XV



Curriculum Vitae

|Date Prepared: |February 16, 2016 |

|Name: |Jennifer Y. Chen |

|Office Address: |Department of Gastroenterology and Hepatology |

| |55 Fruit Street, Blake 4 |

| |Boston, MA 02114 |

|Work Phone: |617-724-6113 |

|Place of Birth: |Rahway, New Jersey |

Education

|09/1999 – 06/2003 |AB |Government |Harvard University |

| |Cum Laude | | |

|09/2004 – 06/2009* |MD |Medicine |Harvard University |

| |Cum Laude | | |

*From 07/01/2007 to 06/30/2008, I participated in the Doris Duke International Clinical Research Fellowship, sponsored through Harvard Medical School.

Postdoctoral Training

|07/2009-06/2012 |Resident Physician |Internal Medicine |Brigham and Women’s Hospital |

Faculty Academic Appointments

|07/2009-06/2012 |Clinical Fellow |Internal Medicine |Brigham and Women’s Hospital |

|07/2012 -06/2016 |Research Fellow |Gastroenterology and Hepatology |Massachusetts General Hospital |

|07/2012 – 06/2016 |Research Fellow |Gastroenterology and Hepatology |Harvard Medical School |

|06/2016- |Assistant |Medicine |Massachusetts General Hospital |

|06/2016- |Instructor |Medicine |Harvard Medical School |

Professional Societies

|2004-present |Massachusetts Medical Society |Member |

|2014-present |American Gastroenterological Association |Member |

|2014-present |American Association for the Study of Liver Diseases|Member |

Honors and Prizes

|2000 |John Harvard Scholarship |Harvard College |Academic Achievement |

|2006, 2009 |Paul Dudley White Fellowship |Harvard Medical School |Research |

|2007 |Doris Duke International Clinical |Harvard Medical School |Research |

| |Research Fellowship | | |

|2009 |Young Investigator’s Award |16th Conference on Retroviruses and |Research |

| | |Opportunistic Infections | |

|2012 |Young Investigator’s Award |19th Conference on Retroviruses and |Research |

| | |Opportunistic Infections | |

|2014 |Center of Expertise |Massachusetts General Hospital |Research |

| |International Travel | | |

| |Scholarship | | |

|2015 |Fellowship2Leadership Fellows’ Travel |Salix Pharmaceuticals |Research |

| |Award | | |

|2015 |Ruth L. Kirschstein |National Institute of Diabetes and |Research |

| |National Research |Digestive and Kidney Diseases | |

| |Service Award Individual | | |

| |Postdoctoral Fellowship | | |

| |(Parent F32) | | |

Report of Funded and Unfunded Projects

Funding Information

Current

|2015-present |PI |NIDDK |$62,066 |

| | |F32DK107197-01A1 | |

|The role of tricyclic antidepressants in the pathogenesis of hepatic fibrosis. |

|The major goal of the study is to identify the mechanism by which tricyclic antidepressants induce hepatic stellate cell quiescence |

|and to determine their effect in a mouse model of hepatic fibrosis. |

Past

|2013-2015 |Trainee |NIDDK | |

| | |T32DK007191 | |

|A small molecule screen to identify novel targets of hepatic fibrosis. |

|The major goal of the study is to develop and conduct a small molecule screen to identify targets of hepatic fibrosis. |

|2007-2009 |PI |Doris Duke International Clinical |$55,000 |

| | |Research Fellowship | |

|Rates of adverse pregnancy outcomes among HIV-infected women in Botswana. |

|The major goal of the study is to determine rates of adverse pregnancy outcomes among HIV-infected by CD4 cell count and by receipt |

|of antiretroviral therapy in pregnancy. |

Report of Local Teaching and Training

Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)

