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NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGACTIVYL:INDOXACARBCats and kittens from 8 weeks of age and older and who weigh 2lbs and greater.Dogs and puppies from 8 weeks of age and older who weigh 4lbs and greater.R: TopicalF: Apply topically once every 4 weeksOnce ingested by the flea, enzymes within the flea are converted to a molecule that is more active.Blocks sodium channels in the nervous system of the flea, causing paralysis and death.?Product only becomes highly active after contact with flea enzyme within the flea itself?.Cessation of feeding, paralysis, and death of adult fleas occurs in 8 to 12 hours after treatment.?Also kills developing stages of fleas in the environment of treated dogs and cats, and prevents flea eggs from developing into larvae or biting adults.Hyper-salivation may occur if animal licks application site immediately after application (correct application will minimize this). ?Sensitive pets may experience temporary irritation and dermatitis at the site of application.Local, temporary oily appearance or hair clumping at application site, or white residue are all normal and will general resolve a few days after application.Clinical signs: squinting, head shaking, salivation, or scratching and rubbing the site of application or face have been?reported.This product only treats for fleas.?Ask your veterinarian about Activyl Tick Plus for dogs.Care should be taken to apply the dose where it will not be licked off and ensure that pets do not groom each other after application.Do not allow animal to swim or be bathed within 48 hours after application.Do not eat, drink, or smoke while handling this product.Wash hands immediately after use.SAFETY HAS NOT BEEN ESTABLISHED IN PREGNANT OR LACTATING DOGS OR CATS?OR IN DOGS OR CATS?INTENDED FOR BREEDING.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGadvantage multi:?imidacloprid + moxidectin-508033591500Cats and kittens from 9 weeks of age and weighing greater than 2lbs.Dogs and puppies from 7 weeks of age and weighing greater than 3lbs.R: TopicalF: Apply topically once every 4 weeksMoxidectin is used for prevention and control of heartworms and intestinal worms by disrupting nerve transmission resulting in paralysis and death of parasite.?Imidacloprid acts on the nervous system of the flea to cause paralysis and then death.??Kills fleas and ticks within 12 hours.Cats:?LethargyBehavioral changes (agitated, hiding, excessive grooming)Discomfort (scratching, rubbing, head shaking)Hyper-salivation within 1 hour after applicationPolydipsia (excessive drinking)Coughing/gaggingDogs:PruritusResidueMedicinal odorLethargyLack of appetiteHyperactivityCats:Fleas: adultHookworm: adult, immature, fourth stage larvaeRoundworm: adult, fourth stage larvaeEar mitesHeartwormDogs:Fleas: adultSaroptic mangeHeartworm: prevents, and kills L3 and L4 larvaeMicrofilariaRoundworms?: adult, fourth stage larvaeRoundworms?: adultHookworms?: adult, immature, fourth stage larvaeWhipworms: ?adultFerrets:Fleas: adultHeartworm: preventsDo not use on sick, debilitated, or underweight animals.Cats may experience hyper-salivation, tremors, vomiting, and decreased appetite.Do not administer orally.For the first 30 minutes after application, do not allow animal to lick the product from the application site on themselves or other animals.Dogs may experience depression, salivation, dilated pupils, incoordination, panting, generalized muscle tremorsSAFETY HAS NOT BEEN ESTABLISHED IN PREGNANT OR LACTATING DOGS, CATS, OR FERRETS?OR IN DOGS, CATS OR FERRETS?INTENDED FOR BREEDING.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGBRAVECTO:fluralanerDogs?and puppies 6 months of age or older and who weigh at least 4.4lbs or more.R: Oral chew for dogs.F: ?Given orally once every 12 weeks.Once given orally, within 2 hours, existing fleas and ticks begin to take up the fluralaner.?The uptake of the killing agent causes nerve overstimulation and inhibits their nervous?system, causing death.Within 12 hours more than 98% of fleas are killed and more than 98.3% of ticks are killed.Starts working within 2 hours, kills 100% of fleas in under 12 hours.Vomiting?Decreased appetiteDiarrheaLethargyExcessive thirstFlatulenceFleas: adult?Ticks: black-legged tick, American dog tick, brown dog tick, lone star tick (only 8 week protection with lone star tick)Keep out of reach of children and pets.?Do not eat, drink, or smoke while handling.Wash hands after handling.Not been shown to be effective for 12 week duration in puppies less than 6 months of age.Not effective against lone star tick after 8 weeks.Safe for pregnant, breeding, and lactating dogs.