Karyotyping Activity



VIRTUAL LAB: University of Arizona Karyotyping Activity

In this activity, you will use a computer model to look at chromosomes and prepare a karyotype. You will diagnose patients for abnormalities and learn the correct notation for characterizing karyotypes.

How to turn in your completed assignment:

1. You can type your work on this existing word document.

2. Save your word document on your desktop with your name (first and last) and period. For example John Doe- Period 5

3. Then you can send it to me either through your email as an attachment or by sharing it on Google doc.

My email address is dplama@cps.edu

SITE 1 Go to: biology.arizona.edu - click on Karyotyping under human biology

OR



Click on Patient Histories. You will be completing a karyotype for Patient A, B & C

Patient A (Click on the link to "Complete Patient A's Karyotype")

*Match the chromosome to its homolog. After all the matches are complete you'll analyze your patient. (Scroll down to view your completed karyotype).

1. What is patient A's history (summarize)

2. How many total chromosomes are in your karyotype - count them _________

(The last set of chromosomes is the sex chromosomes, if you have two large chromosomes, your patient is XX (female), one large and one small indicates and XY (male).

3. What sex chromosomes does your patient have ________

4. Which chromosome set has an extra + _______

5. What diagnosis would you give this patient (what disease)? ______________

Patient B - click on the link to go to Patient B and repeat the above process.

6. What is Patient B's history (summarize)

7. How many total chromosomes are in your karyotype - count them _________

8. What sex chromosomes does your patient have ________

9. Which chromosome set has an extra + _______

10. Finish the notation for this patient's karyotype : 47 X _____

11. What is the diagnosis? __________________________________

Patient C - click on the link to go to Patient C and repeat the above process.

12. What is patient C's history (summarize)? _________________________________

13. How many total chromosomes are in your karyotype - count them _________

14. What sex chromosomes does your patient have ________

15. Which chromosome set has an extra + _______

16. Write out the correct notation for this karyotype. ________

17. What is the diagnosis? _________________________________________

SITE 2:

Go to Making a Karyotype - Try it yourself

Create your own karyotype - turning on hints is okay.

18. What did you find difficult about matching the chromosomes? ____________________

19. Show your teacher and get initials when complete on the computer or with hard copy._________

SITE 3: Go to -Using Karyotypes to Predict Genetic Disorders

20. What is trisomy? ______________________________________

21. What is monosomy? ____________________________________

22. What is a terminal deletion? ______________________________

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