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Supplementary Table S1 Accession numbers of human adenovirus Hexon sequences used in this study isolated from respiratory and ocular infectionAreaSerotypeGene accession numberNameHexon sequences from ocular infectionAd8AB685335Ad8-hexon-Japan1-2011Ad8AB628209Ad8-hexon-Japan2-2011Ad8DQ149614Ad8-hexon- Austria-2005Ad8AB456573Ad8-hexon- Turkey1-2008Ad8AB456572Ad8-hexon- Turkey2-2008Ad8AB456570Ad8-hexon- Turkey3-2008Ad8DQ996035Ad8-hexon- Spain1-2006Ad8DQ996033Ad8-hexon- Spain2-2006Ad8DQ996031Ad8-hexon- Spain3-2006Ad8DQ996029Ad8-hexon- Spain4-2006Ad8DQ996036Ad8-hexon- Spain5-2006Ad8DQ996034Ad8-hexon- Spain6-2006Ad8AB500121Ad8-hexon-Japan-1994Ad8AB448769Ad8-hexon-Japan1-2008Ad8AB448767Ad8-hexon- Japan2-2008Ad8AB448768Ad8-hexon- Japan3-2008Ad8AB091068Ad8-hexon- Japan1-2002Ad8AB091069Ad8-hexon- Japan2-2002Ad8AB090346Ad8-hexon- Japan3-2002Ad8AB090344Ad8-hexon- Japan4-2002Ad8AB090342Ad8-hexon- Japan5-2002Ad8AB090345Ad8-hexon- Japan6-2002Ad8AB369367Ad8-hexon-Japan1-2007Ad8AB361057Ad8-hexon- Japan2-2007Ad8AB361058Ad8-hexon- Japan3-2007Ad8AB361056Ad8-hexon- Japan4-2007Ad8AB330089Ad8-hexon- Japan5-2007Ad8AB023546Ad8-hexon- Japan1-1999Ad8AB248446Ad8-hexon- Japan1-2006Ad8AB248444Ad8-hexon- Japan2-2006Ad8Y17246Ad8-hexon- Germany-1998Ad8X74663Ad8-hexon- Germany-1993Ad8AB098567Ad8-hexon- Japan1-2002Ad8AB099382Ad8-hexon- Japan1-2003Ad8AB090346Ad8-hexon-Japan1-2003(2)Ad8AB099348Ad8-hexon- Japan2-2003Ad8AB099381Ad8-hexon- Japan3-2003Ad19JQ326209Ad19-hexon- USA-2011Ad19DQ149618Ad19-hexon- Austria-2005Ad19DQ115417Ad19-hexon- USA-2005Ad19AY056457Ad19-hexon-USA1-2001Ad19AY056458Ad19-hexon- USA2-2001Ad19AY056456Ad19-hexon- USA3-2001Ad19AB448774Ad19-hexon-Japan1-2001Ad19AB448772Ad19-hexon-Japan1-2008Ad19AB448773Ad19-hexon- Japan1-1997Ad19AB448771Ad19-hexon- Japan2-2008Ad19AB330133Ad19-hexon- Japan1-2007Ad19AB330100Ad19-hexon- Japan2-2007Ad19Y17250Ad19-hexon- Germany1-1998Ad19X98359Ad19-hexon- Germany1-1996Ad19AB099384Ad19-hexon- Japan1-2003Ad19AB099385Ad19-hexon- Japan1-1996Ad19AB099354Ad19-hexon- Japan2-2003Ad19AB023550Ad19-hexon- Japan1-1991Hexon sequences from respiratory infectionAd37FJ169625Ad37-hexon-USA-2008Ad37DQ149632Ad37-hexon-Austria-2005Ad37DQ900900Ad37-hexon-USA-2009Ad37AB500123Ad37-hexon-Japan-2005Ad37AB475153Ad37-hexon- Japan1-2003Ad37AB475151Ad37-hexon- Japan2-2003Ad37AB475149Ad37-hexon- Japan3-2003Ad37AB475147Ad37-hexon- Japan4-2003Ad37AB500122Ad37-hexon-Japan-1998Ad37AB475144Ad37-hexon- Japan5-2003Ad37AB448778Ad37-hexon- Japan-2004Ad37AB448776Ad37-hexon- Japan-1991Ad37AB448777Ad37-hexon- Japan-1996Ad37AB448775Ad37-hexon-Japan-2008Ad37AB330118Ad37-hexon- Japan-2007Ad37X98360Ad37-hexon-Germany-1996Ad37AB162773Ad37-hexon- Japan-2004Ad37AB023555Ad37-hexon-Japan-1999Ad7JQ412716Ad7- hexon-China1-2011Ad7JQ412714Ad7- hexon-China2-2011Ad7JQ412704Ad7- hexon-China3-2011Ad7JF800905Ad7- hexon-China1-2009Ad7JX625134Ad7- hexon-China1-2010Ad7JN860677Ad7- hexon-USA-2009Ad7JN860676Ad7- hexon-USA-1987Ad7GQ478341Ad7- hexon-China1-2008Adenovirus