Module 2



Module 2. Drugs influence internal organs, blood system, human exchange and immunity. Chemotherapeutic drugs.

|Control of theoretical knowledge |Control of practical skills |

|Topic 17 |

|Classification of cardiac glycosides in origin and physico-chemical |Correction of medical prescriptions for cardiac glycosides. |

|properties. |Consultation on safe therapy by cardiac glycosides. Choose from |

|The mechanism of action of cardiac glycosides, their pharmacodynamics. |following the collection of cardiac glycosides: digitalis, |

|Dependence of pharmacokinetics of cardiac glycosides from their |strophanthus, lilies and not glycoside cardiotonic drugs. |

|physico-chemical properties. Influence the pharmacokinetics of cardiac |Among the listed drugs containing macro-and micronutrients (sodium, |

|glycosides on their pharmacodynamics and indications for use. |calcium, potassium, magnesium), choose those that are prescribed for |

|The logical connection between the adverse effects of cardiac glycosides |the prevention of adverse effects of cardiac glycosides. |

|and contraindications to their use. Features of cardiac glycosides |Recommendations to patients on the rules of rational use of cardiac |

|dosage, types of digitalization. Cardiac glycosides intoxication, the |glycosides. |

|principles of prevention and treatment. |Inform the doctor on interchangeability of cardiac glycosides based |

|Classification and main indications for using no glycoside cardiotonics. |on the availability of the pharmaceutical market of original and |

|Classification and features of antiarrhythmic agents depending on the |generic drugs in this group. |

|mechanism of action and the type of arrhythmia. |Correction of medical prescriptions for antiarrhythmic drugs. |

|Topic 18 |

|Classification of hypotensive drugs. Pharmacological characteristic |Correction of medical prescriptions for antihypertensives of the |

|hypotensive drugs of the central action. The logical connection between |central action. |

|the side effects hypotensive drugs of the central action and |Consultation on differences of the use of hypotensive drugs of the |

|contraindications to their use. |central action (depending on the patient, the nature of side |

|Pharmacological characteristics of (-adrenoblockers as hypotensive drugs.|effects); counseling the patient about the rules of rational use of |

|The logical relationship between pharmacological effects and indications |these drugs. |

|for use (-adrenoblockers in essential hypertension. Differences in the |Correction of medical prescriptions for (-adrenoblockers and |

|use of short-form and retard-form of (1-adrenoblockers in essential |(-adrenoblockers. |

|hypertension. |Consultation on the interchangeability of (1-adrenoblockers, the |

|Features of pharmacodynamics and indications for use of cardioselective |availability of new drugs in the pharmaceutical market. |

|and not cardioselective (-adrenoblockers. |Recommendations a doctor on the choice of (-adrenoblockers for |

|The logical connection between the side effects of (1, (-adrenoblockers |pharmacotherapy of essential hypertension based pharmacokinetic and |

|and contraindications to their use. Pharmacological characteristics of |pharmacodynamic properties of drugs in this group, as well as on the |

|sympatholytics. The logical connection between side effects of |benefits of (-adrenoblockers of new generation to traditional drugs. |

|sympatholytics and contraindications to their use. |Consultation of a doctor and a patient to prevent side effects that |

|Pharmacological justification for the use of ganglioplegics as |occur with prolonged use of traditional (-adrenoblockers. |

|antihypertensives. Features of pharmacodynamics of ganglioplegics |Correction of medical prescriptions for SCCB. |

|depending on their pharmacokinetics. The logical connection between side |Recommendation a doctor regarding interchangeability of SCCB |

|effects of ganglioplegics and contraindications to their use. |including pharmacodynamics, pharmacokinetics, medicinal forms, side |

|Classification of slow calcium channel blockers (SCCB) in chemical |effects, international and trade names of drugs. Advantages and |

|structure, pharmacokinetic characteristics and generations. Mechanism of |disadvantages of different medicinal forms of SCCB. |

|the hypotensive action of SCCB. Features of pharmacodynamics and |Correction of medical prescriptions for ACE inhibitors and |

|indications for use of SCCB depending on the chemical structure and |angiotensin II receptor antagonists. |

|dosage form. Comparison of new generation of SCCB compared to first |Recommendations the doctor regarding the dosage of ACE inhibitors, |

