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The state council joint prevention and control mechanism held a press conference in Beijing on April 14 to introduce the progress of COVID 19 drug research and development, vaccine development and other scientific research.The hostNational health commission spokesman, deputy director of the publicity department. Mi FengFirst, let me brief you on the situation.From 0:00 to 24:00 on April 13, the provinces (autonomous regions and municipalities) and Xinjiang production and construction corps reported 89 new confirmed cases, of which 86 were imported from overseas, 79 from Heilongjiang, 6 from Guangdong and 1 from Fujian. Three cases are local to Guangdong. No new deaths; Three new suspected cases were imported from overseas, two from Shanghai and one from Inner Mongolia. On the same day, 75 new patients were cured and discharged from hospital, 1674 close contacts were removed from medical observation, and 5 severe cases were reduced.There are 905 confirmed cases imported from abroad, including 37 severe cases. There are 72 suspected cases. There were 1464 confirmed cases, 559 cured cases and no death cases.As of 24:00 on April 13, according to reports from provinces (autonomous regions and municipalities) and Xinjiang production and construction corps, there are 1,170 confirmed cases, including 116 severe cases. A total of 77738 cases were cured and discharged from hospital, 3,341 cases died, 82,249 cases were confirmed and 72 suspected cases were reported. A total of 720,544 close contacts and 8,612 close contacts under medical observation were traced.There were no new confirmed cases, no new and suspected cases, and no new deaths in Hubei on that day. 25 new cases were cured and discharged from hospital, all of which were from Wuhan. Currently, there are 219 confirmed cases, including 218 in Wuhan. There were 69 severe cases, including 68 in Wuhan. A total of 64,363 cases were cured and discharged, 47,211 of which were in Wuhan. The total number of deaths was 3221, including 2579 in Wuhan. A total of 67,803 cases have been confirmed, including 50008 cases in Wuhan.The provinces (autonomous regions, municipalities directly under the central government) and Xinjiang production and construction corps reported 54 new cases of asymptomatic infection, 5 of which were imported from overseas. On that day, 67 cases were confirmed, among which 66 were imported from abroad. Forty-six cases were released from medical observation on that day, including 9 cases imported from abroad; There are still 1005 cases of asymptomatic infection under medical observation, among which 237 cases were imported from abroad.A total of 1,447 confirmed cases have been reported from Hong Kong, Macao and Taiwan, including 1,009 in the Hong Kong special administrative region, 45 in the Macao special administrative region and 393 in the Taiwan region.On April 13, 89 new cases were confirmed nationwide, of which 67 were asymptomatic. In recent days, local confirmed cases and asymptomatic infections have occurred continuously in some provinces. It is necessary to always do a good job in personal protection and community prevention and control, highlight the epidemiological investigation and medical management of asymptomatic infections and their close contacts, and implement prevention and control measures from household to person.That's the outbreak.Now let's go to the question-and-answer session. Please ask questions about today's release. Please inform your news organization before asking questions.Q:CCTV reporter:My question is that China is advancing the research and development of vaccines through five technical routes, and in April, a new vaccine entered the clinic. How is China's progress in vaccine research and development? thank youA:WU Yuanbin, director of the social development science and technology department of the ministry of science and technology.Thank you for your attention. At the beginning of the outbreak, the scientific research team will vaccine research and development as one of the main direction, to a greater extent improve the success rate of the vaccine in carding after analyzing the different technology and possibility, the scientific research team layout the virus inactivated vaccine, nucleic acid vaccine, recombinant protein vaccines and adenovirus vector vaccine, attenuated influenza virus vector vaccine such five technical route. At the same time, special classes of vaccine research and development have been set up to strengthen the organization and coordination. The research and development units of vaccine, animal experiments, detection and identification, and some corresponding scientific research institutions have been set up to strengthen the cooperation in this aspect.Just now, comrade reporter referred to in the questions now have some new progress, there are three vaccine approved to enter clinical trials, member of the age group of adenovirus vector vaccine first approved to enter clinical studies, was completed at the end of march in a phase of clinical trial subjects of vaccination work, and on April 9 began to recruit volunteers phase ii clinical trials, this is the world's first launch phase ii clinical study of new vaccine varieties. On April 12, the state food and drug administration approved the novel coronavirus inactivated vaccine jointly applied for by Wuhan institute of biological products