|2011 |Management of Endocarditis |Faulkner Hospital |

| |Medicine Housestaff |One-hour lecture |

|2011 |Management of Renal failure |Brigham and Women’s Hospital |

| |Medicine Housestaff |One-hour lecture |

|2011 |Overview of Geriatrics |Faulkner Hospital |

| |Medicine Housestaff |One-hour lecture |

|2011 |Discussion of Pulmonary Hypertension |Faulkner Hospital |

| |Medicine Housestaff |One-hour lecture |

2013 Bigelow Rounds Massachusetts General Hospital

Division of Gastroenterology/Hepatology One-hour lecture

2013 Interhospital Rounds Massachusetts General Hospital

Division of Gastroenterology/Hepatology Thirty-minute lecture

2013 Bigelow Rounds Massachusetts General Hospital

Division of Gastroenterology/Hepatology One-hour lecture

2013 Performing the Abdominal Exam Harvard Medical School

Harvard Medical Students Two-hour session

2014 Interhospital Rounds Massachusetts General Hospital

Division of Gastroenterology/Hepatology Thirty-minute lecture

2014 Performing the Abdominal Exam Massachusetts General Hospital

Harvard Medical Students Two-hour session

2015 Performing the Abdominal Exam Massachusetts General Hospital

Harvard Medical Students Two-hour session

2012-present Journal Club (presented twice annually) Massachusetts General Hospital

Division of Gastroenterology/Hepatology One-hour lecture and discussion

Report of Regional, National and International Invited Teaching and Presentations

International

|2011 |Antiretroviral Treatment Among HIV-Infected Pregnant Women With Low CD4+ Cell Counts in Gaborone, Botswana (Presentation to Botswana |

| |Ministry of Health, Research Community, and Press) |

| |Gaborone, Botswana |

|2011 |Risk Factors for Adverse Pregnancy Outcomes Among HIV-Infected and HIV-Uninfected Women in Botswana |

| |Gaborone, Botswana |

Report of Clinical Activities and Innovations

Current Licensure and Certification

|2012-present |Massachusetts Medical License |

|2016-present |Gastroenterology |

Practice Activities

|2012-present |Ambulatory Care |GI and Liver Clinic, Massachusetts General |One session per week |

| | |Hospital | |

Report of Scholarship

Peer reviewed publications in print or other media

Chen JY, Feeney E, Chung RT. HCV and HIV coinfection: Mechanisms and Management. Nat Rev Gastroenterol Hepatol. 2014 Jun;11(6):362-71.

Kelly P, Saloojee H, Chen JY, Chung RT. Noncommunicable Disease in HIV Infection in Low- and Middle-Income Countries: Gastrointestinal, Hepatic, and Nutritional Aspects. J Acquir Immune Defic Syndr. 2014 Sep; 67:S79-S86.

Chung RT, Umbleja T, Chen JY, Anderson J, Butt A, Sherman KE. Extended Therapy with Peginterferon and Weight-based Ribavirin for HCV-HIV Co-infected Patients. HIV Clin Trials. 2012 Mar-Apr;13(2):70-82.

Chen JY, Chung RT. Future classes of hepatitis C virus therapeutic agents. Infect Dis Clin North Am. 2012 Dec;26(4):949-66.

Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwu A, Lockman S, Powis K, Dryden-Peterson S, Creek T, Jimbo W, Madidimalo T, Makhema J, Essex M, Shapiro RL. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. J Infect Dis. 2012 Dec 1;206(11):1695-705

Chen JY, Ogwu AC, Svab P, Lockman S, Moffat HJ, Gaolathe T, Moilwa S, Størdal K, Dryden-Peterson S, Moffat C, Makhema J, Essex M, Shapiro RL. Antiretroviral Treatment Initiation Among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. JAIDS 2010 May 1;54(1): 102-6.

Parekh N, Ribaudo H, Souda S, Chen JY, Mmalane M, Powis K, Dreyden-Peterson S, Binda K, Lockman S, Essex M, Makhema J, Shapiro RL. Risk Factors for Very Premature Delivery and Very Small for Gestational Age Infants in Botswana. Int J Gynaecol Obstet 2011 Oct; 115(1): 20-5.

