Dfzljdn9uc3pi.cloudfront.net
Public Title:How low do you need to go? Comparing symptoms of diet induction and mood with outcomes from diets containing differing levels of carbohydrate restriction. Working Title /Scientific Title:Does a moderate carbohydrate restriction result in fewer symptoms of dietary induction and greater maintenance of mood, with comparable cardiometabolic results, when compared to more extreme carbohydrate restriction in healthy volunteers?Short Working Title:Comparing cardiometabolic outcomes to symptoms of diet induction and mood in low carbohydrate diets differing in the level of carbohydrate restriction. SummaryA 13-week, 3-arm, randomised trial comparing diets consisting of 5, 15, or 25% calories from carbohydrate, 20% calories from protein and the remainder from lipids. Primary outcomes are change from baseline of symptoms and mood, as measured by a symptoms questionnaire (Symptoms-Q), and Profile of Mood States (POMS-SF), taken on awakening, fasted. Secondary outcomes include change in cardiometabolic (CM) status as measured by change from baseline triglyceride (TAG) to HDL ratio; and TAG, total/LDL/non-HDL/HDL cholesterol, anthropometry (BF%), HbA1c, serum urate, and c-reactive protein. A one week lead-in will be used to determine baseline calories, and mood and symptoms scores, for comparison to completion measures. Calories from the lead-in week will be maintained throughout the study. Symptoms and mood questionnaire will be taken daily, along with BOHB for the first 20 days. CM measures will be repeated upon completion. Symptoms and mood scores will be aggregated and summarised into mean changes from baseline and analysed by treatment group using ANOVA and compared with multiple linear regression. For secondary outcomes, changes in biomarker concentrations and anthropometry will be analysed using ANOVA and multiple linear regression. Tests will be two-tailed and the type-1 error rate of 5% will be used to judge statistical significance.BackgroundReduced carbohydrate diets offer benefits for the prevention and adjunct treatment of health conditions ranging from neurological disorders, cancer, obesity, diabetes and other conditions on the spectrum of metabolic syndrome.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWZldnJlPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWZldnJlPC9BdXRob3I+PFllYXI+MjAwMDwvWWVhcj48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ADDIN EN.CITE.DATA 1-11 They are becoming increasingly popular for mainstream and athletic use for a range of outcomes including weight-loss and maintenance, ADDIN EN.CITE <EndNote><Cite><Author>Bueno</Author><Year>2013</Year><RecNum>98</RecNum><DisplayText><style face="superscript">12</style></DisplayText><record><rec-number>98</rec-number><foreign-keys><key app="EN" db-id="ts5d2zvxe29vvge5e2d5aazi0wr5vwwave25" timestamp="1382317411">98</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bueno,Nassib Bezerra</author><author>de Melo,Ingrid Sofia Vieira</author><author>de Oliveira,Suzana Lima</author><author>da Rocha Ataide,Terezinha</author></authors></contributors><titles><title>Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials</title><secondary-title>British Journal of Nutrition</secondary-title></titles><periodical><full-title>British Journal of Nutrition</full-title></periodical><pages>1178-1187</pages><volume>110</volume><number>07</number><keywords><keyword>Cardiovascular risk factors, Low-carbohydrate diets, Meta-analysis, Obesity, Weight loss</keyword></keywords><dates><year>2013</year></dates><isbn>1475-2662</isbn><urls><related-urls><url> and have been demonstrated to improved satiety and reduce hunger.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW9saTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QYW9saTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl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ADDIN EN.CITE.DATA 13-15 But adaptation from a standard diet to one low in carbohydrates can cause various unpleasant symptoms, ADDIN EN.CITE <EndNote><Cite><Author>Hartman</Author><Year>2007</Year><RecNum>100</RecNum><DisplayText><style face="superscript">16</style></DisplayText><record><rec-number>100</rec-number><foreign-keys><key app="EN" db-id="ts5d2zvxe29vvge5e2d5aazi0wr5vwwave25" timestamp="1382317887">100</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hartman, Adam L</author><author>Vining, Eileen PG</author></authors></contributors><titles><title>Clinical aspects of the ketogenic diet</title><secondary-title>Epilepsia</secondary-title></titles><periodical><full-title>Epilepsia</full-title></periodical><pages>31-42</pages><volume>48</volume><number>1</number><dates><year>2007</year></dates><isbn>1528-1167</isbn><urls></urls></record></Cite></EndNote>16 referred to in common parlance as ‘keto-flu’. These symptoms of carbohydrate restriction are assumed to provide a barrier to the use of, and compliance with low carbohydrate diets. However, these