and Wuhan institute of virology, Chinese academy of sciences, and entered clinical trials. On the 13th, that is, yesterday, we approved the clinical trial of the inactivated vaccine developed by Beijing Kexing Zhongwei Biotechnology co., LTD. It should be said that this is two consecutive days of inactivated vaccine approval to carry out clinical trials.Talked about just now we have five technical route, the other a few technical route of vaccines are also accelerating, attenuated influenza virus vector vaccine has already been completed vaccine strains of building and the establishment of the quality control method, is quality technology was studied and quality appraisal, pilot production, animal poison attack experiment and safety evaluation is carried out in the same period. The recombinant protein vaccine has completed the construction of the virus species, and the identification and genetic stability of the cell and virus species, the animal challenge experiment and the safety evaluation experiment are being carried out. In terms of nucleic acid vaccine, it has also entered the research stage of animal efficacy and safety evaluation, and simultaneously carried out the preparation of clinical samples and quality verification.We have also made a preliminary analysis and arrangement, and it is expected that the vaccine of the above technical route will be declared for clinical trials in April and May. These are the results of our efforts to further strengthen the relevant work organization. Vaccine everyone is concerned about, in addition to the research and development we also very concerned about when to use, to the vaccine this work, we are still in line with the scientific, safe, effective, such a basic premise, because this is special products for use in healthy people, so in the process of vaccine development, despite the emergency project, or a special emphasis on scientific, procedural, so at present, the research and development the fastest, like adenovirus vector vaccine has been launched phase ii clinical trials, and for the third phase of clinical trial, according to the results of clinical trials to finally determine whether or not to use, there are some examination and approval of such programs. Just group of inactivated vaccine in the past two days, this should be a traditional technology of vaccine, should speak, and relatively mature production technology, quality control, protection range is more extensive, as well as internationally accepted about their safety and effectiveness criteria, so this will also be in order to speed up the use of vaccines provide some conditions, we will try to put the vaccine research and development work, provide the service as soon as possible. thank youQ: Guo Guang of China media groupPreliminary research work has played an important role in the anti-epidemic process, and Chinese medicine, convalescent plasma, chloroquine phosphate and other drugs and treatment methods have achieved good results for different stages of the disease. What is the latest progress in the research and development of anti-epidemic drugs? Thank you.A:Sun Yanrong, deputy director of the biology center of the ministry of science and technologyThank you for your question. After the outbreak, the scientific research team in the first place to deploy the emergency scientific research projects, in these projects has been a "remedy" as the main goal, deployment of the drug development and clinical treatment of relevant scientific research projects, has deployed the 27 projects, to undertake the project research units including hospitals, universities, research institutions and enterprises, we made statistics, participating institutions as many as 152, in Wuhan there are 47 in a line. More than 3,200 researchers have participated in the research, and project leaders, including several academicians, have been working on the frontline of clinical treatment in Wuhan. These projects involve 34 drugs and related research and development technologies. Up to now, a series of achievements have been made, including obtaining clinical approval for 4 drugs under clinical development, forming guidance or expert consensus 5, more than 10 achievements have been included in the diagnosis and treatment program and applied in clinical treatment, and a series of achievements have been made. It mainly includes the following aspects:First, the basic pattern of the main drugs was formed through scientific research. Scientific research team has been adhere to the "old drugs with new" basic train of thought, we in the rigorous quickly formed on the basis of in vitro and mechanism research including chloroquine phosphate, horse, wei, and a basic pattern of traditional Chinese medicine, such as main medicines, and effective clinical research, adhere to the specification, quickly identified potentially therapeutic drugs, can into clinical research at an early date. The combination of Chinese and western medicine and the combination of Chinese and western medicine provides a solution for clinical treatment.Second, a series of advances have been made in the research and development of new technologies for clinical treatment. Stem cell therapy has always been a hot topic of great concern. More than 200 cases of stem cell therapy have been completed in Wuhan. According to the current results, the clinical treatment of COVID - 19 using stem cells is safe. At the same