XV
Curriculum Vitae
|Date Prepared: |5/24/2011 |
|Name: |Sunil Sheth, MD |
|Office Address: |Division of Gastroenterology |
| |Beth Israel Deaconess Medical Center |
| |Rabb 423, 330 Brookline Avenue |
| |Boston, MA 02215 |
|Home Address: |8 Whittier Place, Apt # 2K |
| |Boston, MA 02114 |
|Work Phone: |617-667-7957 |
|Work Email: |ssheth@bidmc.harvard.edu |
|Work FAX: |617-667-5826 |
|Place of Birth: |Mumbai, India |
Education
|Year |Degree | | |
|1984-1986 |HSC |Jaihind College, Bombay, India |(Junior College) |
|1986-1992 |MBBS |Seth GS Medical College KEM Hospital | Bombay, India |
Postdoctoral Training
|Year(s) |Title |Specialty/Discipline |Institution |
| | |(Lab PI for postdoctoral research) | |
|1992-1995 |MD, DNB |Residency in Internal Medicine |TN Medical College, BYL Nair Hospital, Bombay, India |
|1995-1996 |Fellow |Clinical Research in Hepatology |Beth Israel Deaconess Medical Center, Harvard Medical School, Boston |
| | |and Gastroenterology | |
|1996-1997 |Intern |Internship in Internal Medicine |Beth Israel Deaconess Medical Center, Harvard Medical School, Boston |
|1997-1998 |Resident |Residency in Internal Medicine |Beth Israel Deaconess Medical Center, Harvard Medical School, Boston |
|1998-2001 |Fellow |Fellowship in Gastroenterology |Beth Israel Deaconess Medical Center, Harvard Medical School, Boston |
|2001-2002 |Fellow |Interventional Gastroenterology Fellowship |Maine Medical Center, Portland, ME |
| | | |University of Vermont |
Faculty Academic Appointments
|Year(s) |Academic Title |Department |Academic Institution |
|1996-2001 |Clinical Fellow |Medicine |Harvard Medical School, Boston |
|2002-2003 |Assistant Professor |Medicine |Tufts University School of Medicine |
|2004-present |Assistant Professor |Medicine |Harvard Medical School, Boston |
Appointments at Hospitals/Affiliated Institutions
|Year(s) |Position Title |Department (Division, if applicable) |Institution |
|2002-2003 |Staff Physician |Division of Gastroenterology, Hepatology and Liver |Lahey Clinic, Burlington, MA |
| | |Transplantation | |
|2003 |Attending Physician |Division of Gastroenterology |Beth Israel Deaconess Medical Center, Boston, MA |
| | |Co-Director, Pancreas Center | |
Committee Service
Local
|Year(s) of |Name of Committee |Institution/Organization |
|Membership | | |
|Dates of Role(s) |Title of Role(s) |
|2002-2003 |CME Committee |Member Lahey Clinic |
|2009 |GI Council Committee |Member BIDMC, MA |
|2008-present |Procedure Prep Committee |Member BIDMC,MA |
Professional Societies
|Year(s) of |Society Name | |
|Membership | | |
|Dates of Role(s) |Title of Role(s) |
|1992-present |Indian Medical Association |(Member) |
|1992-present |Association of Physicians of India |(Member) |
|1992-1995 |American College of Physicians |(Member) |
|1998-present |American Gastroenterology Association (AGA) |(Member) |
|1998-present |American College of Gastroenterology (ACG) |(Member) |
|1998-present |Amercian Society of Gastrointestinal Endoscopy (ASGE) |(Member) |
|2002-present |American Association of Study of Liver Diseases (AASLD) |(Member) |
Editorial Activities
|Journals for which you serve as a reviewer |
|2003-present Reviewer Gastroenterology |
|2008-present Reviewer Journal of Clinical Gastroenterology and Hepatology |
|Year(s) |Role |Journal Name |
Honors and Prizes
|Year |Name of Honor/Prize |Awarding Organization |Achievement for which awarded |
| | | |(if unclear from award title) |
|1986-1991 |First Class with Honors : |Ist, IInd and IIIrd |MBBS Board Examinations |
|1989 |Distinction in Pathology and | | |
| |Pharmacology | | |
|1995 |For ranking first in the Internal |(Bombay University, India): |Dr. Chunibhai S. Patel Gold Medal |
| |Medicine Theory and Practical Board | |Dr Musserwanji F. Surveyor Scholarship |
| |Examinations | |Dr Latif Patel Prize |