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGCapstar:?nitenpyramCats and kittens 4 weeks of age and older, weighing at least 2lbs or more. ?Dogs and puppies 4 weeks of age and older, weighing at least 2lbs or more.R: OralF: Given orally on any day that live fleas are spotted. Can be given on any subsequent day when fleas are again evident.Bind and inhibit the flea specific nicotinic acetylcholine receptors. ?Interferes with normal nerve transmission and leads to the death of the flea.Starts working within 30 minutes of dosing, and continues to work for 24 hours after.Excessive panting?VomitingItchingLack of appetiteDiarrheaHyperactivity or lethargyNervousnessSeizures and tremblingOnly fleas are affected by this product.Keep out of reach of children and pets. ?Wash hands after handling.Check with veterinarian if needing to dose multiple days in a row.Safe for use in pregnant, breeding, and nursing bitches and queens.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGCERTIFECT:FIPRONIL + (S)-METHOPRENE + AMITRAZ Product DiscontinuedNAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGCheristin:?spinetoramCats and kittens who are 8 weeks or older and weighing 1.8lbs or more.R: TopicalF: Apply topically once every?4 weeks.Spinetoram kills fleas fast by activating nicotinic acetylcholine receptors, resulting in the fleas death.Starts working within 30 minutes of application.?Kills 100% of adult fleas within 12 hours.Application site hair loss?Hair change (greasy, clumping, matting)RednessInflammation and itchingInactivityVomitingLack of appetiteAdult fleas are the only parasite affected.Keep out of reach of children and pets.SAFETY HAS NOT BE TESTED IN PREGNANT, NURSING, OR BREEDING CATS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGComfortis: SpinosadCats and kittens 14 weeks and older, who weigh 2lbs or greater.?Dogs and puppies 14 weeks and older (no weight limit given).Oral tabletRemains effective for 30 daysWhen the fleas ingest the spinosad, the drug selectively targets the nervous system of the fleas, which causes the fleas to have involuntary muscle contractions and tremors. ?Induces excitation then leads to prostration of the affected flea, paralysis, and death.Starts killing fleas in 30 minutes with 100% killed in 4 hours.Cats:Vomiting?LethargyDecreased appetiteWeight lossDiarrheaDogs:VomitingDepression/lethargyDecreased appetiteIncoordinationDiarrheaItchingTremblingExcessive salivationSeizuresFleas onlyUse caution in?dogs with pre-existing epilepsy.Dogs: Use with caution in breeding females.? The use in breeding males as not been evaluated.?Cats: ??Safety has not been evaluated in breeding, nursing, or pregnant cats.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGECTOADVANCE FOR CATS:Fipronil +(S)-methopreneProduct DiscontinuedNAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGECTOADVANCE PLUS:FIPRONIL + (S)-METHOPRENEDogs and puppies 8 weeks and older and weighing 4lbs or greaterCats and kittens 8 weeks of age and older and weighing 1.5lbs or greaterTopicallyApply topically every 4 weeksFipronil works by affecting the parasite's nervous system which causes paralysis and then death.?Methoprene prevents the parasites from maturing into functioning adults.Kills 100% of adult fleas within 12 hours.?100% of all ticks and chewing lice within 48 hours.Dogs may experience some temporary irritation at the site of product application such as redness , scratching or other signs of discomfortFleas: kills flea eggs,?flea larvaeTicksChewing liceKeep cats away from treated dogs for 24 hours. ?Do not use on rabbits or animals other than cats or dogs.Safe for pregnant, nursing, and breeding dogs.