Enhanced effects of ferulic acid against the harmful side effects of ...

Gadelmawla et al. The Journal of Basic and Applied Zoology (2022) 83:28

The Journal of Basic and Applied Zoology

RESEARCH

Open Access

Enhanced effects of ferulic acid against the harmful side effects of chemotherapy in colon cancer: docking and in vivo study

Mohamed H. A. Gadelmawla1,2* , Ahmed S. Alazzouni2, AbdelRazik H. Farag3, Mohamed S. Gabri2 and Basma N. Hassan2

Abstract

Background: Colorectal cancer is considered a potential causative agent of morbidity and death, making it a particularly dangerous malignancy. The current study aims to assess the efficacy of ferulic acid (FA) to attenuate the harmful side effect of 5-fluorouracil (5FU) in colon cancer tissues induced by 1,2-dimethylhydrazine (DMH).

Results: Regarding the colon tissues of male Wistar-albino rats (Rattus norvegicus), combined FA and 5FU showed the approximately normal structure of mucosa. The treated groups showed a remarkable reduction in Ki67, Ck20, and an elevation in caspase-3 and P53. There was significant upregulation of P53 in both 5FU and combined FA?5FU groups (p ................
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