PDF Efficacy of IVIg Therapy in Inflammatory Myositis
INTERNATIONAL TRENDS IN IMMUNITY
VOL.1 NO.1
JANUARY 2013
40
ISSN 2326-3121 (Print) ISSN 2326-313X (Online)
Efficacy of IVIg Therapy in Inflammatory Myositis
F. Sunzini, S. Salemi, V. Germano, D. Crialesi, R. Di Rosa and R. D'Amelio
Abstract--The aim of this retrospective study is to evaluate the efficacy and safety of intravenous immune globulin (IVIg) as immunomodulatory treatment in patients with inflammatory myopathies. We analyzed six patients, observed in a single-center from 2004 to 2012, affected by polymyositis (PM), dermatomyositis (DM) or inclusion body myositis (IBM) and treated with IVIg. IVIg has been successfully used as rescue therapy in all patients with a periodical dose of 1-2 g/Kg administered in 5 days. The mean follow-up was 37 months. Beneficial effects of IVIg were evaluated utilizing clinical notes, muscle enzyme levels and clinimetric score. All patients showed an improvement of muscle strength and a significant reduction of muscle enzyme levels (p ................
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