Roopenian 1/3 1



Curriculum Vitae

Derry Charles Roopenian

The Jackson Laboratory

600 Main Street

Bar Harbor, Maine 04609

Phone 207-288-6396

FAX 207-288-6683

dcr@

Education:

1972 B.A. Zoology, University of Vermont, Burlington, VT

1984 Ph.D. Pathobiology, University of Minnesota, Minneapolis, MN

Professional Experience:

1980-1983 Research Assistant, University of Minnesota, Minneapolis, MN, Department of Laboratory Medicine and Pathology

Advisor: Fritz H. Bach

1984 Research Fellow, Harvard Medical School, Boston, MA, Department of Pathology, Advisor: Matthew F. Mescher, Ph.D.

1985 Research Fellow, Dana-Farber Cancer Institute, Boston, MA, Department of Pediatric Oncology, Advisor: Steven J. Burakoff, M.D.

1985-1990 Associate Staff Scientist, The Jackson Laboratory, Bar Harbor, ME

1990-1999 Staff Scientist, The Jackson Laboratory, Bar Harbor, ME

2000-Present Senior Staff Scientist, The Jackson Laboratory, Bar Harbor, ME

2000-Present Adjunct Faculty, Department of Biochemistry, Microbiology, and Molecular Biology, University of Maine

2006-Present Co-Founder and Chief Scientific Officer, Bar Harbor BioTechnology, Inc.

2007 Advisor to the Director, The Jackson Laboratory

Recognition:

1984-1985 American Cancer Society Postdoctoral Fellowship

1994-1995 Merck Scholar in Immunology

1997 Co-organizer, The First International Symposium on Minor Histocompatibility Antigens

2002 Co-organizer, The 2nd International Symposium on Minor Histocompatibility Antigens 2001-2005 Alliance for Lupus Research Investigator

Memberships:

American Association of Immunologists

The Transplantation Society

Editorial Activities:

1989-2004 Editorial Board, Transplantation,

2005-current Associate Editor, PLoS Genetics

Ad Hoc, various journals

Advisory Committee and Professional Activities:

1991-1995 Immunology, Virology and Pathology Study Section, NIH

1995-1999 NIH Reviewers Reserve

2003 Medical Research Council, United Kingdom

2003 Genome Canada

2004 Association for International Cancer Research, United Kingdom

2004-present INBRE Mentor

2005. ZAI1-SV-(J2) Special Emphasis Study Section, NIAAD

2005. AAALAC Board of Trustees AAI Representative

2005 Cancer Research UK

2005 Chair, ZAI1 SV-I(J2) Special Emphasis Study Section, NIAAD

2006 ZAI1-KS-I-M1 Special Study Section, NIAAD

2007 IMB Study Section (Ad Hoc)

2008 Arthritis Foundation Study Section

2005-8 Committee on Public Affairs, American Association of Immunologists

8. Board of Trustees, AAALAC

2007-9 Advisory Board, Xenotransplantation Research Center, Seoul National University Medical School, Seoul, Korea

2008 INSERM Review Panel

Invited Seminars and Conferences (2002-Present):

University of Connecticut, Department of Pathology, January 2002.

Alliance for Lupus Research, February 2002.

Department of Molecular and Cellular Biology, University of California, Berkeley, March 2002.

Co-organizer, 2nd International Symposium on Minor Histocompatibility Antigens, 13th IHWC, Seattle, May 2002.

Harvard Institutes of Medicine, Harvard Medical School, July 2002.

Faculty. The Short Course in Medical and Experimental Medical Genetics, The Jackson Laboratory, July 1993-2007.

Alliance for Lupus Research, New York, NY, March 2003

Scheicher and Schuell, Keene NH. February 2003

New England BioLabs, Beverly MA March 2003

Vanderbilt University School of Medicine, April 2003

Genetic Approaches to Complex Heart, Lung, and Blood Diseases, The Jackson Laboratory, Bar Harbor, Maine, September 2003 

Wyeth Pharmaceutical, Cambridge MA. November 2003

Plenary Speaker, American Society of Hematology, San Diego CA, December 2003

Plenary Speaker, 14th Annual Mark Wilson Conference, San Juan PR, January 2004

Alliance for Lupus Research, New York, NY, April 2004

Genentech, Inc., South Franscisco, CA, August 2004

Mouse Genetics: Accelerating Drug Discovery and Development, The Jackson Laboratory, May 2004

MRC Clinical Sciences Centre, Hammersmith Hospital, London, September 2004

Invited Speaker and Session Chairman, Clinical Sciences Symposium on Minor H Antigens, The Royal Society, London, September 2004

Invited Speaker, The Korean Immunology Society, Seoul Korea, October 2004

Department of Pathology, The University of Seoul, Seoul Korea, October 2004

Department of Veterinary Medicine, University of Maryland, March 2005

The University of Maine, Department of Biochemistry, Microbiology, and Molecular Biology, April 2005

Invited Speaker, Federation of Clinical Immunologists, Boston, June 2005

The Arthritis Foundation, Atlanta GA, June 2005

Invited Speaker, Genetic Approaches to Complex Heart, Lung and Blood Diseases, Bar Harbor September 2005

Department of Immunology and Microbiology, Boston University, November 2005

Invited Speaker, Genetic Approaches to Complex Heart, Lung and Blood Diseases, Bar Harbor September 2006

Medarex, Inc, Milpitas, CA., January 2007.