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGEFFITIX:fipronil + permethrinDogs and puppies 12 weeks of age and older and weighing 5lbs or ically.Apply ever 4 weeks.Fipronil works by affecting the parasite's nervous system which causes paralysis and then death. ?Permethrin kills the parasites that live on the skin.99.6% of fleas killed within 12 hours.Temporary irritation at the site of applicationKills fleas?Kills ticksKills mosquitosKills liceAids in control of sarcoptic mangeCertain medications can interact with pesticides, talk to your veterinarian before applying this product.?Consult with a veterinarian and use Effitix cautiously on medicated, debilitated, aged, pregnant/nursing dogs, or animals known to be sensitive to pesticidesSAFETY HAS NOT BEEN TESTED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGFRONTLINE PLUS:Fipronil +?(S)-methopreneDogs and puppies 8 weeks or older and weighing at least 5lbs.?Cats and kittens 8 weeks or older and weighing over 1.ically.Apply every 4 weeks.Fipronil works by affecting the nervous system of the parasite which causes paralysis and then death.Methoprene works by prevents the parasites from reproducing. It interferes with the insect growth and development.12 to 24 hoursTemporary irritation at the site of applicationFleas: adults, eggs, larvae ?Prevents all stages (eggs, larvae, pupae) from formingTicks: kills all stages of ticksLice: Rapidly eliminates chewing liceMites: Aids in control of sarcoptic mange infestationsConsult a veterinarian before using on medicated animals, animals using this product with other pesticides, and debilitated, or aged animalsSafe in pregnant, nursing, and breeding dogs.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGHEARTGUARD FOR CATS:IVERMECTINCats and kittens 6 weeks of age and older. No weight requirements noted.Chewable tablet.Give once every 4 weeks.Ivermectin works by paralyzing the offspring of most adult worms, resulting in death.No speed of kill givenVomiting?DiarrheaAgitationLoss of appetiteStaggeringDilated pupilsTremorsBlindnessDisorientationEliminates tissue stage of heartworm larvae?Removal and control of adult and immature hookwormsBe cautious with concentrations. Products available online are often concentrated for large animal use, not small animals.Safe to use in pregnant and nursing cats. Safety not tested in breeding.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGHEARTGUARD PLUS FOR DOGS:IVERMECTIN + PYRANTELDogs and puppies 6 weeks of age and older no weight requirements givenChewable tablet.Give once monthly.Ivermectin works by paralyzing the offspring of most adult worms, resulting in death. ?Pyrantel works by making the worms unable to move so the body can naturally remove them?in the stool.No speed of kill given.DepressionLethargyVomitingAnorexiaDiarrheaMydriasisAtaxiaStaggeringConvulsionsHypersalivationTissue stage of heartworms?Treatment and control of ascarids and hookwormsCollie breeds are more sensitive to ivermectin.If not using year round, the last dose should be given 30 days after the last exposure to mosquitosSafe in pregnant, nursing, and breeding dogs.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGIVERHART MAX:ivermectin + pyrantel pamoate + praziquantelDogs and puppies 8 weeks of age and older and weighing at least 6lbs.Oral.Every 4 weeks.Ivermectin works by paralyzing the offspring of most adult worms, resulting in death. ?Pyrantel works by making the worms unable to move so the body can naturally remove them?in the stool.?Praziquantel works by eliminating the tapeworm's ability to prevent digestion from the host and then disintegrate and get absorbed by your pet's body.No speed of kill given.LethargyLimpnessSalivationShakingDiarrheaDecreased appetiteLicking lipsBelchingRoundworms?HookwormsTapewormsPrevention of heartwormsAll dogs should be tested and negative for heartworm before starting preventative?Use with caution in sick, debilitated, or underweight animals and dogs weighing less than 10lbsUse with caution in collie breedsSAFETY HAS NOT BEEN TESTED IN PREGNANT, NURSING, OR BREEDING DOGSNAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGNEXGARD:afoxolanerDogs and puppies 8 weeks of age and older and weighing 4lbs and greater.Oral tablet.Give every 4 weeks.Binds to the nerve and muscle cells, which blocks the transmission of neural signals?Affected parasites are paralyzed and then die.Kills 100% of fleas within 24 hours.VomitingDry/flaky skinDiarrheaLethargyLack of appetiteKills fleasBlack-legged (deer) tickAmerican dog tickLone star tickBrown dog tickUse with caution in dogs with a history of seizures.SAFETY IN PREGNANT, NURSING, BREEDING DOGS HAS NOT BEEN TESTED.