|generation (pharmacokinetic and pharmacodynamic properties, etc.). The |their interchangeability, warning of possible side effects, the |

|logical connection between the major side effects of SCCB and |availability of new brands and generic drugs in the pharmaceutical |

|contraindications to their use. |market. |

|Classification of ACE inhibitors (ACEI) in chemical structure and |Consultation the patient on rational use of ACE inhibitors for the |

|pharmacokinetic characteristics. |prevention of possible complications. |

|Pharmacological characteristics of ACE. The logical connection between |Choose from a collection of vasodilators and spasmolytics of |

|the side effects of ACE inhibitors and contraindications to their use. |myotropic action for the treatment of hypertensive crisis. |

|Angiotensin II receptor antagonists as an alternative to ACE inhibitors |Consultation on the rational use of of antihypertensive drugs of |

|(mechanism of hypotensive action, especially pharmacodynamics, unlike |different groups. |

|ACE). |Correction of medical prescriptions for anti-sclerotic drugs. |

|Peripheral vasodilators and spasmolytics of myotropic action, their |Consultation the patient on rational use of antisclerotic means to |

|mechanism of hypotensive action, pharmacodynamics, indications. |prevent possible complications. |

|Groups of diuretics used in hypertension, features of their application. |Choose from a collection the drugs for the treatment of hypotension, |

|Combined antihypertensive drugs. Rational and irrational combinations of |collapse, shock and antisclerotic drugs. |

|antihypertensive drugs. Means used for the treatment of hypertensive | |

|crisis. | |

|Classification of antisclerotic funds. Mechanism of action and | |

|pharmacodynamics of statins, fibrates, bile acid sequestrants, nicotinic | |

|acid preparations, angioprotectors, essential phospholipids. | |

|The logical connection between the side effects of hypolipidemic drugs | |

|and contraindications to their use. Classification and pharmacological | |

|characteristics of that increase blood pressure. | |

|Topic 19 |

|Classification of of antianginal drugs. Classification of organic |Correction of medical prescriptions for organic nitrates. |

|nitrates in chemical structure and duration. Pharmacological |Consultation on the interchangeability of organic nitrates including |

|characteristics of of organic nitrates. Indications for use of organic |pharmacokinetics, dosage form, the patient's condition and |

|nitrates depending on the medicinal form and pharmacokinetics. |availability of brands and generic drugs in the pharmaceutical |

|Main pharmacokinetic differences of major groups of organic nitrates |market. |

|(glyceryl trinitrate, isosorbide dinitrat, isosorbide mononitrate). The |Recommendations a patient regarding conditions of rational use of |

|mechanism of tolerance to nitrates and ways of correction. |organic nitrates. |

|The logical connection between the adverse effects of organic nitrates |Recommendations doctor about choosing preparations to overcome |

|and contraindications to their use. The mechanism of antianginal action |tolerance that occurs to organic nitrates. |

|(-adrenoblockers. |Choose from a collection of modern medicines (-adrenoblockers to |

|The mechanism of antianginal action SCCB. Pharmacological features SCCB |assign patients with coronary artery disease. |

|depending on the medicinal form of the drug and its chemical structure. |Correction of medical prescriptions for SCCB. |

|Antianginal agents of reflex action, mechanism of action, |Consultation of doctor and patient on modern medicinal forms of |

|pharmacodynamics. Pharmacological characteristics of new antianginal |antianginal agents for the treatment of angina pectoris and the |

|drugs - selective inhibitor f-channels of sinus node (ivabradyn). |prevention of these attacks. |

|Classification and pharmacological characteristic of cardioprotectors, |Choose from a collection of medicines cardioprotectors, antioxidants |

|antioxidants. |of direct and indirect action. Recommendation to a doctor for the |

|Classification and pharmacological characteristics of drugs that improve |rational selection of medicines containing vitamins and minerals to |

|cerebral blood flow: calcium channel blockers, derived of uterine horn, |assign patients with coronary artery disease. Correction of medical |

|Ginko Biloba preparations, and others. |prescriptions for drugs that improve cerebral circulation, |

|The logical relationship between side effects and contraindications to |cardioprotectors and antioxidants. Consultation of a doctor on the |

|the use of drugs that improve cerebral blood flow. |interchangeability of drugs that improve cerebral circulation. |

