Scholar.harvard.edu



Liyuan Zhang

John A. Paulson School of Engineering and Applied Sciences, Harvard University

Mckay lab 517, 9 Oxford Street,, Cambridge, MA, 02138

Phone: 857-756-2985; Email: liyuanzhang@seas.harvard.edu

EDUCATION

Sep. 2012-Present Postdoctoral fellow, Chemical Engineering, Harvard University

Supervisor: David A Weitz

Sep. 2009 - Apr. 2014 Ph.D. in Science, Polymer Chemistry & Physics, Jilin University.

Supervisor: Prof. Hui Na.

Sep. 2012-Apr. 2014 Visiting Ph.D. student in the lab of Prof. David A. Weitz at Harvard University.

Sep. 2005 - Jul. 2009 B.S. in Science, Chemistry, Jilin University (Top-five in China).

Research Interst

Drug delivery, Tissue engineering, Stem cell and immune cell therapy. Lithium ion battery, membrane.

RESEARCH EXPERIENCE

2014/08-now Postdoctoral Fellow, Harvard University, USA

Identifying pathogenic bacteria by phenotyping individual cells (Founded by DARPA, HR001118S0025)

Leading researcher.

Goal: Understanding embryogenesis process and develop a system that enable to study bacterium that affect gene expression.

Develop new approach to encapsulate endothelia stem cells and determine how bacteria can affect stem cell behavior.

Novel method for Reducing Volatility of Pesticide(Founded by BASF chemical Company)

Goal: Reduce the volatility of the pesticide;

Leading researcher;

Develop a new photocrosslinked polymer encapsulation system for volatile materials, increase retention time.

Subcutaneous Delivery of High Viscosity Biologic Drugs Using Droplet Microfluidics(Founded by Harvard University and Wyss Institute)

Goal: Reduce viscosity of therapeutic solution while subcutaneous injection;

Leading researcher;

Develop microfluidic techniques to fabricate microcapsules with the required size, biocompatibility, and storage/release characteristics;

Customer design and synthesize biopolymers for different antibodies.

Smart Core-Shell Nanoparticles for Enhanced Oil Recovery(American Energy Consortium, BEG08-27, Budget 3000,000/year)

Goal: Use swellable nanohydrogel to improve oil recovery.

Sole researcher.

Develop new strategies to fabricate oil-recovery-enhancing nanohydrogel using acrylate monomers by radical polymerization, emulsion polymerization and seeded polymerization. Royal Dutch Shell scientists demonstrate that these nanohydrogels increase oil recovery when used in a standard “core test”.

Stem Cell Niche(Founded by National Institution of Health, NIH RO1EB014703, fund: $1,660,000)

Goal: Use microgels to develop a defined system to study the single cell behavior and stem-cell niche.

Leading researcher.

Develop new approaches to precisely assemble single/multiple cells within one microgel that maintain high viability.

Grow stem cells into multi-cell structures, successfully build stem cell niche in vitro.

2012/09-2014/04 Visiting Ph.D. student, Harvard University, USA

Water-in-Water Encapsulation and Layer-By-Layer Assembly(LBL) in Microfluidic Device

Conceive of, and write grant for the project Water-in-Water Encapsulation and LBL assembly Multilayer Capsules in Microfluidic Device funded by BASF(Budget: $50,000).

Design and perform the experiments to fabricate polymer microcapsules in a new pure water system without using any organic solvent.

Encapsulate therapeutic/mammalian cell with no loss of bioactivity.

Responsible for all formal reports to funding institute (BASF).

2009/09-2014/06 Ph.D., Jilin University, China

Functional Polymer Design and Fabrication for Proton Exchange Membrane Fuel Cell

Design, synthesize and characterize of new side-chain type of functional engineering polymers, such as polyether ether ketone, polybenzimidazole, from molecular level by polycondensation polymerization, radical polymerization and emulsion polymerization.

Functionalize of these polymers as anti-corrosion coating materials, and proton exchange membrane in fuel cell.