Invited Speaker, Amgen, Inc., Mountain View, CA, January 2007.

Invited Speaker, Center for Drug Evaluation and Research, FDA, Silver Springs, MD, March 2007.

Invited Speaker, New Mexico Rheumatology Association, Santa Fe NM, April 2007

Invited Speaker, Genetic Approaches to Complex Heart, Lung and Blood Diseases, Bar Harbor, August 2007

Invited Speaker, Roche Transgenic Animal Workshop, Roche Pharmaceuticals, Penzberg Germany, September 2007

Invited Speaker, Seoul National University Department of Medicine, October 2007

Plenary Speaker, Current status and perspectives on Transplantation Immunology, XRC Symposium, Seoul National University, October 2007

Invited Speaker, JAX Mini-Cancer symposium, Burlingame CA. November CA

Invited Speaker, Roche Pharmaceuticals, Palo Alto CA. November 2007

Invited Speaker, Genentech, South San Francisco CA, November 2007

Invited Speaker, Merck Pharmaceuticals, West Point, January 2008

Original Publications:

Roopenian DC, Click RE. 1980. A new cytotoxic lymphocyte-defined antigen coded for by a gene closely linked to the H-3 locus. Immunogenetics 10:333-341.

Click RE, Schneider D, Roopenian DC. 1981. A new minor histocompatibility locus linked to H-3. J Immunol 126:2378-2381.

Orosz CG, Fidelus RK, Roopenian DC, Widmer MB, Ferguson RM, Bach FH. 1982. Analysis of cloned T cell function. I. Dissection of cloned T cell proliferative responses using cyclosporin A. J Immunol 129:1865-1868.

Hoffman RA, Widmer MB, Roopenian DC, Ascher NL, Simmons RL. 1983. Random locomotion of bulk and cloned lymphocytes during mitogenic and allogeneic stimulation in vitro. Transpl Proc 15:371-373.

Orosz CG, Fidelus RK, Roopenian DC, Widmer MB, Ferguson RM, Bach FH. 1983. A new immunosuppressive mechanism for cyclosporin-A demonstrated with cloned T-lymphocytes. Transpl Proc 15:1927-1929.

Orosz CG, Roopenian DC, Bach FH. 1983. Phorbol myristate acetate and in vitro lymphocyte function. I. PMA may contaminate lymphokine preparations and can interfere with interleukin bioassays. J Immunol 130:1764-1769.

Orosz CG, Roopenian DC, Bach FH. 1983. Phorbol ester mediates reversible reduction of cloned T lymphocyte cytolysis. J Immunol 130:2499-2501.

Orosz CG, Roopenian DC, Bach FH. 1983. Phorbol myristate acetate and in vitro T lymphocyte function. II. Influence of PMA and supernatants from PMA-treated P388D1 cells on the proliferation of cloned T cells. J Immunol 130:2261-2265.

Orosz CG, Roopenian DC, Widmer MB, Bach FH. 1983. Analysis of cloned T cell function. II. Differential blockade of various cloned T cell functions by cyclosporine. Transplantation 36:706-711.

Roopenian DC, Widmer MB, Orosz CG, Bach FH. 1983. Helper cell-independent cytolytic T lymphocytes specific for a minor histocompatibility antigen. J Immunol 130:542-545.

Roopenian DC, Widmer MB, Orosz CG, Bach FH. 1983. Response against single minor histocompatibility antigens. I. Functional and immunogenetic analysis of cloned cytolytic T cells. J Immunol 131:2135-2140.

Widmer MB, Roopenian DC, Bach FH. 1983. Cytolytic T lymphocyte clones with helper-cell characteristics. Transpl Proc 15:393-395.

Orosz CG, Roopenian DC. 1984. Influence of PMA on T-lymphocyte responses to mitogenic lymphokines. Lymphokine Res 3:23-30.

Roopenian DC. 1984. Studies of immune responses against minor histocompatibility antigens. Ph.D. Thesis, University of Minnesota.

Roopenian DC, Orosz CG, Bach FH. 1984. Responses against single minor histocompatibility antigens. II. Analysis of cloned helper T cells. J Immunol 132:1080-1084.

Biel LW, Roopenian DC, Widmer MB, Bach FH. 1985. Induction of immune skin lesions by T-lymphocyte clones of particular subclasses. Transpl Proc 17:610-611.

