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Survey about the use of antimicrobials in horsesThe new EU veterinary medicines regulation 2019/6 will be applicable from January 28th of 2022 and onwards. This new regulatory framework will have a number of consequences for the equine practitioner. Most importantly, major changes regarding the use of antibiotics in horses may be implemented. The exact changes and regulations are currently compiled by the European commission and the member states. The results of this process will shape the use of antimicrobials in all member states for the years to come. FEEVA and FVE are currently trying to influence and give advice from a veterinary perspective for the consultation process with the European Commission and the member states in order to achieve the best outcome for our profession. Therefore, we would like to ask for your help. Please answer the following survey and give us your feedback. The current classification of antibiotics is given below: A file with higher resolution of this image can be found here: questions:In which member state(s) do you work?How large is the proportion of equines in your patient population?? < 10 %? 10-25 %? 25 – 50 %? 50-75 %? 75-90 %? 90-100 %? I only treat horsesAntimicrobials categorised as category A (“Avoid”) and B (“Restrict”) by the Antimicrobial Advice Ad Hoc Expert Group of the European Medicines Agency are at the highest risk for a ban or severe restrictions of their off-label use in veterinary medicine. The most important antimicrobials for horses from these two groups include Rifampicin (Cat A) and all Fluoroquinolones (Enrofloxacin, Marbofloxacin…) and Cephalosporines 3rd and 4th generation (Cefquinome, Ceftiofur…). Do you use drugs categorised as category A and B in your patients? ? Yes? NoIf you answered question 1 a with yes, please fill in examples in the following table:Active substanceIndicationAre there alternative active substances for this indication?What would be the consequences if the active substance wouldn?t be available?Example: EnrofloxacinInfection with bacteria only susceptible to this antibioticNoneHorses could not be treated adequately, which would cause a serious violation of animal welfare According to article 106 of the EU regulation 2019/6, “Veterinary medicinal products (VMPs) shall be used in accordance with the terms of the marketing authorisation”. This means that any deviation from the information given in the product information (SPC) is not allowed. This includes the dosing of a drug (mg/kg, dosage interval, duration of treatment etc.), the route of application, the combination of the veterinary medicinal product with other drugs and potential contraindications. In order to get an overview of frequent deviations from the SPC of antimicrobials approved for horses, we would like to ask you to answer the following and to fill in examples from your own practice in the following table:How frequently do you deviate from the SPC of antibiotics approved for the use in horses??Never?Less than 5 % of cases?5- 25 % of cases?25-50 % of cases?> 50 % of casesName and composition of the VMPRecommended dose according to SPCApplication deviation from SPCReason for deviation from SPC:Example: Genta 100 mg/ml(Gentamicin 100 mg/ml)Dose:6.6 mg/kg Frequency: SIDRoute: ivDuration:3-5 dDose: 10 mg/kgFrequency: SIDRoute: ivDuration:7 dTreatment of infections with bacteria with intermediary sensitivity Several antimicrobials categorised as category C (“caution”) and category D (“prudence”) are not authorised for horses in some member states but are authorised for the use in other species like cattle or pigs. Today, these drugs can be used in horses under the cascade if certain conditions are met. Future restrictions on the use of the cascade for certain antimicrobials could impact the treatment options available in equine medicine negatively. To get an overview of the use of antimicrobials in horses under the cascade, we would like to ask you to answer question the following question and to fill in examples from your own practice in the following table.How frequently do you use antibiotics not approved for horses via the cascade??Never?Less than 5 % of cases?5- 25 % of cases?25-50 % of cases?> 50 % of casesVMP used under the cascade (Name-active substance)VMP used under the cascade approved forFood producing animals – companion animals – humans?IndicationWhat would be the consequences if the active substance wouldn?t available?Example : Baxyl LA 200 mg/ml (Oxytetracycline)Food producing animals (Cattle, Pigs, Sheep)Foals with tendon contracturesFoals couldn?t be treated adequately ................
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