PDF Evaluating the Role of MRSA Nasal Swabs - Mayo Clinic

Evaluating the Role of MRSA Nasal Swabs

Josh Arnold, PharmD PGY1 Pharmacy Resident

Pharmacy Grand Rounds February 28, 2017

?2016 MFMER | slide-1

Objectives

? Identify the pathophysiology of MRSA nasal colonization

? Discuss current evidence for the utility of MRSA nasal swabs in specific patient populations

? Describe the clinical considerations associated with MRSA nasal swabs

?2016 MFMER | slide-2

The burden of infection

Mortality

MRSA

Cost

Drug consequences

Marlowe EM, et al. Journal of Clinical Microbiology. 2011;49(9 Supplement):S53.

?2016 MFMER | slide-3

Pathophysiology

? Primary reservoir of S. aureus is the vestibulum nasi

? Shown to be highest colonization site

Kluytmans J, et al. Clin Micro Rev. 1997;10(3):505-520. Mulcahy ME, et al. PLoS Pathog. 2012;8(12):e1003092.

?2016 MFMER | slide-4

Pathophysiology

? Primary reservoir of S. aureus is the vestibulum nasi

? Shown to be highest colonization site

- S. aureus with ClfB - Loricrin

ClfB: clumping factor B

Kluytmans J, et al. Clin Micro Rev. 1997;10(3):505-520. Mulcahy ME, et al. PLoS Pathog. 2012;8(12):e1003092.

?2016 MFMER | slide-5

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