Orosz CG, Roopenian DC. 1985. Phorbol myristate acetate and in vitro T lymphocyte function. III. Selective impairment by PMA of lethal hit delivery by cloned CTL. Transplantation 39(4):411-418.

Sidman CL, Luther EA, Marshall JD, Nguyen KA, Roopenian DC, Worthen SM. 1987. Increased expression of major histocompatibility complex antigens on lymphocytes from aged mice. Proc Natl Acad Sci USA 84(21):7624-7628.

Roopenian DC, Anderson PS. 1988. Generation of helper cell-independent cytotoxic T lymphocytes is dependent upon L3T4+ helper T cells . J Immunol 141(2):391-397.

Roopenian DC, Anderson PS. 1988. Adoptive immunity in immune-deficient scid/scid mice. I. Differential requirements of naive and primed lymphocytes for CD4+ T cells during rejection of minor histocompatibility antigen-disparate skin grafts. . Transplantation 46(6):899-904.

Roopenian DC, Davis AP. 1989. Responses against antigens encoded by the H-3 histocompatibility locus: Antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics 30(5):335-343.

Davis AP, Roopenian DC. 1990. Complexity at the mouse minor histocompatibility locus H-4. Immunogenetics 31(1):7-12.

Graff RJ, Kurtz ME, Paul R, Martin D, Roopenian DC. 1991. Additional mapping of mouse chromosome 2 genes. Immunogenetics 33(2):96-100.

Roopenian DC, Christianson GJ, Davis AP, Zuberi AR, Mobraaten LE. 1993. The genetic origin of minor histocompatibility antigens. Immunogenetics 38(2):131-140.

Roopenian DC, Davis AP, Christianson GJ, Mobraaten LE. 1993. The functional basis of minor histocompatibility loci. J Immunol 151(9):4595-4605.

Zuberi AR, Roopenian DC. 1993. High-resolution mapping of a minor histocompatibility antigen gene on mouse chromosome 2. Mamm Genome 4(9):516-522.

van der Heyde HC, Elloso MM, Roopenian DC, Manning DD, Weidanz WP. 1993. Expansion of the CD4-, CD8- gamma delta T cell subset in the spleens of mice during non-lethal blood-stage malaria. Eur J Immunol 23(8):1846-1850.

van der Heyde HC, Manning DD, Roopenian DC, Weidanz WP. 1993. Resolution of blood-stage malarial infections in CD8+ cell-deficient beta 2-m0/0 mice. J Immunol 151(6):3187-3191.

Baker PJ, Evans RT, Roopenian DC. 1994. Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Arch Oral Biol 39(12):1035-1040.

King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC. 1994. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics 24(1):159-168.

Schumacher TN, Kantesaria DV, Serreze DV, Roopenian DC, Ploegh HL. 1994. Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. Proc Natl Acad Sci USA 91(26):13004-13008.

Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC. 1994. Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant. Diabetes 43(3):505-509.

Zuberi AR, Dudley ME, Christianson GJ, Roopenian DC. 1994. Gene mapping in a murine cell line by immunoselection with cytotoxic T lymphocytes. Genomics 19(2):273-279.

Buhlmann JE, Foy TM, Aruffo A, Crassi KM, Ledbetter JA, Green WR, Xu JC, Shultz LD, Roopenian DC, Flavell RA, Noelle RJ. 1995. In the absence of a CD40 signal, B cells are tolerogenic. Immunity 2(6):645-653.

Dudley ME, Sundberg JP, Roopenian DC. 1995. Motif-primed polymerase chain reaction-based allelotype of sarcomas induced by 3-methylcholanthrene in interspecific hybrid mice. Oncogene 11(3):517-524.

Blazar BR, Roopenian DC, Taylor BA, Christianson GJ, Panoskolis-Molinari A, Vallera DA. 1996. Lack of GVHD across classical minor histocompatibility locus barriers. Transplantation 61:619-624.

Cariappa A, Flyer DC, Rollins CT, Roopenian DC, Flavell RA, Brown D, Waneck GL. 1996. Glycosylphosphatidylinositol-anchored H-2Db molecules are defective in antigen processing and presentation to cytotoxic T lymphocytes. Eur J Immunol 26:2215-2224.

Christianson GJ, Blankenberg RL, Duffy TM, Panka D, Marshak-Rothstein AM, Roths JB, Roopenian DC. 1996. MHC class I dependence of lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol 156:4932-4939.

Dudley ME, Roopenian DC. 1996. Loss of unique antigen by CTL-immunoselection of a 3-methylcholanthrene-induced sarcoma reveals secondary and shared antigens. J Exp Med 184:441-447.

Dudley ME, Sundberg JP, Roopenian DC. 1996. Adenoma formation in ApcMin mice unaffected by severe combined immunodeficiency (SCID) mutation. Int J Cancer 65:249-253.

Mukherjee R, Yin Z-Q, Zhang Z, Zhong R, Roopenian DC, Jevnikar AM. 1996. Lupus nephritis in the absence of renal MHC class I and class II molecules. J Am Soc Nephrol 7:2445-2452.