| | | |Late Dr R B Billimoria Prize |
| | | |Rani Jagadamba Devi and Dr J K Mehta Prize |
|2001 |Best research presentation by Fellow |North American Conference of |Tampa, Florida |
| | |Gastroenterology Fellows | |
Report of Funded and Unfunded Projects
Funding Information
Past
|Grant title |Grant title |
|Grant type and number |
|Role on Project (if PI or site PI, total indirect costs) |
|Description of the major goals |
|2000-2001 |American College of Gastroenterology Principal Investigator Evaluation of Cystic |
| |Fibrosis Transmembrane Conductance |
| |Regulator (CFTR)Function and Gene |
| |Mutations in Primary |
| |Sclerosing Cholangitis |
|2003-2004 |NIH/NCRR/GCRC CreFF award Principal Investigator Role of probiotics and |
| |PPAR gamma modulation in |
| |ulcerative colitis |
Current
|Grant title |Grant title |
|Grant type and number |
|Role on Project (if PI or site PI, total indirect costs) |
|Description of the major goals |
| |Mechanisms of neuropeptide regulation of brain-gut interactions in irritable bowel syndrome (co-investigator) |
| |Eosinophilic esophagitis is adults (co-investigator) |
| |Identification of modifier genes in Pancreatitis and Primary Sclerosing Cholangitis (co-investigator) |
| |Evaluation of Docosashexaenoic Acid (DHA) for the Treatment of Primary Sclerosing Cholangitis (PSC) (co-investigator) |
| |Assessment of the timing of samples in the secretin pancreatic function test (co-investigator) |
| |Markers of inflammation in duodenal mucosal biopsies in individuals with celiac disease (co-investigator) |
| |Outcomes of the Complications of Celiac Disease (co-investigator) |
| |Circulating markers of celiac disease activity during gluten challenge – a pilot study (co-investigator). |
| |A 12-Week, Randomized, Double-Blind, Dose-Ranging, Placebo-Controlled Study of Asimadoline in Subjects with Irritable Bowel Syndrome |
| |(co-investigator) |
| |Testing the CDAI in non-IBD patients (co-investigator) |
| |Follow-up of suspected early chronic pancreatitis patients referred to the BIDMC Pancreas Center (co-investigator) |
| |Evaluation of causes and distinguishing factors of non celiac causes of enteropathy (co-investigator) |
| |Evaluation of the role of socioeconomic status on celiac disease diagnosis and management (co-investigator) |
| |Evaluation of the utility of HLA testing in suspected celiac disease (co-investigator) |
| |Prospective evaluation of adenoma detection rate during colonoscopy (co-investigator) |
Report of Local Teaching and Training
Teaching of Students in Courses
|Year(s) |Course Title |Location |
| |Type of student/audience |Level of Effort |
|2003-2008 |Abdominal examination Tutor |4 students (HMS III) 4 hours |
Clinical Supervisory and Training Responsibilities
|Year(s) |Type of responsibility |Level of Effort |
|2001-2002 |Flexible Sigmoidoscopy Clinic at Maine Medical Center |Teaching Attending 25 medical residents 100 hours over 25 sessions|
|2002- 2009 |Endoscopy Clinic, ambulatory clinic and inpatient consults at |Supervising and Teaching Attending to |
| |Lahey Clinic(2002-03) and BIDMC (2003- 2011) |gastroenterology fellows, medical students and residents 1200 |
| | |hours |
|2003-present |Primary clinical preceptor and mentor |To second and third year fellows in continuity clinic and |
| | |endoscopic procedures 40 hours/week. Also teaching HMS medical |
| | |students and medical residents at consult rounds, weekly clinics |
| | |and conferences |
Laboratory and Other Research Supervisory and Training Responsibilities
|Year(s) |Type of responsibility |Level of Effort |
|2002-2003 |Research mentor |To Sassan Pazirandeh, MD and James Tung, |
| | |MD, GI fellows at the Lahey Clinic |
|2003-present |Clinical research co-mentor |To GI Fellows,Win Travassos, MD, Sonal |
| | |Patel, MD, David Fefferman, MD, Seema |