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGPREVENTIC COLLAR:AmitrazDogs and puppies over 12 weeks of age, not weight limit given.Collar.Change collar every 90 days.Amitraz rapidly paralyzes the ticks mouth parts before killing the tick.Reaches full effectiveness in 48 hours.IncoordinationSlow heart rateLow body temperatureHigh blood sugar levelsKills ticksDoes not kill fleas?Consult a veterinarian before using on debilitated, aged, or medicated dogs.Do not allow dogs to ingest any part of the collarDo not use on catsPets taking MAOI drugs, tricyclic antidepressants, selective serotonin reuptake inhibitors or pressor agentsUse with caution in diabetic petsSAFETY HAS NOT BEEN TESTED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGPROGRAM:lufenuronDogs and puppies over 4 weeks of age?Cats and kittens over 6 weeks of ageOral suspension or chewable tablet.Give once every 4 weeks.Adult fleas will ingest the product and then pass it on to their eggsInhibits the production of chitin in insects?Without chitin a larval flea will not be able to develop a hard outer shellDoes not kill fleasMild sedation within 24 hours after applicationSkin may become irritated around collar locations. ?Allergic reaction (difficulty breathing, swelling of the lips, tongue or face)HivesBreaks the flea cycle at the egg stages.?Concurrent use of adulticidal insecticides may be used to control adult fleas.Does not kill adult fleas?Administer with foodSAFETY HAS NOT BEEN TESTED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGREVOLUTION:SELAMECTINDogs and puppies at least 6 weeks of age or older and weighing 5lbs or greater.Cats and kittens at least 8 weeks of age and weighing 5lbs or greater.?Topically.Apply once every 4 weeks.Selamectin works by attacking the nervous system of parasites by mimicking an important amino acid that is critical for the control of chloride ion channels. ?This allows chloride ions to flow freely into the nerve cells, and causes paralysis which eventually leads to their deathNo specific answer, some sites say 98% kill within?36 hours.Hair loss at the site of application with or without inflammationVomitingDiarrhea with or without bloodAnorexiaLethargySalivationRapid breathingPruritusUrticariaErythemaAtaxiaFever?Rare reports of seizures in dogsFor dogs: fleas, ticks, ear mites, sarcoptic mange mitesFor Cats:? fleas, ear mites, hookworms, roundwormsDo not use on sick, weak, or underweight animals?Prior to administration, dogs should be tested for heartwormsSafe in pregnant, nursing, and breeding dogs.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGSCALIBOR:DeltamethrinDogs and puppies 12 weeks of age and older.?Collar.Change collar every 6 months.Slow release actions releases the Deltamethrin every time the dog moves and creates friction. It mixes with the natural oils of the dogs body.?Deltamethrin works through contact and ingestion. It disrupts the insects normal nervous system function.Kills 98% of ticks within 24 hours.?No adverse reactions found on product label other than "skin sensitivities may occur". ?Ticks?FleasRepels mosquitos for up to 6 monthsDo not use on debilitated, aged,?or medicated dogs until consulting with veterinarian.?If sensitivities occur, remove collar immediately and bathe dog with a mild soap and large amounts of water.Be sure to wipe collar off with damp cloth prior to applying, and make sure you are able to easily slide two fingers under collar once applied.Cut the extra collar?2 inches from the buckle, wrap the excess in newspaper, and place in trash.Do not use in cats.SAFETY HAS NOT BEEN TESTED IN PREGNANT, BREEDING, OR