| |Recommendation a patient on rational acceptance of drugs that improve|

| |cerebral blood flow. |

|Topic 20 |

|The common definition of "anti-ulcer", "antacid" drugs, |Correction of prescriptions for drugs that are pouring into the |

|"gastroprotectors", "hepatoprotectors". |function of the gastrointestinal tract. |

|Classification and pharmacological characteristics of drugs that affect |Consultation a doctor on assortment of drugs that affect the |

|appetite, the secretory function of the stomach and pancreas. Comparison |secretory function of the stomach and pancreas, on the modern |

|of antisecretory drugs of different mechanism of action and antacids of |pharmaceutical market of interchangeability of drugs based on their |

|different generations. |"pharmacological face". |

|The pharmacological characteristics of drugs that affect the motility of |Informing patients about the conditions of rational use of drugs that|

|the gastrointestinal tract. The logical link between adverse effects and |stimulate appetite, antacids, antisecretory agents. Choose from a |

|contraindications to the use of drugs affecting the secretory and motor |collection of drugs the antacid drugs and their distribution for |

|functions of the gastrointestinal tract. |generations. |

|Classification and the pharmacological characteristic of |Consultation on the interchangeability of hepatoprotectors and |

|hepatoprotectors, choleretic agents. Comparison of hepatoprotectors of |choleretic drugs based on the presence of brands and generic drugs in|

|synthetic and plant origin. Classification and pharmacological |the pharmaceutical market. Choose from a collection of drugs |

|characterization of laxatives, anti-flatulence, and anti- diarrheal |laxatives of different mechanism of action. Patient consultation on |

|drugs. |rational use of laxatives, anti-flatulence, and anti-diarrheal |

| |drugs. |

|Topic 21 |

|The common definition of "diuretic" drugs. |Correction of medical prescriptions for diuretic and drugs for |

|Classification of diuretic drugs on the mechanism of action and origin. |treatment gout. Recommendation a doctor regarding the |

|The logical link between the pharmacological effects of diuretic drugs |interchangeability of diuretics with the peculiarities of their |

|and indications for their use. |mechanism of action and pharmacodynamics. Informing physicians for |

|Comparison of diuretic drugs according to their mechanisms of action and |efficient and safe use of diuretics combined with drugs other groups.|

|pharmacodynamic characteristics. The logical relationship between side | |

|effects and contraindications to the use of diuretic drugs. Features of |Consultation a patient on rational use of diuretic drugs. Choose from|

|the application of plant origin diuretics. |a collection of herbal remedies diuretics and hypoazotemic drugs. |

|Pharmacological characteristic of drugs for treatment of gout with |Consultation a doctor on assortment of modern drugs for treatment |

|different mechanism of action. |gout on the pharmaceutical market. |

|Classification of drugs that affect the myometrium. Definition of |Correction of medical prescriptions for drugs with uterotonic action.|

|"uterotonics". | |

|Classification and pharmacological characteristic of uterotonics. |Informing physicians of the presence on the pharmaceutical market of |

|Comparative characteristics of drugs with uterotonic action: oxytocin, |contemporary uterotonic drugs. |

|uterine horn and prostaglandins. The logical relationship between side |Counseling patients on rational use of uterotonics. |

|effects and contraindications uterotonics. |Choose from a collection the drugs of uterotrophic action, their |

|Definition of "tokolitics." Classification and pharmacological |distribution on uterotonics and tocolitics. |

|characteristic of modern tocolytic agents. Comparison of tokolitics |Correction of medical prescriptions for tocolytic drugs. |

|considering features of their mechanism of action. |Recommendation a doctor regarding the interchangeability of tocolytic|

|The risk / benefit of the use of tocolitics in various term of gestation.|drugs according their pharmacodynamics, side effects and presence in |

|Definition of "prostatoprotectors." Classification and pharmacological |the pharmaceutical market. Correction of medical prescriptions for |

|characteristic prostatoprotectors considering their origin and |prostatoprotectors. |

|composition (combination herbal medicinal products). |Consultation a doctor on the interchangeability of drugs, presence |

|Definition of " erectile dysfunction correctors." Classification and |for new prostatoprotectors on the pharmaceutical market. |

|pharmacological characteristics of erectile dysfunction correctors. Risk |Choose from a collection of erectile dysfunction correctors due to |

