LACDR/BFW Lecture series (caputcolleges)
Master/Ph.D. Course
Pharmacogenomics
|Period: |December 3-7, 2007 (Ph.D.) |
| |December 3-14, 2007 (M.Sc.) |
|Co-ordinators: |Dr. E. Vreugdenhil/Dr. J. Meerman |
| |Tel. 071-5276230 |
| |e-mail: vreugden@lacdr.leidenuniv.nl |
|Language: |English |
|Venue: |Gorlaeus Lab, Einsteinweg 55, Leiden |
|Description |
|Central in pharmacogenomics research are the questions how drugs affect the genome and how the genome affects drug action |
|and disease. The sequencing of the human genome has led to a tremendous impact on pharmacological experimentation. Two main|
|findings in the human genome project turned out to be crucial for this development: Firstly, the sequence of all 25.000 |
|genes became known enabling large scale screening techniques such as DNA microarrays. Secondly, millions so-called single |
|nucleotide polymorphisms (SNP’s) are present in the human genome which are likely responsible for the individual genetic |
|vulnerability towards disease and towards drug therapy. |
|This course deals with established and novel methods in pharmacogenomic and pharmacogenetic research and their application |
|in drug target discovery & validation, and in ‘individualization’ of drug action. The research tools of genomics and |
|genetics will be covered by various lecturers active in these fields. Topics that will be discussed are microarrays, data |
|analysis, laser-capture of target tissue, epigenetics, microRNA, polymorphisms, SNP analysis, real-time PCR. Examples will |
|be presented of applications in target discovery and validation, efficacy testing, diagnostic applications, prediction of |
|individual drug action and toxicology. Finally, some perspectives are discussed for future developments in genomics and |
|their possible applications in drug research. |
| | |
|Students |
|PhD students of the research school LACDR (and Faculty of Mathematics and Natural Sciences) and the International Research |
|and Training Program –IRTG- Leiden/Trier; MSc students BFW. Limited places available for other PhD/MSc students. |
| | |
|Admittance demands |
|Sufficient background knowledge of molecular genetics, molecular celbiology, drug action and drug targets |
Method of Instruction
Lectures will be given in the mornings followed by practical work in the afternoons. MSc students also choose a topic of interest that will be the subject of a short written report/research proposal and at the end of week two, and an oral presentation.
Required reading
Lecture notes (hand-outs), reviews and selected research papers.
Course objective
To make PhD/MSc students familiar with modern pharmacogenomic research
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