time, the clinical results suggest that, on the one hand, it can improve the treatment rate of severe patients by improving the inflammation of the lungs, and at the same time, it can significantly improve the pulmonary fibrosis in patients with severe rehabilitation. In the clinic, the pulmonary lesions were improved and the respiratory function was improved. The second is the convalescent plasma. In February, we issued the call of "one thousand people donate plasma to save one thousand people". Up to now, more than 2,000 convalescent plasma samples have been collected nationwide and more than 700 cases have been clinically applied, showing a very good therapeutic effect. At the same time, the research team has also carried out a randomized, double-blind and controlled clinical study in Wuhan, and is conducting data analysis and systematic summary. Preliminary results showed that convalescent plasma therapy was significantly better than the control group in terms of clinical improvement, and the median length of stay in ICU was significantly lower than the control group. In this way, the convalescent plasma showed a certain therapeutic effect in clinical treatment.Third, the research team is actively promoting the deployment and research process of a new round of projects. Monoclonal antibody has always been the focus of research. In the early stage of scientific research, a number of domestic teams have been deployed to target monoclonal antibody to carry out the corresponding research and development work. Up to now, several therapeutic antibody candidates targeting novel coronavirus have been obtained, and we will further intensify the research work in this regard.In addition, the research on specific immunoglobulin is introduced. With the support of the scientific emergency project, the research team continued to work on the problem and developed the intravenous injection of covid-19 human immunoglobulin, which is derived from the recovered patient's plasma and contains high-purity, high-potency neutralizing antibody. After the successful development, it can be used in the clinical treatment of patients and the passive immune protection of high-risk groups.Based on the above results, the scientific research team never relax, and China's scientific research team continues to intensify researches, we also actively promote the scientific research work of self-developed drugs, attaches great importance to the independent research and development of drugs in our country, accelerate the including traditional Chinese medicine, and the toxin, han has a plain, az, and a series of drugs in clinical research, hope to produce more and faster results applied to epidemic prevention and control. Thank you.Q: reporter:We learned that two more vaccines passed the approval of the state food and drug administration and entered the clinical trial stage yesterday. What are the characteristics of these two vaccines? What are the approval criteria for entering a clinical trial? What must the team do before then? Thank you.A:Wang Junzhi, academician of Chinese academy of engineeringThank you for asking. The research and development of the vaccine is very important and the key to the prevention and control of this outbreak. In the research and development process, the state has deployed five technical routes. In view of these five technical routes, the state food and drug administration has organized relevant professionals to intervene in the early stage, participate in the whole process, conduct research and review, and fully promote the vaccine research and development. As we have just heard, these two newly approved vaccines are actually a technical route, belonging to the novel coronavirus inactivated vaccine. The inactivated vaccine is composed of a complete virus, and its preparation process requires inactivation of its pathogenicity through physicochemical methods and inactivation verification, and still maintains the immunogenicity of the virus. Through the preparation process such as purification process, the candidate vaccine is prepared. Candidate vaccines can stimulate the body's immune response to produce antibodies to achieve protection, this is the inactivated vaccine.Our country in the research and development and has been listed on the vaccine, inactivated vaccine is the basis of good, such as our country has a (H1N1) influenza inactivated vaccines, HAV inactivated vaccines, EV71 HFMD inactivated vaccine, the other IPV Sabin polio vaccine, inactivated vaccine, the foundation of our country in terms of preparation of inactivated vaccine is better. In the process of preparation, at the beginning of the epidemic, is our country the earliest isolated strains, then live virus passes through mass culture, and through the zone spreading mechanism to coordinate research and development unit, the use of our country to establish the biological safety of relatively high production conditions, namely P3 laboratory, so can the cultivation of a lot of live virus, make our research and development have a basic requirement. Department experts in early intervention, to guide all the way, especially to guide enterprises completed the necessary before clinical experiments on animals, the animal experiment on acute toxicity experiment, including safety repeated toxicity experiment, immunogenicity, and animal attack poison protection test, etc, these all finished, and produced