|/ benefit ratio of erectile dysfunction correctors use in patients taking|availability of brands and generic drugs in the pharmaceutical |

|nitrovasodilatators et other medicines. |market. |

| |Information for patients on the rational use of correctors of |

| |erectile dysfunction. |

| |

|Topic 22 |

|Classification of medicines that affect the clotting of blood and |Correction of medical prescriptions for anticoagulants, hemostatics, |

|haemopoiesis. |activators and inhibitors of fibrinolysis, antiplatelet agents. |

|Pharmacological characterization of anticoagulants. Comparative |Information for the doctor on the interchangeability of |

|pharmacological characteristics of low-molecular-weight heparin (LMWH) |anticoagulants based on their pharmacological properties. |

|with heparin; anticoagulants of direct and indirect action. |Choosing antidote in overdose of heparin. Information for doctors to |

|Pharmacological characterization of fibrinolytic agents. Classification |prevent the side effects associated with overdose of anticoagulants |

|and pharmacological characteristics of antiplatelet agents. Features of |of indirect action. Choose from a collection hemostatics drugs of |

|their use in cardiology, nephrology, ophthalmology, obstetrics. |plant origin. |

|Definition of "hemostatics." Classification and pharmacological |Correction of medical prescriptions for drugs that affect |

|characteristic of hemostatics. The logical relationship between |leucopoiesis and erythropoiesis. Consulting physicians regarding the |

|pharmacodynamics and indications for use of coagulants. |range of modern drugs that affect leucopoiesis for |

|Classification and pharmacological characteristics of drugs affecting |interchangeability. |

|leucopoiesis. |Inform a doctor about modern iron preparations and characteristics of|

|Classification and pharmacological characteristics of drugs that |their various dosage forms. Counseling patients on the terms of the |

|stimulate erythropoiesis. |rational use of iron supplements to prevent complications during |

|Classification and pharmacological characteristics of erythropoietin, |pharmacotherapy prepartamy iron. |

|iron, folic acid and cyanocobalamin. Comparison of two- and trivalent | |

|iron. Principles of rational combination of iron supplementation with | |

|vitamins, trace elements, laxatives. Pharmaceutical features of modern | |

|iron drugs. | |

|Topic 23 |

|Sources of hormones, their dosage, types of hormone therapy. |Correction of medical prescriptions for hormones of the hypothalamus,|

|Classification of hormones in chemical structure. Pharmacological |pituitary, thyroid, parathyroid glands, insulin, synthetic |

|characteristics of hormones of the hypothalamus, pituitary, pineal, |antidiabetic drugs. Consultation on the interchangeability of |

|thyroid drugs and parathyroid glands. Antihormonal drugs. Classification |hormones from the knowledge of the international nomenclature, trade |

|of insulin in origin and duration. |names, pharmacological properties, indications for use |

|Pharmacological characteristics of insulin. Features of insulin dosage |Recommendations for patients on the rational use of hormonal and |

|depending on the dosage form. Preparations for first aid in hyperglycemic|antihormonal drugs of different groups. Choice of drug collection |

|and hypoglycemic commas. Classification and pharmacological |antidiabetic drugs of different groups and different generations. |

|characteristic of synthetic oral antidiabetic drugs. Pharmacological |Patient information for rational use of antidiabetic drugs. |

|justification of the combined use of antidiabetic drugs of different | |

|groups. | |

|Topic 24 |

|Classification of steroid hormone drugs. Pharmacological characteristics |Correction of medical prescriptions for adrenal hormones. |

|of mineralocorticosteroids. |Consultation for physicians on interchange, the availability of new |

|Classification of glucocorticosteroids (GCS) for their origin, chemical |drugs from the group of corticosteroids on the pharmaceutical market.|

|structure, route of administration, type of pharmacological action. |Informing patients about side effects of corticosteroids and |

|The logical relationship between the pharmacological effects of |conditions of their rational use, especially during prolonged use. |

|corticosteroids and indications for their use, side effects and |Choose from a collection of drug preparations containing |

|contraindications to their use. |mineralocorticoids, corticosteroids and their antagonists. |

|Comparison of natural and synthetic origin GCS. Differences between |Pick up drugs according to a logical chain: hormones of hypothalamus |

|pharmacokinetics and pharmacodynamics, features of drugs containing |→ pituitary → hormones of adrenal gland / ovarian. |