Serreze DV, Gallichin S, Snider DP, Croituru K, Rosenthal KL, Leiter EH, Christianson GJ, Dudley ME, Roopenian DC. 1996. MHC class I mediated antigen presentation and induction of CD8+ cytotoxic T lymphocyte responses in autoimmune diabetes prone NOD mice. Diabetes 45:902-908.

Zuberi AR, Christianson GJ, Roopenian DC. 1996. Allele sizes at chromosome 2 Mit loci from 129/J, 129/Ola, C57BL/10J, and the autoimmune-prone mouse strains BXSB/MpJ-Yaa, MRL/MpJ, SLJ/J and NZB/B1nJ. Mouse Genome 94:152-154.

Zuberi AR, Nguyen HQ, Taylor BA, Roopenian DC. 1996. A high resolution genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1 including the H3 mouse minor histocompatibility complex. Genomics 33(1):75-84.

von der Weid T, Beebe A, Roopenian DC, Coffman RL. 1996. Early protection of IL-4 and induction of Th2 responses in the lymph nodes originate from a MHC class-I independent CD4+NK1.1- T cell population. J Immunol 1567:4421-4427.

Christianson GJ, Brooks W, Vekasi S, Manolfi EA, Rothlein R, Roopenian DC. 1997. b2 microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective T antibody responses because of increased IgG catabolism. J Immunol 159:4781-4792.

Christianson SW, Greiner DL, Hesselton R-A, Leif JH, Wagner EJ, Schweitzer IB, Rajan TV, Gott B, Roopenian DC, Shultz LD. 1997. Enhanced human CD4+ cell engraftment in b2-microglobulin-deficient NON-scid mice. J Immunol 158:3578-3586.

Ghiasi H, Roopenian DC, Slanina S, Cai S, Nesburn AB, Wechsler SL. 1997. The role of MHC-I and MHC-II in protection of naive and vaccinated mice following lethal HSV-1 challenge. Immunology 91:430-435.

Liu Z, Roopenian DC, Zhou X, Diaz LA, Anderson CL. 1997. b2 Microglobulin-deficient mice are resistant to bullous pemphigoid. J Exp Med 186:777-783.

Mendoza LM, Paz P, Zuberi AR, Christianson GJ, Roopenian D, Shastri N. 1997. Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex. Immunity 7:461-472.

Bilinski P, Roopenian DC, Gossler A. 1998. Maternal IL-11R f23 a function is required for normal deciduation and placentation in mice. Genes Dev 12:2234-2243.

Boesteanu A, Brehm M, Mylin LM, Christianson GJ, Tevethia S, Roopenian D, Joyce S. 1998. A molecular basis for how a single TCR interfaces multiple ligands. J Immunol 161:4719-4727.

DiLorenzo TP, Graser RT, Ono T, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV. 1998. MHC class I-restricted T cells are required for all but the end stages of diabetes development in NOD mice and utilize a prevalent T cell receptor alpha chain gene rearrangement . Proc Natl Acad Sci USA 95:12538-12543.

Malarkannan S, Shih P, Eden P, Zuberi AR, Christianson GJ, Roopenian DC, Shastri N. 1998. The molecular and functional characterization of a dominant minor H antigen, H60. J Immunol 161(7):3501-3509.

Sirak JH, Orosz CG, Roopenian DC, Wakely E, VanBuskirk AM. 1998. Cardiac allograft tolerance: Failure to develop in IL-4 deficient mice correlates with differential loss of self-MHC-restricted cell-mediated immunity. Transplantation 65:1352-1356.

Strausbach MA, Nevela WK, Roopenian DC, Stefanski HE, Wettstein PJ. 1998. Identification of mimotopes for the H4 minor histocompatibility antigen. Int Immunol 10:421-434.

Zuberi AR, Christianson GJ, Dave SB, Bradley JA, Roopenian DC. 1998. Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene. J Immunol. 161: 821-8.

Zuberi AR, Christianson GJ, Mendoza LM, Shastri N, Roopenian DC. 1998. Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex. Immunity 9:687-698.

Baker PJ, Carter S, Dixon M, Evans RT, Roopenian DC. 1999. Serum antibody response to oral infection precedes but does not prevent porphyromonas gingivalis-induced alveolar bone loss in mice. Oral Microbiol Immunol 14:194-196.

Baker PJ, Dixon M, Evans RT, Dufour L, Johnson E, Roopenian DC. 1999. CD4+ T Cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice. Infect Immun 67(6):2804-2809.

Eden PA, Christianson, GJ, Fontaine P, Wettstein PJ, Perreault C, Roopenian, DC. 1999. Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus. J Immunol 162:4502-4510.

