Australian public assessment for Febuxostat (FBX)
Compared to subjects with normal hepatic function, total plasma exposure to FBX is higher in subjects with mild or moderate hepatic impairment (mean FBX unbound C max values 24% higher; and mean unbound AUC 24 values 24 to 28% greater); but there are no other observed changes in PK parameters in subjects with hepatic impairment. ................
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