Birth Defect Prevention: Global Issues
Birth Defect Prevention: Global Issues
Lorenzo D. Botto, MD
Division of Medical Genetics University of Utah, USA
Pierpaolo Mastroiacovo, MD
International Center on Birth Defects Rome, Italy
International Clearinghouse for Birth Defects Surveillance and Research ICBDSR
WHO Collaborating Center
WHO, Geneva, 16 January 2012: Hosts, Dr. Mario Merialdi, Dr. JP Pena-Rosas
WHO 2012 - Global issues in Birth Defect Prevention
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42 Members in 38 Countries, and one Centre (ICBD, Rome)
Canada
National
British Columbia
Utah
Alberta
Western Europe
21 Registries 14 Countries Ukraine
Russia
Atlanta
Texas California
Mexico
Cuba
Costa Rica Colombia
Chile Maule
ECLAMC 10 Countries
WHO 2012 - Global issues in Birth Defect Prevention
Israel Iran
Western Australia Victoria
(China)
Japan India
New Zealand
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Key Points
? 65th World Health Assembly Resolution: call to global action for birth defect surveillance, treatment, prevention
? Modifiable risk factors: what can we do now that works?
? Global opportunities: surveillance, training, prevention
WHO 2012 - Global issues in Birth Defect Prevention
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Key Points
? 65th World Health Assembly Resolution: call to global action for birth defect surveillance, treatment, prevention
? Modifiable risk factors: what can we do now that works?
? Global opportunities: surveillance, training, prevention
WHO 2012 - Global issues in Birth Defect Prevention
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65th World Health Assembly Resolution
The call to action: urges Member States ? To raise awareness of the importance of birth defects as
cause of child morbidity and mortality ? To develop and strengthen registration and surveillance
of birth defects ? To strengthen research and studies on etiology, diagnosis
and prevention of major birth defects
WHO 2012 - Global issues in Birth Defect Prevention
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65th World Health Assembly Resolution
The call to action: requests the Director-General ? To promote the collection of data on the global burden
of mortality and morbidity due to birth defects ? To continue to collaborate with the ICBDSR
to improve collection of data on birth defects ? To support Member States in developing national plans
for implementation of effective interventions to prevent and manage birth defects.
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Birth Defects
3% of all births : minimum estimate burden of disease is high : mortality, morbidity, disability, cost and increasing everywhere: also middle/low income countries
WHO 2012 - Global issues in Birth Defect Prevention
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Global Issues in Birth Defects = Gaps and Opportunities
Evaluation : limited/no surveillance programs Prevention : known causes not addressed
Capacity : limited training/expertise
WHO 2012 - Global issues in Birth Defect Prevention
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Under-5 mortality rate (per 1,000 births) Distribution of causes of deaths (%)
Three congenital conditions account for 25% to 60% of under-5 mortality, and share many risk factors
Congenital conditions: birth defects (malformations, genetic conditions, developmental disabilities of prenatal origin), preterm birth/IUGR, and birth asphyxia
140
60%
120
50%
100 40%
80 30%
60
20% 40
20
10%
0
0%
Birth asphyxia Prematurity Birth defects Under-5 mortality rate
WHO 2012 - Global issues in Birth Defect Prevention
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Key Points
? 65th World Health Assembly Resolution: call to global action for birth defect surveillance, treatment, prevention
? Modifiable risk factors: what can we do now that works?
? Global opportunities: surveillance, training, prevention
WHO 2012 - Global issues in Birth Defect Prevention
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