NURSING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGSENTINEL SPECTRUM:milbemycin oxime + lufenuron + praziquantelDogs and puppies 6 weeks of age and older, who weigh 2lbs or greater.Oral chewable tablet.Give once every 4 weeks.Milbemycin oxime, one of the active ingredients, is a macrocyclic anthelmintic which interferes with invertebrate neurotransmission.?It eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm.Lufenuron, the other active ingredient, is an inset development inhibitor which breaks the life cycle.It interferes with chitin synthesis, polymerization, and deposition. Does not affected adult fleas, but when a female flea bites, it consumes the blood meal containing Lufenuron and then transmits that to the eggs, which are then not able to hatch or turn into mature adults.Praziquantel works by causing severe spasms and paralysis in the worms muscles. The worms will either be destroyed in the intestine, or will be passed in the stool.No speed of kill given.?Vomiting?DiarrheaDepression/lethargyPruritisUrticariaAnorexiaSkin congestionAtaxiaConvulsionsSalvationWeaknessPrevents flea eggs from hatching?HeartwormsRoundwormsHookwormsWhipwormsTapewormsDogs should be tested for heartworm prior to administrating.?Should be given with a meal or immediately after to provide best possibly absorption.SAFETY HAS NOT BEEN STUDIED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGSENTINEL:milbemycin oxime + lufenuronDogs and puppies 4 weeks of age and older, and who weigh 2lbs or greater.Oral chewable tablet.Give once every 4 weeks.Milbemycin oxime, one of the active ingredients, is a macrocyclic anthelmintic which interferes with invertebrate neurotransmission.?It eliminates the tissue stage of heartworm larvae and the adult stage of hookworm, roundworm, and whipworm.Lufenuron, the other active ingredient, is an inset development inhibitor which breaks the life cycle.It interferes with chitin synthesis, polymerization, and deposition. Does not affected adult fleas, but when a female flea bites, it consumes the blood meal containing Lufenuron andthen transmits that to the eggs, which are then not able to hatch or turn into mature adults.No speed of kill given.?Vomiting?Depression/lethargyPruritisUrticariaDiarrheaAnorexiaSkin congestionAtaxiaConvulsionsWeaknessHypersalivationPrevents flea eggs from hatching?HeartwormsRoundwormsHookwormsWhipwormsDogs should be tested for heartworm before administrating.Does not kill adult fleas, may need to use concurrently with an adulticide.To ensure adequate absorption, should be given with or just after a meal.Can be used safely in pregnant, nursing, and breeding dogs (male and female).NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGSeresto:flumethrin + imidacloprid139707442200Cats and kittens 10 weeks of age and older.Small dogs and puppies 7 weeks of age and older weighing up to 18lbs.Dogs and puppies 7 weeks of age and older weighing over 18lbs.R: Topically as a collar.F: Apply a fresh collar every 8 months.Flumethrin acts on he membrane of the nerve cells and blocks the closing of the ion gates of the sodium channel, this disrupts the transmission of nervous impulses.Flumethrin causes the parasites to become paralyzed and then eventually die.Imidacloprid works by interfering with the transmission of nerve impulses in insects by binding to nicotinic acetylcholine receptors.Fleas are killed within 24 hours. Ticks are killed within 48 hours.ScratchingRednessHair lossInflammationDermatitisEczemaLesionsFleasTicks (repels and kills): Deer ticks, American dog ticks, Brown dog ticks, Lone star ticks.Chewing liceSarcoptic mange (treatment and control)Do not attach a leash to Seresto collar. ?Keep the collar in bag and outer package until use.Wash hands after handling.Ask veterinarian before using on debilitated, aged, breeding, pregnant, or nursing animals.For dogs that swim once or more a month, the effectiveness is reduced to 5 months of flea control and 7 months?of tick control.SAFETY HAS NOT BEEN TESTED ON PREGNANT, NURSING, OR BREEDING DOGS OR CATS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGSIMPATICO:?sarolaner??Dogs and puppies 6 months of age and older, and