|fluoride. Features of corticosteroids dosage, depending on the type of |Correction of prescription on the female and male sex hormones, |

|drug therapy (replacement or pharmacodynamic). |anabolic steroids. |

|Classification of estrogens by origin and chemical structure. |Recommendation for a doctor regarding the interchangeability of sex |

|Pharmacological characteristics of hormones on the basis of estrogens and|hormones with their pharmacodynamics, dosage form side effects. |

|progestogens. The logical relationship between the pharmacological |Consultation for a doctor on the appointment of hormonal |

|effects of estrogens, progestogens and indications for their |contraceptives, depending on age and physiological condition of |

|administration, side effects and contraindications to their use. |women, and dosage form of contraceptive drug. |

|Pharmacological characteristics of of androgenic and anabolic steroids. |Counseling patients on the terms of the rational use of hormonal |

|Pharmacological "face" anti-estrogenic, anti-gestahenic and |contraceptives. |

|anti-androgenic drugs. |Choose from a drug collection drugs for "emergency" contraception, |

|Classification and nomenclature of modern contraceptive drugs. |spermicides, mono-, two- and three-phase combined oral |

|Pharmacological characteristics of hormonal and non-hormonal |contraceptives. |

|contraceptives. Combined oral contraceptives, their comparative |Information for patients on modern medical forms of hormonal |

|characteristics depending on the dose of estrogen and progestin |contraceptives (subcutaneous implants, injectable formulations, depot|

|components. Combined oral estrogen-progestin preparations exhibited |preparations, plasters) and the characteristics of their rational |

|anti-androgenic properties, especially their application. Progestin oral |use. |

|contraceptives, peculiarities of their application. The logical | |

|relationship between side effects and contraindications to the use of | |

|hormonal contraceptives. | |

|Topic 25 |

|Classification and nomenclature of drugs that affect cellular and tissue |Correction of medical prescriptions for drugs that affect cellular |

|metabolism: vitamins, enzyme and anti-enzymes drugs. Pharmacological |and tissue metabolism. Monitoring of dosage of vitamins, enzymes and |

|characteristics of water-soluble and fat-soluble vitamins and |anti-enzymes. |

|anti-enzymes preparations. Features of composition, pharmacodynamics and |Interchangeability enzymes for replacement therapy in diseases of the|

|indications for the use of systemic enzyme therapy. |digestive system, in case of the local treatment of purulent necrotic|

|Classification and pharmacological characteristics of plasma substitutes |processes, scars and spike. |

|and desintoxycants amino acids, preparations for parenteral nutrition, |Consultation a patient on rational use of vitamins, enzymes and |

|correction of acid-base status and ion balance in the body. |anti-enzymes. |

|Classification and pharmacological characteristics of biogenic |Inform a doctor of interchangeability multivitamins and combined |

|stimulants, reparants, antioxidants, and anti-hypoxants, |enzyme preparations, rules of rational use of amino acids, plasma |

|chondroprotectors. The logical relationship between the mechanism of |substitutes, alkali preparations, acids, biogenic stimulants, |

|action, pharmacodynamics and indications for their use. |reparants, chondrotectors, antioxidants and anti-hypoxants. |

|Topic 26 |

|Classification of immunotropic drugs based on chemical structure and |Correction of medical prescriptions for immunotropic drugs. |

|origin. Pharmacological characteristics of immunostimulants. The logical |Choose from a collection of drugs immunostimulants and |

|relationship between the mechanism of action, pharmacodynamics and |immunosuppressants. |

|indications for use immunotropic drugs. Mechanism of action and |Inform the doctor about interchangeability immunotropic drugs based |

|pharmacodynamics of immunosuppressive drugs. Indications for use of |on the presence of branded and generic drugs in the pharmaceutical |

|immunosuppressive drugs in oncology, rheumatology, transplantation, |market. |

|obstetrics. |Advising patients on the rational use of immunostimulants and |

| |immunosuppressants. |

|Topic 27 |

|Basic principles of pharmacotherapy of acute poisoning. The concept of |Correction of medical prescriptions for antidotes. |

|antidotes. |Choose from a collection of drug antidotes for first aid for |

|Classification and pharmacological characteristic of antidotes. Methods |poisoning by muscarine, M-cholinomimetics, PhOS, heavy metal ions, |