Ideda A, Zheng QY, Rosentiel P, Maddatu T, Zuberi AR, Roopenian DC, North MA, Naggert JK, Johnson KR, Nishina PM. 1999. Genetic modification of hearing in tubby mice: evidence for the existence of a major gene (moth1) which protects tubby mice from hearing loss. Hum Molec Genet 8(9):1761-1767.

Klinge H, Roopenian DC. 1999. The same genetic regions encode minor histocompatibility antigens detected in the context of different MHC haplotypes. Transplantation 67(8):1178-1183.

Pion S, Christianson GJ, Fontaine P, Roopenian DC, Perreault C. 1999. Shaping the repertoire of cytotoxic T lymphocyte responses: Explanation for the immunodominance effect whereby cytotoxic T lymphotyctes specific for immunodominant antigens prevent recognition of short nondominant antigens. Blood 93(3):952-962.

Schoor M, Schuster-Gossler K, Roopenian D, Gossler A. 1999. Skeletal dysplasias, growth retardation, reduced postnatal survival, and impaired fertility in mice lacking the SNF2/SWI2 family member ETL1. Mech Dev 85:73-83.

Baker PJ, Dixon M, Roopenian DC. 2000. Genetic control of susceptibility to Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(10):5864-5868.

Baker PJ, DuFour L, Dixon M, Roopenian DC. 2000. Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68(6):3103-3107.

Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV. 2000. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 164:3913-3918.

Kingsbury DJ, Mear JP, Witte DP, Taurog JD, Roopenian DC, Colbert RA. 2000. Development of spontaneous arthritis in b2-microglobulin-deficient mice without expression of HLA-B27 . Arthritis Rheum 43(10):2290-2296.

Malarkannan S, Horng T, Eden P, Gonzalez F, Shih P, Brouwenstijn N, Christianson G, Klinge H, Roopenian D, Shastri N. 2000. Differences that matter: Major cytotoxic T cell stimulating minor histocompatibility antigens. Immunity 13(3):333-344.

Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC. 2001. Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. J Immunol 166:4370-4379.

Fleming RE, Holden CC, Tomatsu S, Waheed A, Brunt EM, Britton RS, Waheed A, Bacon BR, Roopenian DC, Sly WS. 2001. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Proc Natl Acad Sci USA 98(5):2707-2711.

Mendoza LM, Villaflor G, Eden P, Roopenian D, Shastri N. 2001. Distinguishing self from nonself: immunogenicity of the murine H47 locus is determined by a single amino acid substitution in an unusual peptide. J Immunol 166:4438-4445.

Sproule TJ, Jazwinska EC, Britton RS, Bacon BR, Sly WS, Roopenian DC. 2001. Naturally variant autosomal and sex-linked loci determine the severity of iron overload in B2-microglobulin-deficient mice. Proc Natl Acad Sci USA 98:5170-5174.

Shreeram Akilesh, Mark E. Dudley, Peter A. Eden, Derry C. Roopenian. 2001. Efficient Chromosomal Mapping of a Methylcholanthrene-induced Tumor Antigen by CTL Immunoselection. J Immunol. 2001 167:5143-9.

Ostrov DA, Roden MM, Shi W, Palmieri E, Christianson GJ, Mendoza L, Villaflor G, Tilley D, Shastri N, Grey H, Almo SC, Roopenian D, Nathenson SG. 2002. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol. 2002 168: 283-9.

Baker PJ, Garneau J, Howe L, Roopenian DC. T-cell contributions to alveolar bone loss in response to oral infection with Porphyromonas gingivalis. Acta Odontol Scand. 2001 59:222-5.

Cerwenka A, O'Callaghan CA, Hamerman, JA, Yadav R, Ajayi W, Roopenian DC, Joyce S, and Lanier LL. The minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D. 2002. J. Immunol. Cutting Edge 168: 3131-4.

Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Subramaniam Malarkannan S , Joyce S, and Roopenian DC. 2002. Real-time T cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft vs host disease. Blood (Plenary Article) 100:4259-65.

Choi EY, Christianson GJ, Sproule TS, Yoshimura Y, Jung N, Joyce S, Roopenian DC. 2002. Immunodominance of H60 is caused by an abnormally high precursor T cell pool. Immunity 17:593-603.

Chadhury C, Mehanz S, Robinson JM, Hayton WL, Pearl DK, Roopenian DC, Anderson CL. 2003. The MHC-related Fc Receptor (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197:315-322.

Roopenian DC, Christianson, GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessyan L, Choi, EY, Shaffer DJ, Eden PA, Anderson CL. 2003. The MHC class I-like IgG receptor (FcRn) controls perinatal IgG transport, IgG homostasis and the fate of IgG-Fc coupled drugs. J Immunol 170:3528-3533.

Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S. 2003. The H4(b) minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications. J Immunol. 170:5133-42.

Haskova Z, Sproule TJ, Roopenian DC, Ksander AB. 2003. An immunodominant minor histocompatibility alloantigen that initiates corneal allograft rejection. Transplantation 75:1368-74

Akilesh S, Shaffer DJ, Roopenian DC. 2003. Customized molecular phenotyping by quantitative gene expression and pattern recognition analysis. Genome Res 13:1719-1727.

