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For DI with significant hypernatremia (sodium >145-150 mmol/L) without hypotension, treatment with desmopressin should be initiated. After an initial IV dose of 1 to 4 g, additional dosing should be titrated to urine output, urine osmolality, and serum sodium. Typically, an additional 1 or 2 g every 6 hours will be required, although higher ... ................
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