early-induction symptoms have not been well described in the scientific literature.So, at this time, it is not clear whether symptoms are related solely to keto-induction (i.e. in very low carbohydrate ketogenic diets) or are more generally, symptoms of carbohydrate withdrawal. Outcomes from ketogenic and non-ketogenic lower carbohydrate diets are likely to be similar ADDIN EN.CITE <EndNote><Cite><Author>Johnston</Author><Year>2006</Year><RecNum>1102</RecNum><DisplayText><style face="superscript">17</style></DisplayText><record><rec-number>1102</rec-number><foreign-keys><key app="EN" db-id="ts5d2zvxe29vvge5e2d5aazi0wr5vwwave25" timestamp="1454526987">1102</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Johnston, Carol S</author><author>Tjonn, Sherrie L</author><author>Swan, Pamela D</author><author>White, Andrea</author><author>Hutchins, Heather</author><author>Sears, Barry</author></authors></contributors><titles><title>Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets</title><secondary-title>The American Journal of Clinical Nutrition</secondary-title></titles><periodical><full-title>The American journal of clinical nutrition</full-title></periodical><pages>1055-1061</pages><volume>83</volume><number>5</number><dates><year>2006</year><pub-dates><date>May 1, 2006</date></pub-dates></dates><urls><related-urls><url> and the degree to which people experience symptoms of carbohydrate withdrawal or keto-induction is also likely to influence compliance. For many, it may not be necessary to restrict carbohydrate to the degree necessary to achieve ketosis, especially if the symptoms resulting from extreme carbohydrate restriction are disproportionate to the beneficial outcomes from the diet. This has not been investigated and this study will seek to address this important clinical topicStudy Hypothesis:A moderate restriction of carbohydrate results in fewer symptoms of dietary induction and greater tolerance and adherence to diet, with comparable results for cardiometabolic outcomes when compared to more extreme carbohydrate restriction. Primary outcome: Symptoms and mood Primary outcome measures: Daily Symptoms-Q, sum of symptoms score; and POMS-SF, total mood disturbance score (TMDS), taken on awakening, before breakfast. Change from baseline. Covariates/Potential confounders: Gender, age, BMI, BF%, baseline CHO/sugar intake, medications, medical conditions, smoking status, alcohol intake.[i.e. as related to hypothesis; symptoms of keto-induction / carb-withdrawal are going to be lower in the moderate group than in the more severe]Secondary Outcomes: Change in cardiometabolic markers Secondary outcome measures: Primary measure for secondary outcome: Change from baseline (TAG/HDL ratio). Also: triglycerides, total/LDL/non-HDL/HDL chol., anthropometry (BF%), HbA1c, serum urate, CRP MethodsA randomised, three-armed, single blinded, trial. Data to be collected at AUT MillenniumRecruitment144 participants will be recruited from the networks of the four researchers, including from Auckland University of Technology at Millennium Institute of Sport and Health (AUT-MISH) (Albany, New Zealand) to participate in the trial. As the focus of this research is not ‘sensitive’, a ‘snowball recruitment’ approach is appropriate, encouraging applicants to share the advertisement for participants amongst their respective networks (for example via social media). ADDIN EN.CITE <EndNote><Cite><Author>National Science Foundation</Author><Year>N.D</Year><RecNum>182</RecNum><DisplayText><style face="superscript">18</style></DisplayText><record><rec-number>182</rec-number><foreign-keys><key app="EN" db-id="ts5d2zvxe29vvge5e2d5aazi0wr5vwwave25" timestamp="1408681452">182</key></foreign-keys><ref-type name="Web Page">12</ref-type><contributors><authors><author>National Science Foundation,</author></authors></contributors><titles><title>How should research involving "snowball samples" be handled from a human subjects perspective?</title></titles><volume>2014</volume><number>22/8/2014</number><dates><year>N.D</year></dates><pub-location>Arlington, Virginia, USA</pub-location><publisher>National Science Foundation,</publisher><urls></urls></record></Cite></EndNote>18 The power calculation for participant numbers is based on the findings of the pilot study: The effect of medium chain triglycerides on time to nutritional ketosis and symptoms of keto-induction in healthy adults (manuscript submitted for publication). The primary outcome chosen for this power calculation is change in POMS-TMDS from baseline. This measure was chosen as a validated questionnaire that is fit for our purpose of evaluating the effect of dietary induction on participants. In the pilot study the mean POMS-TMDS was -11.4 in the control group (SD: 17.3) and -5.1 (SD: 7.2) in the experimental. We expect to see lowest mood disturbances in the NKLCD arm of the study compared to the VLCKD arm. Assuming the ketogenic arm has a change from baseline