Luedtke B, Pooler LM, Choi EY, Tranchita AM, Reinbold C, Brown AC, Shaffer DJ, Roopenian DC, Malarkannan S. 2003. A single nucleotide polymorphism in the Emp3 gene differentially affects the quantity of allelic epitopes that define the H4 minor histocompatibility antigen. Immunogenetics 55:284-95.

Stanic AK, Shashidharamurthy R, Bezbradica JS, Matsuki N, Yoshimura Y, Miyake S, Choi EY, Schell TD, Van Kaer L, Tevethia ST, Roopenian DC, Yamamura T, Joyce, S. 2003. Another view of T cell antigen recognition: Co-operative engagement of glycolipid antigens by Va14Ja18 natural T cell receptor. J Immunol 171:4539-51.

Yoshimura Y, Yadav R, Christianson GJ, Ajayi WU, Roopenian DC, Joyce S. 2004. Duration of Alloantigen Presentation and Avidity of T Cell Antigen Recognition Correlate with Immunodominance of CTL Response to Minor Histocompatibility Antigens. J Immunol 172:6666-74.

Yoshida M, Claypool SM, Mizoguchi E, Mizoguchi A, Roopenian DC, Lencer W, Blumberg RS. 2004. The neonatal Fc receptor transport dependent transcytosis of IgG and IgG/antigen complexes across mucosal epithelial barriers. Immunity. 20:769-83.

Hart GT, Shaffer DJ, Akilesh S, Brown AC, Moran L, Roopenian DC, Baker PJ. 2004. Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss. Infect Immun 72:4471-9.

Akilesh S, Petkova S, Sproule TJ, Shaffer DJ, Christianson GJ, Roopenian DC. 2004. The MHC class I-like Fc Receptor (FcRn) is a critical link between the initiation and effector phases of humorally-mediated autoimmune disease. J Clin Invest 113:1328-33.

Ozaki K, Spolski R, Ettinger R, Kim H-Pyo, Wang G, Qi C-F, Hwu P, Shaffer DJ, Akilesh S, Roopenian DC, Morse HC, Lipsky PE, Leonard WJ. 2004. Regulation of memory B cell development and plasma cell differentiation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol. 173:5361-71.

Brown AC, Kai K, May ME, Brown DC, Roopenian DC. 2004. ExQuest, A novel method for deciphering and displaying quantitative gene expression from ESTs. Genomics 83(3):528-39.

Zhang JQ, Okumura C, McCarty T, Shin MS, Lee CH, Hori M, Naghashfar Z, Roopenian D, Morse HC, Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med 200:1467-78.

Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV. 2005. Activated NKT-cells Inhibit Autoimmune Diabetes Through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes. J Immunol 174:1196-204.

Oh K, Kim S, Park SH, Gu H, Roopenian D, Chung DH, Kim YS, Lee DS. 2005. Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity. J Immunol. 174:2030-6.

Brown AC, Olver W, Donnelly C, May M, Naggert J, Shaffer DJ, Roopenian DC. 2005. Searching QTLs by Gene Expression: Analysis of Diabesity. BMC Genet 10:12.

Motonobu U, Lyons BL, Burzenski LM, Gott B, Shaffer DJ, Roopenian DC, Shultz LD. 2005. Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature. Invest Ophthalmol Vis Sci. 2005 46:4097-106.

Ning Li, Minglang Zhao, Julio Hilario-Vargas, Phillip Prisayanh, Simon Warren, Luis A. Diaz, Derry C. Roopenian, and Zhi Liu. 2005. Complete FcRn Dependence for IVIG Therapy in Autoimmune Skin Blistering Diseases. J Clin Invest 115:3440-50.

Jonghan Kim, C. L. Bronson, William L. Hayton, Michael D. Radmacher, Derry C. Roopenian, John M. Robinson, and Clark L. Anderson. 2006. Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as is produced by the liver. Am J Physiol Gastrointest Liver Physiol. 290:G352-60.

Crowley H, Alroy J, Sproule TJ, Roopenian D, Huber BT. 2006. The MHC Class I-Related Receptor FcRn Ameliorates Murine Lyme Arthritis. Int Immunol. 18:409-14.

Yan J, Parekh VV, Mendez-Fernandez Y, Olivares-Villagómez D, Dragovic SM, Hill T, Roopenian DC, Joyce S, Van Kaer L. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med. 203:647-59.

Petkova S, Konstantinov K, Sproule T, AlAwwami M, and Roopenian D. 2006. Human antibodies induce arthritis in mice deficient in IgG low-affinity inhibitory receptor Fc(RIIB. J Exp Med. 2006 203:275-80.

Liu XY, Pop LM, Roopenian DC, Ghetie V, Vitetta ES, Smallshaw JE. 2006. Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics. Int Immunopharmacol 6:791-9.