| | |Maroo, MD, Noah Zinkin, MD, Brett |
| | |Kalmowitz, MD, Howard Chang, MD, Mary |
| | |Hu, MD, Paola Blanco, MD, Steven Kappler |
| | |MD, Tyler Berzin MD, Paul Sepe, MD, Laura |
| | |Rosenberg, MD, Gyanprakash Ketwaroo, MD |
| | |at the BIDMC. |
Report of Regional, National and International Invited Teaching and Presentations
Invited Presentations and Courses
Regional
|Year(s) |Title of presentation or name of course/ Type of presentation/role(s) (note if presentation the result of a selected abstract) |
|Location (Sponsor, if any) |
|2008 |Faculty at the Boston International Live Endoscopy Course in Boston |
International
|Year(s) |Title of presentation or name of course/ Type of presentation/role(s) (note if presentation the result of a selected abstract) |
|Location (Sponsor, if any) |
|2004 |Invited by Bombay University and Jaslok Hospital, Bombay to lecture on “Chronic pancreatitis” |
Current Licensure and Certification
|Year |Type of License or Certification |
|1992 |FMGEMS: Parts I, II and English Test |
|1992 |MBBS: Bombay University |
|1993 |FLEX (Pennsylvania): Parts I and II |
|1995 |DNB: Diploma of National Board of Medicine, India |
|1995 |MD: Board Certification in Internal Medicine, Bombay University |
|1996 |Massachusetts License Registration (Permanent) |
|1998 |Certification in American Board of Internal Medicine |
|2001-2003 |Maine Medical License (Permanent) |
|2001 |Certification in American Board of Gastroenterology |
Practice Activities
List all clinical activities, both those at Harvard and its affiliates and those outside Harvard, and for each indicate:
| | | | |
If you have no current clinical activities, but have practiced in the past you may provide a brief (1-2 sentence) description of those prior activities
| |
|half day sessions in outpatient gastroenterology and pancreas clinic seeing primary as well as second opinion |
|consults, and seven half day sessions performing endoscopy (diagnostic and therapeutic upper endoscopy, |
|colonoscopy, enteroscopy,) In addition, I attend on the inpatient gastroenterology consultation service for six |
|weeks annually. On an average I perform 45-50 endoscopies and see 40 consults per week. |
Report of Scholarship
|Include only manuscripts that are published or accepted for publication (forthcoming) in print or other media; do not include manuscripts that have been |
|submitted but not accepted for publication or those that are in preparation; Please use bold-faced type for your name in the authorship list. Numbering of|
|contributions should start with "1" in each new section. |
Peer reviewed publications in print or other media
|Group peer reviewed publications in three categories under the following headings: |
| |
| |
|Hakim AS, Sheth SG, Mahe SC, Mehta PJ, Soneji SL. Young’s syndrome : a rare cause of bronchiectasis. J Assoc Phy Ind. 1993; 41:525-6. |
|Drago SD, Sheth SG, Singhal AB, Mehta HG, Nabar ST. Ascites complicating ventriculoperitoneal shunt. Ind Pract. 1994; 5:405-7. |
|Sheth SG, Bichile SK. Thrombocytopenia in HIV disease. Medicine Update. 1994 (Oct):515-8. |
|Sheth SG, Mahe SC, Hakim AS, Mehta PJ, Soneji SL. Organophosphorous compound poisoning : prolonged therapy in the absence of intermediate neurotoxic |
|syndrome. J Assoc Phy Ind. 1995; 43:59-60. |
|Mahe SC, Sheth SG, Hakim AS, Mehta PJ, Soneji SL. Right atrial myxoma. J Assoc Phy Ind.1995; 43:218-9. |
|Sheth SG, Deo AM, Deshpande PA, Makwana PV, Madhusudhan JG, Talim MS, Mehta PJ, Mehtalia SD. Recurrent bilateral primary spontaneous pneumothoraces. J |
|Assoc Phy Ind. 1995; 43:367-70. |
|Singhal AB, Drago SD, Sheth SG, Chowgule BR, Nabar ST. Ruptured type III cervical arteriovenous malformation as a cause of quadriparesis. J Assoc Phy Ind. |
|1995; 43: 565-6. |
|Sheth SG, Sheth munity acquired urinary tract infections : changing pattern of infecting organisms and their antibiogram. Medicine Update. 1995 |