|for decontamination and excretion of toxins, that fell through the mouth,|cardiac glycosides, narcotic analgesics, heparin, radioactive |

|skin, mucous membranes. |substances. |

|The concept of forced diuresis, lymph, plasma and enterosorption. | |

|Peculiarities of application of adsorbing, laxatives, vomiting and | |

|diuretic in acute poisoning. | |

|Topic 28 |

|Classification of chemotherapeutic agents. |Correction of medical prescriptions for antiblastomic drugs. |

|Definition of "Antiblastomic drugs." |Consultation to physicians on interchangeability of antiblastomic |

|Classification of antyblastomic drugs according mechanism of action, |preparations, presence of new antiblastomic drugs in the |

|origin. Nomenclature of drugs (international and trade names). |pharmaceutical market. |

|The definition of "cytotoxic" and "cytostatic" effect. |Choose from a collection of submitted drugs antiblastomic of a |

|The requirements to modern antiblastomic drugs. |particular group. Medical advice on the choice of drugs on the |

|Pharmacological characteristic of antiblastomic drugs based on their |correction side effects antiblastomic drugs. |

|mechanism of action, pharmacodynamics, organotropic properties. |Recommendations to physicians regarding interchangeability of |

|Side effects of antiblastomic drugs and means of their correction. |antiblastomic drugs with the peculiarities of their mechanism of |

|Pharmacological characteristic of correctors of side effects of |action and pharmacodynamics. Advising patients on the prevention or |

|antiblastomic drugs. Radioprotectors: group identification, |elimination of side effects of antiblastomic drugs. |

|classification of pharmacological action, duration of radioprotective |Guidelines for physicians and pharmacists on precautions when |

|effect and duration of action. Nomenclature of radioprotectors. Features |handling chemotherapy-radioprotectors and antiblastomic drugs. Choose|

|of the mechanism of action and pharmacological characteristics of various|from a drug collection radioprotectors a group considering different |

|subgroups of radioprotectors. |mechanisms of action. Consultation on interchangeability of |

| |radioprotectors. |

| |Information for patients on the rational use of radioprotectors. |

|Topic 29 |

|The principles of rational antibiotic therapy. |Correction of medical prescriptions for (-lactam antibiotics. |

|Classification of antibiotics in chemical structure, mechanisms of |Consultation a doctor on matters of interchangeability of |

|action, type and range of antimicrobial activity. |penicillins, cephalosporins, carbapenems and monobactams with their |

|Classification of (-lactam antibiotics, mechanism of action, type of |range of action, pharmacokinetics, toxicity, interactions with drugs |

|antimicrobial action. |from other pharmacological groups. |

|Classification, nomenclature and pharmacological characteristics of |Terms of rational use of -(lactam antibiotics as a way to prevent |

|penicillin. Natural penicillins: pharmacokinetic characteristics, |adverse reactions in their application (consultation of the patient).|

|spectrum of antimicrobial action, indications for use. Semisynthetic |Measures to prevent antibiotic resistance. |

|penicillins: features of pharmacodynamics, spectrum antimicrobial action |Choose from a drug collection (-lactam antibiotics. |

|of antistaphylococcal penicillins, aminopenicillins, antipseudomonal |Correction of medical prescriptions for macrolides and azalides. |

|penicillins, indications for their use. |Recommendation to the doctor regarding interchange of macrolides |

|Comparison of amoxicillin and ampicillin for pharmacodynamic and |based of antimicrobial spectrum, pharmacokinetics, efficacy. |

|pharmacokinetic parameters. Comparison of antipseudomonal penicillins. |Consultation the doctor on issues of combined use of macrolides. |

|Inhibitor protected penicillins: pharmacodynamic characteristics, unlike |Correction of medical prescriptions for lincosamides. |

|other drugs in this group. Side effects of antibiotics of the penicillin |Recommendation to the doctor regarding the combined use of |

|group, contraindications to their use. |lincosamides, side effects of this group of antibiotics to prevent or|

|Classification of cephalosporins by generation, spectrum of antimicrobial|reduce the manifestation of possible complications. |

|action. Comparison of cephalosporin of I-IV groups by antimicrobial |Correction of prescriptions for tetracyclines. Recommendations to |