Masaru Yoshida, Timothy T. Kuo, Lynn Bry, Jonathan N. Glickman, Steven M. Claypool, Arthur Kaser, Takashi Nagaishi, Darren Higgins, Emiko Mizoguchi, Yoshio Wakatsuki, Derry C. Roopenian, Atsushi Mizoguchi, Wayne I. Lencer, and Richard S. Blumberg. Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria. J Clin Inv, in press.

Chen Feng Qi, Jeff X. Zhou, Chang Hoon Lee, Zohreh Naghashfar, Shao Xiang, Sisir K. Chattopadhyay, Torgny N. Fredrickson, Janet W. Hartley, Derry Roopenian, Wendy F. Davidson, Siegfried Janz, Herbert C. Morse III. Anaplastic, plasmablastic and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late stage differentiation of normal B cells. Cancer Res, in press.

Stefka B. Petkova, Shreeram Akilesh, Thomas J. Sproule., Gregory J. Christianson, Hana Al Khabbaz, Leonard G. Presta, Y. Gloria Meng, and Derry C. Roopenian. 2006...Enhanced Half-life of Genetically Engineered Human IgG1 Antibodies in a Humanized FcRn Mouse Model: Potential Application in Humorally Mediated Autoimmune Disease. Int Immunol 2006 18:1759-69.

Brown AC, Lerner CP, Graber JH, Shaffer DJ, Roopenian, DC. 2006. Pooling and PCR As a Method to Combat Low Frequency Gene Targeting in ES Cells. Cytotechnology 51:81-88.

Ostrov DA, Barnes CL, Smith LE, Binns S, Brusko TM, Brown AC, Quint PS, Litherland SA, Roopenian DC, Iczkowski KA. 2007. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue Antigens 69:181-8.

Shatry AM, Roopenian DC, Levy RB. Survival and Function of MiHA Epitope-Specific Host CD8 TM Cells Following Ablative Conditioning and HCT. Biol Blood Marrow Transplant. 2007 Mar;13:293-8.

Woo Y, Wright SM, Maas SA, Alley TL, Caddle LB, Kamdar S, Affourtit J, Foreman O, Akeson EC, Shaffer D, Bronson RT, Morse HC 3rd, Roopenian D, Mills KD. 2007. The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity. Oncogene. 2007 Mar 26; [Epub ahead of print].

Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007 May 31; [Epub ahead of print]

Bubier JA, Bennet SM, Sproule TJ, Lyon BL, Olland S, Young DA, Roopenian DC. Treatment of BXSB-Yaa mice with Il21-Fc fusion protein minimally attenuates SLE disease. NY Acad Sci, 1110: 590-601.

Akilesh S, Christianson GJ, Roopenian DC, Shaw AS.  FcRn expression in bone marrow-derived cells functions to protect serum IgG from catabolism.  J Immunol, 179: 4580-8.

Liu X, Ye L, Christianson GJ, Yang JQ, Roopenian DC, Zhu X. Intronic NF-kB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG. J Immunol, 179: 2999-3011.

Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP. 2007. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun Jul;8(5):416-21.

Shatry AM, Roopenian DC, Levy RB. 2007. Survival and Function of MiHA Epitope-Specific Host CD8 TM Cells Following Ablative Conditioning and HCT. Biol Blood Marrow Transplant March;13(36):2439-47.

Woo Y, Wright SM, Maas SA, Alley TL, Caddle LB, Kamdar S, Affourtit J, Foreman O, Akeson EC, Shaffer D, Bronson RT, Morse HC 3rd, Roopenian D, Mills KD. 2007. The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity. Oncogene Sept 6;26(41):6010-20.

Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS. 2008. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci U S A 105(3):967-972.

Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS. 2008. Podocytes use FcRn to clear IgG from the glomerular basement membrane. Proc Natl Acad Sci USA 105(3):967-972.

Serreze DV, Choisy-Rossi CM, Grier A, Holl M, Chapman HD, Gahagan JR, Osborne MA, Zhang W, King BL, Brown A, Roopenian DC, Marron MP 2008. Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in NOD mice1. J Immunol 180(5):3250-9.

Qiao S-W, Kobayashi K, Johansen, Sollid LM, Andersen JT, Milford E, Roopenian DC, Lencer WI, Blumberg RS. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci, in press.

Dong-Mi Shin , Daniel J Shaffer, Derry C Roopenian, Herbert C Morse III. Identification of Notch as a component of the transcriptional networks regulating cell growth and survival in mouse plasmacytomas. Submitted.

Jason A. Bubier, Thomas J. Sproule, Oded Foreman, Rosanne Spolski, Daniel J. Shaffer, Herbert C. Morse III, Warren J. Leonard, and Derry C. Roopenian.. A Critical Role for IL21 Receptor Signaling in the Pathogenesis of Systemic Lupus Erythematosus in BXSB-Yaa Mice. Proc Natl Acad Sci, in press.