three batch samples of clinical trials, should pass the food and drug verification research institute of China inspection. In this process, all materials shall be submitted on a rolling basis at the same time, and shall be examined and approved in accordance with the procedures for special examination and approval of SFDA and the relevant technical requirements. The result of the examination and approval is that the requirements for emergency approval of clinical trials are met and the application for clinical trials is approved. Thank you.Q:People's Daily reporterIn the fight against this new epidemic, we have seen the important role of traditional Chinese medicine, which has become a highlight of China's epidemic prevention and control. To this end, section research also specially set up Chinese medicine special class, how is the work of special class carried out excuse me? What is the progress so far? Thank you.A:State administration of traditional Chinese medicine science and technology department director, Li YuThank you for your interest in Chinese medicine. Traditional Chinese medicine (TCM) has played an important role in the fight against the epidemic, and has gained widespread attention from all walks of life. Coping COVID - 19 defense under the State Council under the spreading mechanism of scientific research team specifically set up a special class of traditional Chinese medicine, as a whole advancing the epidemic prevention and control of key scientific research work of Chinese medicine and the establishment of long-term mechanism combining Chinese and western medicine disease control and prevention, Chinese medicine program, led by li dean of China academy of engineering total responsibility, the state administration of traditional Chinese medicine fully, Ministry of Science and Technology, Ministry of Education, the National Development and Reform Commission, the national health committee, the Ministry of Industry and Information Technology, Chinese Academy of Sciences, state food and drug administration departments such as joint, to advance the work together. Under the special class of traditional Chinese medicine, an expert group was set up. The expert group was composed of academicians of both houses of the Chinese academy of medicine, masters of traditional Chinese medicine, experts of traditional Chinese medicine and experts of pharmacy. On the basis of the previous clinical observation, our clinical treatment group summarized and introduced the effective prescription of traditional Chinese medicine (TCM) represented by lung-clearing and detoxification decoction, "three-party and three-drug", which played an important role in clinical treatment. Our team for the mechanism of clearing lung detoxification mechanism of soup on the basis of the related research, through the study found that the party can through multiple components, multiple target integral adjustment effect, and to participate in the immune, anti-inflammatory, endocrine, signal transduction, such as biological processes, can inhibit the production of bacterial endotoxin, rise to balance the role of immunity, eliminate inflammation, prevent or alleviate inflammation of the storm. Program is aimed at convalescence rehabilitation intervention of traditional Chinese medicine of traditional Chinese medicine has conducted a special study, the work, led by academician of Chinese Academy of Sciences, 8, Xiao Lin, the early stage of the study was embodied in the national health committee and the state administration of traditional Chinese medicine jointly issued by the "COVID - 19 recovery rehabilitation guidance of traditional Chinese medicine", at the moment, is to plan optimization. At the same time, the special class also pays close attention to the research on the intervention of traditional Chinese medicine for the people who gather after returning to work and classes and the asymptomatic infected people. These two projects specially arrange two teams of academician Wang Qi and academician Huang Luqi to conduct special research. Thank You.Q:CCTV network of the China media groupTraditional Chinese medicine has played an important role in the fight against the epidemic. We would like to know about the emergency approval of traditional Chinese medicine. What has the state food and drug administration done? Thank you.A:National food and drug administration of the drug registration department deputy director Yang shengThank you for your question. In the prevention and control of this epidemic, traditional Chinese medicine has played an important role. The state food and drug administration actively supports the development of traditional Chinese medicine, and supports the use of proprietary Chinese medicines and TCM preparations in medical institutions in the treatment of covid-19 under the guidance of traditional Chinese medicine theories. Regarding the work of emergency approval, the state food and drug administration carried out its work in a scientific and orderly manner. First, the mechanism for emergency approval was activated immediately. We adhered to the law and regulations and handled special matters to ensure that emergency approval was scientific, accurate, standardized, orderly and efficient. Second, we should actively tackle key problems in drug research. As for the application for emergency approval and consultation of potential effective drugs, we are able to receive