|(Jan): 813-8. |
|Sheth SG, Mani S, Tamhankar H, Mehta PJ. Spleen size in health and disease : a sonographi assessment. J Assoc Phy Ind. 1995; 43:182-4. |
|Sheth SG, Deo AM, Bichile SK, Amarapurkar DN, Chopra KB, Mehta PJ. Coagulation abnormalities in non-cirrhotic portal fibrosis and extra hepatic portal vein|
|obstruction. J Assoc Phy Ind. 1996; 44:790-1. |
|Sheth SG, Amarapurkar DN, Chopra KB, Mani SA, Mehta PJ. Ultrasonic evaluation of portosystemic collateral circulation in portal hypertension. J Assoc Phy |
|Ind.1996; 44:537-9. |
|Mani S, Sheth SG, Ranavare R. Sonographic analysis of prevalence of cholelithiasis in cirrhosis of liver due to chronic alcohol abuse in males. Bom Hosp J.|
|1996; 38:105-6. |
|Sheth SG, Amarapurkar DN, Chopra KB, Mehta PJ. Significance of radioisotope bone marrow uptake on 99m technetium sulphocolloid scan in portal hypertension.|
|J Assoc Phy Ind. 1996; 44:310-2. |
|Sheth SG, Amarapurkar DN, Chopra KB, Mani SA, Mehta PJ. Evaluation of splenomegaly in portahypertension. J Clin Gastroenterol. 1996; 22:28-30. |
|Mani S, Cunha N, Sachdev R, Sheth SG. Tuberculosis and Addison’s disease. The role of CT in diagnosis and follow up. Ind Pract. 1997; 50 : 170-2. |
|Sheth SG, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. Am J Gastroenterol. 1998; |
|98:44-48 |
|Sheth SG, Morrin MM, Saldinger P. Image of the month. Echinoccocal cyst of the liver. Gastroenterology. 1999; 117: 1042, 1261. |
|Sheth SG, Shea JC, Bishop MD, Chopra S, Regan MM, Malmberg E, Walker C, Ricci R, Tsui TC, Durie PR, Zielenski J, Freedman SD. Increased prevalence of CFTR|
|mutations and variants and decreased chloride secretion in primary sclerosing cholangitis. Hum Genet 2003; 113: 286-292. |
|Shah RJ, Howell DA, Desilets DA, Sheth SG, Parsons WG, Okolo P, Lehman GA, Sherman S, Baillie J, branch SM, Pleskow D, Chuttani R, Bosco JJ. |
|Multicenter randomized trial of the spiral Z- stent compared to the wall stent for malignant biliary obstruction. Gastrointest Endosc 2003; 57:830-6 |
|Howell DA, Lawrence Christopher, Sheth S, Shah RJ. Dropped clip endoscope obstruction: Recognition and Management. J Clin Gastroenterol. 2005; 39 : 549 |
|Pazirandeh S, Gordon FG, Yantiss RK, Khettry U, Sheth SG. Cyclooxygenase-2 (COX-2) is highly expressed in cirrhosis and hepatocellular carcinoma. Dig Dis |
|Sci.2006; 52: 220-7. |
|Tummala S, Sheth S, Goldsmith J, Goldar-Najafi A, Murphy C, Osburne M, Mullin S, Buxton D, Wagner D, Kelly CP. Quantifying gastric Helicobacter pylori |
|infection: a comparison of quantitative culture, urease breath testing and histology. Dig Dis Sci.2007; 52 396-401. |
|Keates AC, Tummala S,Peek RM, Sheth S, Kelly CP, Robson S, Keates S. Helicobacter pylori infection stimulates plasminogen activator inhibitor-1 (PAI-1) |
|production by gastric epithelial cells. Infection and Immunity. 2008;76(9):3992-9. |
|Kent TS, Pedrosa I, Sheth S, Brown A, Callery MP, and Vollmer CM. Functional MR Imaging of Pancreatic Disease. Oral presentation at HPB video session at |
|SSAT/DDW San Diego, 2008. |
|Lembo AJ, Ganz RA, Sheth S, Cave D, Kelly C, Levin P, Kazlas PT, Baldwin PC 3rd, Lindmark WR, McGrath JR, Hamblin MR. Treatment of Helicobacter pylori |
|infection with intra-gastric violet light phototherapy: a pilot clinical trial. Lasers Surg Med. 2009, Jul;41(5):337-44. |
|Lukens FJ, Howell DA, Upender S, Sheth SG, Jafri SM. ERCP in the very eldery: Outcomes Among patients older than eighty. Dig Dis Sci 2009 April 1 |
|Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Kelly CP. Interaction between psychiatric and autoimmune disorders in celiac|
|disease patients in northeastern United States. Aliment Pharmacol ther. 2009 15; 29 (8): 898-905. |
|Sheth S, Bleibel W, Thukral C, A-Rahim Y, Beldi G, Csizmadia E, Robson SC. Heightened BTPDase-1/CD39 expression and angiogenesis in radiation proctitis. |
