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Supplementary table 1. Characteristics of MRI studies included in the meta-analysis.StudyImaging modality and analysis methodsNAge(SD)Gender(male%)Task (s)Group contrastsFociCorrection for multiple comparisonsCovariatesSON et al. (2018) ADDIN EN.CITE <EndNote><Cite><Author>Son</Author><Year>2018</Year><RecNum>2</RecNum><DisplayText><style face="superscript">[1]</style></DisplayText><record><rec-number>2</rec-number><foreign-keys><key app="EN" db-id="p220zsa5gvsvzyervp7p5wa6xd2wvz9da99r">2</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Son, Y. D.</author><author>Kang, J. M.</author><author>Cho, S. J.</author><author>Lee, J. S.</author><author>Hwang, H. Y.</author><author>Kang, S. G.</author></authors></contributors><auth-address>Department of Biomedical Engineering, College of Health Science, Gachon University, Incheon, Republic of Korea.
Department of Psychiatry, Gil Medical Center, College of Medicine, Gachon University, 21, Namdong-daero 774 beon-gil, Namdong-gu, Incheon, 21565, Republic of Korea.
Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Department of Radiology, Gachon University Gil Medical Center, Incheon, Republic of Korea.</auth-address><titles><title>fMRI brain activation in patients with insomnia disorder during a working memory task</title></titles><pages>487-493</pages><volume>22</volume><number>2</number><dates><year>2018</year><pub-dates><date>May</date></pub-dates></dates><isbn>1520-9512</isbn><accession-num>28980102</accession-num><urls><related-urls><url>;[1]Task fMRI21/2636.6 (9.8)/33.2 (7.1)43%/42%working memoryInsomnia > HC2uncorrected p < 0.001NRLI et al. (2018) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051
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ADDIN EN.CITE.DATA [3]Task fMRI14/1849.0 (12.3)/42.7 (12.3)29%/22%sleep-related stimuliInsomnia > HC6uncorrected p < 0.001six motion parametersHUANG et al. (2017) ADDIN EN.CITE <EndNote><Cite><Author>Huang</Author><Year>2017</Year><RecNum>13</RecNum><DisplayText><style face="superscript">[4]</style></DisplayText><record><rec-number>13</rec-number><foreign-keys><key app="EN" db-id="p220zsa5gvsvzyervp7p5wa6xd2wvz9da99r">13</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Huang, S.</author><author>Zhou, F.</author><author>Jiang, J.</author><author>Huang, M.</author><author>Zeng, X.</author><author>Ding, S.</author><author>Gong, H.</author></authors></contributors><auth-address>Department of Radiology, Jiangxi Province Children's Hospital.
Department of Radiology, The First Affiliated Hospital, Nanchang University.
Jiangxi Province Medical Imaging Research Institute, Nanchang, People's Republic of China.</auth-address><titles><title>Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title><alt-title>Neuropsychiatric disease and treatment</alt-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title><abbr-1>Neuropsychiatric disease and treatment</abbr-1></periodical><alt-periodical><full-title>Neuropsychiatr Dis Treat</full-title><abbr-1>Neuropsychiatric disease and treatment</abbr-1></alt-periodical><pages>1449-1462</pages><volume>13</volume><edition>2017/06/28</edition><dates><year>2017</year></dates><isbn>1176-6328 (Print)
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ADDIN EN.CITE.DATA [8]DTI23/3041.08 (10.50)/ 41.60 (9.48)43%/60% Insomnia < HC6FWE p <0.05LI et al. (2016) ADDIN EN.CITE <EndNote><Cite><Author>Li</Author><Year>2016</Year><RecNum>17</RecNum><DisplayText><style face="superscript">[9]</style></DisplayText><record><rec-number>17</rec-number><foreign-keys><key app="EN" db-id="p220zsa5gvsvzyervp7p5wa6xd2wvz9da99r">17</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Li, Y.</author><author>Liu, L.</author><author>Wang, E.</author><author>Zhang, H.</author><author>Dou, S.</author><author>Tong, L.</author><author>Cheng, J.</author><author>Chen, C.</author><author>Shi, D.</author></authors></contributors><auth-address>People's Hospital of Zhengzhou University, Zhengzhou, China.