all of them, study and make judgment as soon as possible, and then report back to the research institutions immediately after the judgment, so as to jointly promote the progress of the project. To strengthen communication with research institutions, provide technical support, and prepare for service registration. Third, carry out emergency review and approval in a race against time. For those whose research results prove to be basically safe and effective, they shall be included in the emergency examination and approval channel in the first time. Under the criterion of "safety is the bottom line, efficacy has evidence, quality can be guaranteed, and examination and approval is beyond the norm", the joint review and parallel review shall be conducted to effectively speed up the review and improve the efficiency of the review. Taking the "three drugs and three parties" of traditional Chinese medicine as an example, we have set up a special expert group with the academicians of traditional Chinese medicine, especially the experts on the frontline of anti-epidemic clinical work, to play a guiding role, organize special personnel to actively contact with the production enterprises and research and development units of "three drugs and three parties", and provide technical guidance and registration services. On the basis of the good results achieved in the early anti-epidemic clinical practice, we have accelerated the transformation of the results of the "three drugs" and are working hard to promote the transformation of the results of the "three drugs".In addition, the SFDA also actively guided local governments to issue policies on the emergency management of preparations made by medical institutions, and carried out the filing, approval and dispensing of preparations made by medical institutions of traditional Chinese and ethnic medicine in accordance with laws and regulations, so as to give full play to the role of traditional Chinese medicine in epidemic prevention and control.In the future, the SFDA will continue to follow the principle of "unified command, early intervention, on-arrival evaluation and scientific review" to make full efforts in emergency approval and ensure the need of epidemic prevention and control drugs. Thank you.Q:Kazakhstan 24KZ TV reporterSome countries say that BCG can reduce the likelihood of COVID-19. Has China done any relevant research?A:Academician, Chinese academy of engineering, Jun-zhi WangThe question is, there is a rumor abroad, because BCG vaccine is actually the vaccine of childhood immunization program, which is widely used in our country. However, we have not seen the exact research data to support this claim, so we still do not know. Thank you.Q:Reporter of China media groupNow COVID - 19 epidemic has swept the world, in the early stage of scientific research in China to verify whether the drug with obvious clinical effect has been promoted in the world, for the global anti-epidemic to make what contribution to provide what Chinese experience and reference? Thank you.A:Deputy director of biology center of ministry of science and technology,Sun YanrongThank you for your question. Indeed, we all see that the current global epidemic continues to spread, and the clinical research and application progress of anti-epidemic drugs studied in China in the early stage are attracting global attention. The Chinese experience and reference we have provided for the global epidemic prevention and control are mainly reflected in the following aspects.First of all, the Chinese research team carried out clinical research on covid-19 in China, and the research results were published in international journals in the form of academic papers in the first time, so as to share Chinese clinical experience and results with the world at the fastest speed.The second aspect is that China's research teams continue to conduct exchanges and academic discussions with many countries and regions in a high frequency. According to incomplete statistics, more than 140 countries and regions have conducted exchanges and academic discussions. The main contents include traditional Chinese medicine, phosphaquine, famirovir, tozumab, and a series of products such as convalescent plasma and stem cells, as well as research achievements. The clinical research progress and clinical application experience of covid-19 are the key points in the communication. In this way, we can provide Chinese experience and Chinese solutions for global epidemic prevention and control.The third aspect is that China's achievements in drug research and development in the early stage have been adopted by some countries and incorporated into the corresponding clinical treatment programs. At the same time, who and a number of countries are also carrying out clinical research on chloroquine, hydroxychloroquine and other drugs, and many countries have approved the use of convalescent plasma, tozumab and other drugs involved in the Chinese program for the treatment of COVID 19 or for clinical research.COVID - 19, as we all know, drug research and development is to form a quick research pattern, the pattern of the formation of condensing the wisdom of the world and all mankind, chloroquine phosphate invented by scientists in Germany 80 years ago, the horse, wei is by Japanese scientists invented in 20 years ago, the China's independent research and development of we are pushing the toxin