|Purinergic Signal. 2009 5 (3): 321-6. |
|Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D, Dennis M, Leffler D. Celiac crisis is a rare but serious complication of |
|celiac disease in adults. J. Clin Gastroenterol Hepatol 2010: 8:587-90. |
|Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan D, Sheth S, Kelly CP. Small intestinal release mesalamine for the treatment of refractory celiac |
|disease type I. J. Clin Gastroenterol hepatol. 2011. 45: 30-3. |
|Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum of|
|refractory celiac disease in a north American referral center. Am j Gastroenterol. 2011; 106: 923-8. |
Non-peer reviewed scientific or medical publications/materials in print or other media
|Group materials into the following categories: |
| |
| |
| |
| |
|Sheth SG, Bichile SK, Butch HG. Thrombocytopenia : an uncommon cause of digital gangrene. Medicine Update. 1993; 1:573-6. |
|Sheth SG, Bichile SK. Treatment of Aplastic Anemia. Medicine Update.1994 (Sept): 395-8. |
|Sheth SG, Deo AM, Bichile SK. Hematopoietic growth factors. Medicine Update. 1994 (Nov):579-82. |
|Makwana PV, Sheth SG, Deo AM, Deshpande PA, Talim MS, Mehta PJ, Mehtalia SD. Kyphoscoliosis and Lung. Medicine Update. 1995; 2:1039-42. |
|Sheth SG, Deshpande PA, Deo AM, Talim MS, Makwana PV, Madhusudhan JG, Mehta PJ, Mehtalia SD. A case of convulsions. Medicine Update 1995; 3; 149-52. |
|Sheth SG, Chopra S. Nonalcoholic steatohepatitis. UpToDate (CD Rom). |
|Sheth SG, LaMont JT. Toxic Megacolon. UpToDate (CD Rom). |
|Sheth SG, Gordon FD, Chopra S. Nonalcoholic steatohepatitis. Ann Intern Med. 1997; 126: 137-45. Also comment (letter): Ann Intern Med. 1997; 127: 410-11. |
|Sheth SG, Bates C, Federman M, Chopra S. Fulminant hepatic failure caused by microsporidial infection in a patient with AIDS. AIDS. 1997; 11: 553-4. |
|Sheth SG, LaMont JT. Toxic Megacolon. Lancet. 1998; 351:509-13. |
|Sheth SG, Bedford A, Chopra S. Primary Gallbladder Cancer: Recognition of risk factors and the role of prophylactic cholecystectomy. Am J Gatroenterol. |
|2000; 95: 1402-11. |
|Sheth SG, Chopra S. Transjugular, laparoscopic and fine needle aspiration liver biopsy. UpTodate (CD Rom). |
|Sheth SG, Chopra S. Percutaneous liver biopsy. UpTodate (CD Rom). |
|Sheth SG, LaMont JT. Gastrointestinal problems in the chronically critically ill. Clin in Chest Med. 2001; 22:135-48. |
|Bravo AA, Sheth SG, Chopra S. Liver Biopsy.N Engl J Med. 2001; 344:495-500. |
|Sheth SG, Howell DA. Intraductal papillary mucinous tumors of the pancreas. UpTodate (CD Rom). |
|Sheth SG, Howell DA. What are really the true late complications of endoscopic biliary sphincterotomy? Am J Gastroenterol 2002; 97: 2699-70. |
|Howell DA, Sheth SG, Shah, RJ. 10 french pancreatoscopy for intraductal papillary mucinous tumors (IPMT): Impact of the new video baby-scope. Oral |
|presentation at ASGE video forum, DDW San Francisco, 2002. |
|Howell DA, Sheth SG, Shah, RJ. Therapeutic 10 french pancreatoscopy: Electrohydraulic lithotripsy of impacted pancreatic duct stone. Oral presentation at |
|ASGE video forum, DDW San Francisco, 2002. |
|Howell DA, Lukens F, ShethSG. Endoscopic technique of safe ampullary polypectomy: application at the major and minor papilla. Oral presentation at ASGE |
|video forum, DDW Orlando, 2003. |
Thesis
|Provide full citation for doctoral thesis |
|Sheth SG. The Spleen in Portal Hypertension. Bombay University, 1995. |
|A prospective study of the demographic, clinical, biochemical, hematological, radiological and endoscopic features of 101 consecutive patients with |
|cirrhotic and non-cirrhotic portal hypertension. |
Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings
|List abstracts published and exhibits presented at meetings during the last 3 years which have not already been published as full length manuscripts. May |
|also list all abstracts or exhibits, regardless of date or publication as full-length manuscript, which received special recognition at a meeting (e.g., |
|juried poster presentation, meeting commendation). |
|Sheth SG, Saldinger P, Taylor NS, Chopra S, Cheney C, Afdhal N, Anastopoulos H, Fox JG. Neither helicobacter nor other bacterial species are found in liver|
|biopsy specimens of patients with chronic liver disease. Hepatology 2000; 32: 502A. |
|Shah RJ, Sheth SG, Desilets DJ, Dy RM, Hanson BL, Elton EJ, Howell DA. Diffuse duodenal ulcerations secondary to biliary obstruction: Endoscopic and |
|clinical features. Gastrointest Endosc. 2001; 53: AB 206. |
|Sheth SG, Greenberg HL, Pleskow DP, Anastopoulos H, Farrell R, Qawi I, Csizmadias E, LaMont JT, Robson SC. Neovascularization in radiation-induced |
|proctitis is associated with increased endothelial expression of NTPDase-1/CD39. Gastroenterology. 2001; 120: A40. |
|Zaman MM, Blanco PG, Yantiss RK, Nasser IA, Calvo I, Sheth SG, Freedman SD. Bile duct injury in CF knockout mice with colitis: Further evidence of an |
|association between CFTR mutations and primary sclerosing cholangitis. Gastroenterology. 2001; 120: A64. |
|Blanco PG, Shea JC, O’Sullivan BP, Zaman MM, Bishop MD, Sheth SG, Weed DA, Ollero M, Gelrud A, Regan MM, Laposata M, Ellis L, Zielenski J, Durie PR, |
|Alvarez JG, Freedman SD. AA/DHA ratio in nasal mucosa scrapings differentiates cystic fibrosis patients from healthy and disease controls and correlates |
|with nasal potential difference testing. Pediatric Pulmonol, 2001 Supplement 22. |
|Yantiss RK, Sheth SG, Resnick RH, Chopra S, Afdhal NA, Nasser IA. “ Large cell dysplasia” in cirrhosis secondary to hepatitis C virus infection: A |
|predictor of the development of hepatocellular carcinoma? Mod Pathol 2002; 15: 297A. |
|Mazzaglia P, Howell DA, Sheth SG, Roy MA, Shah RJ, Desilets DJ. Clinical value of tissue sampling at ERCP. Gastrointest Endosc 2002; 55: AB170. |
|Sheth SG, Howell DA, Mazzaglia P, Shah RJ, Desilets DJ. The new spiral Z stent for malignant biliary obstruction of the hepatic bifurcation: preliminary |
|experience. Gastrointest Endosc 2002; 55: AB168. |
|Sheth SG, Howell DA, Mazzaglia P, Shah RJ, Desilets DJ. Prophylactic epinephrine injection to prevent delayed bleeding in high-risk patients undergoing |
|endoscopic biliary sphincterotomy. Gastrointest Endosc 2002; 55: AB153. |
|Sheth SG, Howell DA, Shah RJ, Desilets DJ. Does increasing complexity of ERCP procedures necessitate an increase in complications and failure? An evidence|
|based outcome study. Gastrointest Endosc 2002; 55: AB151. |
|Mazzaglia P, Howell DA, Sheth SG, Shah RJ. Enteric stent placement for duodenal obstruction complication pancreatic carcinoma: poor outcome demands |
|caution. Gastrointest Endosc 2002; 55: AB139. |
|Howell DA, Sheth SG, Shah RJ, Desilets DJ. Successful polyp removal from difficult to visualize areas of the duodenum and colon using a prototype oblique |
|viewing thereapeutic endoscope. Gastrointest Endosc 2002; 55: AB114. |
|Lukens F, Howell DA, Sheth SG. ERCP placement of the new Zilver metal expandable endoprostheses for treatment of malignant biliary obstruction below the |
|bifurcation: A pilot study. Gastrointest Endosc. 2003; 57: AB81. |
|Lukens FJ, Howell DA, Upender S, ShethSG, Desilets DL. ERCP in the very elderly: Outcomes among older than eighty. Gastrointest Endosc. 2003; 57: AB82. |
|Howell DA, Lukens FJ, Shah RJ, Sheth SG, Mazzaglia P, Mattia A. What is the true yield of tissue sampling at ERCP? Gastrointest Endosc. 2003: 57: AB196. |
|Lawrence C, Howell DA, Lukens FJ, Sheth SG, Mattia A, Conklin DE. ERCP tissue sampling to maximize yield: Randomized study of two forceps types during |
