ICU SEDATION GUIDELINES

Diazepam has a long half-life and is hepatically metabolized to several active metabolites. Propofol is classified as a short acting sedative-hypnotic agent and is useful in the management of refractory intracranial hypertension; however, its ability to reduce ICP is dose dependent (>50 mcg/kg/min). Its use has been associated with hypotension ... ................
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