is invented by Chinese scientists in 30 years ago, thus it can be seen that only the wisdom of mankind, global together can better control the epidemic situation facing the world today.At present, the research team is actively expanding the channels of international scientific and technological cooperation, promoting the initiation or participation of international multi-center clinical research, and continuously improving the Chinese plan to fight the epidemic by pooling global wisdom. In the following work, we will continue to follow the latest developments of the epidemic, closely follow the latest progress of research at home and abroad, focus on key tasks, and provide strong scientific and technological support and Chinese programs for the prevention and control of the epidemic. Thank you.Q:Hong Kong economic herald reporterWe have noticed that there are currently 3 covid-19 vaccines that have passed emergency approval and entered clinical trials. The question I would like to ask is whether the safety of the vaccine can be guaranteed with such a fast speed of emergency approval. If all goes well, how long will it take to get covid-19? Thank you.A:Academician, Chinese academy of engineering, Jun-zhi wangThank you for your question. Vaccine itself is a special drugs used for healthy people, safety is first, so in the process of emergency approval, always adhere to the respect for science, follow the rules, in a safe and effective as the fundamental policy, adhere to the center office, a lot of research and development in the process steps from serial to parallel, research review, scroll to submit research material, with pay increases with the increasing audit evaluation. Under the premise that the standard is not lowered, the efficiency of research and development and the efficiency of evaluation are greatly improved through seamless connection, and both of them are maximized. Therefore, this is the reason for the fast speed.In terms of safety, is mainly determined by pre-clinical studies, so the safety and effectiveness of related animal experiments to finish all in accordance with the relevant laws and regulations and technical requirements, including acute toxicity experiment, repeated toxicity experiment, immunogenicity, and even animals against poison protection test, these experiments must conform to the requirements, the requirements of the reach, can only be approved on clinical. This should fully guarantee the safety of the subjects after the clinical trial, which is our goal. When is the vaccine going to be available, the vaccine itself going from pre-clinical to clinical, that's a big step forward, a big step forward in the future, what must be done in clinical trials? Generally speaking, the usual clinical trials are divided into three phases, namely three phases. The objectives and meanings of the three phases are different. According to the design of research and development, the schemes are different and the time required is different. However, it is necessary to comply with the drug clinical trial quality management practice, which is commonly referred to as the GCP, and to comply with such requirements as informed consent. A key phase of clinical trial is to observe the safety of the use, mainly through a few easy feeling healthy volunteers as the subjects of different doses of the vaccine will be to determine the safety profile and understand its preliminary results, are generally in the relatively small size, are dozens of people, or about one hundred people, in small scale, this is a period of clinical must do. Phase ii is to expand the sample size and target population, in order to further confirm the preliminary efficacy and safety results of the vaccine in the population, and to determine the immunization procedure and dose, which must be done in phase ii. The average number of subjects is hundreds, and the second phase is hundreds or more. It is important to note that phase I and phase ii clinical trials are conducted by healthy volunteers and are relatively easy to collect. Depending on the immunization program and protocol, it may take several months. There are also phase iii clinical trials to really determine the effectiveness of the vaccine, and phase iii clinical trials require a larger sample size. For general infectious diseases, it is generally necessary to observe an epidemic cycle to determine the protection rate of the susceptible population, and the scale of these trials is thousands, or even tens of thousands of people. Generally, the scientific basis for phase iii clinical trials to finally get the vaccine approved for marketing is to go through three parts, and this is under normal circumstances. Even if we are in an emergency situation, in fact, the evaluation criteria for safety and efficacy of the vaccine cannot be lowered in the whole review process.At present, the public is highly concerned about vaccines, and we are looking forward to seeing a breakthrough in China's vaccine research and development as soon as possible, so as to bring a safe and effective vaccine to the market as soon as possible. Thank you.Q:Reporter from southern metropolis dailyBig epidemic gives good medicine, a batch of effective Chinese patent medicine and classic pharmacy appear in this battle, "3 medicine 3 parties" be the representative among them, what new progress is there in this respect in the near future excuse me? Thank