|triple sampling. Gastrointest Endosc. 2004. |
|Lawrence C, Desilets DJ, Conklin DE, Lukens FJ, Sheth SG, Parsons WG, Howell DA. Endoscopic 6mm Zilver self-expanding metal stents (SEMS) for malignant |
|obstruction of the bifurcation: A pilot study. Gastrointest Endosc 2004. |
|Pazirandeh S, Gordon FG, Yantiss RK, Khettry U, Sheth SG. Cyclooxygenase-2 (COX-2) is highly expressed in cirrhosis and hepatocellular carcinoma. |
|Gastroenterolgy 2004. |
|Tummala S, Sheth S, Goldsmith J, Goldar-Najafi A, Murphy C, Osburne M, Mullin S, Buxton D, Wagner D, Kelly CP. Quantifying gastric Helicobacter pylori |
|infection: a comparison of quantitative culture, urease breath testing and histology. Am J Gastro 2005 ( abstract) |
|Martins N, Fefferman D, Andersson C, Zaman M, Farrell RJ, Freedman SD, Sheth S. Probioticsincrease mucosal PPAR-γ expression in Ulcerative Colitis: An Open|
|Label Study Am J Gastro 2005 ( abstract) |
|Brown A, Sheth S, Dasilva D, Malinn V, Freedman SD. Characteristics after Secretin Stimulation Test of Subjects with Chronic Abdominal Pain and Normal |
|Abdominal Imaging. Pancreas 2006; 33: 449-450. |
|Brown A, Young B, Freedman SD, Sheth S. Rate of progression to imaging positive chronic pancreatitis with positive secretin stimulation test and negative |
|abdominal imaging: Results of a ten year follow up. Gastroenterology 2007; 132: A45. |
|Wilschanski M, Zaman M, Dasilva D, Dimonda T, Brown A, Sheth S, Rosenberg R, O’Sullivan B, Freedman S.Electrophysiological studies on rectal biopsies |
|as a therapeutic endpoint measure in cystic fibrosis Pediatric Pulmonology, Volume 44, S32 :70 |
|Blanco P, Keach J, Petz J, Zaman M, Bhaskar K, Cluette-Brown J, Sheth S, Brown A, Afdhal N, Lindor K, Freedman S.Novel therapeutic approach to Primary |
|Sclerosing Cholangitis. Hepatology 2008. 48:598A |
|Safaie P, Ahmed A, Tariq S, Gashin L, Leffler D, Sheth S, Lembo A, Moss AC, Cheifetz A. Characteristics of elevated CDAI scores in patients with functional|
|GI disease.Gastroenterology 2011; 140 (5); Su 1172. |
Narrative Report
|In general, we suggest the following structure for the narrative: |
|An opening paragraph that provides an overall summary of your major activities and achievements. Include an estimate of the proportion of your effort |
|dedicated to teaching, research, clinical service, administrative activities and other relevant professional roles |
|Description of achievements in your Area of Excellence (Investigation, Teaching and Educational Leadership, or Clinical Expertise and Innovation); may |
|include a description of work in progress such as pending grants or manuscripts in preparation |
|Description of contributions to Teaching and Education (if not your area of excellence). This may include a description of mentorship activities not |
|discussed elsewhere in the CV |
|Description of contributions in Significant Supporting Activities, if any |
|A final paragraph that integrates and summarizes the contributions described above |
|I am the Co Director of the multidisciplinary Pancreas Center at the Beth Israel Deaconess Medical Center. I see patients for a second opinion, from within|
|Massachusetts and well as out of state with an established diagnosis of pancreatic disease as well as patients with unexplained chronic abdominal pain. I |
|personally take care of more than 200 patients with chronic pancreatitis, or those with abdominal pain thought to be from chronic pancreatitis, recurrent |
|acute pancreatitis, autoimmune pancreatitis, pancreatitis associated with mutations of cystic fibrosis gene and patients with cystic neoplasms of the |
|pancreas. In addition to providing consultative service in the Pancreas Center, I am actively involved in several clinical and translational research |
|projects including examining the role of MR secretin pancreatography and endoscopic pancreatic secretin stimulation testing in patients with chronic |