weighing 2.8lbs or greater.Chewable tablet.Give every 4 weeks, effective for 35 days.Sarolaner is an acaricide and insecticide belonging to the isoxazoline group.Sarolaner?stops the functions of the neurotransmitter GABA receptor and glutamate receptor, and works at the neuromuscular junction in the fleas and ticks.This creates uncontrolled neuromuscular activity leading to death in fleas and ticks.Starts killing fleas in 3 hours and ticks within 8 hours.VomitingDiarrheaFleasTicksDo not use in cats?Neurological signs include tremors, unsteadiness, and seizures.Do not use in dogs less than 6 months old.SAFETY HAS NOT BEEN EVALUATED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGTrifexis:?spinosad + milbemycin oximeDogs and puppies 8 weeks of age and older and weighing 5lbs or greater.R: OralF: Give orally once every 4 weeksThe Spinosad creates involuntary muscle contractions and tremors resulting from the activation of motor neurons. The prolonged hyper-excitement causes paralysis and flea death. ?The Milbemycin oxime portion will bind to the glutamate-gated chloride ion channels in nerve and muscle cells. This causes paralysis and death. It may also disrupt the transmission of invertebrate neurotransmitters.Begins to kill fleas within 30 minutes after administration, with 100% effectiveness within 4 hours.Vomiting?Depression/lethargyItchingDecreased appetiteDiarrheaFleas?Heartworm: preventionAdult hookwormAdult roundwormAdult whipwormUse with caution in dogs with pre-existing epilepsyDogs should be tested for heartworms before administeringUse with caution in breeding femalesSafety has not been tested in?breeding male dogsNAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGVectra 3d:Dinotefuran + Pyriproxyfen + permethrinDogs and puppies from 8 weeks of age and older and weighing 5lbs or more.R: TopicallyF: Apply topically once every 4 weeks.Once applied, the insecticide portion begins to kill the live parasites on the dog’s fur and skin. ?The Dinotefuran acts on nerve receptors and Permethrin, which mainly acts on ticks, interferes with the sodium channels on the nerves that plays the role of transmitting signals.The Pyriproxyfen is an insect growth regulator which puts a stop to the flea cycle by causing production of infertile eggs and also blocks development of young flea stages into adults.Starts reducing flea feeding in?5 minutes. Kills fleas in?6 hours.Application site irritation?RednessItchingFleas: adult, and prevents the development of all immature stages of fleas (eggs, larvae, pupae)?Ticks: brown dog ticks, American dog ticks, deer ticks, gulf coast ticks, lone star ticksMosquitosBiting and Sand FliesLiceMites (not mange mites)Do not use on debilitated, aged, or medicated cats until consulting veterinarian. ?Wash hands after handling.Do not eat, drink, or smoke while handling.Keep cats away from dogs for 24 hours to prevent them from grooming before product is absorbed.SAFETY HAS NOT BEEN TESTED IN PREGNANT, NURSING, OR BREEDING DOGS.NAMEFOR USE INROUTE/FREQUENCYMECHANISM OF ACTIONSPEED OF KILLADVERSE REACTIONSOTHER PARASITES AFFECTEDADDITIONAL PRECAUTIONSPREGNANT, NURSING, BREEDINGVectra for cats:?Dinotefuran + Pyriproxyfen-77724065659000Cats and kittens 8 weeks of age and older and who weigh 2lbs or greater.R: TopicalF: Apply topically once every 4 weeks.Once applied, part of the product contains an insecticide that starts killing the adult fleas.The product also contains an Insect growth regulator which does not outright kill the fleas, but instead it affects their ability to grow into functioning adult fleas.?IGR can either block the flea's ability to turn into an adult or it can cause it to change into an adult before it is physically able to reproduce.Starts killing fleas within 6 hours.Temporary irritation at application siteRednessItchingOnly kills adult fleas, flea eggs, flea larvae, and flea pupae.Do not use on debilitated, aged, or medicated cats until contacting veterinarian?Wash hands after handlingDo not eat, drink, or smoke while handlingSAFETY HAS NOT BEEN TESTED ON PREGNANT, NURSING, OR BREEDING CATS. ................
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