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Guanethidine: 25-50mg/day Dosing Interval Clonidine: bd Absorption Bioavailability Methyldopa: 25% Clonidine: 95%. Guanethidine: 3-50% Half life Methyldopa: 2hrs Clonidine: 8-12hrs . Guanethidine: 5 days Duration of Action Methyldopa: max effect in 4-6hrs, can last up to 24hrs, persisting after drug has left system as metabolite does effect. Clonidine: shorter as directly related to drug conc ... ................
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