|pancreatitis and unexplained abdominal pain. Our research has shown that endoscopic pancreatic secretin stimulation is a very sensitive test in detecting |
|early chronic pancreatitis in patients with normal radiologic and endoscopic testing. Approximately forty percent of patients with normal imaging studies |
|and suspected chronic pancreatitis who have abnormal secretin tests, when followed prospectively, developed imaging abnormalities at a median of two year |
|follow up. |
| |
|I am an active member of our world renowned celiac center and follow more than 400 patients with an established diagnosis of celiac disease. As a celiac |
|center clinician I see patients from all over New England and from other parts of the country. I am a co-investigator in several research projects |
|including treatment of refractory celiac disease with mesalamine, disorders mimicking celiac disease, HLA testing in celiac disease and the impact of |
|socioeconomic status on management of celiac disease. |
| |
|My research on cystic fibrosis (CF) gene mutations and liver disease established a novel link to primary sclerosing cholangitis (PSC). We showed that a |
|very high proportion of patients with inflammatory bowel disease and PSC had disease causing CF mutations. These findings lead to a collaborative study |
|with the Mayo Clinic to examine the role of docosahexaenoic acid (DHA) in the treatment of PSC. This was also based on the fact that our prior research |
|had shown that CF homozygous and heterozygous mice with chemical colitis developed changes mimicking PSC. Some of these changes could be reversed by |
|administration of DHA. |
| |
|I have an active interest and advanced training in endoscopy. I am also the lead teacher in endoscopic techniques for fellows. Active research in advanced |
|endoscopy and quality improvement includes projects examining adenoma detection rates at index colonoscopy as well as predicting polyp histology non |
|invasively at colonoscopy using narrow band imaging. |
| |
|I am one of the leading clinician-educators of our Gastroenterology Division and play a pivotal role in training GI fellows. For the past 8 years I have |
|a) trained our second year GI fellows in endoscopic procedures one day per week and b) have been a primary mentor to the third year GI fellows in out |
|patient clinics as well as endoscopy sessions 3 days each week. During these sessions I have provided ongoing training in general Gastroenterology and |
|Hepatology consultations as well as advanced training in pancreatology and in celiac disease. I also provide our GI trainees with advanced training in |
|therapeutic endoscopy including stricture dilatation, removal of large polyps, endoscopic mucosal resection, control of active bleeding with new hemostasis|
|techniques and placement of wireless pH probes. I also play a major role in teaching Harvard medical students and rotating medical residents on a regular |
|basis on the GI consult service and in the out patient clinics. |
| |
|In summary, I am an established and well recognized clinician, educator and clinical investigator in the Division of Gastroenterology at the Beth Israel |
|Deaconess Medical Center. My special areas of focus and achievement lie in my GI clinical expertise and acumen, in education in general gastroenterology, |
|and in my advanced expertise in both pancreatology and celiac disease. I am proud and happy to act as a lead educator of future gastroenterology fellows |
|in both GI consultation and endoscopy skills. I am also actively and enthusiastically involved in translational research in pancreatic and celiac disease |
|research in collaboration with my colleagues at BIDMC and beyond. |
| |
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