you.A:Director of the science and technology department of the state administration of traditional Chinese medicine, Xu JunmingThank you for your question. A great epidemic leads to a good cure, and a great epidemic leads to a good doctor. This time in the fight against disease, through clinical screening effective prescription of traditional Chinese medicine "three medicine three parties", have played an important role, "three drugs" golden flower clear sense of particles, even take antipyretic granules and capsules, blood will net injection, and the early after examination and approval of all three drugs are already listed on the older drugs, this time in the treatment of COVID - 19 play an important role, and show good clinical effect. Among them, jinhua qinggan granules is an effective Chinese medicine developed in 2009 in the fight against influenza a (H1N1). Jinhua qinggan granule has a definite curative effect on the treatment of mild and ordinary COVID-19 patients, which can shorten the time of fever, not only improve the recovery rate of lymphocytes and leukocytes, but also improve the related immunological indexes. Recently, jinhua qinggan granules were also administered by the state food and drug administration as a class a non-prescription drug, which can well meet the needs of clinical treatment.Lianhua qingwen capsule has shown good efficacy in the treatment of light and ordinary patients, and has obvious efficacy in relieving symptoms such as fever, cough and fatigue. At the same time, it can effectively reduce the transfer rate. Xubijing injection can promote the elimination of inflammatory factors, mainly used in the early and middle treatment of severe and critical patients, can improve the cure rate, discharge rate, reduce the conversion of severe to critical patients. In view of the "three drugs, three drugs", especially the important role of "three drugs" in this outbreak and the good clinical evidence obtained, China food and drug administration has approved the treatment of covid-19 to be included in the new indications of "three drugs"."Tripartite" refers to the lung detoxification soup, wet disease, xuan lung disease and three prescriptions, including clearing lung detoxification soup is derived from the five classical prescriptions of treatise on febrile disease of fusion, on February 6, the national health committee, the state administration of traditional Chinese medicine in the early stage of the clinical curative effect good, on the basis of which to the recommended clearing lung detoxification decoction for the treatment of COVID - 19 patients with each model, and after a long period of clinical observation, clear lung detoxification soup showed in blocking light, normal to the important role in the development of heavy duty and severe type. At the same time in the heavy and critical rescue process also played a very good role. Clear lung detoxification soup is recommended in the national treatment program is a general prescription. In the clinical treatment process of Wuhan frontline, academician Huang Luqi's team and academician Zhang Bally's team summarized the effective prescriptions according to the clinical observation, which have good efficacy in blocking the development of the disease and improving the symptoms, especially in shortening the course of the disease. A few days ago, clear lung detoxification particles and chemical dampness toxic particles have been approved by the state food and drug administration, obtained the national clinical trial approval. Thank you.Q:Science and technology daily reporterAt present, China's progress in the prevention and control of the epidemic has been further consolidated, and the pressure to prevent the importation of the epidemic has been increasing. Facing the new situation of epidemic prevention and control, what are the next important considerations? Thank you.A:Director of social development science and technology department, ministry of science and technology, Yuan-bing WuJust as the reporter said, the phases of the epidemic prevention and control in China has further strengthened, in the scientific research work is based on the need to constantly adjust the focus, just have some colleagues in the process of introduction, the early stage of the drug screening, medical treatment, around the detection technology, around vaccine research and development, including the source, animal model to build these aspects focus on work, to promote science and technology to support the entire epidemic prevention and control. These results, some progress, on the whole, the work of science and technology in the protection of the epidemic prevention and control of played a very positive role, such as in medicines and treatments, a selection of more than 10 kinds of drugs and treatment scheme to implement into the related diagnosis and treatment, including just outlined in the Xu Junming, secretary of traditional Chinese medicine, "the three of three drugs", these aspects are well used in practice. The establishment of animal models provides the basis for vaccine and drug evaluation. In terms of detection, there are more than 26 varieties of detection reagent products on the market, which provide scientific and technological support for the overall prevention and control.Just talked about, into the new stage, we are now outside the input, the rebound, to further strengthen in these aspects, to