|spectrum, pharmacokinetic properties, indications for use. The logical |doctors and patients in terms of rational use of tetracyclines for |

|connection between the adverse effects of cephalosporins and |the prevention of adverse effects. |

|contraindications to their use. |Correction of medical prescriptions for aminoglycosides. |

|Pharmacological characteristics of carbapenems. Comparison of carbapenem |Recommendation to a doctor to reduce the toxic manifestations in |

|and meropenem for antimicrobial spectrum, antibacterial activity, |using aminoglycosides including dosage, duration of treatment, the |

|toxicity. Features of spectrum of antimicrobial action of monobactames. |patient's age, condition of kidney and liver, etc.. |

|Indications for use monobactamts, side effects and contraindications to |Recommendations to a patient regarding conditions of rational use of |

|their use. |aminoglycosides. |

|Classification of macrolides in chemical structure and method of receipt.|Correction of medical prescriptions for glycopeptides. |

|Pharmacological characteristics of macrolides and azalides. |Recommendations doctors and patients in terms of rational use of |

|Comparison of new macrolides with traditional (peculiarities of |glycopeptides. |

|pharmacokinetics, antibacterial spectrum, efficiency). Interaction of |Correction of medical prescriptions for rifamycins, polypeptide |

|macrolides with other antibiotics and drugs from other pharmacological |antibiotics, oxazolidinones and phosphonates. |

|groups and the possibility of severe complications. |Consultation a doctor and a patient on rational use of rifamycins, |

|The mechanism of action, type and range of antibacterial action, |polypeptide antibiotics, phosphonates, oxazolidinones for the |

|pharmacological characteristics of lincosamides. Side effects |prevention of possible complications in their application. |

|lincosamides and contraindications to their use. Comparison of |Recommendations to the doctor about rational choice of drugs |

|lincosamides with other antibiotics and drugs from other pharmacological|prebiotics and probiotics for prevention and treatment of dysbiosis. |

|groups. | |

|Classification and nomenclature of tetracyclines, mechanism of the | |

|action, type and range of antibacterial action. Features of | |

|pharmacokinetics and indications for use of tetracyclines. Problems of | |

|toxicity and contraindications of tetracyclines. | |

|Classification of aminoglycosides for generations, mechanism of action, | |

|type of antibacterial action. Comparison of aminoglycosides from | |

|different generations in antimicrobial spectrum. Indications for use, | |

|manifestations of toxicity, contraindications to use of aminoglycoside | |

|antibiotics. Factors contributing to the development of side effects of | |

|aminoglycosides. | |

|Synergistic and antagonistic aminoglycosides combination with other | |

|drugs. | |

|Mechanism, type and antibacterial spectrum of chloramphenicols. | |

|Indications, side effects and contraindications to the use of | |

|chloramphenicols. Preparations of chloramphenicols of resorptive and | |

|local application. | |

|Mechanism, type and range of antimicrobial action of glycopeptides. | |

|Indications for use of glycopeptides. Toxic manifestations arising from | |

|the use of glycopeptides, conditions conducive to the development of | |

|these symptoms. | |

|Contraindications to the use of glycopeptides. Comparison of teicoplanin | |

|and vancomycin. | |

|Mechanism, type and range of antimicrobial action of rifamycins. | |

|Indications for use, side effects and contraindications for rifamycins. | |

|Mechanism, type and range of of antimicrobial action of polypeptide | |

|antibiotics: polymyxin B and M sulfate, gramicidin, bacitracin. | |

|Indications, side effects and contraindications to the use of polypeptide| |

|antibiotics. Mechanism and features of antimicrobial spectrum of fuzidin,| |

|indications, side effects and contraindications to its use. | |

|Antibiotics phosphonates, mechanism, type and range of antimicrobial | |

|action. Indications for use fosfomycin, its side effects. | |

|Pharmacological characteristics of oxazolidinone, features of | |

|antimicrobial spectrum. Indications for use of linezolid. | |

|The concept of reserve antibiotics, post antibiotic effect of some groups| |

|of antibiotics. | |

|The concept of dysbiosis and the causes of its development, the possible | |

|ways of of correction of this condition. | |

|The concept of pre-and probiotics, mechanisms of action, features of | |

|microorganisms that are part of probiotics. Pharmacological effects of | |

|pre-and probiotics, indications for their use. | |

|Topic 30 |

|Classification of sulfanilamides. Mechanism of antimicrobial action, |Correction of medical prescriptions for sulfanilamide preparations. |