2005/09-2009/06 B.S., Jilin University, China

Electronic Packing Materials

Provide leadership for synthesizing and optimizing the procedure of new phenol epoxy resin fabrication, which used as encapsulation and electronic packing materials.

Develop new methods for scaling up electronic packing materials and complete middle test.

TEACHING & ADVISING

Teaching Assistant, Polymer Chemistry and Physics, Jilin University, China

Taught three semesters (Fall 2009; Fall 2010; Fall 2011). Delivered guest lectures; led section discussions; supervised labs; graded all assignments; met with students individually during office hours; helped students individually with research projects. 25-30 undergraduate students.

Advising

Four Harvard graduate student (2015~2018)

Three Visiting Ph.D. Students (2015~2017)

GRANTS & AWARDS

Grants

Conceive and write” Water-in-Water Encapsulation and LBL assembly Multilayer Capsules in Microfluidic Device”, BASF Chemical Company (2013-2015)

Academic support and recognition

Third Prize Elite Cup Scholarship, Jilin University (2014)

National Scholarship for Visiting Ph.D. Student, China Scholarship Council (2012)

LIST OF PARTIAL PUBLICATION

Full publications are list on Google Scholar.

1. L. Zhang, S. Parsa, F. Cassiola, D. A. Weitz, Programmable Nanohydrogels for Flow Control in Porous Media, Physics Review Letter (In process).

2. L. Zhang, L. Qu, H. Zhang, X. Qu, W. Zheng, Z. Yang, D. Chen, H. A. Santos, M. Hai*, Gold Nanorods Conjugated Magnetite-(Chitosan)-Reduced Graphene Oxide Based Photothermal Agents for NIR Photothermal Antibacterial Applications, Advanced Materials (Under Review).

3. B. Pang†, L. Zhang†(co-first author), H. Liao, W. Liu, H. Wang*, Microfluidic Engineered Single Mesenchymal Stem Cell laden Microgels for Accelerate Osteogenesis of Single Mesenchymal Stem Cells. Advanced Functional Materials (Under Review).

4. L. Zhang, A. S. Mao, B. R. Seo, D. J Mooney, D. A Weitz*. Microcapsules for Niche Modeling and Therapeutic Delivery. Advanced Functional Materials (In preparation).

5. W. Li†, L. Zhang †(co-first author), X. Ge†, B. Xu, W. Zhang, L. Qu, C. Choi, J. Xu, H. Lee,* D. A. Weitz*, Microfluidic fabrication of microparticles for biomedical applications, Chemical Society Review, 2018,47, 5646-5683. Highlighted in the same issue and Selected as Cover.

6. L. Zhang, K. Chen, H. Zhang, B. Pang, C. Choi, A. S. Mao, S. Utech, D. J. Mooney, H. Wang*, D. A. Weitz*, Microfluidic Templated Multi-compartment Microgels for 3D Encapsulation and Paring of Single Cells, Small 14 (2018), 1702955.

7. A. Chen, X. Ge, J. Chen, L. Zhang*(co-corresponding author), J. Xu*, Multi-functional micromotor: Microfluidic fabrication and water treatment application, Lab on a Chip, 17 (2017), 4220. Highlighted in the same issue and Selected as Cover.

8. L. Zhang, P. S. Lienemann, T. Rossow, I. Polenz, H. Na, D. J. Mooney, D. A Weitz*, One-Step Microfluidic Fabrication of Polyelectrolyte Microcapsules in Aqueous Conditions for Protein Release. Angewandte Chemie International Edition. 43 (2016), 13470.

9. L. Zhang, D. Qi, C. Zhao, H. Na*, In-situ Self-crosslinked Alkyl Side Chain Sulfonated Poly(arylene ether ketone) Designed for Enhanced Performance, Journal of Membrane Science, 508 (2016), 15.

10. L. Zhang, D. Qi, G. Zhang, C. Zhao, H. Na*. Corsslinked tri-side chain type sulfonated poly(arylene ether ether ketones) with enhanced Proton Conductivity by a Friedel-Crafts acrylation reaction. RSC Adv., 4 (2014), 51916.

