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Oral Premarin raised free cortisol levels by 50% and lowered free T4 by 10%, transdermal estradiol had no effect on either. (Shifren 2007) Ahokas A, Kaukoranta J, Wahlbeck K, Aito M. Estrogen deficiency in severe postpartum depression: successful treatment with sublingual physiologic 17beta-estradiol: a preliminary study. ................
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