Lupus Related Kidney Diseases
Lupus Related Kidney Diseases
Jason Cobb MD Assistant Professor
Renal Division Emory University School of Medicine
October 14, 2017
Financial Disclosures
? MedImmune
? Lupus Nephritis Kidney Biopsy Biomarkers Research Study
? Co-investigator
? NIH R25
? SUPERR (Summer Undergraduate Program in Emory Renal Research) grant
Renal Disease in SLE
? About 50% - 75% of systemic lupus erythematosus (SLE) patients have renal disease.
? Abnormal urinalysis
? Hematuria >5 rbc/hpf ? Proteinuria >500 mg/day
? Elevation of creatinine
Kelley WN et al. Clinical Features of SLE. Textbook of Rheumatology. WB Saunders Philadelphia 2000 Appel et al. JASN 2009: 20; 1103-12
Renal Disease in SLE
? Pathogenesis
? Immune-complex mediated glomerulonephritis (GN) with formation of immune deposits.
? Anti-double stranded DNA (dsDNA) antibodies against nucleosomes in the kidney.
? Consumption of complement with low C3/C4 levels.
? Elevated dsDNA ? Low complements (low C3 and C4 levels)
GBM
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