11. L. Zhang, G. Zhang, C. Zhao, H. Na*. High Proton-Conducting Polymer Elelctrolyte based on Multi-pendent Poly(arylene ether ketone) for Proton Exchange Membrane. International Journal of Hydrogen Energy. 28 (2013), 12363.

12. L. Zhang, G. Zhang, C. Zhao, H. Na*. Cross-linked Tri-side Chains Poly(arylene ether ketone)s Containing Pendant Alkylsulfonic Acid Groups for Proton Exchange Membrane. Journal of Power Sources, 201 (2012), 142.

13. C. Choi, H. Wang, H. Lee, J. Hwan Kim, L. Zhang, A. Mao, D. J Mooney, D. A Weitz*, One-step generation of cell-laden microgels using double emulsion drops with a sacrificial ultra-thin oil shell, Lab on a chip 16, (2016), 1549.

14. A. S. Mao, J. Shin, S. Utech, H. Wang, O. Uzun, W. Li, M. Cooper, Y. Hu, L. Zhang, D. A. Weitz, D. J. Mooney*, Deterministic encapsulation of single cells in thin tunable microgels for niche modeling and therapeutic delivery, Nature Materials, 16 (2017), 236.

15. D Qi, C Zhao, L. Zhang, X Li, G Li, H Na, Novel in situ-foaming materials derived from a naphthalene-based poly (arylene ether ketone) containing thermally labile groups, Polymer Chemistry 6 (2015), 5125.

16. F Kong, H Zhang, X Zhang, D Liu, D Chen, W Zhang, L Zhang, HA Santos, Drug Co-Delivery: Biodegradable Photothermal and pH Responsive Calcium Carbonate@ Phospholipid@ Acetalated Dextran Hybrid Platform for Advancing Biomedical Applications, Advanced Functional Materials, 26 (2016), 6138.

17. Z Liu, H Wang, L Zhang, D Sun, L Cheng, C Pang, Composition and degradation of turbine oil sludge, Journal of Thermal Analysis and Calorimetry 125 (2016), 155.

18. M Li, G. Zhang, S Xu, C Zhao, M Han, L Zhang, H Jiang, H Na, Cross-linked polyelectrolyte for direct methanol fuel cells applications based on a novel sulfonated cross-linker, Journal of Power Sources 255 (2014) 101.

19. H. Jiang, X. Guo, G. Zhang, J. Ni, C. Zhao, Z. Liu, L. Zhang, M. Li, S. Xu, H. Na, Cross-linked high conductive membranes based on water soluble ionomer for high performance proton exchange membrane fuel cells, Journal of Power Sources 2013, 241, 529.

20. M. Li, G. Zhang, H. Zuo, M. Han, C. Zhao, H. Jiang, Z. Liu, L. Zhang, H. Na, End-group cross-linked polybenzimidazole blend membranes for high temperature proton exchange membrane, Journal of membrane science 423 (2012) 495.

21. J. Wang, C. Zhao, L. Zhang, M. Li, J Ni, S. Wang, W. Ma, Z. Liu, H. Na, Cross-linked proton exchange membranes for direct methanol fuel cells: Effects of the cross-linker structure on the performances, International journal of hydrogen energy 37 (2012), 12586.

22. S Xu, G Zhang, Y Zhang, C Zhao, W Ma, H Sun, N Zhang, L Zhang, H. Na, Synthesis and properties of a novel side-chain-type hydroxide exchange membrane for direct methanol fuel cells (DMFCs), Journal of Power Sources 209 (2012), 228.

23. H Sun, G Zhang, Z Liu, N Zhang, L Zhang, W Ma, C Zhao, D Qi, G Li, H Na, Self-crosslinked alkaline electrolyte membranes based on quaternary ammonium poly (ether sulfone) for high-performance alkaline fuel cells, International Journal of Hydrogen Energy 37 (2012), 9873.