</auth-address><titles><title>Abnormal Neural Network of Primary Insomnia: Evidence from Spatial Working Memory Task fMRI</title><secondary-title>Eur Neurol</secondary-title><alt-title>European neurology</alt-title></titles><periodical><full-title>Eur Neurol</full-title><abbr-1>European neurology</abbr-1></periodical><alt-periodical><full-title>Eur Neurol</full-title><abbr-1>European neurology</abbr-1></alt-periodical><pages>48-57</pages><volume>75</volume><number>1-2</number><edition>2016/01/20</edition><keywords><keyword>Adult</keyword><keyword>Brain/physiopathology</keyword><keyword>Brain Mapping/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Magnetic Resonance Imaging/*methods</keyword><keyword>Male</keyword><keyword>Memory, Short-Term/*physiology</keyword><keyword>Middle Aged</keyword><keyword>Nerve Net/*physiopathology</keyword><keyword>Sleep Initiation and Maintenance Disorders/*physiopathology</keyword></keywords><dates><year>2016</year></dates><isbn>0014-3022</isbn><accession-num>26784899</accession-num><urls><related-urls><url>;[9]Task fMRI 30/3039.36 (8.53)/36.15 (8.61)57%/NRSpatialWorking MemoryInsomnia > HC5uncorrected p < 0.001Insomnia < HC9LI et al. (2016) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051
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ADDIN EN.CITE.DATA [18]PET7/2034.2 (8.9)/32.6 (8.4)43%/35%Insomnia < HC2p < 0.05global metabolism and ageAbbreviations: ALFF, amplitude of low-frequency fluctuation; DTI, diffusion tensor imaging; FDR, false discovery rate; fMRI, functional magnetic resonance imaging; FWE, family wise error; GM, grey matter; HC, healthy controls; MRI, magnetic resonance imaging; ReHo, regional homogeneity; rs-fMRI, resting-state?fMRI; VBM, voxel-based morphometry; WM, white matter.Supplementary table 2. ALE results for ID-related MRI meta-analysisCluster #Volume (mm3)Weighted Center (MNI)Extrema valueMaximum ALE value (MNI)SideBAAnatomical labelxyzxyzALE results for VBM studies (42 ID and 42 HC)HC > ID (42 foci, 2 experiments)148051.91531.50.1433794521532Right9Middle Frontal GyrusALE results for PET studies (51 ID and 60 HC)HC > ID (6 foci, 2 experiments)1264360-240.009739360-24RightAmygdala22641230-100.0097391230-10Right24Anterior Cingulate326412-40220.00973912-4022Right23Posterior CingulateALE results for DTI studies (51 ID and 65 HC)HC > ID (8 foci, 2 experiments)1744-200140.0090624-20014LeftPutamen2744200140.009062420014RightCaudate BodyALE results for rs-fMRI studies (ALFF) (127 ID and 115 HC)HC > ID (10 foci, 4 experiments)1552-43.7-35.5-14.20.008627-44-34-18Left20Fusiform Gyrus2256-57-3-270.008126-57-3-27Left21Middle Temporal Gyrus324056.8-62.9-30.0089657-63-3Right19Middle Temporal Gyrus422415-42-300.0084915-42-30RightAnterior Lobe5216-6-4860.008998-6-486Left29Posterior CingulateHC < ID (16 foci, 4 experiments)1256-2133-210.00896-2133-21Left11Middle Frontal GyrusALE results for rs-fMRI studies (ReHo) (83 ID and 71 HC)HC > ID (7 foci, 2 experiments)1288-42-39-90.008211-42-39-9Left36Parahippocampal Gyrus2288-361-50.009356-361-5LeftSub-lobar3288-3-90210.009356-3-9021Left18Cuneus4264-30-6540.010067-30-654Left6Precentral Gyrus522415-42-300.0084915-42-30RightAnterior Lobe62241242210.009705124221Right32Anterior Cingulate722433-12480.00970533-1248Right4Precentral GyrusHC < ID (3 foci, 2 experiments)1648-36-48-120.010067-36-48-12Left37Fusiform Gyrus26403-45360.0093563-4536Left31Precuneus34489-9360.0082119-936Right24Cingulate GyrusALE results for working memory-related studies (51 ID and 56 HC)HC > ID (7 foci, 2 experiments)1472-37.510.4-42.10.00887-3612-39Left38Superior Temporal Gyrus0.008279-399-45Left38Middle Temporal Gyrus22885127-60.0079695127-6Right47Inferior Frontal Gyrus3288-57-36-30.008569-57-36-3LeftMiddle Temporal Gyrus428824-81270.00856924-8127Right18Cuneus5256579-150.007713579-15Right38Superior Temporal GyrusAbbreviations: ALE, anatomic likelihood estimation; BA, Brodmann area; DTI, diffusion tensor imaging; fMRI, functional magnetic resonance imaging; HC, healthy controls; ID, insomnia disorder; MNI, montreal neurologic institute; rs-fMRI, resting-state?fMRI; VBM, voxel-based morphometry.Supplementary references: ADDIN EN.REFLIST [1]SON Y D, KANG J M, CHO S J, et al. fMRI brain activation in patients with insomnia disorder during a working memory task [J]. 2018, 22(2): 487-93.[2]LI G, ZHANG X, ZHANG J, et al. 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