vaccine strainsAd7AY495969Human adenovirus type 7 vaccine strainAd4AY594254Human adenovirus type 4 vaccine strainSupplementary Table S2 The Haplotype distribution of Hexon sequences listed in Median-joining network figure (Figure 2) No. of HaplotypeTotal Hexon sequencesHexon sequence nameHap_12Ad8-hexon-Japan1-2011Ad8-hexon-Japan4-2002Hap_24Ad8-hexon-Japan2-2011Ad8-hexon-Japan3-2002Ad8-hexon-Japan5-2002Ad8-hexon-Japan1-1999Hap_36Ad8-hexon-_Austria-2005Ad8-hexon-Japan-1994Ad8-hexon-Japan2-2007Ad8-hexon-Japan3-2007Ad8-hexon-Japan4-2007Ad8-hexon-Japan5-2007Hap_47Ad8-hexon-Turkey1-2008Ad8-hexon-Turkey2-2008Ad8-hexon-Turkey3-2008Ad8-hexon-Japan1-2003Ad8-hexon-Japan1-2003(2)Ad8-hexon-Japan2-2003Ad8-hexon-Japan3-2003Hap_56Ad8-hexon-Spain1-2006Ad8-hexon-Spain2-2006Ad8-hexon-Spain3-2006Ad8-hexon-Spain4-2006Ad8-hexon-_Spain5-2006Ad8-hexon-_Spain6-2006Hap_61Ad8-hexon-Japan1-2008Hap_72Ad8-hexon-Japan2-2008Ad8-hexon-Japan3-2008Hap_82Ad8-hexon-Japan1-2002 Ad8-hexon-Japan2-2002Hap_93Ad8-hexon-Japan6-2002 Ad8-hexon-Japan1-2006 Ad8-hexon-Japan2-2006Hap_102Ad8-hexon-Japan1-2007 Ad8-hexon-Japan1-2002Hap_111Ad8-hexon-Germany-19Hap_121Ad8-hexon-Germany-19Hap_132Ad19-hexon-USA-2011 Ad19-hexon-_Japan2-2008Hap_142Ad19-hexon-Austria-2005Ad19-hexon-Japan2-2007Hap_152Ad19-hexon-USA-2005 Ad19-hexon-USA1-2001Hap_162Ad19-hexon-USA2-2001 Ad19-hexon-USA3-2001Hap_178Ad19-hexon-Japan1-2001 Ad19-hexon-Japan1-2008Ad19-hexon-_Japan1-1997 Ad37-hexon-USA-2009 Ad37-hexon-Japan-2004 Ad37-hexon-Japan-1991 Ad37-hexon-Japan-1996 Ad37-hexon-Japan-2008Hap_181Ad19-hexon-Japan1-2Hap_192Ad19-hexon-Germany-1998Ad19-hexon-Japan2-2003Hap_202Ad19-hexon-Germany-1991Ad19-hexon-Japan1-1996Hap_212Ad19-hexon-Japan1-2003Ad19-hexon-Japan1-1996Hap_221Ad37-hexon-USA-2008Hap_238Ad37-hexon-Austria-2005 Ad37-hexon-Japan-2005 Ad37-hexon-Japan2-2003 Ad37-hexon-Japan3-2003 Ad37-hexon-Japan4-2003 Ad37-hexon-Japan-1998 Ad37-hexon-Japan5-2003 Ad37-hexon-Japan-2007Hap_241Ad37-hexon-Japan1-2003Hap_253Ad37-hexon-Germany-1996Ad37-hexon-Japan-2004 Ad37-hexon-Japan-1999Hap_263Ad7-hexon-China1-2011 Ad7-hexon-China2-2011 Ad7-hexon-China3-2011Hap_274Ad7-hexon-China1-2009 Ad7-_hexon-China1-2010 Ad7-hexon-USA-2009 Ad7-hexon-USA-1987Hap_281Ad7-hexon-China1-2008Hap_291Human-adenovirus-type-7-vaccine- strainHap_301Human-adenovirus-type-4-vaccine- strainSupplementary Table S3 The main serotype of adenovirus infected with ocluar infectionSpeciesSerotypesReceptorAssociated ocular diseasesA12,18,31CARnoB13，7，14CD64PCFB211, 14, 21CD80/86ConjunctivitisB33, 7XnoB411, 21noB534, 35, 50, 55noC1, 2, 5, 6CARHSPnoD8–10, 13, 15, 17, 19, 20, 22-30, 32, 33, 36-39, 42–49, 51-54, 56CARSACD46EKC and follicular conjunctivitisE4CARConjunctivitisF40,41noG52noHSP: Human sulfate proteoglycansSA: Sialic acid; CAR: Coxsackie/adenovirus receptor ................
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