24. J. Wang, C Zhao, M Li, L Zhang, J Ni, W Ma, H Na, Benzimidazole-cross-linked proton exchange membranes for direct methanol fuel cells, International Journal of Hydrogen Energy 37 (2012), 9330.

25. S Xu, G Zhang, Y Zhang, C Zhao, L Zhang, M Li, J Wang, N Zhang, H Na, Cross-linked hydroxide conductive membranes with side chains for direct methanol fuel cell applications, Journal of Materials Chemistry 22 (2012), 13295.

26. S Wang, G Zhang, M Han, H Li, Y Zhang, J Ni, W Ma, M Li, J Wang, Z Liu, L. Zhang, H. Na, Novel epoxy-based cross-linked polybenzimidazole for high temperature proton exchange membrane fuel cells, International Journal of Hydrogen Energy 36 (2011), 8412.

27. G Zhang, H Li, W Ma, L. Zhang, CM Lew, D Xu, M Han, Y Zhang, J Wu, Cross-linked membranes with a macromolecular cross-linker for direct methanol fuel cells, Journal of Materials Chemistry 21 (2011), 5511.

28. H. Li, G. Zhang, J. Wu, C. Zhao, Q Jia, CM Lew, L. Zhang, Y. Zhang, M. Han, A facile approach to prepare self-cross-linkable sulfonated poly (ether ether ketone) membranes for direct methanol fuel cells, Journal of Power Sources 95 (2010), 8061.

PRESENTATIONS

Invited talks

1. Programmable Nanohydrogel for Flow control in Porous Media, Society of Petrophysicists and Well Log Analysts, Boston, 2018

2. Drop-based Microfluidic for Cell Microenvironment Control, ACS-ICHEM meeting, Dalian Institute of Chemical Physics & Chinese Academy of Sciences, Dalian, 2017

3. Microfluidic for Controlling Microenvironment, Dalian University of Technology, Dalian, 2017

4. Assembly Stem Cell at Single Cell Level by Microfluidic, Shanghai University, Shanghai, 2017

5. Mesenchymal Stem Cell 3D Assembly in multi-compartmental micro-hydrogel, Florida A&M University and Florida State University, Tallahassee, 2015.

Submitted Talks

1. Microfluidic templated Multi-compartment Microgel for control 3D cell assembly, 2018 Gordon Research Conference New Hamshire.

2. Functionalized Ultra-thin Shell microcapsules for targeted delivery and release, 2018 ACS meeting, Boston

3. Controlled single cells encapsulation and assembly using multi-compartment microgels for study of cell-cell interaction, 2017 MRS Fall Meeting & Exhibit, Boston

4. Nanoparticles for conformance control in porous medium, 2016, New England Complex fluid workshop, Boston.

5. Polyelectrolyte microcapsules by interfacial complexation in all aqueous condition for protein release, 2016 MRS Fall Meeting & Exhibit, Boston.

6. Multi-compartmental microgel for controlled 3D cell assembly, 90thACS Colloid & Surface Science Symposium, 2013, Boston.

7. Multi-compartmental microgel for controlled 3D cell assembly, 2015 MRS Fall Meeting & Exhibit, Boston.

8. Multi-layer polyelectrolyte capsules assembly in microfluidic device, 248th ACS National Meeting, San Francisco.

9. Fluctuation-induced dynamics of monodisperse capsules in aqueous two-phase systems, 2013 BASF Forum, New York.

PROFESSION MEMBERSHIP

American Chemical Society Materials Research Society

American Physical Society

REFERENCE

David A. Weitz

Mallinckrodt Professor of Physics and Applied Physics at Harvard University

Pierce Hall 231, 29 Oxford ST, Cambridge, MA, 02138.

Phone: +1-617-496-9788

Email: weitz@seas.harvard.edu

David J. Mooney

Robert P. Pinkas Family Professor of Bioengineering at Harvard University

Pierce Hall 319, 29 Oxford Street, Cambridge, MA, 02138

Phone: +1-617-384-9624

Email: mooneyd@seas.harvard.edu

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