ????? FORMTEXT ?????CONSULTANT COSTS FORMTEXT ????? FORMTEXT ?????EQUIPMENT (Itemize) FORMTEXT ????? FORMTEXT ?????SUPPLIES (Itemize by category) FORMTEXT ????? FORMTEXT ?????TRAVEL FORMTEXT ????? FORMTEXT ?????INPATIENT CARE COSTS FORMTEXT ????? FORMTEXT ?????OUTPATIENT CARE COSTS FORMTEXT ????? FORMTEXT ?????ALTERATIONS AND RENOVATIONS (Itemize by category) FORMTEXT ????? FORMTEXT ?????OTHER EXPENSES (Itemize by category) FORMTEXT ????? FORMTEXT ?????CONSORTIUM/CONTRACTUAL COSTSDIRECT COSTS FORMTEXT ?????SUBTOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD (Item 7a, Face Page)$ FORMTEXT ?????CONSORTIUM/CONTRACTUAL COSTSFACILITIES AND ADMINISTRATIVE COSTS FORMTEXT ?????TOTAL DIRECT COSTS FOR INITIAL BUDGET PERIOD $ FORMTEXT ?????BUDGET FOR ENTIRE PROPOSED PROJECT PERIODDIRECT COSTS ONLYBUDGET CATEGORYTOTALSINITIAL BUDGETPERIOD(from Form Page 4)2nd ADDITIONAL YEAR OF SUPPORT REQUESTEDPERSONNEL: Salary and fringe benefits. Applicant organization only. FORMTEXT ????? FORMTEXT ?????CONSULTANT COSTS FORMTEXT ????? FORMTEXT ?????EQUIPMENT FORMTEXT ????? FORMTEXT ?????SUPPLIES FORMTEXT ????? FORMTEXT ?????TRAVEL FORMTEXT ????? FORMTEXT ?????INPATIENT CARECOSTS FORMTEXT ????? FORMTEXT ?????OUTPATIENT CARE COSTS FORMTEXT ????? FORMTEXT ?????ALTERATIONS ANDRENOVATIONS FORMTEXT ????? FORMTEXT ?????OTHER EXPENSES FORMTEXT ????? FORMTEXT ?????DIRECT CONSORTIUM/CONTRACTUALCOSTS FORMTEXT ????? FORMTEXT ?????SUBTOTAL DIRECT COSTS(Sum = Item 8a, Face Page) FORMTEXT ????? FORMTEXT ?????F&A CONSORTIUM/CONTRACTUALCOSTS FORMTEXT ????? FORMTEXT ?????TOTAL DIRECT COSTS FORMTEXT ????? FORMTEXT ?????TOTAL DIRECT COSTS FOR ENTIRE PROPOSED PROJECT PERIOD$ FORMTEXT ?????JUSTIFICATION. Follow the budget justification instructions exactly. Use continuation pages as needed. FORMTEXT ?????Attach: Biosketches of PI and Mentor(s)Mentor’s Letter of Support (should include the statement “I have read and discussed this application with ________ and am supportive of its submission)Letters of support (Only include letters from collaborators essential to the proposed project. Biosketches are not required from collaborators) Institutional Letter of SupportNote: If your application is selected for funding, all investigators will need to complete Human Subjects Training. Email your completed application to cfardev@uw.edu by January 18, 2021.Please also consider completing and returning to cfardev@uw.edu the attached demographic data questionnaire, which takes only 2-5 minutes to complete. Your responses will remain confidential.-2171700-444500UW/Fred Hutch Center for AIDS ResearchDevelopmental CoreCONFIDENTIAL Investigator Demographic DataWe ask that you provide the following demographic data so we can track our ability to reach applicants who are underrepresented in biomedical research. This information is confidential and will not affect consideration of your grant application or access to services. Reporting the requested information is voluntary. Additionally, as part of UW/FH CFAR’s commitment to diversity and inclusion, this form expands the options provided to us by our funders to allow applicants to self-identify beyond the binary male/female. Investigator?????Last Name: FORMTEXT ?????First Name: FORMTEXT ?????What is your current gender identity? (please check one):?? Male? Female? Transgender Male/Trans Man ? Transgender Female/Trans Woman? Non-binary/Genderqueer? Prefer to self-describe: FORMTEXT ?????? Decline to state Racial category (please check one):? American Indian/Alaska Native? Asian? Native Hawaiian or Other Pacific Islander? Black or African American? White? More than one race: FORMTEXT ?????? Decline to state Ethnic Category (please check one):? Hispanic or Latinx? Not Hispanic or Latinx? Decline to state Do you fit the National Institutes of Health definition of an individual with a disability? (Note: Clicking the hyperlink will navigate you away from this form.)? Yes? No? Decline to stateDo you fit the National Institutes of Health definition of an individual from a disadvantaged background? (Note: Clicking the hyperlink will navigate you away from this form.)? Yes? No? Decline to state ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download