Shapiro RL, Ribaudo H, Powis K, Chen JY, Parekh N. Extended antenatal use of triple antiretroviral therapy for prevention of mother-to-child transmission of HIV-1 correlates with favorable pregnancy outcomes. AIDS 2012 Jan 2; 26(1):120-1.

Matthews L, Ribaudo H, Parekh N, Chen JY, Binda K, Ogwu A, Lockman S, Makhema J, Essex M, Shapiro R. Birth Weight for Gestational Age Norms for a Large Cohort of Infants born to HIV-negative Women in Botswana compared with norms for US-born black infants. BMC Pediatr 2011 Dec 16; 11(1): 115.

Dryden-Peterson S, Lockman S, Zash R, Lei Quonhong, Chen JY, Souda S, Petlo C, Dintwa E, Lebelonyane R, Mmalane M, Shapiro RL. Initial Programmatic Implementation of WHO Option B in Botswana Associated With Increased Projected MTCT. J Acquir Immune Defic Syndr 2015;68:245–249

Zhang Y, Lu L, Li HQ, Liu W, Tang ZR, Fang H, Chen JY, Ma Y, Zhao Y, Chen RY, Zhang FJ. Engaging HIV-infected patients in antiretroviral therapy services: CD4 cell count testing after HIV diagnosis from 2005 to 2009 in Yunnan and Guangxi, China. Chin Med J 2011 May; 124(10): 1488-92.

Belkora JK, Loth MK, Chen DF, Chen JY, Volz S, and Esserman LJ, Monitoring the Implementation of Consultation Planning, Recording, and Summarizing in a Breast Care Center. Patient Educ Couns, 2008 Dec;73(3):536-43.

Non-peer reviewed scientific or medical publications/materials in print or other media

Chen JY, Chung RT. Can we use the “c” word with confidence? Cure for chronic hepatitis C. Gastroenterology 2011 Mar; 140(3): 766-8.

Chen JY, Andersson KL: Autoimmune Hepatitis. Scientific American Gastroenterology, Hepatology, and Endoscopy. Burakoff R, Ed. Decker Intellectual Properties, Hamilton, ON, 2015

Thesis

An Analysis of Risk Factors for Adverse Pregnancy Outcomes Among HIV-Infected and HIV-Uninfected Women in Gaborone and Molepolole, Botswana. Awarded Cum Laude in a Special Field by Harvard Medical School.

Abstracts, Poster Presentations and Exhibits Presented at Professional Meetings

York SR, Zhou C, Chen JY, Daneshvar K, Mullen A. Identification of long noncoding RNAs induced in hepatic stellate cell myofibroblasts. Awarded AASLD Presidential Poster of Distinction, Liver Meeting 2014, Boston, MA.

Dryden-Peterson S, Souda S, Zash R, Chen JY, Petlo C, Dintwa E, Lebelonyane R, Mmalane M, Lockman S, Shapiro RL. Programmatic Implementation of WHO Option B in Botswana Associated with Increased Projected MTCT [abstract 882]. Boston: CROI, 2014.

Chen JY, Ribaudo H, Ogwu A, Svab P, Wester C, Tumbare E, Moffat H, Makhema J, Essex M, Shapiro RL. Risk Factors for Adverse Pregnancy Outcomes in Gaborone, Botswana. 16th Conference on Retroviruses and Opportunistic Infections. [abstract 949]. In: Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections. Boston: CROI, 2008.

Chen JY, Ribaudo H, Parekh N, Souda S, Ogwu A, Lockman S, Dryden-Peterson, S, Makhema J, Essex M, Shapiro RL. HAART and Adverse Birth Outcomes Among HIV-infected Women in Botswana. 19th Conference on Retroviruses and Opportunistic Infections. [abstract 1028]. In: Program and abstracts of the 19th Conference on Retroviruses and Opportunistic Infections. Seattle: CROI, 2012.

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