Systemic Lupus and Related Connective Tissue Diseases - Yale University

Systemic Lupus and Related Connective Tissue Diseases

Fotios Koumpouras, M.D. Assistant Professor of Medicine Director, Yale Lupus Program Associate Program Director Yale School of Medicine 2019

SLIDE 1

Outline

? Clinical Overview of SLE ? Cellular Overview of SLE ? Organ Involvement Focus on Nephritis ? Related Diseases ? Yale and Future Directions

SLIDE 2

Lupus is Dangerous

SLIDE 3

SLE: Etiopathogenesis

? SLE is a systemic immune complex inflammatory disorder

? Characterized by measurable auto-antibody production and protean manifestations

? Loss of T-cell tolerance to nuclear self antigens

? Stimulation of na?ve T-follicular helper cells by APC causes B-cell stimulation and class switching to produce a specific B-cell response

? Production of germinal centers in LN ? Memory B cell population

? abnormal STAT-4 expression in Tfh

SLIDE 4

SLE: Etiopathogenesis

? Autoantibody production causes inflammation

? dsDNA, SS-A, aCL

? Inflammation leads to damage

? Usually begins after menarche, reduced incidence after menarche

? Estrogen plays a role

? Estrogens can activate B cells and produce Ab

SLIDE 5

 ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download