|determination of bactericidal, bacteriostatic action. Features of |Control of single and daily doses of sulfonamides. |

|pharmacokinetics of sulfonamides. Conditions of rational dose of |Inform a doctor about the interchangeability of of sulfonamides and |

|sulfonamides of various duration (impact, maintenance dose, the |anti-TB drugs. |

|multiplicity of admission). Factors that reduce the risk of side effects |Recommendations to patients on the rational use of of sulfonamides |

|of sulfonamides. The relationship between the indications, side effects |and anti-TB agents. |

|and contraindications to the use of sulfonamides. |Choose from a collection of modern medicine that contain sulfonamides|

|Classification of anti-TB drugs by the mechanism of action and |and anti-TB agents of first and second row. |

|effectiveness. Comparative pharmacological characteristics of drugs of | |

|first and second row. | |

|Topic 31 |

|Classification of antiviral agents. The mechanism of action, indications |Correction of medical prescriptions for antiviral drugs. Choose from |

|and contraindications for use, side effects of drugs for treatment of |a collection of antiviral drugs for the treatment of herpes |

|influenza. Antiherpethetical drugs, mechanism of action, indications, |infections (topical and resorptive), influenza. |

|side effects. Classification of antiretroviral drugs, mechanism of |Inform a doctor for an effective and safe use of antiviral agents. |

|action, indications for use. |Recommendations to patients to prevent side effects of antiviral |

|Comparison of groups of antiretroviral drugs. The main side effects of |drugs. |

|antiretroviral drugs, contraindications to the use. |Features of antiviral agents of topical action. |

|Interferons, classification, pharmacological effects of interferons, |Choose from a collection of interferon drugs that stimulate the |

|indications for use. Side effects of interferons. Inductors of interferon|synthesis of endogenous interferon. |

|synthesis, their classification, pharmacodynamics, indications for use. | |

|Comparison of interferons and their inductors. | |

|Topic 32 |

|Antifungal drugs: pharmacological characteristic of the group, |Correction of medical prescriptions for antifungal drugs. |

|classification of the ways of application, forms of fungal infection. The|Pharmacological and pharmaceutical characteristics of different |

|concept of fungicidal and fungistatic effects of the drugs. |formulations of antifungal agents. |

|The logical relationship between chemical structure, mechanism of action |Consultation a doctor on the rational use of antifungal drugs in |

|and pharmacodynamics of antifungal drugs. Comparison of antifungal drugs |long-term treatment of systemic and localized fungal infections. |

|and their rational use at different location and severity of disease. |Informing the patient about the effective and safe use of antifungal |

|Features of combination therapy with antifungal agents, |agents in the treatment of dermatomycoses, onychomycosis, |

|glucocorticosteroids, antihistamines and anti-bacterial drugs. |trychomycosis. |

|Anthelmintic drugs: classification and pharmacological characteristics of|Correction of medical prescriptions for Anthelmintic drugs. Choose |

|the group. The logical relationship between the mechanism of action of |from a collection of anthelmintic drugs of different groups. |

|drugs, pharmacodynamics and indications for use in nematodoses, |Consultation of a doctor on new and traditional anthelmintic drugs |

|cestodoses, trematodoses and extraintestinal forms of helminthiasis. |represented the pharmaceutical market. Inform the patient on rational|

|Conditions of rational use of anthelmintic drugs and combinations of |use of antigelminthic drugs. |

|drugs of other groups. | |

|Topic 33 |

|Classification, pharmacological characteristics antiprotozoal and |Correction of medical prescriptions for antiprotozoal and |

|antispirochaetic drugs. The concept of asepsis, antisepsis, disinfection |antispirochaetic drugs. |

|and peculiarities in pharmaceutical practice. Factors affecting |Inform a doctor about the interchangeability of drugs according to |

|antiseptic and disinfectant action of drugs. Rules for safe handling with|their pharmacological effects, international nomenclature and trade |

|disinfectants. |names. |

| |Distribution of antiseptics and disinfectants to those used mainly in|

| |surgery, obstetrics, clinical infectious diseases, pathologoanatomic |

| |departments |

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