of 11.4 (SD 17.4) and the minimum change in the NK arm is +9.2 units higher with a restricted SD, as seen in the pilot (SD 7), then 36 participants per arm is required to detect this difference with a false positive (α) rate of 5% and false negative of (β) 20%. We will allow for 48 per group to allow for dropouts based on pilot. Criteria for inclusion: Non-obese, non-diabetic, between the ages of 25 and 49. Exclusion: BMI <19 or >30, diagnosed metabolic condition such as diabetes, or cardiovascular disease, chronic kidney or liver disease. Pregnancy or breastfeeding. Habitual intake of >40% calories from carbohydrate.Lead-in weekA one-week lead-in phase will be carried out, in which participants will record dietary intake using a phone and web-based application, ‘Fat Secret’ Professional’, and complete a daily questionnaire and record fasting blood BOHB and the online questionnaire described below, on awakening. Participants will be instructed to not substantively change activity levels for the duration of the entire study period, and thus, differences in activity will be accounted for by the baseline information collected. The lead-in phase will provide baseline characteristics of the habitual eating of the participants and of their mood-state and any symptoms they are currently experiencing. It will also familiarise the participants with the blood-prick measures, online questionnaires and the use of the food tracking app. RandomisationParticipants will be allocated into one of three groups by a randomised sequence prepared by the study statistician and given a sealed envelope with their diet allocation.Intervention groupsAfter the lead-in, participants will be assessed at baseline for:Blood lipid and cardiometabolic profile including TAG, total cholesterol, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), c-reactive protein (CRP), glycated haemoglobin (HbA1c).Anthropometric assessments; weight, waist girth measurement, hip girth measurement, waist to hip ratio. Participants will be instructed on the dietary interventions by a qualified and registered clinical nutritionist and dietitian, with meal plans provided. Blood measures and anthropometric assessment will also be carried out at the conclusion of the study for comparison to baseline measures. Average daily calorie intake per person will be calculated from data collected during the lead-in phase and this intake will be maintained over the study duration. Participants will continue to track their diets using ‘Fat Secret Professional’ for 20 days, attempting to meet targets for carbohydrate, protein and lipids based on their prescribed diets. Diets will consist of the following targets, individualised to each participant in grams per day, based on their baseline, habitual calorie consumption.ProteinCarbFatVery Low Carbohydrate Ketogenic Diet~20%5%~75%Modified Ketogenic Diet~20%15%~65%Non-ketogenic Low Carbohydrate Diet~20%25%~55%Participants will be provided with a nutrition plan and calorie and macronutrient prescription but they will also have freedom to choose meal timing and frequency, so long as they are adhering to the calorie and macronutrient guidelines in their plan. Blood BOHB measures will continue to be taken daily for the first twenty days of the study, in the morning upon waking (fasted). Participants will also complete a daily questionnaire in the morning upon rising, consisting of a ketogenic diet questionnaire (Symptom-Q) previously developed by the author and Profiles of Mood States, short-form questionnaire (POMS-SF), for the entire study duration, along with daily weight measure. They will also be instructed to continue to continue where able, to track daily calories. From day 20 onwards, participants will be instructed to continue their carbohydrate allocation, as a percentage of ad libitum calories, as best able. Explanation of daily measures: Beta-hydroxybutyrate (BOHB). Participants will be provided with a ‘FreeStyle Neo’ blood-prick ketometer/glucometer (Abbott Industries). Participants will be required to use the device (by way of a personal blood prick) to measure and record BOHB daily upon waking. Taken for the first twenty days. Online survey. Indicators of general and psychological health and subjective symptoms of carbohydrate withdrawal will be evaluated by a daily electronic (online) survey, using Typeform software which will include: 1) a modified 5-point mood scale and 2) a carbohydrate restriction symptoms questionnaire using a Likert Scale (developed by the primary researcher). The symptoms checklist will be used to monitor the commonly observed symptoms resulting from carbohydrate withdrawal, namely constipation, headache, halitosis, muscle cramps, diarrhoea, general weakness and rash.