Books, Book Chapters and Reviews

Bach FH, Alter BJ, Roopenian DC, Widmer MB. 1982. T lymphocyte responses to major histocompatibility complex encoded antigens. Proceedings 14th Course on Transplantation and Clinical Immunology, Lyon.

Bach FH, Wee SL, Roopenian DC, Chen LK, Orosz CG, Widmer MB. 1982. Helper cell-independentcytotoxic T lymphocytes (HITc) in mouse and man. In: Intercellular Communication in Leucocyte Function, Parker JW, O'Brien RL (eds), Proceedings of 15th International Leucocyte Culture Conference, Chichester, John Wiley & Sons, Ltd, pp. 109-116.

Bach FH, Roopenian DC, Wee SL, Isakov BL, Widmer MB. 1983. T cell responses to MHC and non-MHC antigens: Re-examining the LD-SD concept. In: Proceedings 5th International Congress on Immunology, Tada T (ed). Kyoto, Japan, Academic Press.

Widmer MB, Roopenian DC, Biel LW, Bach FH. 1985. Characterization of alloreactive murine T cell clones in vitro. In: T Cell Clones, von Boehmer H, Haas W (eds). Research Monographs in Immunology, Vol. 8 Elsevier, New York, pp. 131-138.

Widmer MB, Roopenian DC, Biel LW, Bach FH. 1985. Characterization of alloreactive murine T cell clones in vivo. In: T Cell Clones, von Boehmer H, Haas W (eds), Research Monographs in Immunology, Vol. 8 Elsevier, New York, pp. 201-208.

Roopenian DC, Davis AP. 1990. Products of separate genes within minor histocompatibility loci stimulate class I and class II MHC-restricted T cells. In: Transgenic Mice and Mutants in MHC Research, Egorov I, David C (eds), Springer-Verlag, Heidelberg 58-60.

Roopenian DC. 1992. What are minor histocompatibility loci? A new look at an old question. Immunol Today 13(1):7-10.

Roopenian DC. 1997. Minor histocompatibility loci - congenic strains. In: Handbook of Experimental Immunology, Vol. 4. Blackwell Scientific Publications, Boston, 152.1-152.5.

Simpson E, Roopenian DC. 1998. Minor histocompatibility antigens. Curr Opin Immunol 9:655-661.

Simpson E, Roopenian DC, Goulmy E. 1998. Much ado about minor histocompatibility antigens. Immunol Today 19:108-112.

Mendoza LM, Paz P, Zuberi AR, Christianson GJ, Roopenian D, Shastri N. 2000. Identifying T cell-defined histocompatibility antigens by expression cloning. In: Minor Histocompatibility Antigens: From the Laboratory to the Clinic, Roopenian DC, Simpson E, (eds). Landes Bioscience, Georgetown, TX. 37-45.

Roopenian DC. 2000. Lessons from H3, a model autosomal mouse minor histocompatibility locus. In: Minor Histocompatibility Antigens: From the Laboratory to the Clinic, Roopenian DC, Simpson E (eds), Landes Bioscience, Georgetown, TX 1-14.

Roopenian DC, Simpson E. 2000. Minor Histocompatibility Antigens: From the Laboratory to the Clinic, Roopenian DC, Simpson E, (eds), Landes Bioscience, Georgetown, TX.

Haskova Z, Arancibia-Carcamo CV, Christianson GJ, Roopenian DC, Ksander BR. 2000. Defective antigen processing and presentation by MHC Class molecules on ocular tissue. In: Uveitis in the Third Millennium, First Edition, Dodds EM, Couto CA (eds), Elsevier, Amsterdam, The Netherlands 7-10.

Baker, P.J. Roopenian, D.C. 2002. Genetic susceptibility to chronic periodontal disease. Microbes Infect. 2002 4 :1157-67.

Roopenian DC. 2002. The immunogenomics of minor histocompatibility antigens. Immunol Rev 190:86-94.

Serreze DV, Roopenian DC. 2004. Was there type 1 diabetes in the Olduvai Gorge? Adv Exp Med Biol. 552:322-5.

Morse HC 3rd, Morel L, Roopenian D, Lipsky P, Leonard W, Davidson W. 2004. Untying the gordian knot of autoimmunity and B cell lineage lymphomas. Autoimmun Rev. 2004 Suppl 1:S10-1.

Roopenian DC, Akilesh S. 2007. FcRn: The neonatal Fc receptor comes of age. Nat Rev Immunol Sept;7(9):715-25.

Patents

FcRn-based therapeutics for the treatment of auto-immune disorders 6,992,234 issued.

Transgenic mouse expressing human FcRn protein, 7,358,416, issued.

Expression data analysis systems and methods, 20060129331, pending.

IL-21 As a Regulator of Immunoglobulin Production, 20050193434, pending.

Expression data analysis systems and methods, 20060129331, pending.

................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download