strengthen this work, especially outside the input side, science and technology team to further strengthen and the interaction of customs ports and other departments to focus on promoting the rapid detection technology research and development and has been listed on the testing technology, the use of the product, will detect the reach mark, discover the entry of the patients, to provide accurate input of disease prevention and control of science and technology support. At the same time, in terms of internal anti-rebound, the research and development of high-sensitivity detection reagent should be promoted to further improve the detection rate of patients with low viral load. At the same time, we will accelerate the research and development of high-throughput detection reagents and improve the detection speed and capability. All these aspects are the focus of our work to further strengthen.In general, the scientific and technological breakthrough will also focus on some aspects of the scientific and technological support needed in the outbreak process, timely adjust our focus, strengthen the combination of scientific and technological forces, especially the backbone and dominant forces in this field, and also make full use of the multi-sector collaborative working mechanism to provide scientific and technological support. Thank you.Q:Reporter of China education televisionAt present, most of the patients have been cured and discharged from hospital. What are the advantages of traditional Chinese medicine in convalescent patients? What are the specific jobs? Thank you.A:Director of the science and technology department of the state administration of traditional Chinese medicine, Xu JunmingThank you for your question. You can from the national health committee today released figures, we nearly 78000 patients have been cured and discharged, in the healing of the hospital patients, although there are also a significant number of nucleic acid detection has been negative, still not reach the level of a full recovery, but also need constant medical intervention and psychological rehabilitation. In this respect, traditional Chinese medicine has rich experience accumulation and technical means of intervention. Recently, the team of academician Tong Xiaolin of the Chinese academy of sciences is carrying out relevant research, and some of the research results have been promoted and used in clinical practice. In addition, the competent departments of traditional Chinese medicine are organizing relevant expert teams to guide the rehabilitation intervention of traditional Chinese medicine and integrated traditional Chinese and western medicine to the convalescent patients, which has achieved good results. On February 22, the national health committee and the state administration of traditional Chinese medicine have jointly issued the COVID - 19 convalescence rehabilitation guidance of TCM, TCM intervention measures are put forward in the proposal, means and methods, including traditional Chinese medicine prescription, Chinese medicine appropriate technology, and dietary guidance, five categories of modern therapy and other methods. State administration of traditional Chinese medicine experts to guide the Wuhan took the lead in the country set up the Chinese and western medicine combined with rehabilitation clinics and rehabilitation stations, combined with the power of multiple disciplines, Chinese and western medicine adopt the comprehensive technical means to intervene, especially the prescription of traditional Chinese medicine, acupuncture, moxibustion, acupuncture point massage, ear bean, foot bath, meals, including fitness method and the comprehensive methods such as mind control, also has received the good effect. Clinical research shows that the clinical efficacy of comprehensive intervention with traditional Chinese medicine is significantly different from that without comprehensive intervention with traditional Chinese medicine. At the same time, we are actively exploring to establish a national COVID - 19 rehabilitation collaborative network, using the method of combining traditional Chinese and western medicine, give full play to the characteristics of TCM advantages and provide guidance to carry out rehabilitation intervention for recovery in patients with Chinese medicine, this platform not only got more active participation of medical institutions in Hubei province, it has received the national medical institutions and a number of positive response, in the national health committee, under the guidance of the state administration of traditional Chinese medicine has been preliminarily formed the pattern of combining Chinese and western medicine integrated comprehensive intervention. Thank you.The hostNational health commission spokesman, deputy director of the publicity department. Mi FengThank you. At today's press conference, several guests introduced the progress of covid-19 drug and vaccine research and development. At tomorrow's press conference, we will focus on prevention and control of key areas, key units and key populations. At that time, we will invite leaders of relevant departments and bureaus of the national health commission and relevant experts to answer questions from the media. We welcome your continued attention. This concludes today's press conference. Thank you very much. ................
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