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5jeTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ZYW5jeTwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA 20Data analysisSubjects will be compared with regard to baseline variables by treatment allocation arm to check for balance. Exploratory data analysis will consider the variation in different facets of the symptom scores with time from commencing the diet, by treatment arm, and by sociodemographic and clinical characteristics. Correlation between individual items in the score and baseline characteristics will be undertaken using principal components and biplots. Similar analyses will be carried out for associations between. Daily symptoms scores will be aggregated and summarised into mean changes from baseline. These changes will then be analysed by treatment group using ANOVA. These analyses will be compared with multiple linear regression, with baseline characteristics included in the regression model. Similarly, for secondary outcomes, changes in biomarker concentrations and anthropometry will be analysed using ANOVA and multiple linear regression. Linear mixed effects models, with within individual All tests will be two tailed and the type-1 (false positive) error rate of 5% will be used to judge statistical significance. References ADDIN EN.REFLIST 1.Lefevre F, Aronson N. Ketogenic Diet for the Treatment of Refractory Epilepsy in Children: A Systematic Review of Efficacy. Pediatrics. 2000;105(4):e46.2.Keene DL. A Systematic Review of the Use of the Ketogenic Diet in Childhood Epilepsy. Pediatric Neurology. 2006;35(1):1-5.3.Levy RG, Cooper PN, Giri P, Pulman J. Ketogenic diet and other dietary treatments for epilepsy. The Cochrane Library. 2012.4.Henderson CB, Filloux FM, Alder SC, Lyon JL, Caplin DA. Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis. Journal of Child Neurology. 2006;21(3):193-8.5.Neal EG, Chaffe H, Schwartz RH, Lawson MS, Edwards N, Fitzsimmons G, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. The Lancet Neurology. 2008;7(6):500-6.6.Paoli A, Rubini A, Volek J, Grimaldi K. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. European journal of clinical nutrition. 2013;67(8):789-96.7.Sumithran P, Proietto J. Ketogenic diets for weight loss: A review of their principles, safety and efficacy. Obesity Research & Clinical Practice. 2008;2(1):1-13.8.Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain research reviews. 2009;59(2):293-315.9.Castro K, Faccioli LS, Baronio D, Gottfried C, Perry IS, dos Santos Riesgo R. Effect of a ketogenic diet on autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders. 2015;20:31-8.10.Varshneya K, Carico C, Ortega A, Patil CG. The Efficacy of Ketogenic Diet and Associated Hypoglycemia as an Adjuvant Therapy for High-Grade Gliomas: A Review of the Literature. Cureus. 2015;7(2):e251.11.Kulak D, Polotsky AJ. Should the ketogenic diet be considered for enhancing fertility? Maturitas. 2013;74(1):10-3.12.Bueno NB, de Melo ISV, de Oliveira SL, da Rocha Ataide T. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. British Journal of Nutrition. 2013;110(07):1178-87.13.Paoli A, Bosco G, Camporesi E, Mangar D. Ketosis, ketogenic diet and food intake control: a complex relationship. Frontiers in Psychology. 2015;6.14.McClernon FJ, Yancy WS, Jr., Eberstein JA, Atkins RC, Westman EC. The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms. Obesity (Silver Spring, Md). 2007;15(1):182-7.15.Johnstone AM, Horgan GW, Murison SD, Bremner DM, Lobley GE. Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum. The American Journal of Clinical Nutrition. 2008;87(1):44-55.16.Hartman AL, Vining EP. Clinical aspects of the ketogenic diet. Epilepsia. 2007;48(1):31-42.17.Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears B. Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. The American Journal of Clinical Nutrition. 2006;83(5):1055-61.18.National Science Foundation. How should research involving "snowball samples" be handled from a human subjects perspective? Arlington, Virginia, USA: National Science Foundation,; N.D [19.Shacham S. A Shortened Version of the Profile of Mood States. Journal of Personality Assessment. 1983;47(3):305-6.20.Yancy WS, Jr., Olsen MK, Guyton JR, Bakst RP, Westman EC. A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial. Annals of Internal Medicine. 2004;140(10):769-77. ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related download
- cbq no 14 what life style changes can the client who is
- for immediate release prweb
- a 45 year old female presents with a complaint of
- foundations of personal fitness
- adults with eating disorders management of inpatients
- health safety risk review state
- high blood pressure
- healthy living and understanding your body
Related searches
- personal financial management marine net pdf
- company net worth lookup
- comenity net dental first financing
- marine net financial management pdf
- amazon net sales 2017
- average net profit small business
- amazon net profit 2018
- marine net personal finance answers
- hong kong net scheme
- business net worth lookup
- free net worth search
- company net worth search